Target Organs and Levels of Evidence for TR-566
Toxicology and Carcinogenesis Studies of Diethylamine (CASRN 109-89-7) in F344/N Rats and B6C3F1 Mice (Inhalation studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Diethylamine 109-89-7 |
11/19/2009 |
Inhalation R: 0, 31, 62.5, OR 125 PPM M: 0, 16, 31, OR 62.5 PPM; 50/SEX/SPECIES/DOSE |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; goblet cell, hyperplasia; inflammation, suppurative; olfactory epithelium, accumulation, hyaline droplet; olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; respiratory epithelium, ulcer; turbinate, necrosis
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; goblet cell, hyperplasia; inflammation, suppurative; olfactory epithelium, accumulation, hyaline droplet; olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; respiratory epithelium, ulcer; turbinate, necrosis
- Pleura: Inflammation, chronic
- Lung: Alveolus, infiltration cellular, histiocyte; inflammation, chronic
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; glands, respiratory epithelium, hyperplasia; inflammation, suppurative; olfactory epithelium, atrophy; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, metaplasia, squamous; turbinate, hyperostosis
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; glands, respiratory epithelium, inflammation, chronic active; glands, respiratory epithelium, hyperplasia; inflammation, suppurative; olfactory epithelium, atrophy; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, metaplasia, squamous; respiratory epithelium, necrosis; turbinate, hyperostosis
|