National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2085

TR 386 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         TETRANITROMETHANE


NTP Experiment-Test: 05072-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32




       Facility:  Midwest Research Institute

       Chemical CAS #:  509-14-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      6            3            8                                                  
    Moribund Sacrifice                                19           13           27                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           34           15                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (48)         (48)                                                
      Inflammation, Acute, Necrotizing                 1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Parasite Metazoan                                3 (6%)       2 (4%)                                                          
   Intestine Large, Colon                             (50)         (49)         (48)                                                
      Parasite Metazoan                                5 (10%)     10 (20%)      5 (10%)                                            
      Artery, Inflammation, Chronic Active, Focal      1 (2%)                                                                       
      Muscularis, Mineralization, Multifocal                        1 (2%)                                                          
   Intestine Large, Rectum                            (49)         (49)         (49)                                                
      Parasite Metazoan                                7 (14%)      7 (14%)      6 (12%)                                            
      Muscularis, Mineralization, Multifocal                        1 (2%)                                                          
   Intestine Small, Ileum                             (46)         (49)         (46)                                                
      Infiltration Cellular, Diffuse, Lymphocyte                                 1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Focal                               3 (6%)       2 (4%)                                                          
      Angiectasis, Multifocal                                                    1 (2%)                                             
      Basophilic Focus                                 2 (4%)       2 (4%)       8 (16%)                                            
      Basophilic Focus, Multiple                      24 (48%)     29 (58%)     15 (30%)                                            
      Basophilic Focus, Two                            1 (2%)       6 (12%)      7 (14%)                                            
      Cytomegaly, Multifocal                                        1 (2%)                                                          
      Cytoplasmic Alteration, Focal                    1 (2%)       2 (4%)                                                          
      Eosinophilic Focus                               1 (2%)       2 (4%)                                                          
      Fatty Change, Diffuse                            6 (12%)      2 (4%)                                                          
      Fatty Change, Focal                              2 (4%)                                                                       
      Fatty Change, Multifocal                         3 (6%)       6 (12%)      6 (12%)                                            
      Fibrosis, Multifocal                                          1 (2%)       1 (2%)                                             
      Granuloma, Multifocal                           15 (30%)     28 (56%)     16 (32%)                                            
      Hemorrhage, Acute, Multifocal                                              2 (4%)                                             
      Hepatodiaphragmatic Nodule                       5 (10%)      4 (8%)       5 (10%)                                            
      Hyperplasia, Nodular                                          1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
      Mitotic Alteration                               2 (4%)       3 (6%)       1 (2%)                                             
      Mixed Cell Focus                                 2 (4%)       2 (4%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mixed Cell Focus, Multiple                       1 (2%)                                                                       
      Necrosis, Acute, Focal                           1 (2%)                    1 (2%)                                             
      Necrosis, Acute, Multifocal                      2 (4%)       2 (4%)       2 (4%)                                             
      Necrosis, Focal, Subacute                        1 (2%)                                                                       
      Vacuolization Cytoplasmic, Multifocal            1 (2%)       2 (4%)                                                          
      Bile Duct, Hyperplasia, Multifocal              10 (20%)      6 (12%)      3 (6%)                                             
      Centrilobular, Atrophy, Diffuse                  2 (4%)                    1 (2%)                                             
      Centrilobular, Atrophy, Multifocal               3 (6%)       2 (4%)       2 (4%)                                             
      Centrilobular, Congestion, Multifocal                         1 (2%)                                                          
      Centrilobular, Fatty Change, Diffuse             3 (6%)                    2 (4%)                                             
      Centrilobular, Necrosis, Acute, Diffuse                                    1 (2%)                                             
      Centrilobular, Necrosis, Acute, Multifocal                    1 (2%)       1 (2%)                                             
      Median Lobe, Hepatodiaphragmatic Nodule                                    1 (2%)                                             
      Periportal, Cytomegaly, Diffuse                               1 (2%)                                                          
      Periportal, Fatty Change, Diffuse                1 (2%)       1 (2%)       1 (2%)                                             
      Periportal, Fatty Change, Multifocal             2 (4%)       2 (4%)       2 (4%)                                             
      Periportal, Inflammation, Chronic, Multifocal    1 (2%)                                                                       
      Portal, Inflammation, Chronic, Multifocal        1 (2%)       1 (2%)                                                          
      Serosa, Inflammation, Multifocal,                                                                                             
          Proliferative                                                          1 (2%)                                             
   Mesentery                                          (4)          (6)          (8)                                                 
      Accessory Spleen                                 2 (50%)                                                                      
      Artery, Mineralization, Multifocal                            1 (17%)                                                         
      Fat, Necrosis, Focal                             2 (50%)      3 (50%)      3 (38%)                                            
      Fat, Necrosis, Multifocal                                     1 (17%)      1 (13%)                                            
      Vein, Thrombosis                                              1 (17%)                                                         
   Pancreas                                           (50)         (50)         (49)                                                
      Ectopic Tissue                                                             1 (2%)                                             
      Inflammation, Chronic, Multifocal                1 (2%)       1 (2%)                                                          
      Necrosis, Acute, Focal                                                     1 (2%)                                             
      Acinus, Atrophy                                                            2 (4%)                                             
      Acinus, Atrophy, Diffuse                         1 (2%)                    2 (4%)                                             
      Acinus, Atrophy, Focal                           1 (2%)                    1 (2%)                                             
      Acinus, Atrophy, Multifocal                     12 (24%)      8 (16%)      5 (10%)                                            
      Acinus, Hyperplasia, Focal                       1 (2%)       2 (4%)                                                          
      Artery, Angiectasis, Multifocal                               1 (2%)                                                          
      Artery, Inflammation, Chronic Active, Focal                                1 (2%)                                             
      Artery, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   1 (2%)                    2 (4%)                                             
      Artery, Mineralization, Multifocal                            1 (2%)                                                          
      Serosa, Inflammation, Chronic Active                          1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)                                                
      Cytomegaly, Focal                                                          1 (2%)                                             
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Acinus, Atrophy, Focal                                        1 (2%)                                                          
      Duct, Hyperplasia, Focal                         1 (2%)       1 (2%)                                                          
      Duct, Inflammation, Chronic Active, Focal        1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (50)         (49)         (50)                                                
      Edema                                                                      1 (2%)                                             
      Erosion, Focal                                   1 (2%)                                                                       
      Hyperplasia, Basal Cell, Focal                                             1 (2%)                                             
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                     6 (12%)      3 (6%)       4 (8%)                                             
      Necrosis, Acute, Focal                                                     1 (2%)                                             
