Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/853667

Target Organs and Levels of Evidence for TR-593

TR-593 Toxicology and Carcinogenesis Studies of 2,3-Butanedione (CASRN 431-03-8) in Wistar Han [Crl:WI (Han)] Rats and B6C3F1/N Mice (Inhalation Studies)

Chemical
CASRN
(Study Title)		 Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
2,3-Butanedione
431-03-8		 07/13/2017 Flavorant. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Inhalation
0, 12.5, 25, or 50 ppm; R&M: 50/sex/species/concentration		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: squamous cell carcinoma (0/50, 0/50, 0/50, 3/50); squamous cell papilloma or carcinoma (0/50, 0/50, 0/50, 4/50)
Non-Neoplastic Lesions
  • Nasal Cavity: inflammation, suppurative; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, necrosis; turbinate, hyperostosis; lamina propria, fibrosis
  • Larynx: inflammation, chronic active; squamous epithelium, hyperplasia; squamous epithelium, ulcer, focal; respiratory epithelium, metaplasia, squamous
  • Trachea: inflammation, chronic active; epithelium, hyperplasia; epithelium, metaplasia, squamous; epithelium, regeneration; epithelium, atrophy; epithelium, necrosis; submucosa, fibrosis
  • Lung: inflammation, suppurative; peribronchial, inflammation, chronic active; bronchus, epithelium, hyperplasia; bronchiole, epithelium, hyperplasia; bronchus, epithelium, atrophy; bronchus, epithelium, regeneration; bronchus, submucosa, fibrosis; alveolus, infiltration cellular, histiocyte; alveolar epithelium, hyperplasia; interstitium, fibrosis
  • Eye: cornea, inflammation, chronic active; anterior chamber, inflammation, suppurative; cornea, epithelium, hyperplasia; cornea, epithelium, ulcer; lens, cataract
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: squamous cell carcinoma (0/50, 0/50, 0/50, 3/50)
Non-Neoplastic Lesions
  • Nasal Cavity: inflammation, suppurative; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; turbinate, hyperostosis; lamina propria, fibrosis
  • Larynx: inflammation, chronic active; squamous epithelium, hyperplasia; squamous epithelium, ulcer, focal; respiratory epithelium, metaplasia, squamous
  • Trachea: inflammation, chronic active; epithelium, hyperplasia; submucosa, fibrosis
  • Lung: inflammation, granulomatous; peribronchial, inflammation, chronic active; bronchus, epithelium, hyperplasia; bronchiole, epithelium, hyperplasia; bronchus, epithelium, atrophy; alveolus, infiltration cellular, histiocyte; interstitium, fibrosis
  • Eye: cornea, inflammation, chronic active; anterior chamber, inflammation, suppurative; iris, inflammation, acute; cornea, epithelium, hyperplasia; cornea, epithelium, ulcer; lens, cataract; unilateral, phthisis bulbi
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: inflammation, suppurative; respiratory epithelium, metaplasia, squamous; respiratory epithelium, hyperplasia; glands, sinus, metaplasia, respiratory; respiratory epithelium, necrosis; mucosa, regeneration; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, necrosis; turbinate, atrophy; turbinate, necrosis; septum, perforation; lamina propria, fibrosis
  • Larynx: inflammation, chronic active; respiratory epithelium, metaplasia, squamous; squamous epithelium, hyperplasia; respiratory epithelium, hyperplasia; respiratory epithelium, necrosis; respiratory epithelium, regeneration
  • Trachea: inflammation, chronic active; lumen, exudate; necrosis; epithelium, regeneration; epithelium, hyperplasia; epithelium, metaplasia, squamous; submucosa, fibrosis; carina, submucosa, fibrosis; carina, submucosa, mineralization; carina, submucosa, inflammation, chronic active
  • Lung: bronchus, epithelium, regeneration; mediastinum, inflammation, chronic active
  • Eye: cornea, inflammation, acute; cornea, mineralization; cornea, epithelium, hyperplasia; anterior chamber, inflammation, suppurative
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Nasal Cavity: adenocarcinoma (0/50, 0/50, 0/50, 2/50)
Non-Neoplastic Lesions
  • Nasal Cavity: inflammation, suppurative; respiratory epithelium, metaplasia, squamous; glands, sinus, metaplasia, respiratory; respiratory epithelium, necrosis; mucosa, regeneration; olfactory epithelium, atrophy; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, necrosis; turbinate, atrophy; turbinate, necrosis; septum, perforation; lamina propria, fibrosis
  • Larynx: inflammation, chronic active; lumen exudate; respiratory epithelium, metaplasia, squamous; squamous epithelium, hyperplasia; respiratory epithelium, necrosis; respiratory epithelium, regeneration
  • Trachea: inflammation, chronic active; lumen, exudate; necrosis; epithelium, regeneration; submucosa, fibrosis; carina, submucosa, fibrosis; carina, submucosa, mineralization
  • Lung: bronchus, epithelium, regeneration; bronchus, submucosal fibrosis; inflammation, suppurative; pleura, inflammation, suppurative; mediastinum, inflammation, suppurative; mediastinum, inflammation, chronic active
  • Eye: cornea, inflammation, acute; cornea, epithelium, ulcer; cornea, necrosis; cornea, mineralization; cornea, epithelium, hyperplasia