Target Organs and Levels of Evidence for TR-581
Toxicology Studies of Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Cobalt Metal in F344/NTac Rats and B6C3F1/N Mice (Inhalation Studies)
Chemical CASRN (Study Title) |
Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
---|---|---|---|---|
Cobalt 7440-48-4 |
10/29/2013 | Nuclear medicine and research, industry, paints, water treatment, metallurgy (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. | Inhalation R&M: 0, 1.25, 2.5, or 5 mg/m3; 50/sex/species/dose |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
May Have Been Related |
|
Non-Neoplastic Lesions |
|
Female Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
May Have Been Related |
|
Non-Neoplastic Lesions |
|
Male Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
May Have Been Related |
|
Non-Neoplastic Lesions |
|