Vinylidene Chloride: Target Organs and Levels of Evidence for TR-582
Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical
CASRN
(Study Title)
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Peer Review Date
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Primary Uses
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Route/Exposure Levels
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Study Laboratory
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Vinylidene Chloride
75-35-4
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10/29/2013
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Copolymerized with vinychloride or acrylonitrile for saran and saran fibers. A widely used chemical intermediate and monomer.
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Inhalation
R: 0, 25, 50, or 100 ppm; M: 0, 6.25, 12.5, or 25 ppm; 50/sex/species/dose
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Battelle Northwest Laboratory
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Levels of Evidence
Male Rats: Clear Evidence
Type
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Organ/Tissue (Lesion)
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Neoplastic Lesions
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-
All Organs: malignant mesothelioma 1/50 12/50 28/50 23/50
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Kidney: renal tubule carcinoma 0/50 2/50 1/49 1/50
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Nasal Cavity: respiratory epithelium, adenoma 0/49 0/50 1/50 4/50
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Non-Neoplastic Lesions
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Nasal Cavity: turbinate, atrophy; turbinate, hyperostosis; olfactory epithelium, metaplasia, respiratory; respiratory epithelium, hyperplasia; inflammation, chronic active
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Lung: alveolar epithelium hyperplasia
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Liver: chronic inflammation; diffuse fatty change; cystic degeneration
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Female Rats: Some Evidence
Type
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Organ/Tissue (Lesion)
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Neoplastic Lesions
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Thyroid Gland C-Cell: adenoma 3/50 4/50 6/48 11/50; carcinoma 0/50 6/50 2/48 2/50 adenoma or carcinoma 3/50 10/50 8/48 13/50
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All Organs: mononuclear cell leukemia 10/50 11/50 13/50 25/50
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May Have Been Related
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All Organs: malignant mesothelioma 0/50 1/50 1/50 0/50
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Non-Neoplastic Lesions
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-
Nasal Cavity: turbinate, atrophy; turbinate, hyperostosis; olfactory epithelium, metaplasia, respiratory; respiratory epithelium, hyperplasia; inflammation, chronic active
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Liver: chronic inflammation; diffuse fatty change; cystic degeneration; necrosis
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Male Mice: Clear Evidence
Type
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Organ/Tissue (Lesion)
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Neoplastic Lesions
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-
Kidney: renal tubule adenoma 0/50 5/50 19/50 10/50 renal tubule carcinoma 0/50 7/50 31/50 18/50 renal tubule adenoma or carcinoma 0/50 11/50 37/50 27/50
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May Have Been Related
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Liver: hepatocholangiocarcionoma 1/50 2/50 2/50 3/50
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Non-Neoplastic Lesions
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Kidney: renal tubule hyperplasia
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Nasal Cavity: turbinate, atrophy; hyperostosis; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, accumulation, hyaline droplet
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Female Mice: Clear Evidence
Type
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Organ/Tissue (Lesion)
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Neoplastic Lesions
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-
All Organs: hemangioma or hemangiosarcoma 4/50 6/50 6/50 11/50
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Liver: hepatocellular adenoma 25/50 21/50 36/50 29/50 hepatocellular carcinoma 8/50 14/50 12/50 17/50 hepatocellular adenoma or carcinoma 28/50 30/50 37/50 38/50 hepatocholangiocarcinoma 0/50 1/50 1/50 2/50
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May Have Been Related
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Lung: alveolar/bronchiolar carcinoma 1/50 2/50 7/50 5/49
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Intestines (Small): (Ileum): carcinoma 1/50 1/50 1/50 3/50
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Non-Neoplastic Lesions
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-
Nasal Cavity: turbinate, atrophy; hyperostosis; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia
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