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https://ntp.niehs.nih.gov/go/LOE-TR-582

Target Organs and Levels of Evidence for TR-582

Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical
CASRN
(Study Title)		 Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Vinylidene Chloride
75-35-4		 10/29/2013 Copolymerized with vinychloride or acrylonitrile for saran and saran fibers. A widely used chemical intermediate and monomer. Inhalation
R: 0, 25, 50, or 100 ppm; M: 0, 6.25, 12.5, or 25 ppm; 50/sex/species/dose		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • All Organs: malignant mesothelioma 1/50 12/50 28/50 23/50
  • Kidney: renal tubule carcinoma 0/50 2/50 1/49 1/50
  • Nasal Cavity: respiratory epithelium, adenoma 0/49 0/50 1/50 4/50
Non-Neoplastic Lesions
  • Nasal Cavity: turbinate, atrophy; turbinate, hyperostosis; olfactory epithelium, metaplasia, respiratory; respiratory epithelium, hyperplasia; inflammation, chronic active
  • Lung: alveolar epithelium hyperplasia
  • Liver: chronic inflammation; diffuse fatty change; cystic degeneration
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland C-Cell: adenoma 3/50 4/50 6/48 11/50; carcinoma 0/50 6/50 2/48 2/50 adenoma or carcinoma 3/50 10/50 8/48 13/50
  • All Organs: mononuclear cell leukemia 10/50 11/50 13/50 25/50
May Have Been Related
  • All Organs: malignant mesothelioma 0/50 1/50 1/50 0/50
Non-Neoplastic Lesions
  • Nasal Cavity: turbinate, atrophy; turbinate, hyperostosis; olfactory epithelium, metaplasia, respiratory; respiratory epithelium, hyperplasia; inflammation, chronic active
  • Liver: chronic inflammation; diffuse fatty change; cystic degeneration; necrosis
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney: renal tubule adenoma 0/50 5/50 19/50 10/50 renal tubule carcinoma 0/50 7/50 31/50 18/50 renal tubule adenoma or carcinoma 0/50 11/50 37/50 27/50
May Have Been Related
  • Liver: hepatocholangiocarcionoma 1/50 2/50 2/50 3/50
Non-Neoplastic Lesions
  • Kidney: renal tubule hyperplasia
  • Nasal Cavity: turbinate, atrophy; hyperostosis; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, accumulation, hyaline droplet
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • All Organs: hemangioma or hemangiosarcoma 4/50 6/50 6/50 11/50
  • Liver: hepatocellular adenoma 25/50 21/50 36/50 29/50 hepatocellular carcinoma 8/50 14/50 12/50 17/50 hepatocellular adenoma or carcinoma 28/50 30/50 37/50 38/50 hepatocholangiocarcinoma 0/50 1/50 1/50 2/50
May Have Been Related
  • Lung: alveolar/bronchiolar carcinoma 1/50 2/50 7/50 5/49
  • Intestines (Small): (Ileum): carcinoma 1/50 1/50 1/50 3/50
Non-Neoplastic Lesions
  • Nasal Cavity: turbinate, atrophy; hyperostosis; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia