Target Organs and Levels of Evidence for TR-597
TR-597 Toxicology and Carcinogenesis Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
This table lists chemical name, peer review date, routes/exposure levels, laboratory, level of evidence, and lesions for 2-Hydroxy-4-methoxybenzophenone
Chemical
CASRN
(Study Title) |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
2-Hydroxy-4-methoxybenzophenone
131-57-7 |
12/12/2019 |
Dosed-Feed R&M: 0, 1000, 3000, or 10000 ppm; R: 60/sex/dose @ 0 or 10000 and 50/sex/dose @ 1000 or 3000, M: 50/sex/dose |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
This table lists neoplastic and non-neoplastic lesions and organs for Male Rats
| Type |
Organ/Tissue (Lesion) |
| May Have Been Related |
- Brain: malignant meningioma (0/50, 1/50, 3/50, 0/50)
|
| Non-Neoplastic Lesions |
- Testis: interstitial cell, hyperplasia
|
Female Rats: Equivocal Evidence
This table lists neoplastic and non-neoplastic lesions and organs for Female Rats
| Type |
Organ/Tissue (Lesion) |
| May Have Been Related |
- Thyroid gland: C-cell adenoma (5/50, 11/50, 17/50, 10/50)
- Uterus/Cervix: stromal polyp (8/50, 15/50, 18/50, 10/50)
|
| Non-Neoplastic Lesions |
- Uterus/Cervix: endometrium, atypical hyperplasia
- Adrenal cortex: hypertrophy, focal
|
Male Mice: No Evidence
This table lists neoplastic and non-neoplastic lesions and organs for Male Mice
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- Bone marrow: pigment
- Spleen: pigment
- Liver: hepatocyte, syncytial alteration
- Kidney: renal tubule, cytoplasmic alteration
|
Female Mice: No Evidence
This table lists neoplastic and non-neoplastic lesions and organs for Female Mice
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- Bone marrow: pigment
- Spleen: pigment
- Kidney: metaplasia, osseous
|
