National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1301

TR 399 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       TITANOCENE DICHLORIDE


NTP Experiment-Test: 05047-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/06/94
Route: GAVAGE                                                                                                     Time: 21:41:21




       Facility:  TSI Mason Research

       Chemical CAS #:  1271-19-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          80           80           80                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          19           25           21                                                  
    Dead                                               4            5            7                                                  
    Accident                                                        1                                                               
    Moribund Sacrifice                                                           1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           30           31                                                  
    Moribund                                           1                                                                            
  Aborted                                             10            9           10                                                  
  Animals Examined Microscopically                    60           61           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)         (59)         (59)                                                
      Erosion                                                       1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Parasite                                         2 (4%)                    1 (2%)                                             
   Intestine Small, Duodenum                          (59)         (57)         (56)                                                
      Hyperplasia, Adenomatous                                      1 (2%)                                                          
      Pigmentation                                                 25 (44%)     34 (61%)                                            
   Intestine Small, Ileum                             (59)         (56)         (58)                                                
      Fibrosis                                                      1 (2%)                                                          
      Inflammation, Acute                                           2 (4%)                                                          
      Pigmentation                                                  1 (2%)       1 (2%)                                             
   Intestine Small, Jejunum                           (58)         (56)         (56)                                                
      Pigmentation                                                  1 (2%)       9 (16%)                                            
   Liver                                              (60)         (61)         (60)                                                
      Abscess                                                                    1 (2%)                                             
      Angiectasis                                                   2 (3%)       2 (3%)                                             
      Basophilic Focus                                45 (75%)     45 (74%)     48 (80%)                                            
      Clear Cell Focus                                 1 (2%)       3 (5%)      10 (17%)                                            
      Degeneration, Cystic                             1 (2%)       1 (2%)                                                          
      Eosinophilic Focus                                                         2 (3%)                                             
      Fatty Change, Diffuse                           11 (18%)      6 (10%)     10 (17%)                                            
      Fatty Change, Focal                             15 (25%)     11 (18%)     14 (23%)                                            
      Hepatodiaphragmatic Nodule                       4 (7%)       6 (10%)     10 (17%)                                            
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Granulomatous                      6 (10%)     24 (39%)     33 (55%)                                            
      Mixed Cell Focus                                 2 (3%)       5 (8%)       3 (5%)                                             
      Necrosis                                         3 (5%)       6 (10%)      7 (12%)                                            
      Pigmentation                                     3 (5%)      45 (74%)     50 (83%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Thrombosis                                       1 (2%)                                                                       
      Bile Duct, Hyperplasia                          17 (28%)      4 (7%)                                                          
   Mesentery                                          (3)          (9)          (10)                                                
      Fat, Inflammation, Chronic Active                             2 (22%)      2 (20%)                                            
      Fat, Necrosis                                    1 (33%)      7 (78%)      6 (60%)                                            
   Pancreas                                           (60)         (61)         (59)                                                
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Acinus, Atrophy                                               1 (2%)                                                          
      Acinus, Hyperplasia                              6 (10%)      4 (7%)       8 (14%)                                            
   Salivary Glands                                    (60)         (61)         (60)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
   Stomach                                            (60)         (60)         (60)                                                
      Fat, Proliferation                                           15 (25%)     41 (68%)                                            
      Polyp Adenomatous, Inflammation                               1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (60)                                                
      Acanthosis                                      11 (18%)     20 (33%)     27 (45%)                                            
      Hyperkeratosis                                  10 (17%)     23 (38%)     21 (35%)                                            
      Inflammation, Acute                              1 (2%)                    4 (7%)                                             
      Necrosis                                         6 (10%)                                                                      
   Stomach, Glandular                                 (60)         (60)         (60)                                                
      Erosion                                          2 (3%)      11 (18%)     10 (17%)                                            
      Fibrosis                                                     39 (65%)     51 (85%)                                            
