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Target Organs and Levels of Evidence for TR-595

TR-595 Toxicology and Carcinogenesis Studies in Hsd:Sprague Dawley SD Rats Exposed to Whole-Body Radio Frequency Radiation at a Frequency (900 MHz) and Modulations (GSM and CDMA) Used by Cell Phones

Chemical CASRN (Study Title)	Peer Review Date	Primary Uses	Route/Exposure Levels	Study Laboratory
Cell Phone Radiation: GSM CELLPRADGSM	03/26/2018	Cellular phones using Global System for Mobile communications (GSM)	Whole Body Exposure Rats: 0, 1.5, 3, and 6 W/kg 900 MHz	IIT Research Institute
Cell Phone Radiation: CDMA CELLPRADCDMA	03/26/2018	Cellular phones using Code Division Multiple Access (CDMA) technology	Whole Body Exposure Rats: 0, 1.5, 3, and 6 W/kg 900 MHz	IIT Research Institute

Levels of Evidence: GSM

Male Rats: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Heart: schwannoma malignant (0/90, 2/90, 1/90, 5/90) Brain: glioma malignant (0/90, 3/90, 3/90, 2/90) Adrenal Gland Medulla: benign, malignant, or complex pheochromocytoma (11/88, 24/90, 28/89, 14/87)
May Have Been Related	Brain: meninges, granular cell tumor benign or malignant (1/90, 3/90, 4/90, 3/90) Prostate Gland: adenoma or carcinoma (2/90, 2/90, 7/90, 3/90) Pituitary Gland: pars distalis, adenoma (17/89, 28/90, 26/90, 26/90) Pancreas Islet Cell: adenoma or carcinoma (13/90, 27/89, 19/86, 16/85)
Non-Neoplastic Lesions	Heart: ventricle right, cardiomyopathy; Schwann cell hyperplasia Brain: glial cell, hyperplasia Prostate gland: epithelium, hyperplasia

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
May Have Been Related	Heart: schwannoma malignant (0/90, 0/90, 2/90, 0/90)
Non-Neoplastic Lesions	Heart: ventricle right, cardiomyopathy Thyroid gland: C-cell, hyperplasia Adrenal medulla: hyperplasia

Levels of Evidence: CDMA

Male Rats: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Heart: schwannoma malignant (0/90, 2/90, 3/90, 6/90) Brain: glioma malignant (0/90, 0/90, 0/90, 3/90)
May Have Been Related	Pituitary Gland: pars distalis, adenoma (17/89, 25/90, 34/90, 13/90) Liver: hepatocellular adenoma or carcinoma (combined) (0/90, 2/90, 4/89, 1/88)
Non-Neoplastic Lesions	Heart: Schwann cell hyperplasia Brain: glial cell, hyperplasia Prostate gland: epithelium, hyperplasia

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
May Have Been Related	Heart: schwannoma malignant (0/90, 2/90, 0/90, 2/90) Brain: glioma malignant (0/90, 3/90, 0/90, 0/90) Adrenal Gland Medulla: benign, malignant, or complex pheochromocytoma (1/86, 9/89, 5/87, 4/88)
Non-Neoplastic Lesions	Brain: glial cell, hyperplasia