Target Organs and Levels of Evidence for TR-594
TR-594 Toxicology and Carcinogenesis Studies of p-Chloro-a,a,a-trifluorotoluene (CASRN 98-56-6) in Sprague Dawley Rats (Hsd:Sprague Dawley SD) and B6C3F1/N Mice (Inhalation Studies)
Chemical CASRN (Study Title) |
Peer Review Date |
Primary Uses |
Route/Exposure Levels |
Study Laboratory |
p-Chloro-a,a,a-trifluorotoluene 98-56-6 |
07/13/2017 |
Dye intermediate; solvent & dielectric fluid; intermediate for herbicides |
Inhalation R: 0, 100, 300, or 1000 ppm; M: 0, 100, 200, or 400 ppm; 50/sex/species |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Thyroid Gland: C-cell adenoma (2/50, 5/49, 3/49, 12/50)
|
May Have Been Related |
- Lung: alveolar/bronchiolar adenoma or carcinoma (0/50, 2/50, 0/50, 3/50)
|
Non-Neoplastic Lesions |
- Lung: inflammation, chronic; fibrosis; hemorrhage
- Liver: centrilobular, hepatocyte, hypertrophy; fatty change; eosinophilic focus
- Kidney: severity of nephropathy
- Nasal Cavity: exudate
|
Female Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Thyroid Gland: C-cell adenoma (2/50, 8/50, 8/50, 14/50)
- Adrenal Gland Medulla: benign pheochromocytoma (0/49, 3/50, 4/50, 6/50)
- Uterus: adenocarcinoma (1/50, 1/50, 0/50, 5/50); stromal polyp (7/50, 9/50, 16/50, 12/50)
|
Non-Neoplastic Lesions |
- Lung: inflammation, chronic; fibrosis; hemorrhage
- Liver: centrilobular, hepatocyte, hypertrophy; fatty change; mixed cell focus; clear cell focus
- Adrenal medulla: hyperplasia
- Uterus: endometrium, atypical hyperplasia
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: hepatocellular carcinoma (8/50, 19/50, 16/50, 35/50); hepatoblastoma (1/50, 1/50, 1/50, 15/50)
|
Non-Neoplastic Lesions |
- Lung: alveolar/bronchiolar epithelium, hyperplasia; peribronchiolar, fibrosis
- Liver: eosinophilic focus; centrilobular, hepatocyte, hypertrophy; hepatocyte, multinucleated; hepatocyte, necrosis; intrahepatocellular erythrocytes
- Forestomach: inflammation
- Larynx: squamous epithelium, hyperplasia
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: hepatocellular adenoma (12/50, 14/50, 24/50, 34/50); hepatocellular carcinoma (7/50, 8/50, 12/50, 34/50); hepatoblastoma (0/50, 0/50, 1/50, 8/50)
- Harderian Gland: adenoma (2/50, 6/50, 6/50, 8/50); adenoma or adenocarcinoma (2/50, 6/50, 9/50, 8/50)
|
Non-Neoplastic Lesions |
- Lung: alveolar/bronchiolar epithelium, hyperplasia; peribronchiolar, fibrosis
- Liver: eosinophilic focus; centrilobular, hepatocyte, hypertrophy; hepatocyte, multinucleated; hepatocyte, necrosis
- Forestomach: epithelium, hyperplasia
|