      Hemorrhage                                                    3 (5%)       2 (3%)                                             
      Hyperplasia                                                  24 (40%)     23 (38%)                                            
      Hyperplasia, Adenomatous                                      1 (2%)                                                          
      Inflammation, Acute                                           4 (7%)       5 (8%)                                             
      Metaplasia                                                   36 (60%)     51 (85%)                                            
      Mineralization                                                7 (12%)      2 (3%)                                             
      Pigmentation                                                 19 (32%)     24 (40%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (61)         (60)                                                
      Bacterium                                        1 (2%)                                                                       
      Cardiomyopathy                                  23 (38%)     23 (38%)     23 (38%)                                            
      Mineralization                                                1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (61)         (60)                                                
      Degeneration                                                  1 (2%)                                                          
      Degeneration, Cystic                                          1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      3 (5%)       2 (3%)       1 (2%)                                             
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Pigmentation, Ceroid                                          1 (2%)                                                          
   Adrenal Gland, Medulla                             (58)         (60)         (59)                                                
      Hyperplasia                                     13 (22%)      8 (13%)      6 (10%)                                            
   Parathyroid Gland                                  (55)         (53)         (51)                                                
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (59)         (59)         (60)                                                
      Cyst                                             1 (2%)                                                                       
      Pars Distalis, Angiectasis                      27 (46%)     21 (36%)     23 (38%)                                            
      Pars Distalis, Cyst                              4 (7%)       4 (7%)       2 (3%)                                             
      Pars Distalis, Hyperplasia                      13 (22%)     18 (31%)     24 (40%)                                            
      Pars Distalis, Pigmentation                      1 (2%)                                                                       
      Pars Intermedia, Cyst                            1 (2%)       1 (2%)                                                          
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (60)         (57)         (59)                                                
      C-Cell, Hyperplasia                              8 (13%)     17 (30%)     13 (22%)                                            
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                                               2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
      Hemorrhage                                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (56)         (55)         (56)                                                
      Inflammation, Acute                                                        1 (2%)                                             
      Necrosis                                         1 (2%)       1 (2%)                                                          
   Ovary                                              (58)         (61)         (60)                                                
      Cyst                                             3 (5%)       6 (10%)      1 (2%)                                             
      Degeneration, Cystic                                          1 (2%)                                                          
      Hyperplasia, Tubular                                          1 (2%)                                                          
   Uterus                                             (60)         (61)         (60)                                                
      Cyst                                                                       2 (3%)                                             
      Decidual Reaction                                                          1 (2%)                                             
      Hemorrhage                                                    2 (3%)       3 (5%)                                             
      Inflammation, Acute                                                        2 (3%)                                             
      Necrosis                                                                   1 (2%)                                             
      Prolapse                                                                   1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Cervix, Hemorrhage                               1 (2%)                                                                       
      Cervix, Inflammation, Acute                                                2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Endometrium, Hyperplasia                                      2 (3%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (61)         (59)                                                
      Pigmentation                                                  8 (13%)     26 (44%)                                            
   Lymph Node                                         (60)         (61)         (60)                                                
      Lumbar, Degeneration, Cystic                                               1 (2%)                                             
      Mediastinal, Angiectasis                         1 (2%)                                                                       
      Mediastinal, Congestion                                                    1 (2%)                                             
      Mediastinal, Hemorrhage                                       1 (2%)                                                          
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                      1 (2%)                                                          
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                  12 (20%)     21 (34%)     27 (45%)                                            
      Mediastinal, Pigmentation                        1 (2%)      23 (38%)     25 (42%)                                            
      Pancreatic, Angiectasis                                       1 (2%)       1 (2%)                                             
      Pancreatic, Hematopoietic Cell Proliferation                               1 (2%)                                             
      Pancreatic, Infiltration Cellular, Histiocyte    3 (5%)       5 (8%)      17 (28%)                                            
