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Target Organs and Levels of Evidence for TR-597

TR-597 Toxicology and Carcinogenesis Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice

This table lists chemical name, peer review date, routes/exposure levels, laboratory, level of evidence, and lesions for 2-Hydroxy-4-methoxybenzophenone
Chemical CASRN (Study Title)	Peer Review Date	Route/Exposure Levels	Study Laboratory
2-Hydroxy-4-methoxybenzophenone 131-57-7	12/12/2019	Dosed-Feed R&M: 0, 1000, 3000, or 10000 ppm; R: 60/sex/dose @ 0 or 10000 and 50/sex/dose @ 1000 or 3000, M: 50/sex/dose	Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence

This table lists neoplastic and non-neoplastic lesions and organs for Male Rats
Type	Organ/Tissue (Lesion)
May Have Been Related	Brain: malignant meningioma (0/50, 1/50, 3/50, 0/50)
Non-Neoplastic Lesions	Testis: interstitial cell, hyperplasia

Female Rats: Equivocal Evidence

This table lists neoplastic and non-neoplastic lesions and organs for Female Rats
Type	Organ/Tissue (Lesion)
May Have Been Related	Thyroid gland: C-cell adenoma (5/50, 11/50, 17/50, 10/50) Uterus/Cervix: stromal polyp (8/50, 15/50, 18/50, 10/50)
Non-Neoplastic Lesions	Uterus/Cervix: endometrium, atypical hyperplasia Adrenal cortex: hypertrophy, focal

Male Mice: No Evidence

This table lists neoplastic and non-neoplastic lesions and organs for Male Mice
Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	Bone marrow: pigment Spleen: pigment Liver: hepatocyte, syncytial alteration Kidney: renal tubule, cytoplasmic alteration

Female Mice: No Evidence

This table lists neoplastic and non-neoplastic lesions and organs for Female Mice
Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	Bone marrow: pigment Spleen: pigment Kidney: metaplasia, osseous