Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/LOE-TR-575

Acrylamide: Target Organs and Levels of Evidence for TR-575

Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Acrylamide
79-06-1		04/05/2011Dosed-Water
R&M: 0, 0.0875, 0.175, 0.35, OR 0.70 mM		National Center for Toxicological Research

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Epididymis or Testis: malignant mesothelioma 2/48 2/48 1/48 5/48 8/48
  • Testis: malignant mesothelioma 1/48 2/48 1/48 1/48 5/48
  • Epididymis: malignant mesothelioma 2/48 2/48 1/48 5/48 8/48
  • Heart: malignant Schwannoma 1/48 2/48 3/48 4/48 6/48
  • Pancreas Islet Cell: adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48
  • Thyroid Gland: follicular cell adenoma 0/47 1/48 1/47 1/48 3/48 follicular cell carcinoma 1/47 2/48 3/47 6/48 6/48 follicular cell adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48
Non-Neoplastic Lesions
  • Eye: retina degeneration
  • Peripheral nerve (sciatic): axon degeneration
  • Preputial gland: duct ectasia
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Clitoral Gland: carcinoma 1/4 6/48 12/47 3/48 8/47
  • Heart: malignant Schwannoma 2/48 1/48 0/48 2/48 4/48
  • Liver: adenoma 0/48 0/48 1/48 1/48 3/48
  • Mammary Gland: fibroadenoma 16/48 18/48 24/46 22/47 31/48
  • Oral Cavity: squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48
  • Skin: subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48
  • Thyroid Gland: follicular cell adenoma 0/48 0/48 1/48 0/48 2/47 follicular cell carcinoma 0/48 0/48 1/48 3/48 2/47 follicular cell adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47
Non-Neoplastic Lesions
  • Adrenal cortex: hypertrophy; cytoplasmic vacuolization
  • Bone marrow: hyperplasia
  • Eye: retina degeneration
  • Ovary: atrophy
  • Peripheral nerve (sciatic): axon degeneration
  • Spleen: hematopoietic cell proliferation
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47
  • Lung: alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48
  • Forestomach: squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44
Non-Neoplastic Lesions
  • Eye: cataract
  • Lung: alveolar epithelium hyperplasia
  • Preputial gland: inflammation
  • Spleen: hematopoietic cell proliferation
  • Forestomach: epithelium hyperplasia
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: adenoma 0/45 8/44 20/48 32/47 31/43
  • Lung: alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45
  • Mammary Gland: adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42
  • Ovary: benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42
  • Skin: fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43
  • Forestomach: squamous cell papilloma 4/46 0/46 2/48 5/45 8/42
Non-Neoplastic Lesions
  • Eye: cataract
  • Ovary: cyst
  • Spleen: hematopoietic cell proliferation
  • Forestomach: epithelium hyperplasia