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Target Organs and Levels of Evidence for TR-570

Toxicology and Carcinogenesis Studies of alpha/beta-Thujone (CASRN 76231-76-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review Date Route/Exposure Levels Study Laboratory
alpha/beta Thujone mixture
01/26/2011 Gavage
R: 0, 12.5, 25, OR 50 MG/KG M: 0, 3, 6, 12, OR 25 MG/KG 50/SEX/SPECIES
Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Preputial Gland: Carcinoma 1/49 0/49 5/50; adenoma or carcinoma 3/49 1/49 9/50
May Have Been Related
  • Adrenal Gland Medulla: Benign pheochromocytoma 6/50 850 12/49
Non-Neoplastic Lesions
  • Brain: necrosis, severity, pigmentation, severity
  • Spleen: pigmentation
  • Kidney: mineralization
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Brain: pigmentation, severity
  • Pituitary gland: pars distalis, atrophy, Rathkes cleft, dilatation
  • Spleen: pigmentation
Male Mice: No Evidence
Female Mice: No Evidence