      Pancreatic, Pigmentation                                     10 (16%)     18 (30%)                                            
      Renal, Angiectasis                                                         1 (2%)                                             
      Renal, Infiltration Cellular, Histiocyte                                   1 (2%)                                             
   Lymph Node, Mandibular                             (56)         (59)         (60)                                                
      Infiltration Cellular, Histiocyte                9 (16%)      6 (10%)     22 (37%)                                            
      Pigmentation                                                 34 (58%)     26 (43%)                                            
   Lymph Node, Mesenteric                             (60)         (61)         (60)                                                
      Angiectasis                                                                2 (3%)                                             
      Degeneration, Cystic                             1 (2%)                                                                       
      Depletion Lymphoid                                            1 (2%)                                                          
      Infiltration Cellular, Histiocyte               27 (45%)     45 (74%)     47 (78%)                                            
      Pigmentation                                     1 (2%)      47 (77%)     49 (82%)                                            
   Spleen                                             (60)         (60)         (60)                                                
      Angiectasis                                                                3 (5%)                                             
      Depletion Lymphoid                               2 (3%)       3 (5%)       2 (3%)                                             
      Fibrosis                                         1 (2%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation                33 (55%)     43 (72%)     43 (72%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Infiltration Cellular, Histiocyte               34 (57%)     28 (47%)     34 (57%)                                            
      Inflammation, Granulomatous                                                1 (2%)                                             
      Necrosis                                         2 (3%)                                                                       
      Pigmentation                                     1 (2%)      34 (57%)     33 (55%)                                            
      Pigmentation, Hemosiderin                        9 (15%)     25 (42%)     36 (60%)                                            
      Capsule, Hemorrhage                              1 (2%)                                                                       
      Capsule, Necrosis                                1 (2%)                                                                       
   Thymus                                             (55)         (56)         (58)                                                
      Cyst                                             1 (2%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Depletion Lymphoid                               1 (2%)       1 (2%)                                                          
      Pigmentation                                     5 (9%)      34 (61%)     41 (71%)                                            
      Epithelial Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (56)         (56)         (49)                                                
      Galactocele                                     21 (38%)     12 (21%)      7 (14%)                                            
      Acinus, Hyperplasia                                                        1 (2%)                                             
   Skin                                               (60)         (61)         (58)                                                
      Abscess                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (61)         (60)                                                
      Hyperplasia                                                                1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (61)         (60)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (61)         (60)                                                
      Atelectasis                                      3 (5%)       5 (8%)       5 (8%)                                             
      Bacterium                                        1 (2%)                                                                       
      Congestion                                       3 (5%)       4 (7%)       3 (5%)                                             
      Edema                                            3 (5%)       5 (8%)       6 (10%)                                            
      Hemorrhage                                       2 (3%)       7 (11%)      3 (5%)                                             
      Infiltration Cellular, Histiocyte               22 (37%)     48 (79%)     46 (77%)                                            
      Inflammation, Acute                              2 (3%)       4 (7%)       9 (15%)                                            
      Inflammation, Granulomatous                                   3 (5%)       8 (13%)                                            
      Metaplasia, Osseous                              1 (2%)                                                                       
      Pigmentation                                     1 (2%)      23 (38%)     35 (58%)                                            
      Pigmentation, Cholesterol                                                  1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)       4 (7%)                                             
   Nose                                               (60)         (61)         (60)                                                
      Fungus                                           1 (2%)       2 (3%)       1 (2%)                                             
      Hemorrhage                                       2 (3%)                                                                       
      Inflammation, Acute                              7 (12%)     13 (21%)     15 (25%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Submucosa, Glands, Hyperplasia                                             1 (2%)                                             
   Trachea                                            (60)         (59)         (60)                                                
      Erosion                                                                    1 (2%)                                             
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Metaplasia, Squamous                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)          (6)                                                 
      Inflammation, Acute                                                        1 (17%)                                            
      Canal, Abscess                                                1 (100%)     2 (33%)                                            
   Eye                                                (5)          (11)         (18)                                                
