Methyl trans-styryl ketone: Target Organs and Levels of Evidence for TR-572
Toxicology and Carcinogenesis Studies of Methyl trans-Styryl Ketone (CASRN 1896-62-4) in F344/N Rats and B6C3F1 Mice (Feed and Dermal Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Methyl trans-styryl ketone
1896-62-4 | 01/26/2011 | Topical Application
R&M: 0, 10, 30, or 90 mg/kg; 50/sex/species/dose | Southern Research Institute |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis; site of application, inflammation, chronic; site of application, hyperplasia, melanocyte
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis; site of application, inflammation, chronic; site of application, hyperplasia, melanocyte
|