      Ulcer, Multifocal                                1 (2%)                    2 (4%)                                             
      Ulcer, Single                                    2 (4%)       2 (4%)       1 (2%)                                             
      Epithelium, Hyperplasia, Diffuse                 2 (4%)       1 (2%)       2 (4%)                                             
      Epithelium, Hyperplasia, Focal                   2 (4%)       1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia, Multifocal                                        2 (4%)                                             
   Stomach, Glandular                                 (48)         (49)         (50)                                                
      Erosion                                          1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)       2 (4%)                                                          
      Necrosis, Focal, Subacute                                     1 (2%)                                                          
      Mucosa, Mineralization                                        1 (2%)                                                          
      Mucosa, Necrosis, Acute, Focal                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  34 (68%)     39 (78%)     36 (72%)                                            
      Mineralization, Multifocal                                    1 (2%)                                                          
      Necrosis, Acute, Multifocal                                   1 (2%)       1 (2%)                                             
      Artery, Amyloid Deposition, Multifocal                        1 (2%)                                                          
      Artery, Adventitia, Hyperplasia                                            1 (2%)                                             
      Artery, Adventitia, Mineralization, Focal                                  1 (2%)                                             
      Artery, Epicardium, Thrombosis                                             1 (2%)                                             
      Atrium Left, Embolus, Focal                                                1 (2%)                                             
      Atrium Left, Inflammation, Acute, Multifocal                               1 (2%)                                             
      Atrium Left, Thrombosis                          1 (2%)                                                                       
      Epicardium, Inflammation, Chronic, Focal         1 (2%)                                                                       
      Mitral Valve, Degeneration, Mucoid                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Capsule, Accessory Adrenal Cortical Nodule       2 (4%)       1 (2%)       1 (2%)                                             
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Angiectasis, Focal                                            1 (2%)                                                          
      Angiectasis, Multifocal                          1 (2%)       1 (2%)                                                          
      Congestion                                                    1 (2%)       2 (4%)                                             
      Degeneration, Diffuse, Fatty                     3 (6%)                    4 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Degeneration, Fatty, Focal                      10 (20%)      7 (14%)      9 (18%)                                            
      Degeneration, Fatty, Multifocal                  1 (2%)       1 (2%)       7 (14%)                                            
      Degeneration, Focal                                                        1 (2%)                                             
      Hyperplasia, Focal                              13 (26%)      9 (18%)      4 (8%)                                             
      Hyperplasia, Multifocal                          2 (4%)       5 (10%)      1 (2%)                                             
      Hypertrophy, Focal                               4 (8%)       5 (10%)      2 (4%)                                             
      Hypertrophy, Multifocal                          2 (4%)       1 (2%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (43)         (48)         (45)                                                
      Fibrosis, Diffuse                                1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)       1 (2%)       4 (9%)                                             
      Hyperplasia, Multifocal                          1 (2%)       1 (2%)       3 (7%)                                             
   Islets, Pancreatic                                 (50)         (50)         (49)                                                
      Atrophy, Diffuse                                                           1 (2%)                                             
      Hyperplasia, Focal                               2 (4%)       2 (4%)                                                          
      Hyperplasia, Multifocal                          5 (10%)      6 (12%)      3 (6%)                                             
   Parathyroid Gland                                  (44)         (47)         (45)                                                
      Hyperplasia, Diffuse                             1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Focal                                                         1 (2%)                                             
      Hypertrophy, Focal                                            1 (2%)                                                          
   Pituitary Gland                                    (50)         (48)         (50)                                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Pars Distalis, Abscess, Chronic                               1 (2%)                                                          
      Pars Distalis, Angiectasis, Focal                1 (2%)       1 (2%)       1 (2%)                                             
      Pars Distalis, Angiectasis, Multifocal           4 (8%)       2 (4%)       5 (10%)                                            
      Pars Distalis, Cyst                              5 (10%)      2 (4%)       3 (6%)                                             
      Pars Distalis, Cyst, Multiple                    5 (10%)      3 (6%)       4 (8%)                                             
      Pars Distalis, Hyperplasia                                    1 (2%)                                                          
      Pars Distalis, Hyperplasia, Focal                4 (8%)       4 (8%)       8 (16%)                                            
      Pars Distalis, Hyperplasia, Multifocal           1 (2%)                                                                       
      Pars Intermedia, Angiectasis, Multifocal         1 (2%)       1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      C-Cell, Hyperplasia                              1 (2%)                                                                       
      C-Cell, Hyperplasia, Focal                       3 (6%)       3 (6%)       2 (4%)                                             
      C-Cell, Hyperplasia, Multifocal                 11 (22%)     10 (20%)     12 (24%)                                            
      Follicular Cell, Hypertrophy, Diffuse            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (48)         (44)                                                
      Abscess                                                       2 (4%)       1 (2%)                                             
      Ectasia                                          2 (4%)       3 (6%)       6 (14%)                                            
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Diffuse                                          1 (2%)                                                          
      Hyperplasia, Focal                               3 (6%)       3 (6%)       1 (2%)                                             
      Inflammation, Chronic Active, Focal              1 (2%)                                                                       
      Inflammation, Focal, Granulomatous                            1 (2%)                                                          
      Inflammation, Granulomatous, Multifocal          2 (4%)                    1 (2%)                                             
      Necrosis, Acute                                  1 (2%)                                                                       
   Ovary                                              (50)         (50)         (48)                                                
      Cyst                                             3 (6%)       5 (10%)      5 (10%)                                            
      Bilateral, Cyst                                                            1 (2%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                    3 (6%)                                             
      Cyst, Multiple                                   1 (2%)       3 (6%)                                                          
      Dilatation                                       3 (6%)       1 (2%)       4 (8%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation, Acute, Suppurative                              1 (2%)                                                          
      Prolapse                                         1 (2%)                                                                       
      Cervix, Dilatation                               1 (2%)                                                                       
   Vagina                                             (2)          (1)                                                              
      Inflammation, Chronic Active                     1 (50%)                                                                      
      Epithelium, Hyperplasia, Multifocal              1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (50)         (50)                                                
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Hyperplasia                                     23 (48%)     20 (40%)     25 (50%)                                            
      Myelofibrosis, Focal                             1 (2%)                                                                       
   Lymph Node                                         (50)         (50)         (50)                                                
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
      Axillary, Hemorrhage, Acute                                   1 (2%)                                                          