      Hemorrhage                                                                 1 (6%)                                             
      Inflammation, Acute                                           1 (9%)       1 (6%)                                             
      Synechia                                         2 (40%)      1 (9%)       3 (17%)                                            
      Lens, Cataract                                   1 (20%)      5 (45%)      4 (22%)                                            
      Retina, Atrophy                                  3 (60%)                   2 (11%)                                            
   Harderian Gland                                    (4)          (8)          (14)                                                
      Pigmentation                                                  1 (13%)      5 (36%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (61)         (60)                                                
      Bacterium                                        1 (2%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Nephropathy                                     32 (53%)     26 (43%)     35 (58%)                                            
      Cortex, Mineralization                           4 (7%)       4 (7%)       2 (3%)                                             
      Papilla, Mineralization                          5 (8%)      10 (16%)      6 (10%)                                            
      Pelvis, Mineralization                           2 (3%)                                                                       
      Renal Tubule, Hyperplasia                                                  1 (2%)                                             
      Renal Tubule, Pigmentation                      35 (58%)     32 (52%)     40 (67%)                                            
   Urinary Bladder                                    (60)         (58)         (60)                                                
      Hemorrhage                                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          80           80           80                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                              11           15           17                                                  
    Moribund                                           8           14           17                                                  
    Accident                                                        1            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           30           24                                                  
  Aborted                                             10           10           10                                                  
  Animals Examined Microscopically                    60           60           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (54)         (54)         (55)                                                
      Pigmentation                                                               1 (2%)                                             
   Intestine Large, Colon                             (56)         (54)         (57)                                                
      Parasite                                         4 (7%)       2 (4%)       4 (7%)                                             
      Pigmentation                                                               1 (2%)                                             
   Intestine Large, Rectum                            (54)         (55)         (54)                                                
      Parasite                                         5 (9%)                    1 (2%)                                             
   Intestine Small, Duodenum                          (59)         (54)         (53)                                                
      Pigmentation                                                 23 (43%)     36 (68%)                                            
   Intestine Small, Ileum                             (55)         (52)         (57)                                                
      Pigmentation                                                               3 (5%)                                             
      Lymphoid Tissue, Hyperplasia                                               1 (2%)                                             
   Intestine Small, Jejunum                           (53)         (53)         (51)                                                
      Pigmentation                                                  1 (2%)      14 (27%)                                            
      Lymphoid Tissue, Hyperplasia                                               1 (2%)                                             
   Liver                                              (60)         (59)         (60)                                                
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                46 (77%)     36 (61%)     40 (67%)                                            
      Clear Cell Focus                                16 (27%)     14 (24%)     14 (23%)                                            
      Congestion                                                                 1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                             1 (2%)       3 (5%)       4 (7%)                                             
      Eosinophilic Focus                               4 (7%)       7 (12%)     14 (23%)                                            
      Fatty Change, Diffuse                            5 (8%)       6 (10%)                                                         
      Fatty Change, Focal                              9 (15%)     19 (32%)     19 (32%)                                            
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hepatodiaphragmatic Nodule                       4 (7%)       5 (8%)       2 (3%)                                             
      Infarct                                          1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                                  16 (27%)     14 (23%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mixed Cell Focus                                 1 (2%)       1 (2%)       8 (13%)                                            
      Necrosis                                         2 (3%)       1 (2%)       5 (8%)                                             
      Pigmentation                                     1 (2%)      39 (66%)     41 (68%)                                            
      Thrombosis                                                                 1 (2%)                                             
      Bile Duct, Hyperplasia                          30 (50%)     15 (25%)     11 (18%)                                            
   Mesentery                                          (6)          (4)          (5)                                                 
      Fibrosis                                                      1 (25%)                                                         
      Artery, Necrosis, Fibrinoid                      1 (17%)                   1 (20%)                                            
      Fat, Hemorrhage                                                            1 (20%)                                            
      Fat, Inflammation, Chronic Active                1 (17%)      2 (50%)                                                         
