National Toxicology Program

National Toxicology Program

Literature Review of Bisphenol A (BPA) Analogues

Usage and exposure to chemicals with structural or functional similarity to bisphenol A (BPA), referred to as BPA analogues, has been the focus of recent attention in the scientific community. BPA analogues have been detected in foodstuff (Cacho et al. 2012; Liao and Kannan 2013), house dust (Liao et al. 2012a), lake and river surface sediment (Liao et al. 2012c), and thermal paper (Becerra and Odermatt 2013; Liao et al. 2012b). Compared to BPA, relatively little is known about the potential toxicity of these compounds. The National Toxicology Program (NTP) is undertaking a number of research activities related to BPA analogues, including rodent toxicology studies of bisphenol S (BPS) and bisphenol AF (BPAF) and conducting toxicokinetic characterization of BPS following oral and intravenous exposure and characterizing the metabolic profiles of BPS derivatives (NTP Board of Scientific Counselors, see June 2014 meeting materials). As a complement to the research activities, the NTP Office of Health Assessment and Translation (OHAT) is conducting a comprehensive evaluation of published literature on BPA analogues to guide further in vitro and in vivo research efforts.

Future updates on this project will be posted on this webpage.

Individuals interested in receiving updates on this project are encouraged to register to the NTP Listserv.


Becerra V, Odermatt J. 2013. Interferences in the direct quantification of bisphenol s in paper by means of thermochemolysis. J Chromatogr A 1275:70-77.

Cacho JI, Campillo N, Vinas P, Hernandez-Cordoba M. 2012. Stir bar sorptive extraction coupled to gas chromatography-mass spectrometry for the determination of bisphenols in canned beverages and filling liquids of canned vegetables. J Chromatogr A 1247:146-153.

Liao C, Liu F, Guo Y, Moon HB, Nakata H, Wu Q, et al. 2012a. Occurrence of eight bisphenol analogues in indoor dust from the united states and several asian countries: Implications for human exposure. Environ Sci Technol 46:9138-9145.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.