      Mediastinal, Cyst                                                          2 (4%)                                             
      Mediastinal, Edema                                            1 (2%)                                                          
      Mediastinal, Hemorrhage                          7 (14%)      7 (14%)      9 (18%)                                            
      Mediastinal, Hyperplasia                                                   1 (2%)                                             
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Inflammation, Acute                 1 (2%)                                                                       
      Pancreatic, Hemorrhage                           4 (8%)       3 (6%)       2 (4%)                                             
      Pancreatic, Hyperplasia, Lymphoid                                          1 (2%)                                             
   Lymph Node, Mandibular                             (49)         (50)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage, Acute                                1 (2%)                    2 (4%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       2 (4%)                                             
      Hyperplasia, Plasma Cell                         2 (4%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Re Cell                                                       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    2 (4%)                                             
   Lymph Node, Mesenteric                             (47)         (49)         (49)                                                
      Atrophy                                                       1 (2%)                                                          
      Hemorrhage, Acute                                6 (13%)      4 (8%)       6 (12%)                                            
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Re Cell                             1 (2%)       1 (2%)       5 (10%)                                            
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
      Congestion                                       2 (4%)       1 (2%)                                                          
      Depletion Lymphoid                               1 (2%)       1 (2%)       1 (2%)                                             
      Fibrosis, Focal                                                            1 (2%)                                             
      Fibrosis, Multifocal                                          1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)      14 (28%)                                            
      Hyperplasia, Re Cell                                                       1 (2%)                                             
      Pigmentation, Hemosiderin                        6 (12%)      9 (18%)      8 (16%)                                            
      Capsule, Fibrosis, Multifocal                                              1 (2%)                                             
   Thymus                                             (48)         (46)         (42)                                                
      Congestion                                                                 1 (2%)                                             
      Depletion Lymphoid                               1 (2%)                                                                       
      Epithelial Cell, Hyperplasia                     4 (8%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (50)                                                
      Ectasia, Diffuse                                 1 (2%)                    4 (8%)                                             
      Ectasia, Multifocal                             16 (33%)     18 (36%)     19 (38%)                                            
      Fibrosis, Focal                                                            1 (2%)                                             
      Galactocele                                                                3 (6%)                                             
      Hyperplasia, Diffuse                            10 (21%)      4 (8%)       5 (10%)                                            
      Hyperplasia, Focal                                            2 (4%)       3 (6%)                                             
      Hyperplasia, Multifocal                          3 (6%)       3 (6%)       3 (6%)                                             
      Inflammation, Granulomatous, Multifocal          1 (2%)                    1 (2%)                                             
      Mineralization, Multifocal                                    1 (2%)                                                          
      Duct, Ectasia, Focal                                          2 (4%)                                                          
      Duct, Ectasia, Multifocal                                     1 (2%)                                                          
      Duct, Hyperplasia, Multifocal                                 1 (2%)                                                          
   Skin                                               (50)         (50)         (50)                                                
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Inflammation, Chronic Active, Focal                                        1 (2%)                                             
      Inflammation, Multifocal, Subacute                                         1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Epidermis, Hyperplasia, Focal                    1 (2%)                                                                       
      Subcutaneous Tissue, Abscess                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (49)                                                
      Fibrous Osteodystrophy                           1 (2%)       1 (2%)                                                          
      Osteopetrosis                                    3 (6%)       4 (8%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                     11 (22%)     12 (24%)      5 (10%)                                            
      Hemorrhage, Multifocal                           2 (4%)                                                                       
      Hydrocephalus                                    5 (10%)      5 (10%)      3 (6%)                                             
      Choroid Plexus, Hyperplasia, Focal               1 (2%)       1 (2%)                                                          
   Spinal Cord                                        (1)                       (1)                                                 
      Degeneration, Multifocal, Secondary Wallerian                              1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (48)         (49)         (49)                                                
      Hyperplasia, Focal, Papillary                    1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute                                           2 (4%)       2 (4%)                                             
      Inflammation, Chronic                            4 (8%)       4 (8%)       6 (12%)                                            
      Inflammation, Chronic Active                     7 (15%)     10 (20%)      8 (16%)                                            
   Lung                                               (50)         (50)         (50)                                                
      Hemorrhage, Acute, Focal                                      1 (2%)                                                          
      Hemorrhage, Acute, Multifocal                                              1 (2%)                                             
      Inflammation, Acute, Multifocal, Necrotizing                               1 (2%)                                             
      Inflammation, Multifocal, Necrotizing,                                                                                        
          Subacute                                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Atypical,                                                                                   
           Focal                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       5 (10%)                                                         
      Alveolar Epithelium, Hyperplasia, Multifocal                 38 (76%)     50 (100%)                                           
      Alveolus, Infiltration Cellular, Multifocal,                                                                                  
           Histiocyte                                               1 (2%)                                                          
      Artery, Mineralization, Multifocal               1 (2%)                                                                       
      Bronchiole, Hyperplasia, Focal                                2 (4%)                                                          
      Bronchiole, Hyperplasia, Multifocal                          26 (52%)     48 (96%)                                            
      Bronchiole, Alveolus, Inflammation, Acute,                                                                                    
           Multifocal, Suppurative                                               2 (4%)                                             
      Bronchus, Hyperplasia, Focal, Papillary                       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Interstitium, Inflammation, Chronic, Focal                    1 (2%)                                                          
      Interstitium, Inflammation, Chronic,                                                                                          
          Multifocal                                   1 (2%)                                                                       
      Interstitium, Mineralization, Multifocal                      1 (2%)                                                          
   Nose                                               (49)         (50)         (50)                                                
      Foreign Body                                     2 (4%)                                                                       
      Thrombosis, Multifocal                           2 (4%)                    1 (2%)                                             
      Mucosa, Erosion, Multifocal                                                1 (2%)                                             
      Mucosa, Foreign Body                                          1 (2%)                                                          
      Mucosa, Inflammation, Acute                                                1 (2%)                                             
