https://ntp.niehs.nih.gov/go/727777

Target Organs and Levels of Evidence for TR-586

Toxicology and Carcinogenesis Studies of CIMSTAR 3800 (CASRN CIMSTAR3800) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)

Chemical
CASRN
(Study Title)		 Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Metal working fluids (CIMSTAR 3800)
CIMSTAR3800		 05/22/2014 Semisynthetic; metalworking fluid Inhalation
R&M: 0, 10, 30, or 100 mg/m3; 50/sex/species/dose		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Prostate Gland: adenoma 1/50 1/50 1/50 3/50 adenoma or carcinoma 1/50 1/50 2/50 3/50
Non-Neoplastic Lesions
  • Nasal Cavity: goblet cell, hyperplasia; glands, olfactory epithelium, hyperplasia; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet
  • Larynx: metaplasia, squamous
  • Lung: inflammation, lymphohistiocytic; bronchus-associated lymphoid tissue, hyperplasia, lymphohistiocytic; alveolar epithelium, hyperplasia
  • Lymph node, bronchial: hyperplasia, lymphohistiocytic
  • Lymph node, mediastinal: hyperplasia, lymphohistiocytic
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Skin: squamous cell papilloma or keratoacanthoma 0/50 0/50 0/50 4/50
  • Uterus: adenocarcinoma or mixed malignant Müllerian tumor (original and residual longitudinal evaluation combined) 1/50 4/50 5/50 6/50
Non-Neoplastic Lesions
  • Nasal Cavity: goblet cell, hyperplasia; glands, olfactory epithelium, hyperplasia; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet
  • Larynx: metaplasia, squamous
  • Lung: inflammation, lymphohistiocytic; bronchus-associated lymphoid tissue, hyperplasia, lymphohistiocytic
  • Lymph node, bronchial: hyperplasia, lymphohistiocytic
  • Lymph node, mediastinal: hyperplasia, lymphohistiocytic
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Lung: bronchiole, hyperplasia; alveolar epithelium, hyperplasia; infiltration cellular, histiocyte
  • Nasal Cavity: olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, atrophy; inflammation, chronic active
  • Larynx: metaplasia, squamous; inflammation, chronic active
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland: follicular cell carcinoma 0/50 0/48 0/50 3/50
  • Lung: alveolar/bronchiolar carcinoma 4/50 1/50 4/50 8/50 alveolar/bronchiolar adenoma or carcinoma 4/50 5/50 6/50 12/50
Non-Neoplastic Lesions
  • Thyroid gland: follicular cell, hyperplasia
  • Lung: bronchiole, hyperplasia; alveolar epithelium, hyperplasia; infiltration cellular, histiocyte; perivascular, inflammation, chronic active
  • Nasal Cavity: olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet; olfactory epithelium, metaplasia, respiratory
  • Larynx: metaplasia, squamous; inflammation, chronic active