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Target Organs and Levels of Evidence for TR-576

Toxicology and Carcinogenesis Studies of Trimethylolpropane triacrylate (CASRN 15625-89-5) in F344/N Rats (Topical Application Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Trimethylolpropane triacrylate 15625-89-5	02/08/2012	Topical Application R&M: 0, 0.3, 1.0, OR 3.0 MG/KG; 65/SEX/SPECIES/DOSE	Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
May Have Been Related	Malignant Mesothelioma: 0/50, 2/50, 2/50, 5/50
Non-Neoplastic Lesions	Skin (site of application): epidermis, hyperplasia; hyperkeratosis

Female Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	Skin (site of application): epidermis, hyperplasia; hyperkeratosis

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	Skin (site of application): epidermis, hyperplasia; hyperplasia, melanocyte; inflammation, chronic

Female Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: hepatoblastoma 0/50, 4/50, 0/50, 3/50; hepatocholangiocarcinoma 0/50, 0/50, 1/50, 2/50 Uterus: stromal polyp or stromal sarcoma 0/50, 1/50, 2/50, 6/50
Non-Neoplastic Lesions	Skin (site of application): epidermis, hyperplasia; hyperplasia, melanocyte; inflammation, chronic