      Mucosa, Inflammation, Chronic                                 2 (4%)       1 (2%)                                             
      Mucosa, Inflammation, Chronic Active            10 (20%)      7 (14%)     20 (40%)                                            
      Mucosa, Inflammation, Chronic Active,                                                                                         
          Suppurative                                  3 (6%)                   10 (20%)                                            
      Mucosa, Ulcer                                                              1 (2%)                                             
      Mucosa, Ulcer, Multifocal                                                  1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic         9 (18%)      3 (6%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       3 (6%)       3 (6%)       2 (4%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active, Suppurative                                       2 (4%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative                  1 (2%)                                                          
      Olfactory Epithelium, Atrophy                                              1 (2%)                                             
      Olfactory Epithelium, Metaplasia, Squamous       1 (2%)                                                                       
      Respiratory Epithelium, Hyperplasia              5 (10%)      2 (4%)      21 (42%)                                            
      Respiratory Epithelium, Hyperplasia,                                                                                          
          Papillary                                                 1 (2%)       1 (2%)                                             
      Respiratory Epithelium, Metaplasia, Squamous                               1 (2%)                                             
   Trachea                                            (49)         (50)         (50)                                                
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            3 (6%)                    2 (4%)                                             
      Inflammation, Chronic Active                                  2 (4%)       2 (4%)                                             
      Inflammation, Necrotizing, Subacute                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (3)                                                              
      Cataract                                         2 (50%)      1 (33%)                                                         
      Anterior, Synechia                                            1 (33%)                                                         
      Cornea, Neovascularization, Multifocal                        1 (33%)                                                         
      Posterior Chamber, Synechia                      1 (25%)                                                                      
      Retina, Degeneration                             2 (50%)      1 (33%)                                                         
      Retina, Dysplasia, Focal                         1 (25%)                                                                      
   Lacrimal Gland                                     (2)                                                                           
      Ectopic Tissue                                   1 (50%)                                                                      
      Inflammation, Chronic                            1 (50%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Pigmentation                                     1 (50%)                                                                      
   Zymbal's Gland                                                  (1)                                                              
      Ectasia                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Infarct                                                                    2 (4%)                                             
      Nephropathy, Chronic                            43 (86%)     47 (94%)     44 (88%)                                            
      Pigmentation, Diffuse                            9 (18%)      2 (4%)                                                          
      Pigmentation, Multifocal                                                   1 (2%)                                             
      Artery, Mineralization, Multifocal                            1 (2%)                                                          
      Bilateral, Hydronephrosis                                                  1 (2%)                                             
      Capsule, Inflammation, Chronic                                1 (2%)                                                          
      Medulla, Mineralization, Multifocal              1 (2%)                                                                       
      Pelvis, Epithelium, Hyperplasia                  1 (2%)                                                                       
      Pelvis, Epithelium, Mineralization               1 (2%)       3 (6%)       3 (6%)                                             
      Proximal Convoluted Renal Tubule,                                                                                             
          Hyperplasia, Atypical, Focal                              1 (2%)                                                          
      Proximal Convoluted Renal Tubule, Necrosis,                                                                                   
           Acute                                       2 (4%)       2 (4%)                                                          
   Urinary Bladder                                    (49)         (50)         (48)                                                
      Inflammation, Acute, Diffuse                     1 (2%)                                                                       
      Serosa, Inflammation, Chronic Active             2 (4%)                                                                       
      Transitional Epithelium, Hyperplasia, Focal      1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                27           25           39                                                  
    Natural Death                                      5            8            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                18           17            4                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (50)         (50)                                                
      Serosa, Hemorrhage, Chronic, Focal               1 (2%)                                                                       
   Intestine Large, Cecum                             (45)         (49)         (49)                                                
      Edema                                                                      1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Parasite Metazoan                                4 (9%)       2 (4%)                                                          
   Intestine Large, Colon                             (49)         (47)         (49)                                                
      Edema                                            1 (2%)                                                                       
      Parasite Metazoan                                3 (6%)       3 (6%)       8 (16%)                                            
      Muscularis, Mineralization, Multifocal                                     1 (2%)                                             
   Intestine Large, Rectum                            (46)         (48)         (48)                                                
      Parasite Metazoan                                4 (9%)       3 (6%)       3 (6%)                                             
      Serosa, Inflammation, Chronic                    1 (2%)                                                                       
   Intestine Small                                    (50)         (50)         (49)                                                
      Peyer's Patch, Hyperplasia                                    1 (2%)                                                          
   Intestine Small, Duodenum                          (48)         (49)         (48)                                                
      Ectopic Tissue                                                             1 (2%)                                             
      Mucosa, Inflammation, Acute, Necrotizing                      1 (2%)                                                          
      Muscularis, Hyperplasia, Focal                                1 (2%)                                                          
   Intestine Small, Ileum                             (46)         (45)         (46)                                                
      Infiltration Cellular, Eosinophil, Histiocyte    1 (2%)                                                                       
      Mucosa, Atrophy, Diffuse                                                   1 (2%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)                                             
   Intestine Small, Jejunum                           (47)         (42)         (45)                                                
      Congestion                                                                 1 (2%)                                             
      Diverticulum                                                  1 (2%)                                                          
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Focal                               3 (6%)       3 (6%)       2 (4%)                                             
      Angiectasis, Multifocal                          1 (2%)       2 (4%)                                                          
      Basophilic Focus                                 6 (12%)      1 (2%)       4 (8%)                                             
      Basophilic Focus, Multiple                       4 (8%)       5 (10%)      5 (10%)                                            
      Basophilic Focus, Two                            1 (2%)       5 (10%)      6 (12%)                                            
      Clear Cell Focus                                 1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Congestion, Diffuse                              1 (2%)                    2 (4%)                                             
      Cytomegaly, Diffuse                              1 (2%)                                                                       
      Cytomegaly, Multifocal                           3 (6%)                                                                       
