Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

alpha/beta Thujone mixture: Target Organs and Levels of Evidence for TR-570

Toxicology and Carcinogenesis Studies of alpha/beta-Thujone (CASRN 76231-76-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DateRoute/Exposure LevelsStudy Laboratory
alpha/beta Thujone mixture
R: 0, 12.5, 25, OR 50 MG/KG M: 0, 3, 6, 12, OR 25 MG/KG 50/SEX/SPECIES
Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Preputial Gland: Carcinoma 1/49 0/49 5/50; adenoma or carcinoma 3/49 1/49 9/50
May Have Been Related
  • Adrenal Gland Medulla: Benign pheochromocytoma 6/50 850 12/49
Non-Neoplastic Lesions
  • Brain: necrosis, severity, pigmentation, severity
  • Spleen: pigmentation
  • Kidney: mineralization
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Brain: pigmentation, severity
  • Pituitary gland: pars distalis, atrophy, Rathkes cleft, dilatation
  • Spleen: pigmentation
Male Mice: No Evidence
Female Mice: No Evidence