https://ntp.niehs.nih.gov/go/38186

Target Organs and Levels of Evidence for TR-576

Toxicology and Carcinogenesis Studies of Trimethylolpropane triacrylate (CASRN 15625-89-5) in F344/N Rats (Topical Application Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Trimethylolpropane triacrylate
15625-89-5		 02/08/2012 Topical Application
R&M: 0, 0.3, 1.0, OR 3.0 MG/KG; 65/SEX/SPECIES/DOSE		 Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Malignant Mesothelioma: 0/50, 2/50, 2/50, 5/50
Non-Neoplastic Lesions
  • Skin (site of application): epidermis, hyperplasia; hyperkeratosis
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin (site of application): epidermis, hyperplasia; hyperkeratosis
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin (site of application): epidermis, hyperplasia; hyperplasia, melanocyte; inflammation, chronic
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hepatoblastoma 0/50, 4/50, 0/50, 3/50; hepatocholangiocarcinoma 0/50, 0/50, 1/50, 2/50
  • Uterus: stromal polyp or stromal sarcoma 0/50, 1/50, 2/50, 6/50
Non-Neoplastic Lesions
  • Skin (site of application): epidermis, hyperplasia; hyperplasia, melanocyte; inflammation, chronic