      Cytoplasmic Alteration, Focal                                 2 (4%)                                                          
      Degeneration, Ballooning, Focal                  3 (6%)       1 (2%)       3 (6%)                                             
      Degeneration, Ballooning, Multifocal             1 (2%)       2 (4%)                                                          
      Eosinophilic Focus                               1 (2%)       2 (4%)                                                          
      Fatty Change, Diffuse                            2 (4%)       1 (2%)       1 (2%)                                             
      Fatty Change, Multifocal                         8 (16%)      4 (8%)       3 (6%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Granuloma, Multifocal                            6 (12%)      4 (8%)       3 (6%)                                             
      Hemorrhage, Acute, Multifocal                                 2 (4%)                                                          
      Hyperplasia, Multifocal, Nodular                              2 (4%)                                                          
      Inflammation, Multifocal, Subacute                            1 (2%)                                                          
      Mitotic Alteration                               2 (4%)       1 (2%)       1 (2%)                                             
      Necrosis, Acute, Focal                                        1 (2%)                                                          
      Necrosis, Acute, Multifocal                      1 (2%)       5 (10%)      6 (12%)                                            
      Necrosis, Multifocal, Subacute                                4 (8%)                                                          
      Vacuolization Cytoplasmic, Diffuse                            1 (2%)                                                          
      Vacuolization Cytoplasmic, Multifocal            3 (6%)                                                                       
      Bile Duct, Hyperplasia, Multifocal              29 (58%)     30 (60%)     31 (62%)                                            
      Centrilobular, Atrophy, Diffuse                  2 (4%)       1 (2%)       1 (2%)                                             
      Centrilobular, Atrophy, Multifocal               4 (8%)       3 (6%)       6 (12%)                                            
      Centrilobular, Congestion                                     1 (2%)       1 (2%)                                             
      Centrilobular, Degeneration, Diffuse                                       1 (2%)                                             
      Centrilobular, Degeneration, Multifocal                                    2 (4%)                                             
      Centrilobular, Fatty Change, Diffuse             1 (2%)       2 (4%)       1 (2%)                                             
      Centrilobular, Fatty Change, Multifocal          1 (2%)                    1 (2%)                                             
      Centrilobular, Necrosis, Diffuse                 1 (2%)       1 (2%)                                                          
      Centrilobular, Necrosis, Multifocal              1 (2%)       2 (4%)                                                          
      Median Lobe, Hepatodiaphragmatic Nodule          2 (4%)       1 (2%)       3 (6%)                                             
      Periportal, Cytomegaly, Diffuse                  1 (2%)                                                                       
      Periportal, Fatty Change, Multifocal             1 (2%)                                                                       
      Portal, Fibrosis, Multifocal                     2 (4%)       1 (2%)       5 (10%)                                            
      Portal, Inflammation, Chronic, Multifocal        1 (2%)                                                                       
      Portal, Inflammation, Granulomatous,                                                                                          
          Multifocal                                   1 (2%)                                                                       
      Serosa, Inflammation, Chronic Active, Focal,                                                                                  
           Proliferative                               1 (2%)                                                                       
      Vein, Thrombosis                                 1 (2%)                    2 (4%)                                             
   Mesentery                                          (4)          (7)          (6)                                                 
      Accessory Spleen                                              1 (14%)                                                         
      Infiltration Cellular, Multifocal, Lymphocyte                              1 (17%)                                            
      Inflammation, Subacute                                                     1 (17%)                                            
      Pigmentation                                     1 (25%)                                                                      
      Artery, Mineralization                                                     1 (17%)                                            
      Artery, Adventitia, Inflammation, Chronic                                                                                     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
          Active, Multifocal                                        1 (14%)                                                         
      Fat, Necrosis, Focal                             1 (25%)      2 (29%)                                                         
   Pancreas                                           (49)         (48)         (50)                                                
      Angiectasis, Focal                                                         1 (2%)                                             
      Fibrosis, Focal                                                            1 (2%)                                             
      Inflammation, Focal                                           1 (2%)                                                          
      Pigmentation                                     1 (2%)                                                                       
      Acinus, Atrophy, Diffuse                                      2 (4%)                                                          
      Acinus, Atrophy, Focal                           1 (2%)       3 (6%)       1 (2%)                                             
      Acinus, Atrophy, Multifocal                     18 (37%)     12 (25%)     18 (36%)                                            
      Acinus, Hyperplasia, Focal                                    2 (4%)                                                          
      Artery, Adventitia, Inflammation, Chronic                                                                                     
          Active, Multifocal                           1 (2%)       1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (49)                                                
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Duct, Inflammation, Chronic Active,                                                                                           
          Multifocal                                                             1 (2%)                                             
      Duct, Metaplasia, Multifocal, Squamous                                     1 (2%)                                             
      Parotid Gland, Inflammation, Chronic Active,                                                                                  
           Diffuse                                     1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (49)         (50)                                                
      Erosion                                                       1 (2%)                                                          
      Hemorrhage, Multifocal                                        1 (2%)                                                          
      Hyperkeratosis, Multifocal                                                 1 (2%)                                             
      Inflammation, Acute, Focal                       1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                            2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)       6 (12%)      8 (16%)                                            
      Ulcer                                            4 (8%)       2 (4%)       4 (8%)                                             
      Epithelium, Hyperplasia, Diffuse                 5 (10%)      2 (4%)       1 (2%)                                             
      Epithelium, Hyperplasia, Focal                   1 (2%)       3 (6%)       3 (6%)                                             
      Epithelium, Hyperplasia, Multifocal                           1 (2%)       1 (2%)                                             
      Mucosa, Mineralization, Multifocal                            1 (2%)                                                          
      Muscularis, Hyperplasia, Focal                   1 (2%)                                                                       
   Stomach, Glandular                                 (48)         (47)         (50)                                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mucosa, Mineralization                                        2 (4%)       1 (2%)                                             
      Mucosa, Necrosis, Acute, Multifocal              1 (2%)                                                                       
   Tongue                                             (2)          (1)                                                              
      Epithelium, Hyperplasia, Focal                   1 (50%)                                                                      
   Tooth                                              (1)                                                                           
      Abscess                                          1 (100%)                                                                     
      Developmental Malformation                       1 (100%)                                                                     
      Gingiva, Inflammation                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)          (3)          (2)                                                 
      Inflammation, Chronic, Focal, Necrotizing        1 (50%)                                                                      
