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https://ntp.niehs.nih.gov/go/LOE-TR-575

Acrylamide: Target Organs and Levels of Evidence for TR-575

Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Acrylamide
79-06-1		04/05/2011Dosed-Water
R&M: 0, 0.0875, 0.175, 0.35, OR 0.70 mM		National Center for Toxicological Research

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Epididymis or Testis: malignant mesothelioma 2/48 2/48 1/48 5/48 8/48
  • Testis: malignant mesothelioma 1/48 2/48 1/48 1/48 5/48
  • Epididymis: malignant mesothelioma 2/48 2/48 1/48 5/48 8/48
  • Heart: malignant Schwannoma 1/48 2/48 3/48 4/48 6/48
  • Pancreas Islet Cell: adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48
  • Thyroid Gland: follicular cell adenoma 0/47 1/48 1/47 1/48 3/48 follicular cell carcinoma 1/47 2/48 3/47 6/48 6/48 follicular cell adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48
Non-Neoplastic Lesions
  • Eye: retina degeneration
  • Peripheral nerve (sciatic): axon degeneration
  • Preputial gland: duct ectasia
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Clitoral Gland: carcinoma 1/4 6/48 12/47 3/48 8/47
  • Heart: malignant Schwannoma 2/48 1/48 0/48 2/48 4/48
  • Liver: adenoma 0/48 0/48 1/48 1/48 3/48
  • Mammary Gland: fibroadenoma 16/48 18/48 24/46 22/47 31/48
  • Oral Cavity: squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48
  • Skin: subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48
  • Thyroid Gland: follicular cell adenoma 0/48 0/48 1/48 0/48 2/47 follicular cell carcinoma 0/48 0/48 1/48 3/48 2/47 follicular cell adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47
Non-Neoplastic Lesions
  • Adrenal cortex: hypertrophy; cytoplasmic vacuolization
  • Bone marrow: hyperplasia
  • Eye: retina degeneration
  • Ovary: atrophy
  • Peripheral nerve (sciatic): axon degeneration
  • Spleen: hematopoietic cell proliferation
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47
  • Lung: alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48
  • Forestomach: squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44
Non-Neoplastic Lesions
  • Eye: cataract
  • Lung: alveolar epithelium hyperplasia
  • Preputial gland: inflammation
  • Spleen: hematopoietic cell proliferation
  • Forestomach: epithelium hyperplasia
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: adenoma 0/45 8/44 20/48 32/47 31/43
  • Lung: alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45
  • Mammary Gland: adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42
  • Ovary: benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42
  • Skin: fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43
  • Forestomach: squamous cell papilloma 4/46 0/46 2/48 5/45 8/42
Non-Neoplastic Lesions
  • Eye: cataract
  • Ovary: cyst
  • Spleen: hematopoietic cell proliferation
  • Forestomach: epithelium hyperplasia