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Target Organs and Levels of Evidence for TR-597

TR-597 Toxicology and Carcinogenesis Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice

This table lists chemical name, peer review date, routes/exposure levels, laboratory, level of evidence, and lesions for 2-Hydroxy-4-methoxybenzophenone
Chemical
CASRN
(Study Title)
Peer Review Date Route/Exposure Levels Study Laboratory
2-Hydroxy-4-methoxybenzophenone
131-57-7
12/12/2019 Dosed-Feed R&M: 0, 1000, 3000, or 10000 ppm; R: 60/sex/dose @ 0 or 10000 and 50/sex/dose @ 1000 or 3000, M: 50/sex/dose Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
This table lists neoplastic and non-neoplastic lesions and organs for Male Rats
Type Organ/Tissue (Lesion)
May Have Been Related
  • Brain: malignant meningioma (0/50, 1/50, 3/50, 0/50)
Non-Neoplastic Lesions
  • Testis: interstitial cell, hyperplasia
Female Rats: Equivocal Evidence
This table lists neoplastic and non-neoplastic lesions and organs for Female Rats
Type Organ/Tissue (Lesion)
May Have Been Related
  • Thyroid gland: C-cell adenoma (5/50, 11/50, 17/50, 10/50)
  • Uterus/Cervix: stromal polyp (8/50, 15/50, 18/50, 10/50)
Non-Neoplastic Lesions
  • Uterus/Cervix: endometrium, atypical hyperplasia
  • Adrenal cortex: hypertrophy, focal
Male Mice: No Evidence
This table lists neoplastic and non-neoplastic lesions and organs for Male Mice
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Bone marrow: pigment
  • Spleen: pigment
  • Liver: hepatocyte, syncytial alteration
  • Kidney: renal tubule, cytoplasmic alteration
Female Mice: No Evidence
This table lists neoplastic and non-neoplastic lesions and organs for Female Mice
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Bone marrow: pigment
  • Spleen: pigment
  • Kidney: metaplasia, osseous