      Mineralization, Focal                            1 (50%)                                                                      
      Aorta, Mineralization, Multifocal                             1 (33%)                                                         
      Artery, Aneurysm                                              1 (33%)                                                         
      Artery, Arteriosclerosis, Multifocal                          1 (33%)                                                         
      Intima, Fibrosis, Multifocal                     1 (50%)                                                                      
      Pulmonary Artery, Mineralization                                           1 (50%)                                            
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  45 (90%)     43 (86%)     36 (72%)                                            
      Dilatation                                                    1 (2%)                                                          
      Inflammation, Chronic Active, Focal                                        1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Atrium Left, Thrombosis                          2 (4%)       3 (6%)       2 (4%)                                             
      Atrium Right, Dilatation                                      1 (2%)       2 (4%)                                             
      Epicardium, Hyperplasia                                                    3 (6%)                                             
      Epicardium, Inflammation, Chronic, Focal                                   1 (2%)                                             
      Mitral Valve, Inflammation, Chronic                                        1 (2%)                                             
      Mitral Valve, Thrombosis                                      1 (2%)                                                          
      Myocardium, Inflammation, Chronic, Focal         1 (2%)                                                                       
      Ventricle Left, Dilatation                       1 (2%)                                                                       
      Ventricle Left, Hypertrophy, Focal                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Capsule, Accessory Adrenal Cortical Nodule       4 (8%)       5 (10%)      8 (16%)                                            
   Adrenal Gland, Cortex                              (50)         (49)         (48)                                                
      Angiectasis, Multifocal                                       1 (2%)                                                          
      Congestion                                                    1 (2%)       1 (2%)                                             
      Degeneration, Diffuse, Fatty                     3 (6%)      10 (20%)     14 (29%)                                            
      Degeneration, Fatty, Focal                      10 (20%)      5 (10%)      2 (4%)                                             
      Degeneration, Fatty, Multifocal                  3 (6%)       4 (8%)       7 (15%)                                            
      Degeneration, Multifocal                         1 (2%)                                                                       
      Hemorrhage, Acute, Multifocal                                 1 (2%)                                                          
      Hyperplasia, Focal                               6 (12%)      4 (8%)       4 (8%)                                             
      Hyperplasia, Multifocal                          1 (2%)       5 (10%)      1 (2%)                                             
      Hypertrophy, Focal                               1 (2%)       2 (4%)       1 (2%)                                             
      Necrosis, Acute, Focal                           1 (2%)       1 (2%)                                                          
      Necrosis, Acute, Multifocal                                   1 (2%)                                                          
   Adrenal Gland, Medulla                             (46)         (47)         (47)                                                
      Hyperplasia, Focal                               7 (15%)      9 (19%)      4 (9%)                                             
      Hyperplasia, Multifocal                          9 (20%)     11 (23%)     13 (28%)                                            
      Necrosis, Acute, Focal                           1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (48)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Focal                               2 (4%)       7 (15%)      2 (4%)                                             
      Hyperplasia, Multifocal                                       1 (2%)       3 (6%)                                             
   Parathyroid Gland                                  (47)         (48)         (43)                                                
      Hyperplasia, Diffuse                             3 (6%)       4 (8%)       1 (2%)                                             
      Hyperplasia, Focal                                            1 (2%)                                                          
   Pituitary Gland                                    (49)         (49)         (48)                                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Necrosis, Subacute                                                         1 (2%)                                             
      Pars Distalis, Angiectasis                       2 (4%)       3 (6%)       1 (2%)                                             
      Pars Distalis, Cyst                              1 (2%)       3 (6%)       1 (2%)                                             
      Pars Distalis, Cyst, Multiple                    1 (2%)       1 (2%)       2 (4%)                                             
      Pars Distalis, Developmental Malformation        1 (2%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia                       4 (8%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia, Focal                1 (2%)       3 (6%)       6 (13%)                                            
      Pars Distalis, Hyperplasia, Multifocal                                     1 (2%)                                             
      Pars Distalis, Hypertrophy, Focal                             1 (2%)       1 (2%)                                             
      Pars Distalis, Hypertrophy, Multifocal                        1 (2%)                                                          
      Pars Intermedia, Angiectasis, Multifocal                                   1 (2%)                                             
   Thyroid Gland                                      (49)         (49)         (50)                                                
      C-Cell, Hyperplasia, Focal                       3 (6%)       2 (4%)       5 (10%)                                            
      C-Cell, Hyperplasia, Multifocal                  2 (4%)       6 (12%)      2 (4%)                                             
      Follicle, Cyst                                                1 (2%)                                                          
      Follicle, Cyst, Multiple                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)          (1)                                                              
      Abscess, Chronic, Multiple                                    1 (100%)                                                        
      Hyperplasia                                                   1 (100%)                                                        
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Epididymis                                         (49)         (49)         (50)                                                
      Atrophy                                          2 (4%)                                                                       
      Ectasia                                          1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Serosa, Granuloma, Multifocal                    1 (2%)                                                                       
   Preputial Gland                                    (49)         (48)         (49)                                                
      Abscess                                                                    1 (2%)                                             
      Atrophy                                                                    1 (2%)                                             
      Cyst                                                                       1 (2%)                                             
      Ectasia                                          3 (6%)       4 (8%)       7 (14%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Foreign Body                                                  3 (6%)                                                          
      Hyperplasia                                      1 (2%)       1 (2%)       2 (4%)                                             
      Hyperplasia, Squamous                                         1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (6%)                                                                       
      Inflammation, Granulomatous                     28 (57%)     28 (58%)     30 (61%)                                            
   Prostate                                           (48)         (50)         (46)                                                
      Abscess                                          1 (2%)       2 (4%)       1 (2%)                                             
      Ectasia, Focal                                                             1 (2%)                                             
      Hemorrhage, Acute                                1 (2%)                                                                       
      Hyperplasia, Focal                               6 (13%)      3 (6%)       3 (7%)                                             
      Hyperplasia, Multifocal                          4 (8%)       5 (10%)      2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     5 (10%)      1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active, Suppurative        1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization, Multifocal                                    1 (2%)                                                          
   Seminal Vesicle                                    (46)         (47)         (49)                                                
      Atrophy                                                       3 (6%)       1 (2%)                                             
      Concretion                                       1 (2%)                                                                       
