Target Organs and Levels of Evidence for TR-582
Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical CASRN (Study Title) |
Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
---|---|---|---|---|
Vinylidene Chloride 75-35-4 |
10/29/2013 | Copolymerized with vinychloride or acrylonitrile for saran and saran fibers. A widely used chemical intermediate and monomer. | Inhalation R: 0, 25, 50, or 100 ppm; M: 0, 6.25, 12.5, or 25 ppm; 50/sex/species/dose |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|
Female Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
May Have Been Related |
|
Non-Neoplastic Lesions |
|
Male Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
May Have Been Related |
|
Non-Neoplastic Lesions |
|
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
May Have Been Related |
|
Non-Neoplastic Lesions |
|