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Target Organs and Levels of Evidence for TR-592

TR-592 Toxicology and Carcinogenesis Study of Dietary Zinc (CASRN 5263-02-5) in Sprague Dawley Rats (Hsd:Sprague Dawley SD) (Feed Studies)

Chemical CASRN (Study Title)	Peer Review Date	Primary Uses	Route/Exposure Levels	Study Laboratory
Zinc Carbonate, Basic 5263-02-5	07/13/2017	Antiseptic (topical); astringent; dietary supplement.	Dosed-Feed R: 3.5, 7, 38 (control), 250, or 500 ppm zinc; 60/sex/group	Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
May Have Been Related	Pancreas Acinar Cell: adenoma (21/50, 19/48, 11/49, 13/48, 10/48)
Non-Neoplastic Lesions	Pancreas: acinus, atrophy Testis: bilateral, germinal epithelium, atrophy; germinal epithelium, atrophy; germinal epithelium, atrophy, includes bilateral

Female Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	Pancreas: acinus, atrophy