National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/rochandbook

Handbook for Preparing Report on Carcinogens (RoC) Monographs

The handbook provides instructions for conducting the cancer hazard evaluation and preparing the RoC monographs.

The handbook includes methods for:

  • planning for the evaluation
  • conducting literature searches
  • assessing study quality and sensitivity of individual studies
  • synthesizing evidence across cancer studies to reach preliminary level of evidence conclusions
  • evaluating mechanistic and other relevant data
  • integrating evidence to reach a preliminary listing recommendation

The handbook is a living document and may be updated on a periodic basis.

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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.