Target Organs and Levels of Evidence for TR-587
Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats and B6C3F1/N Mice (Gavage Studies)
Chemical
CASRN
(Study Title) |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Tetrabromobisphenol A
79-94-7 |
10/29/2013 |
Gavage
R&M: 0, 250, 500, or 1000 mg/kg; 50/sex/species/dose |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| May Have Been Related |
- Testis: interstitial cell, adenoma 0/50 0/50 1/50 3/50
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Uterus: adenoma (original transverse review) 0/50 0/50 3/50 4/50 adenocarcinoma (original transverse review) 3/50 3/50 8/50 9/50 (original transverse and residual longitudinal reviews, combined) 4/50 10/50 15/50 16/50 malignant mixed Müllerian tumor (original transverse review) 0/50 4/50 0/50 2/50 adenoma, adenocarcinoma, or malignant mixed Müllerian tumor (original transverse review) 3/50 7/50 11/50 13/50 (original transverse and residual longitudinal reviews, combined) 6/50 11/50 16/50 19/50
|
| Non-Neoplastic Lesions |
- Uterus: endometrium, hyperplasia, atypical (residual longitudinal review)
- Ovary: rete ovarii cyst
|
Male Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: hepatoblastoma 2/50 11/50 8/50
|
| May Have Been Related |
- Intestines (Large): (Cecum or Colon) adenoma or carcinoma 0/50 0/50 3/50
- All Organs: (Hemangiosarcoma) 1/50 5/50 8/50
|
| Non-Neoplastic Lesions |
- Liver: clear cell focus; eosinophilic focus
- Kidney: renal tubule, cytoplasmic alteration
- Forestomach: ulcer; infiltration cellular, mononuclear cell; inflammation; epithelium, hyperplasia
|
Female Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- Forestomach: ulcer; infiltration cellular, mononuclear cell; inflammation; epithelium, hyperplasia
|
