Ginkgo biloba extract: Target Organs and Levels of Evidence for TR-578
Toxicology and Carinogenesis Studies of Ginkgo Biloba Extract (CASRN 90045-36-6) in F344/N Rats and B6C3F1/N Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Ginkgo biloba extract
90045-36-6 | 02/08/2012 | Gavage
R: 0, 100, 300, OR 1000 MG/KG; M: 0, 200, 600, OR 2000 MG/KG; 50/SEX/SPECIES/DOSE | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland:
follicular cell, adenoma 2/50, 1/50, 3/49, 5/45
|
| May Have Been Related | - Mononuclear Cell Leukemia:
9/50, 12/50, 22/50, 21/50
- Liver:
hepatocellular adenoma 0/50, 3/50, 3/50, 0/50
|
| Non-Neoplastic Lesions | - Liver: hepatocyte, hypertrophy; bile duct, hyperplasia; oval cell, hyperplasia; degeneration, cystic; necrosis
- Thyroid gland: follicular cell hypertrophy; follicle, hyperplasia
- Kidney: severity of nephropathy
- Nasal Cavity: transitional epithelium, hyperplasia; respiratory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, respiratory metaplasia; nerve, olfactory epithelium, atrophy; olfactory epithelium, pigmentation; inflammation, chronic active; goblet cell, respiratory epithelium, hyperplasia; submucosa, fibrosis
|
Female Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Thyroid Gland:
follicular cell, adenoma 1/49, 0/50, 3/49, 1/49; follicular cell, carcinoma 0/49, 0/50, 1/49, 1/49
|
| May Have Been Related | - Nasal Cavity:
respiratory epithelium, adenoma 0/49, 0/49, 2/50, 0/46
|
| Non-Neoplastic Lesions | - Liver: hepatocyte, hypertrophy; bile duct, hyperplasia; fatty change, focal
- Thyroid gland: follicular cell, hypertrophy
- Nasal Cavity: transitional epithelium, hyperplasia; respiratory epithelium, hyperplasia; olfactory epithelium, atrophy; olfactory epithelium, respiratory metaplasia; nerve, olfactory epithelium, atrophy; olfactory epithelium, pigmentation; inflammation, chronic active; goblet cell, respiratory epithelium, hyperplasia
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
hepatocellular carcinoma 22/50, 31/50, 41/50, 47/50; hepatoblastoma 3/50, 28/50, 36/50, 38/50
- Thyroid Gland:
follicular cell, adenoma 0/50, 0/50, 2/50, 2/50
|
| Non-Neoplastic Lesions | - Liver: hypertrophy; erythrophagocytosis; hematopoietic cell proliferation; inflammation; necrosis
- Thyroid gland: follicle hyperplasia; follicular cell hypertrophy
- Forestomach: inflammation; epithelium hyperplasia; epithelium hyperkeratosis; epithelium ulcer
- Nasal Cavity: olfactory epithelium, hyaline droplet accumulation; olfactory epithelium, pigmentation
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver:
hepatocellular adenoma 17/50, 37/50, 41/50, 48/50; hepatocellular carcinoma 9/50, 10/50, 15/50, 44/50; hepatoblastoma 1/50, 1/50, 8/50, 11/50
|
| Non-Neoplastic Lesions | - Liver: hypertrophy; erythrophagocytosis; vacuolization cytoplasmic; eosinophilic focus; mixed cell focus
- Thyroid gland: follicular cell hypertrophy
- Forestomach: inflammation; epithelium hyperplasia; epithelium hyperkeratosis; epithelium ulcer
- Nasal Cavity: olfactory epithelium, hyaline droplet accumulation; olfactory epithelium, pigmentation
|