      Fat, Mineralization                              1 (17%)                                                                      
      Fat, Necrosis                                    3 (50%)      1 (25%)      3 (60%)                                            
   Pancreas                                           (59)         (56)         (59)                                                
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Acinus, Focal Cellular Change                    1 (2%)                                                                       
      Acinus, Hyperplasia                             14 (24%)     20 (36%)     16 (27%)                                            
      Artery, Inflammation, Chronic Active             3 (5%)       1 (2%)                                                          
      Artery, Necrosis, Fibrinoid                                                1 (2%)                                             
   Salivary Glands                                    (60)         (59)         (59)                                                
      Necrosis                                                      1 (2%)                                                          
   Stomach                                            (59)         (59)         (60)                                                
      Artery, Necrosis, Fibrinoid                                                1 (2%)                                             
      Fat, Proliferation                                            2 (3%)      14 (23%)                                            
   Stomach, Forestomach                               (57)         (59)         (59)                                                
      Acanthosis                                       8 (14%)     25 (42%)     26 (44%)                                            
      Fibrosis                                                      1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hyperkeratosis                                   5 (9%)      13 (22%)     17 (29%)                                            
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)       2 (3%)       1 (2%)                                             
      Necrosis                                         2 (4%)                    1 (2%)                                             
      Pigmentation                                                               1 (2%)                                             
   Stomach, Glandular                                 (58)         (59)         (58)                                                
      Erosion                                          1 (2%)       9 (15%)     13 (22%)                                            
      Fibrosis                                                     30 (51%)     37 (64%)                                            
      Hemorrhage                                                    2 (3%)       5 (9%)                                             
      Hyperplasia                                                  10 (17%)     24 (41%)                                            
      Hyperplasia, Adenomatous                                      2 (3%)                                                          
      Inflammation, Acute                                           9 (15%)     10 (17%)                                            
      Metaplasia                                                   26 (44%)     36 (62%)                                            
      Mineralization                                                2 (3%)       1 (2%)                                             
      Pigmentation                                                  8 (14%)     19 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)                                                
      Bacterium                                                                  1 (2%)                                             
      Cardiomyopathy                                  50 (83%)     52 (87%)     43 (72%)                                            
      Mineralization                                                1 (2%)                                                          
      Pigmentation                                                               2 (3%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Artery, Necrosis, Fibrinoid                      1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (60)                                                
      Hyperplasia                                      2 (3%)       3 (5%)       3 (5%)                                             
      Infarct                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (60)         (60)         (59)                                                
      Hyperplasia                                     25 (42%)     18 (30%)     13 (22%)                                            
   Islets, Pancreatic                                 (58)         (56)         (59)                                                
      Hyperplasia                                      1 (2%)       2 (4%)       1 (2%)                                             
   Parathyroid Gland                                  (56)         (54)         (51)                                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (56)         (59)         (56)                                                
      Cyst                                             1 (2%)                                                                       
      Pars Distalis, Angiectasis                      18 (32%)     15 (25%)     11 (20%)                                            
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                      14 (25%)     11 (19%)     13 (23%)                                            
      Pars Distalis, Pigmentation                      1 (2%)                                                                       
      Pars Intermedia, Cyst                                                      1 (2%)                                             
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
      Rathke's Cleft, Cyst                                          1 (2%)                                                          
   Thyroid Gland                                      (60)         (55)         (58)                                                
      C-Cell, Hyperplasia                              6 (10%)      5 (9%)      10 (17%)                                            
      Follicular Cell, Cyst                            1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (58)         (60)                                                
      Spermatocele                                     1 (2%)                                                                       
   Preputial Gland                                    (56)         (59)         (56)                                                
      Inflammation, Chronic Active                     2 (4%)       1 (2%)                                                          
      Necrosis                                         4 (7%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Prostate                                           (59)         (57)         (60)                                                
      Abscess                                          1 (2%)                                                                       
