Kava kava extract: Target Organs and Levels of Evidence for TR-571
Toxicology and Carcinogenesis Studies of Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Kava kava extract
9000-38-8 | 01/26/2011 | Gavage
R: 0, 0.1, 0.3, OR 1.0 G/KG; M: 0, 0.25, 0.5, OR 1.0 G/KG; 50/SEX/SPECIES/DOSE | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| May Have Been Related | - Testis:
Interstitial cell adenoma 37/49 44/50 49/50 46/50
|
| Non-Neoplastic Lesions | - Liver: Hepatocyte, hypertrophy; centrilobular, fatty change
- Stomach, Forestomach: inflammation; ulcer; epithelium, hyperplasia
- Kidney: Severity of nephropathy; pelvis, transitional epithelium, hyperplasia
- Eye: Retina, degeneration
- Pancreas: Acinus, metaplasia, hepatocyte
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Liver: Hepatocyte, hypertrophy
- Stomach, Forestomach: inflammation; ulcer; epithelium, hyperplasia
- Kidney: Nephropathy
- Eye: Retina, degeneration
- Pancreas: Acinus, metaplasia, hepatocyte
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
Hepatoblastoma 0/50 4/50 9/50 12/50
|
| Non-Neoplastic Lesions | - Liver: Centrilobular, hypertrophy; eosinophilic focus; angiectasis; necrosis
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
Hepatocellular carcinoma 3/50 13/50 8/50 8/50 hepatocellular adenoma or carcinoma 10/50 21/50 20/50 13/50
|
| Non-Neoplastic Lesions | - Liver: Centrilobular, hypertrophy; eosinophilic focus
- Stomach, Forestomach: Inflammation, chronic; epithelium, hyperplasia; erosion; ulcer
|
