https://ntp.niehs.nih.gov/go/38187

Target Organs and Levels of Evidence for TR-574

Toxicology and Carcinogenesis Studies of Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1 Mice (Topical Application Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Pyrogallol
87-66-1		 02/08/2012 Topical Application
R&M: 0, 5, 20, OR 75 MG/KG; 50/SEX/SPECIES/DOSE		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin (site of application): hyperplasia; hyperkeratosis; inflammation; sebaceous gland, hyperplasia
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin (site of application): hyperplasia; hyperkeratosis; inflammation; sebaceous gland, hyperplasia
Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Skin: (site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 2/50
Non-Neoplastic Lesions
  • Skin (site of application): hyperplasia; hyperkeratosis; inflammation; fibrosis; pigmentation; sebaceous gland, hyperplasia; ulcer
  • Skin: hyperplasia; hyperkeratosis; ulcer; inflammation; fibrosis
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Skin: (site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 4/50
Non-Neoplastic Lesions
  • Skin (site of application): hyperplasia; hyperkeratosis; inflammation; fibrosis; pigmentation; sebaceous gland, hyperplasia; ulcer
  • Skin: hyperplasia; hyperkeratosis; ulcer; inflammation; fibrosis; sebaceous gland, hyperplasia
  • Mammary gland: hyperplasia