Target Organs and Levels of Evidence for TR-603
Toxicology and Carcinogenesis Studies of Black Cohosh Root Extract (CASRN 84776-26-1) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and Female B6C3F1/N Mice
| Chemical CASRN (Study Title) |
Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|---|---|---|
| Black Cohosh 84776-26-1 |
01/01/2023 | Gavage Rats: 0, 75, 250, or 750 mg/kg/day; 50/sex/dose. Female mice: 0, 30, 100, 300, or 1000 mg/kg/day; 70/dose |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence (Perinatal Exposure Only)
Female Rats: Equivocal Evidence (Perinatal Exposure and Postweaning Dosing)
| Type | Organ/Tissue (Lesion) |
|---|---|
| May Have Been Related |
|
| Non-Neoplastic Lesions |
|
Female Mice: No Evidence (Postweaning Dosing Only)
| Type | Organ/Tissue (Lesion) |
|---|---|
| Non-Neoplastic Lesions |
|