Target Organs and Levels of Evidence for TR-576
Toxicology and Carcinogenesis Studies of Trimethylolpropane triacrylate (CASRN 15625-89-5) in F344/N Rats (Topical Application Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Trimethylolpropane triacrylate
15625-89-5 |
02/08/2012 |
Topical Application
R&M: 0, 0.3, 1.0, OR 3.0 MG/KG; 65/SEX/SPECIES/DOSE |
Southern Research Institute |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| May Have Been Related |
- Malignant Mesothelioma: 0/50, 2/50, 2/50, 5/50
|
| Non-Neoplastic Lesions |
- Skin (site of application): epidermis, hyperplasia; hyperkeratosis
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- Skin (site of application): epidermis, hyperplasia; hyperkeratosis
|
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- Skin (site of application): epidermis, hyperplasia; hyperplasia, melanocyte; inflammation, chronic
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: hepatoblastoma 0/50, 4/50, 0/50, 3/50; hepatocholangiocarcinoma 0/50, 0/50, 1/50, 2/50
- Uterus: stromal polyp or stromal sarcoma 0/50, 1/50, 2/50, 6/50
|
| Non-Neoplastic Lesions |
- Skin (site of application): epidermis, hyperplasia; hyperplasia, melanocyte; inflammation, chronic
|
