https://ntp.niehs.nih.gov/go/n544586

Target Organs and Levels of Evidence for TR-605

Toxicology and Carcinogenesis Studies of Sulfolane (CASRN 126-33-0) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
Sulfolane
126-33-0		06/01/2025Dosed-Water
0, 30, 100, 300, or 1,000 mg/L
  • RTI International Laboratory
  • Battelle Columbus Laboratory

Levels of Evidence

Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Mammary gland: adenoma (1/50, 4/50, 7/50, 2/50, 5/50)
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • All organs (systemic): hemangiosarcoma (3/50, 6/50, 4/50, 3/50, 12/50) 
  • Liver: hemangiosarcoma (3/50, 5/50, 3/50, 2/50, 11/50) 
  • Spleen: hemangiosarcoma (0/49, 5/50, 1/50, 1/50, 3/50)
Non-Neoplastic Lesions
  • Liver: mixed cell focus
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Liver: hepatocellular carcinoma (2/50, 3/50, 5/50, 5/50, 8/50)
Non-Neoplastic Lesions
  • Liver: clear cell focus; fatty change, focal 
  • Ovary: follicles, cyst