      Epithelium, Hyperplasia                         12 (20%)      4 (7%)       7 (12%)                                            
   Seminal Vesicle                                    (60)         (59)         (60)                                                
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Testes                                             (60)         (60)         (60)                                                
      Atrophy                                                       1 (2%)                                                          
      Infarct                                                                    1 (2%)                                             
      Interstitial Cell, Hyperplasia                  26 (43%)     26 (43%)     32 (53%)                                            
      Seminiferous Tubule, Atrophy                    29 (48%)     34 (57%)     36 (60%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (58)         (60)                                                
      Pigmentation                                                 20 (34%)     37 (62%)                                            
   Lymph Node                                         (60)         (59)         (60)                                                
      Axillary, Angiectasis                                                      1 (2%)                                             
      Axillary, Infiltration Cellular, Histiocyte                                1 (2%)                                             
      Lumbar, Infiltration Cellular, Histiocyte                                  1 (2%)                                             
      Lumbar, Pigmentation                                                       1 (2%)                                             
      Mediastinal, Angiectasis                                                   1 (2%)                                             
      Mediastinal, Degeneration, Cystic                1 (2%)                                                                       
      Mediastinal, Hematopoietic Cell Proliferation                              1 (2%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   8 (13%)      5 (8%)      30 (50%)                                            
      Mediastinal, Pigmentation                        6 (10%)     20 (34%)     25 (42%)                                            
      Pancreatic, Infiltration Cellular, Plasma                                                                                     
          Cell                                         1 (2%)                                                                       
      Pancreatic, Infiltration Cellular, Histiocyte    3 (5%)       6 (10%)      5 (8%)                                             
      Pancreatic, Pigmentation                                      7 (12%)      2 (3%)                                             
      Renal, Angiectasis                                            1 (2%)                                                          
      Renal, Infiltration Cellular, Histiocyte                      1 (2%)       1 (2%)                                             
      Renal, Pigmentation                                           1 (2%)       1 (2%)                                             
   Lymph Node, Mandibular                             (58)         (56)         (56)                                                
      Bacterium                                                                  1 (2%)                                             
      Degeneration                                     1 (2%)                                                                       
      Degeneration, Cystic                             5 (9%)       1 (2%)       3 (5%)                                             
      Infiltration Cellular, Plasma Cell               1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Histiocyte                2 (3%)       3 (5%)      20 (36%)                                            
      Pigmentation                                     2 (3%)      28 (50%)     17 (30%)                                            
   Lymph Node, Mesenteric                             (59)         (54)         (58)                                                
      Bacterium                                                                  1 (2%)                                             
      Infiltration Cellular, Mast Cell                 1 (2%)       2 (4%)       3 (5%)                                             
      Infiltration Cellular, Histiocyte               26 (44%)     40 (74%)     45 (78%)                                            
      Mineralization                                                             3 (5%)                                             
      Pigmentation                                     9 (15%)     42 (78%)     44 (76%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (58)         (56)         (59)                                                
      Angiectasis                                                   1 (2%)                                                          
      Depletion Lymphoid                               2 (3%)       5 (9%)       6 (10%)                                            
      Fibrosis                                         3 (5%)       3 (5%)       2 (3%)                                             
      Hematopoietic Cell Proliferation                24 (41%)     35 (63%)     28 (47%)                                            
      Hemorrhage                                       1 (2%)                    2 (3%)                                             
      Infiltration Cellular, Histiocyte               15 (26%)     24 (43%)     33 (56%)                                            
      Inflammation, Granulomatous                                                1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Pigmentation                                                 33 (59%)     32 (54%)                                            
      Pigmentation, Hemosiderin                        9 (16%)     35 (63%)     37 (63%)                                            
      Thrombosis                                                                 1 (2%)                                             
      Capsule, Cyst                                                 1 (2%)                                                          
   Thymus                                             (55)         (50)         (52)                                                
      Cyst                                             1 (2%)                                                                       
      Depletion Lymphoid                                            5 (10%)      7 (13%)                                            
      Ectopic Parathyroid Gland                                                  1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Pigmentation                                                 25 (50%)     31 (60%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (36)         (41)                                                
      Galactocele                                      4 (10%)      1 (3%)       1 (2%)                                             
   Skin                                               (58)         (60)         (59)                                                
