Target Organs and Levels of Evidence for TR-588
Toxicology and Carcinogenesis Studies of Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and B6C3F1/Nctr Mice (Dosed-Water Studies)
Chemical
CASRN
(Study Title) |
Peer Review Date |
Primary Uses |
Route/Exposure Levels |
Study Laboratory |
Glycidamide
5694-00-8 |
10/29/2013 |
Metabolite of acrylamide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. |
Dosed-Water
R&M: 0, 0.0875, 0.175, 0.35, OR 0.70 MM |
National Center for Toxicological Research |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Epididymis: malignant mesothelioma 0/48 1/45 3/48 10/47 17/47
- Testis: malignant mesothelioma 0/48 1/47 3/48 6/47 13/48
- Epididymis or Testis: malignant mesothelioma 0/48 1/48 3/48 10/47 17/48
- Heart: malignant schwannoma 2/48 3/48 3/48 7/47 8/48
- Oral Cavity: Oral mucosa: squamous cell papilloma 1/48 1/48 0/48 2/47 3/48 squamous cell carcinoma 1/48 0/48 1/48 1/47 0/48
- Oral Cavity: Tongue: squamous cell papilloma 0/48 1/48 0/48 1/47 4/48
- Oral Cavity: Oral mucosa or tongue: squamous cell papilloma or carcinoma 2/48 2/48 2/48 3/47 7/48
- Thyroid Gland Follicular Cell: adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46
|
| May Have Been Related |
- Mononuclear Cell Leukemia: 21/48 26/48 27/48 27/47 31/48
|
| Non-Neoplastic Lesions |
- Brain: gliosis
- Epididymis: exfoliated germ cells
- Liver: hepatocyte degeneration; necrosis
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Clitoral Gland: carcinoma 4/48 6/48 7/48 11/48 14/47
- Mammary Gland: fibroadenoma 16/48 26/48 35/48 33/48 36/48
- Oral Cavity: Oral mucosa: squamous cell papilloma 1/48 1/48 2/48 0/48 4/48 squamous cell carcinoma 0/48 0/48 0/48 1/48 2/48
- Oral Cavity: Tongue: squamous cell papilloma 0/48 1/48 0/48 1/48 0/48 squamous cell carcinoma 0/48 0/48 0/48 0/48 1/48
- Oral Cavity: Oral mucosa or tongue: squamous cell papilloma or carcinoma 1/48 2/48 2/48 2/48 7/48
- Forestomach: squamous cell papilloma 0/48 1/48 0/48 0/47 3/46
- Thyroid Gland Follicular Cell: adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47
- Mononuclear Cell Leukemia: 14/48 11/48 21/48 19/48 27/48
|
| Non-Neoplastic Lesions |
- Brain: gliosis
- Bone marrow: hyperplasia
- Spinal cord (lumbar): axonal degeneration
- Uterus: endometrial hyperplasia
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Harderian Gland: adenoma 3/47 17/47 23/47 32/46 42/47
- Lung: alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47
- Skin: squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46
- Forestomach: squamous cell papilloma 0/47 2/45 3/48 2/45 10/41 squamous cell carcinoma 0/47 0/45 0/48 0/45 2/41 squamous cell papilloma or carcinoma 0/47 2/45 3/48 2/45 12/41
|
| Non-Neoplastic Lesions |
- Eye: cataract; corneal inflammation
- Preputial gland: degeneration; ductal dilatation; inflammation
- Spleen: hematopoietic cell proliferation
- Forestomach: epithelial hyperplasia
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Harderian Gland: adenoma 2/45 19/47 20/47 24/46 40/46
- Lung: alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44
- Mammary Gland: adenoacanthoma 0/45 0/48 0/47 1/47 8/45 adenocarcinoma 1/45 1/48 2/47 9/47 11/45 adenoacanthoma or adenocarcinoma 1/45 1/48 2/47 9/47 18/45
- Skin: fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45
- Forestomach: squamous cell papilloma 1/45 1/45 1/47 5/45 9/44
|
| May Have Been Related |
- Ovary: granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44
|
| Non-Neoplastic Lesions |
- Eye: cataract; corneal inflammation
- Liver: angiectasis; necrosis
- Ovary: cyst
- Spinal cord (cervical): axonal degeneration
- Spleen: hematopoietic cell proliferation
- Forestomach: epithelial hyperplasia
|
