Target Organs and Levels of Evidence for TR-582
Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical CASRN (Study Title) |
Peer Review Date |
Primary Uses |
Route/Exposure Levels |
Study Laboratory |
Vinylidene Chloride 75-35-4 |
10/29/2013 |
Copolymerized with vinychloride or acrylonitrile for saran and saran fibers. A widely used chemical intermediate and monomer. |
Inhalation R: 0, 25, 50, or 100 ppm; M: 0, 6.25, 12.5, or 25 ppm; 50/sex/species/dose |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- All Organs: malignant mesothelioma 1/50 12/50 28/50 23/50
- Kidney: renal tubule carcinoma 0/50 2/50 1/49 1/50
- Nasal Cavity: respiratory epithelium, adenoma 0/49 0/50 1/50 4/50
|
Non-Neoplastic Lesions |
- Nasal Cavity: turbinate, atrophy; turbinate, hyperostosis; olfactory epithelium, metaplasia, respiratory; respiratory epithelium, hyperplasia; inflammation, chronic active
- Lung: alveolar epithelium hyperplasia
- Liver: chronic inflammation; diffuse fatty change; cystic degeneration
|
Female Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Thyroid Gland C-Cell: adenoma 3/50 4/50 6/48 11/50; carcinoma 0/50 6/50 2/48 2/50 adenoma or carcinoma 3/50 10/50 8/48 13/50
- All Organs: mononuclear cell leukemia 10/50 11/50 13/50 25/50
|
May Have Been Related |
- All Organs: malignant mesothelioma 0/50 1/50 1/50 0/50
|
Non-Neoplastic Lesions |
- Nasal Cavity: turbinate, atrophy; turbinate, hyperostosis; olfactory epithelium, metaplasia, respiratory; respiratory epithelium, hyperplasia; inflammation, chronic active
- Liver: chronic inflammation; diffuse fatty change; cystic degeneration; necrosis
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney: renal tubule adenoma 0/50 5/50 19/50 10/50 renal tubule carcinoma 0/50 7/50 31/50 18/50 renal tubule adenoma or carcinoma 0/50 11/50 37/50 27/50
|
May Have Been Related |
- Liver: hepatocholangiocarcionoma 1/50 2/50 2/50 3/50
|
Non-Neoplastic Lesions |
- Kidney: renal tubule hyperplasia
- Nasal Cavity: turbinate, atrophy; hyperostosis; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, accumulation, hyaline droplet
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- All Organs: hemangioma or hemangiosarcoma 4/50 6/50 6/50 11/50
- Liver: hepatocellular adenoma 25/50 21/50 36/50 29/50 hepatocellular carcinoma 8/50 14/50 12/50 17/50 hepatocellular adenoma or carcinoma 28/50 30/50 37/50 38/50 hepatocholangiocarcinoma 0/50 1/50 1/50 2/50
|
May Have Been Related |
- Lung: alveolar/bronchiolar carcinoma 1/50 2/50 7/50 5/49
- Intestines (Small): (Ileum): carcinoma 1/50 1/50 1/50 3/50
|
Non-Neoplastic Lesions |
- Nasal Cavity: turbinate, atrophy; hyperostosis; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia
|