Trimethylolpropane triacrylate: Target Organs and Levels of Evidence for TR-576
Toxicology and Carcinogenesis Studies of Trimethylolpropane triacrylate (CASRN 15625-89-5) in F344/N Rats (Topical Application Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Trimethylolpropane triacrylate
15625-89-5 | 02/08/2012 | Topical Application
R&M: 0, 0.3, 1.0, OR 3.0 MG/KG; 65/SEX/SPECIES/DOSE | Southern Research Institute |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| May Have Been Related | - Malignant Mesothelioma:
0/50, 2/50, 2/50, 5/50
|
| Non-Neoplastic Lesions | - Skin (site of application): epidermis, hyperplasia; hyperkeratosis
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Skin (site of application): epidermis, hyperplasia; hyperkeratosis
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Skin (site of application): epidermis, hyperplasia; hyperplasia, melanocyte; inflammation, chronic
|
Female Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
hepatoblastoma 0/50, 4/50, 0/50, 3/50; hepatocholangiocarcinoma 0/50, 0/50, 1/50, 2/50
- Uterus:
stromal polyp or stromal sarcoma 0/50, 1/50, 2/50, 6/50
|
| Non-Neoplastic Lesions | - Skin (site of application): epidermis, hyperplasia; hyperplasia, melanocyte; inflammation, chronic
|
