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Target Organs and Levels of Evidence for TR-580

Toxicology and Carcinogenesis Studies of beta-Picoline (CASRN 108-99-6) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
Peer Review Date Route/Exposure Levels Study Laboratory
02/08/2012 Dosed-Water
R: 0, 156.25, 312.5, or 625 mg/L M: 0, 312.5, 625, or 1250 mg/L; 50/sex/species/dose
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar adenoma 0/50 3/50 2/50 5/50 alveolar/bronchiolar adenoma or carcinoma 0/50 4/50 2/50 5/50
Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Lung: alveolar/bronchiolar adenoma 6/50 11/50 16/50 8/50 alveolar/bronchiolar adenoma or carcinoma 14/50 19/50 21/50 15/50
Non-Neoplastic Lesions
  • Nasal Cavity: olfactory epithelium, metaplasia, respiratory
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hepatocellular carcinoma 11/49 20/50 26/50 23/50 hepatoblastoma 1/49 3/50 4/50 4/50
  • Lung: alveolar/bronchiolar adenoma 5/50 6/50 4/49 11/50 carcinoma 7/50 8/50 10/49 13/50 alveolar/bronchiolar adenoma or carcinoma 11/50 13/50 13/49 21/50
Non-Neoplastic Lesions
  • Lung: alveolar epithelium, hyperplasia
  • Nasal Cavity: olfactory epithelium, metaplasia, respiratory; olfactory epithelium, atrophy