https://ntp.niehs.nih.gov/go/926815

Target Organs and Levels of Evidence for TR-599

Toxicology and Carcinogenesis Studies of Sodium Tungstate Dihydrate (CASRN 10213-10-2) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice (Drinking Water Studies)

Chemical
CASRN
(Study Title)		 Peer Review Date Route/Exposure Levels Study Laboratory
Sodium Tungstate Dihydrate
10213-10-2		 04/02/2021 Dosed-Water
R: 0, 250, 500, or 1000 mg/L; M: 0, 500, 1000, or 2000 mg/L; 50/sex/species/group		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Kidney: renal tubule, inflammation, suppurative
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Thyroid Gland C-Cell: C-cell adenoma (5/50, 13/50, 13/49, 8/50); C-cell carcinoma (2/50, 2/50, 2/49, 4/50); C-cell adenoma or carcinoma (combined) (7/50, 15/50, 14/49, 11/50)
Non-Neoplastic Lesions
  • Kidney: renal tubule, inflammation, suppurative; renal tubule, regeneration
  • Uterus: atypical hyperplasia
Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Kidney: renal tubule adenoma (0/50, 0/50, 1/50, 0/50); renal tubule carcinoma (0/50, 0/50, 0/50, 2/50); renal tubule adenoma or carcinoma (combined) (0/50, 0/50, 1/50, 2/50)
Non-Neoplastic Lesions
  • Kidney: renal tubule, regeneration
  • Large intestine: cecum, pigment
  • Testis: germinal epithelium, degeneration
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Kidney: renal tubule, regeneration
  • Large intestine: cecum, pigment