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Target Organs and Levels of Evidence for TR-592

TR-592 Toxicology and Carcinogenesis Study of Dietary Zinc (CASRN 5263-02-5) in Sprague Dawley Rats (Hsd:Sprague Dawley SD) (Feed Studies)

(Study Title)
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Zinc Carbonate, Basic
07/13/2017 Antiseptic (topical); astringent; dietary supplement. Dosed-Feed
R: 3.5, 7, 38 (control), 250, or 500 ppm zinc; 60/sex/group
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Pancreas Acinar Cell: adenoma (21/50, 19/48, 11/49, 13/48, 10/48)
Non-Neoplastic Lesions
  • Pancreas: acinus, atrophy
  • Testis: bilateral, germinal epithelium, atrophy; germinal epithelium, atrophy; germinal epithelium, atrophy, includes bilateral
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Pancreas: acinus, atrophy