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https://ntp.niehs.nih.gov/go/804209

Target Organs and Levels of Evidence for TR-591

TR-591 Toxicology and Carcinogenesis Studies of Trim® VX (CASRN TRIMVX) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)

Chemical
CASRN
(Study Title)		 Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Metal Working Fluids: TRIM® VX
TRIMVX		   Soluble oil; metalworking fluid Inhalation
R&M: 0, 10, 30, or 100 mg/m3; 50/sex/species/dose		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Lung: alveolar/bronchiolar carcinoma 0/50 0/50 0/50 2/50 alveolar/bronchiolar adenoma or carcinoma 0/50 0/50 0/50 3/50
Non-Neoplastic Lesions
  • Lung: alveolar epithelium, hyperplasia; alveolar/ bronchiolar epithelium, hyperplasia; fibrosis; infiltration cellular, histiocyte; inflammation, chronic active; alveolar epithelium, metaplasia, squamous; bronchus-associated lymphoid tissue, hyperplasia, lymphohistiocytic; alveolus, proteinosis
  • Nasal Cavity: glands, olfactory epithelium, hyperplasia; goblet cell, hyperplasia; inflammation, suppurative; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia
  • Larynx: epiglottis, hyperplasia, squamous; epiglottis, metaplasia, squamous; infiltration cellular, mixed cell
  • Lymph node, bronchial: hyperplasia, lymphohistiocytic
  • Lymph node, mediastinal: hyperplasia, lymphohistiocytic
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Liver: alveolar/bronchiolar adenoma 0/50 0/50 1/50 3/50
Non-Neoplastic Lesions
  • Lung: alveolar epithelium, hyperplasia; alveolar/ bronchiolar epithelium, hyperplasia; fibrosis; infiltration cellular, histiocyte; inflammation, chronic active; alveolar epithelium, metaplasia, squamous; bronchus-associated lymphoid tissue, hyperplasia, lymphohistiocytic; alveolus, proteinosis
  • Nose: glands, olfactory epithelium, hyperplasia; goblet cell, hyperplasia; inflammation, suppurative; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia; transitional epithelium, hyperplasia
  • Larynx: epiglottis, hyperplasia, squamous; epiglottis, metaplasia, squamous; infiltration cellular, mixed cell
  • Lymph node, bronchial: hyperplasia, lymphohistiocytic
  • Lymph node, mediastinal: hyperplasia, lymphohistiocytic
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar adenoma or carcinoma 14/50 14/50 11/49 23/50
Non-Neoplastic Lesions
  • Lung: alveolar/bronchiolar epithelium, hyperplasia; infiltration cellular, histiocyte; inflammation, chronic; alveolar epithelium, hyperplasia; fibrosis
  • Nasal Cavity: exudate; inflammation, chronic active; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, atrophy; respiratory epithelium, necrosis; turbinate, atrophy; turbinate, perforation; nasopharyngeal duct, perforation
  • Larynx: epiglottis, hyperplasia, squamous; epiglottis, metaplasia, squamous
  • Lymph node, bronchial: hyperplasia, lymphoid; infiltration cellular, histiocyte
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar carcinoma 5/50 3/50 6/50 14/50 alveolar/bronchiolar adenoma or carcinoma 9/50 8/50 8/50 20/50
Non-Neoplastic Lesions
  • Lung: alveolar/bronchiolar epithelium, hyperplasia; infiltration cellular, histiocyte; inflammation, chronic; alveolar epithelium, hyperplasia; fibrosis
  • Nose: exudate; inflammation, chronic active; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, atrophy; respiratory epithelium, necrosis; turbinate, atrophy; turbinate, perforation; nasopharyngeal duct, perforation
  • Larynx: epiglottis, hyperplasia, squamous; epiglottis, metaplasia, squamous