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hyperkeratosis                                                1 (2%)       1 (2%)                                             
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Metaplasia, Osseous                                           1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)                                                
      Costochondral Junction, Fibrosis                              1 (2%)                                                          
      Costochondral Junction, Inflammation,                                                                                         
          Chronic Active                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (60)                                                
      Bacterium                                                                  1 (2%)                                             
      Metaplasia, Osseous                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)                                                
      Atelectasis                                                  10 (17%)     14 (23%)                                            
      Bacterium                                                                  1 (2%)                                             
      Congestion                                       6 (10%)      5 (8%)       6 (10%)                                            
      Edema                                                         9 (15%)     11 (18%)                                            
      Fibrosis                                                      1 (2%)                                                          
      Hemorrhage                                       4 (7%)       3 (5%)       8 (13%)                                            
      Infiltration Cellular, Histiocyte                9 (15%)     46 (77%)     49 (82%)                                            
      Inflammation, Acute                              1 (2%)      13 (22%)     10 (17%)                                            
      Inflammation, Granulomatous                                  10 (17%)     20 (33%)                                            
      Mineralization                                                3 (5%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Pigmentation                                                 34 (57%)     50 (83%)                                            
      Pigmentation, Cholesterol                                     3 (5%)       5 (8%)                                             
      Alveolar Epithelium, Hyperplasia                 4 (7%)       6 (10%)      5 (8%)                                             
      Artery, Mediastinum, Necrosis, Fibrinoid                                   1 (2%)                                             
      Bronchiole, Hyperplasia                                       1 (2%)                                                          
      Bronchiole, Epithelium, Metaplasia, Squamous                               1 (2%)                                             
      Bronchus, Inflammation, Chronic                                            1 (2%)                                             
   Nose                                               (59)         (60)         (56)                                                
      Erosion                                                                    1 (2%)                                             
      Fungus                                           1 (2%)       6 (10%)      8 (14%)                                            
      Inflammation, Acute                              8 (14%)     18 (30%)     22 (39%)                                            
   Trachea                                            (60)         (58)         (60)                                                
      Erosion                                                       1 (2%)       1 (2%)                                             
      Inflammation, Acute                                           1 (2%)       3 (5%)                                             
      Metaplasia, Squamous                                                       3 (5%)                                             
      Pigmentation                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (3)          (1)                                                 
      Canal, Inflammation, Acute                                    2 (67%)                                                         
   Eye                                                (6)          (13)         (9)                                                 
      Hemorrhage                                                    1 (8%)                                                          
      Inflammation, Acute                                           1 (8%)                                                          
      Lens, Cataract                                   1 (17%)      6 (46%)      1 (11%)                                            
      Retina, Atrophy                                               1 (8%)       1 (11%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05047-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:41:21  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
   Harderian Gland                                    (6)          (10)         (7)                                                 
      Inflammation, Chronic Active                                               1 (14%)                                            
      Pigmentation                                                  1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)                                                
      Abscess                                                                    1 (2%)                                             
      Bacterium                                                                  1 (2%)                                             
      Cyst                                                                       1 (2%)                                             
      Nephropathy                                     56 (93%)     39 (65%)     34 (57%)                                            
      Pigmentation                                                  2 (3%)                                                          
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Cortex, Mineralization                           1 (2%)       3 (5%)       1 (2%)                                             
      Papilla, Mineralization                          6 (10%)     15 (25%)     10 (17%)                                            
      Renal Tubule, Hyperplasia                        1 (2%)       1 (2%)                                                          
      Renal Tubule, Pigmentation                      24 (40%)     20 (33%)     29 (48%)                                            
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
   Urinary Bladder                                    (60)         (55)         (56)                                                
      Calculus Gross Observation                                    1 (2%)       1 (2%)                                             
      Calculus Micro Observation Only                               2 (4%)       2 (4%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 95303-95303/95303


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.