Target Organs and Levels of Evidence for TR-593
TR-593 Toxicology and Carcinogenesis Studies of 2,3-Butanedione (CASRN 431-03-8) in Wistar Han [Crl:WI (Han)] Rats and B6C3F1/N Mice (Inhalation Studies)
Chemical CASRN (Study Title) |
Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
---|---|---|---|---|
2,3-Butanedione 431-03-8 |
07/13/2017 | Flavorant. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. | Inhalation 0, 12.5, 25, or 50 ppm; R&M: 50/sex/species/concentration |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|
Female Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|
Male Mice: No Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Non-Neoplastic Lesions |
|
Female Mice: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|---|
May Have Been Related |
|
Non-Neoplastic Lesions |
|