September 30, 2020 Symposium Webinar: Use of the Kinetically Derived Maximum Dose in Toxicity Testing
Videos
There are no videos available for this meeting.
There are no videos available for this meeting.
Welcome and Introductions
Nicole Kleinstreuer, Ph.D., NICEATM
Use and Evaluation of KMD Data at USEPA's Office of Pesticide Programs
Anna Lowit, Ph.D., EPA
Current State-of-play: OECD Discussions on Doses Selection in Chronic Toxicity Studies
Anne Gourmelon, OECD
Problem Formulation: Background, Motivation, and Expected Outcomes
Michelle Embry, Ph.D., Health and Environmental Sciences Institute
Maximum Tolerated Dose: Concepts and Background
Chad Blystone, Ph.D., DABT, NTP
Concepts of Non-linear Pharmacokinetics and KMD
Alan Boobis, Ph.D., Imperial College London
Implications of Non-linear PK in Toxicity Testing and Interpretation of Dose-response Data
Salil Pendse, Nuventra, Inc.
Determining an Inflection Point from External-internal Dose Data
Philip Villanueva, EPA
Estimating Human Exposures and Comparison to Doses Used in Testing
Jeff Dawson, EPA
Dose Setting and Considerations for the 3Rs
Fiona Sewell, Ph.D., National Centre for the Replacement Refinement & Reduction of Animals in Research
Integration of TK into Toxicity Studies and Dose Level Setting
Jean Domoradzki, Ph.D., DABT, Corteva Agriscience
Integrating KMD/TK Data with MoA and Other Information in a Weight of Evidence Approach
Harvey Clewell, Ph.D., Ramboll