Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/LOE-TR-566

Target Organs and Levels of Evidence for TR-566

Toxicology and Carcinogenesis Studies of Diethylamine (CASRN 109-89-7) in F344/N Rats and B6C3F1 Mice (Inhalation studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Diethylamine
109-89-7		 11/19/2009 Inhalation
R: 0, 31, 62.5, OR 125 PPM M: 0, 16, 31, OR 62.5 PPM; 50/SEX/SPECIES/DOSE		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; goblet cell, hyperplasia; inflammation, suppurative; olfactory epithelium, accumulation, hyaline droplet; olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; respiratory epithelium, ulcer; turbinate, necrosis
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; goblet cell, hyperplasia; inflammation, suppurative; olfactory epithelium, accumulation, hyaline droplet; olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; respiratory epithelium, ulcer; turbinate, necrosis
  • Pleura: Inflammation, chronic
  • Lung: Alveolus, infiltration cellular, histiocyte; inflammation, chronic
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; glands, respiratory epithelium, hyperplasia; inflammation, suppurative; olfactory epithelium, atrophy; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, metaplasia, squamous; turbinate, hyperostosis
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; glands, respiratory epithelium, inflammation, chronic active; glands, respiratory epithelium, hyperplasia; inflammation, suppurative; olfactory epithelium, atrophy; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, metaplasia, squamous; respiratory epithelium, necrosis; turbinate, hyperostosis