https://ntp.niehs.nih.gov/go/857885

Target Organs and Levels of Evidence for TR-595

TR-595 Toxicology and Carcinogenesis Studies in Hsd:Sprague Dawley SD Rats Exposed to Whole-Body Radio Frequency Radiation at a Frequency (900 MHz) and Modulations (GSM and CDMA) Used by Cell Phones

Chemical
CASRN
(Study Title)		 Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Cell Phone Radiation: GSM
CELLPRADGSM		 03/26/2018 Cellular phones using Global System for Mobile communications (GSM) Whole Body Exposure
Rats: 0, 1.5, 3, and 6 W/kg 900 MHz		 IIT Research Institute
Cell Phone Radiation: CDMA
CELLPRADCDMA		 03/26/2018 Cellular phones using Code Division Multiple Access (CDMA) technology Whole Body Exposure
Rats: 0, 1.5, 3, and 6 W/kg 900 MHz		 IIT Research Institute

Levels of Evidence: GSM

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Heart: schwannoma malignant (0/90, 2/90, 1/90, 5/90)
  • Brain: glioma malignant (0/90, 3/90, 3/90, 2/90)
  • Adrenal Gland Medulla: benign, malignant, or complex pheochromocytoma (11/88, 24/90, 28/89, 14/87)
May Have Been Related
  • Brain: meninges, granular cell tumor benign or malignant (1/90, 3/90, 4/90, 3/90)
  • Prostate Gland: adenoma or carcinoma (2/90, 2/90, 7/90, 3/90)
  • Pituitary Gland: pars distalis, adenoma (17/89, 28/90, 26/90, 26/90)
  • Pancreas Islet Cell: adenoma or carcinoma (13/90, 27/89, 19/86, 16/85)
Non-Neoplastic Lesions
  • Heart: ventricle right, cardiomyopathy; Schwann cell hyperplasia
  • Brain: glial cell, hyperplasia
  • Prostate gland: epithelium, hyperplasia
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Heart: schwannoma malignant (0/90, 0/90, 2/90, 0/90)
Non-Neoplastic Lesions
  • Heart: ventricle right, cardiomyopathy
  • Thyroid gland: C-cell, hyperplasia
  • Adrenal medulla: hyperplasia

 

Levels of Evidence: CDMA

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Heart: schwannoma malignant (0/90, 2/90, 3/90, 6/90)
  • Brain: glioma malignant (0/90, 0/90, 0/90, 3/90)
May Have Been Related
  • Pituitary Gland: pars distalis, adenoma (17/89, 25/90, 34/90, 13/90)
  • Liver: hepatocellular adenoma or carcinoma (combined) (0/90, 2/90, 4/89, 1/88)
Non-Neoplastic Lesions
  • Heart: Schwann cell hyperplasia
  • Brain: glial cell, hyperplasia
  • Prostate gland: epithelium, hyperplasia
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Heart: schwannoma malignant (0/90, 2/90, 0/90, 2/90)
  • Brain: glioma malignant (0/90, 3/90, 0/90, 0/90)
  • Adrenal Gland Medulla: benign, malignant, or complex pheochromocytoma (1/86, 9/89, 5/87, 4/88)
Non-Neoplastic Lesions
  • Brain: glial cell, hyperplasia