      Ectasia                                          2 (4%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)                                                
      Mineralization, Focal                                         2 (4%)       1 (2%)                                             
      Mineralization, Multifocal                       4 (8%)       3 (6%)       1 (2%)                                             
      Artery, Inflammation, Chronic                    1 (2%)       1 (2%)       1 (2%)                                             
      Artery, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   1 (2%)       3 (6%)                                                          
      Interstitial Cell, Hyperplasia                   9 (18%)     16 (32%)     21 (42%)                                            
      Seminiferous Tubule, Atrophy                    12 (24%)      9 (18%)     12 (24%)                                            
      Seminiferous Tubule, Degeneration                2 (4%)       1 (2%)       1 (2%)                                             
      Serosa, Necrosis, Focal                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)                                                
      Hyperplasia                                     12 (24%)     13 (27%)      6 (12%)                                            
      Myelofibrosis, Focal                                          1 (2%)                                                          
      Myeloid Cell, Hyperplasia                                                  1 (2%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Inguinal, Hemorrhage, Acute                                   1 (2%)                                                          
      Mediastinal, Cyst                                                          3 (6%)                                             
      Mediastinal, Cyst, Multiple                                                4 (8%)                                             
      Mediastinal, Hemorrhage, Acute                   3 (6%)       7 (14%)      5 (10%)                                            
      Mediastinal, Hemorrhage, Subacute                2 (4%)       3 (6%)       4 (8%)                                             
      Mediastinal, Hyperplasia                                                   1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hyperplasia, Re Cell                1 (2%)                                                                       
      Mediastinal, Pigmentation                                                  2 (4%)                                             
      Pancreatic, Edema                                1 (2%)                                                                       
      Pancreatic, Granuloma, Multifocal                             1 (2%)                                                          
      Pancreatic, Hemorrhage, Acute                    1 (2%)                    1 (2%)                                             
      Pancreatic, Hyperplasia                                                    1 (2%)                                             
      Renal, Hemorrhage, Acute                                                   1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (44)         (46)                                                
      Hemorrhage, Acute                                1 (2%)       2 (5%)       2 (4%)                                             
      Hemorrhage, Subacute                                                       1 (2%)                                             
      Hyperplasia                                                   2 (5%)       1 (2%)                                             
      Hyperplasia, Plasma Cell                         7 (15%)      2 (5%)       4 (9%)                                             
      Inflammation, Chronic Active                                               2 (4%)                                             
   Lymph Node, Mesenteric                             (47)         (48)         (48)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hemorrhage, Acute                                4 (9%)      10 (21%)      6 (13%)                                            
      Hemorrhage, Subacute                                          1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Hyperplasia, Re Cell                             1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
   Spleen                                             (50)         (49)         (50)                                                
      Congestion, Acute                                                          1 (2%)                                             
      Depletion Lymphoid                               1 (2%)       1 (2%)       1 (2%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Fibrosis, Diffuse                                             1 (2%)       1 (2%)                                             
      Fibrosis, Focal                                  5 (10%)      6 (12%)      1 (2%)                                             
      Fibrosis, Multifocal                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 2 (4%)       4 (8%)       7 (14%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Focal, Re Cell                      1 (2%)                                                                       
      Infarct                                          1 (2%)       1 (2%)                                                          
      Necrosis, Multifocal, Subacute                                             1 (2%)                                             
      Pigmentation, Hemosiderin                        4 (8%)                    1 (2%)                                             
      Capsule, Fibrosis, Multifocal                                 1 (2%)                                                          
   Thymus                                             (36)         (42)         (43)                                                
      Atrophy                                                       1 (2%)                                                          
      Ectopic Parathyroid Gland                        1 (3%)       2 (5%)       2 (5%)                                             
      Hemorrhage, Acute                                             2 (5%)                                                          
      Epithelial Cell, Hyperplasia                     1 (3%)       6 (14%)      2 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (43)         (46)         (47)                                                
      Ectasia, Diffuse                                 4 (9%)       1 (2%)       1 (2%)                                             
      Ectasia, Multifocal                             11 (26%)     11 (24%)      8 (17%)                                            
      Hyperplasia, Diffuse                             2 (5%)       3 (7%)       5 (11%)                                            
      Artery, Adventitia, Inflammation, Chronic                                                                                     
          Active, Focal                                             1 (2%)                                                          
   Skin                                               (50)         (49)         (50)                                                
      Cyst Dermoid                                                  2 (4%)       2 (4%)                                             
      Hyperkeratosis                                   1 (2%)                                                                       
      Inflammation, Chronic Active, Focal,                                                                                          
          Suppurative                                                            1 (2%)                                             
      Forelimb, Right, Hemorrhage, Chronic, Focal,                                                                                  
           Subacute                                                 1 (2%)                                                          
      Subcutaneous Tissue, Developmental                                                                                            
          Malformation                                              1 (2%)                                                          
      Tail, Inflammation, Chronic                                                1 (2%)                                             
      Tail, Subcutaneous Tissue, Inflammation,                                                                                      
           Chronic, Proliferative                      1 (2%)                                                                       
      Tail, Epithelium, Hyperplasia                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (49)                                                
      Fibrous Osteodystrophy                                        2 (4%)       1 (2%)                                             
      Hyperostosis, Focal                                           1 (2%)                                                          
      Necrosis, Acute                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                     14 (28%)     10 (20%)      3 (6%)                                             
      Hemorrhage, Multifocal                           1 (2%)       1 (2%)       4 (8%)                                             
      Hydrocephalus                                    6 (12%)      3 (6%)       1 (2%)                                             
      Necrosis, Focal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (47)         (49)         (50)                                                
      Foreign Body                                     2 (4%)       1 (2%)                                                          
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            4 (9%)       4 (8%)       2 (4%)                                             
      Inflammation, Chronic Active                     9 (19%)     10 (20%)      4 (8%)                                             
      Epithelium, Hyperplasia                                       2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Lung                                               (50)         (50)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Giant Cell, Multifocal                                        1 (2%)                                                          
      Hemorrhage, Acute, Focal                                                   1 (2%)                                             
      Hemorrhage, Acute, Multifocal                                 2 (4%)       1 (2%)                                             
