Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/926982

Target Organs and Levels of Evidence for TR-600

TR-600 Toxicology and Carcinogenesis Studies of Di-n-butyl Phthalate (CASRN 84-74-2) Administered in Feed to Sprague Dawley(Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice

Chemical
CASRN
(Study Title)
Peer Review Date Route/Exposure Levels Study Laboratory
Dibutyl Phthalate
84-74-2
04/02/2021 Dosed-Feed
R: 0, 300, 1000, 3000, or 10,000 ppm; M: 0, 1000, 3000, or 10,000 ppm; 50/sex/species/group
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Pancreas Acinar Cell: acinus adenoma (4/49, 4/50, 3/50, 1/50, 10/49)
Non-Neoplastic Lesions
  • Testis: edema (includes bilateral); germinal epithelium, atrophy (includes bilateral); interstitial cell, hyperplasia, diffuse, bilateral; interstitial cell, hyperplasia, focal (includes bilateral); rete testis, fibrosis (includes bilateral); rete testis, sperm granuloma; seminiferous tubule, dysgenesis (includes bilateral)
  • Epididymis: hypospermia (includes bilateral)
  • Prostate gland: decreased secretory fluid
  • Seminal vesicle: decreased secretory fluid
  • Pituitary gland: pars distalis, hypertrophy
  • Liver: hepatocyte, cytoplasmic alteration
Other Considerations
  • Testis: small (1/48, 0/49, 4/48, 2/49, 36/46); enlarged (0/48, 0/49, 1/48, 1/49, 1/46); fluid or blood filled (1/48, 0/49, 0/48, 1/49, 3/46); right, not present (0/48, 0/49, 0/48, 0/49, 2/46); right or left; abdominal; undescended (1/48, 3/49, 2/48, 2/49, 29/46); right or left; inguinal; undescended (1/48, 0/49, 0/48, 0/49, 7/46); right or left; abdominal or inguinal; undescended (2/48, 3/49, 2/48, 2/49, 32/46)
  • Epididymis: small (0/48, 0/49, 3/48, 0/49, 27/46); right, agenesis (0/48, 0/49, 0/48, 0/49, 2/46)
  • Prostate gland: small (0/48, 0/49, 1/48, 2/49, 4/46); right or left, ventral, dorsal or lateral, agenesis (0/48, 0/49, 0/48, 1/49, 2/46)
  • Seminal vesicle: small (1/48, 2/49, 2/48, 1/49, 7/46)
  • Vas deferens: right, not present (0/48, 0/49, 0/48, 0/49, 2/46)
  • Gubernaculum: right, not present (0/48, 0/49, 0/48, 0/49, 1/46)
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Liver: hepatocyte, cytoplasmic alteration; bile duct, hyperplasia
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Testis: germinal epithelium, degeneration (includes bilateral)
  • Epididymis: duct, exfoliated germ cell (includes bilateral)
  • Liver: hepatocyte, cytoplasmic alteration; hepatocyte, multinucleated
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Liver: hepatocyte, cytoplasmic alteration
  • Kidney: renal tubule, hyperplasia