https://ntp.niehs.nih.gov/go/n462021

Target Organs and Levels of Evidence for TR-602

TCPP is produced as a mixture of four isomers and all NTP studies have utilized a procured isomeric mixture. Herein, TCPP is referenced with CASRN 13674-84-5, which represents the major isomer of the TCPP mixture.

Toxicology and Carcinogenesis Studies of an Isomeric Mixture of Tris(chloropropyl) Phosphate Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice

Chemical
CASRN
(Study Title)		 Peer Review Date Route/Exposure Levels Study Laboratory
Tris(Chloropropyl) Phosphate (TCPP)
13674-84-5		 11/01/2022 Dosed-Feed
Rats: 0, 2500, 5000, 10,000 or 20,000 ppm; Male mice: 0, 1250, 2500, or 5000 ppm; Female mice: 0, 2500, 5000 or 10,000 ppm; 50/sex/species/group		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hepatocellular adenoma or carcinoma (combined) (1/50, 0/50, 1/50, 7/50, 6/49)
Non-Neoplastic Lesions
  • Liver: basophilic focus; eosinophilic focus; mixed-cell focus; pigment; bile duct, hyperplasia
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Uterus: adenoma or adenocarcinoma (combined) (3/50, 4/50, 6/50, 8/49, 9/50)
May Have Been Related
  • Liver: hepatocellular adenoma (1/50, 3/50, 0/50, 3/50, 3/50)
Non-Neoplastic Lesions
  • Liver: basophilic focus; eosinophilic focus; mixed-cell focus; pigment; bile duct, cyst; bile duct, hyperplasia
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hepatocellular carcinoma (includes multiple) (5/50, 14/50, 17/50, 14/50)
Non-Neoplastic Lesions
  • Liver: basophilic focus; eosinophilic focus
  • Kidney: renal tubule, cytoplasmic alteration
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hepatocellular adenoma (includes multiple) (11/50, 5/50, 13/50, 23/50); hepatocellular carcinoma (includes multiple) (1/50, 2/50, 5/50, 10/50); hepatocellular adenoma or carcinoma (combined) (12/50, 7/50, 16/50, 29/50)
Non-Neoplastic Lesions
  • Liver: eosinophilic focus; hepatocellular, cytoplasmic alteration