Report on Carcinogens Handbook on Methods for Conducting Cancer Hazard Evaluations
The Report on Carcinogens (RoC) Handbook (2025) updates the 2015 version. It provides methods for conducting a robust and transparent evaluation to determine whether a substance is a cancer hazard. Collectively, the handbook includes a suite of tools, approaches, resources, and guidance that reflect scientific best practices.
The RoC Handbook has methods for all steps of the cancer hazard evaluation process. The topics covered include:
- Developing and planning the evaluation framework
- Human exposure data evaluation
- Human cancer studies evaluation
- Experimental animal cancer studies evaluation
- Disposition and toxicokinetic data evaluation
- Mechanistic data evaluation
- Evidence integration and cancer hazard conclusion
The RoC Handbook will be updated as methods, tools, and approaches for cancer hazard evaluations evolve.
- NIEHS Environmental Factor article (June 2, 2025) Cancer assessments handbook updated, published; Video
Documents
| Date | Document |
|---|---|
| Jun 02, 2025 |
NTP Report on Carcinogens Handbook on Methods for Conducting Cancer Hazard Evaluations Preferred Citation: National Toxicology Program (NTP). 2025. NTP report on carcinogens handbook on methods for conducting cancer hazard evaluations. Research Triangle Park, NC: National Toxicology Program. DOI: https://doi.org/10.22427/NTP-OTHER-1008 |
| July 26, 2023 | Standard Search Strings for Literature Database Searches for Preparing Report on Carcinogens Monographs |