Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS)
The NTP conducted a systematic review to evaluate the evidence on exposure to PFOA or PFOS and immune-related health effects to determine whether exposure to either chemical is associated with immunotoxicity for humans. The NTP concludes that both PFOA and PFOS are presumed to be an immune hazard to humans based on a high level of evidence from animal studies that PFOA and PFOS suppressed the antibody response and a moderate level of evidence from studies in humans. The evidence that these chemicals affect multiple aspects of the immune system supports the overall conclusion that both PFOA and PFOS alter immune functions in humans.
- Final Monograph
- Preferred Citation: NTP (National Toxicology Program). 2016. Monograph on Immunotoxicity Associated with Exposure to Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). Research Triangle Park, NC: National Toxicology Program. http://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf
- Literature Search Results (May 2016)
- Protocol (June 2015)
- Request for Information and Nominations of Scientific Experts for Proposed Peer Review Meeting (August 14, 2015)
- Meeting Announcement: Peer Review of the Draft Monograph on Immunotoxicity Associated with Exposure to PFOA or PFOS (February 26, 2016)
Information about the Peer Review Meeting is available on the meeting page.