      Hemorrhage, Multifocal, Subacute                              2 (4%)                                                          
      Infiltration Cellular, Focal, Histiocyte                      1 (2%)                                                          
      Infiltration Cellular, Multifocal, Histiocyte                 1 (2%)       1 (2%)                                             
      Inflammation, Acute, Multifocal                  2 (4%)                                                                       
      Metaplasia, Focal, Osseous                       1 (2%)                                                                       
      Necrosis, Acute, Multifocal                                                1 (2%)                                             
      Pigmentation, Diffuse, Hemosiderin                            1 (2%)                                                          
      Pigmentation, Hemosiderin, Multifocal                         2 (4%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       7 (14%)                                                         
      Alveolar Epithelium, Hyperplasia, Multifocal                 37 (74%)     50 (100%)                                           
      Artery, Thrombosis                                            1 (2%)                                                          
      Artery, Adventitia, Mediastinum,                                                                                              
          Inflammation, Chronic Active, Multifocal                  1 (2%)                                                          
      Artery, Mediastinum, Mineralization                                        1 (2%)                                             
      Bronchiole, Hyperplasia                          1 (2%)                                                                       
      Bronchiole, Hyperplasia, Focal                                2 (4%)                                                          
      Bronchiole, Hyperplasia, Multifocal                          21 (42%)     45 (90%)                                            
      Bronchiole, Metaplasia, Focal, Squamous                       1 (2%)                                                          
      Bronchus, Hyperplasia, Focal                                  1 (2%)                                                          
      Bronchus, Metaplasia, Squamous                                             1 (2%)                                             
      Bronchus, Alveolus, Inflammation, Chronic                                                                                     
          Active, Multifocal                           1 (2%)                                                                       
      Interstitium, Fibrosis, Multifocal                            1 (2%)                                                          
      Interstitium, Inflammation, Chronic, Diffuse                  1 (2%)                                                          
      Interstitium, Inflammation, Chronic,                                                                                          
          Multifocal                                   1 (2%)                    1 (2%)                                             
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Diffuse                                                  1 (2%)                                                          
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Multifocal                                  1 (2%)                                                                       
      Interstitium, Mineralization, Multifocal                      1 (2%)       1 (2%)                                             
      Mediastinum, Angiectasis                                                   1 (2%)                                             
      Mediastinum, Cyst                                                          1 (2%)                                             
      Mediastinum, Pigmentation                                                  1 (2%)                                             
      Peribronchiolar, Perivascular, Granuloma,                                                                                     
           Multifocal                                  1 (2%)                                                                       
   Nose                                               (48)         (49)         (50)                                                
      Foreign Body                                     3 (6%)      10 (20%)      3 (6%)                                             
      Lumen, Exudate                                                             1 (2%)                                             
      Mucosa, Inflammation, Acute                                   1 (2%)                                                          
      Mucosa, Inflammation, Chronic                    2 (4%)                                                                       
      Mucosa, Inflammation, Chronic Active             9 (19%)     16 (33%)     16 (32%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mucosa, Inflammation, Chronic Active,                                                                                         
          Suppurative                                  1 (2%)       4 (8%)      21 (42%)                                            
      Mucosa, Thrombosis, Multifocal                   2 (4%)       3 (6%)       3 (6%)                                             
      Nasolacrimal Duct, Exudate                                    1 (2%)                                                          
      Nasolacrimal Duct, Hyperplasia                   1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                  3 (6%)       2 (4%)                                                          
      Nasolacrimal Duct, Inflammation, Chronic         2 (4%)       4 (8%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)       2 (4%)       2 (4%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active, Suppurative                                       1 (2%)                                                          
      Olfactory Epithelium, Atrophy                                              3 (6%)                                             
      Olfactory Epithelium, Metaplasia                 3 (6%)                                                                       
      Respiratory Epithelium, Hyperplasia              7 (15%)     15 (31%)     29 (58%)                                            
      Respiratory Epithelium, Metaplasia, Squamous                  1 (2%)      13 (26%)                                            
   Trachea                                            (50)         (50)         (50)                                                
      Inflammation, Chronic                            1 (2%)       3 (6%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Bilateral, External Ear, Hyperkeratosis                                    1 (100%)                                           
   Eye                                                (1)          (3)          (4)                                                 
      Bilateral, Cornea, Mineralization, Multifocal    1 (100%)                                                                     
      Lens, Cataract                                                1 (33%)      2 (50%)                                            
      Retina, Degeneration                                          2 (67%)      2 (50%)                                            
   Harderian Gland                                                 (1)                                                              
      Inflammation, Chronic                                         1 (100%)                                                        
   Zymbal's Gland                                     (1)          (2)          (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst, Two                                                                  1 (2%)                                             
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                                       2 (4%)       1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte                 1 (2%)                                                          
      Nephropathy, Chronic                            47 (94%)     47 (94%)     49 (98%)                                            
      Pigmentation, Diffuse                            4 (8%)       3 (6%)       3 (6%)                                             
      Pigmentation, Multifocal                         1 (2%)       3 (6%)       1 (2%)                                             
      Artery, Thrombosis                                            1 (2%)                                                          
      Bilateral, Hydronephrosis                        1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
NTP Experiment-Test: 05072-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:16:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2 PPM        5 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cortex, Cyst, Multiple                                        2 (4%)                                                          
      Cortex, Renal Tubule, Hyperplasia, Atypical,                                                                                  
           Focal                                       2 (4%)                    1 (2%)                                             
      Pelvis, Inflammation, Acute, Diffuse             1 (2%)                                                                       
      Pelvis, Transitional Epithelium, Hyperplasia     1 (2%)                                                                       
      Proximal Convoluted Renal Tubule, Necrosis,                                                                                   
           Acute                                                                 1 (2%)                                             
   Ureter                                             (1)                       (1)                                                 
      Inflammation, Chronic                            1 (100%)                                                                     
   Urinary Bladder                                    (49)         (49)         (48)                                                
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       1 (2%)                                             
      Transitional Epithelium, Hyperplasia,                                                                                         
          Multifocal                                   1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   21                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.