https://ntp.niehs.nih.gov/go/testpgm

Testing Program

Male and female scientists using microscopes in laboratory

Overview

NTP evaluates substances and circumstances for a variety of cancer and noncancer health-related effects, usually (but not always) using rodent models. Listed below are the most widely used NTP test methods and protocols. You can see reports and summaries of NTP studies, including carcinogenicity and effects on development and reproduction, by visiting the publications section of this website.

Study Types

Female scientist looking through a microscope in a laboratory

Toxicology/Carcinogenicity

Learn how toxicology and carcinogenicity studies are being used to better understand the potential toxic effects of the substances we study. Go
Tissue on chip

Alternative Testing Models

Learn about our efforts to develop testing alternatives for toxicological research that will reduce, replace, or refine animal use. Go
Technician placing blood tubes in laboratory centrifuge

Chemical Disposition & Toxicokinetics

Learn about chemical disposition and toxicokinetic studies. Go
Mitosis of embryo under microscope

Developmental & Reproductive Toxicity

Learn about prenatal developmental toxicity, modified one-generation, and reproductive studies. Go
Scientist examines DNA molecule

Genetic Toxicology

Learn about the in vitro and in vivo tests used to evaluate the potential of substances to damage DNA. Go
Plasma cells segregating antibodies to destroy viruses

Immunotoxicity

Learn about the techniques used for evaluating the potential of substances to damage the immune system. Go
Rat image

Neurotoxicity

Learn about in vitro and in vivo models to evaluate potential neurotoxicants. Go