TR 399 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TITANOCENE DICHLORIDE
NTP Experiment-Test: 05047-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/06/94
Route: GAVAGE Time: 21:41:21
Facility: TSI Mason Research
Chemical CAS #: 1271-19-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 80 80 80
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 19 25 21
Dead 4 5 7
Accident 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 36 30 31
Moribund 1
Aborted 10 9 10
Animals Examined Microscopically 60 61 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57) (59) (59)
Erosion 1 (2%)
Inflammation, Acute 1 (2%)
Parasite 2 (4%) 1 (2%)
Intestine Small, Duodenum (59) (57) (56)
Hyperplasia, Adenomatous 1 (2%)
Pigmentation 25 (44%) 34 (61%)
Intestine Small, Ileum (59) (56) (58)
Fibrosis 1 (2%)
Inflammation, Acute 2 (4%)
Pigmentation 1 (2%) 1 (2%)
Intestine Small, Jejunum (58) (56) (56)
Pigmentation 1 (2%) 9 (16%)
Liver (60) (61) (60)
Abscess 1 (2%)
Angiectasis 2 (3%) 2 (3%)
Basophilic Focus 45 (75%) 45 (74%) 48 (80%)
Clear Cell Focus 1 (2%) 3 (5%) 10 (17%)
Degeneration, Cystic 1 (2%) 1 (2%)
Eosinophilic Focus 2 (3%)
Fatty Change, Diffuse 11 (18%) 6 (10%) 10 (17%)
Fatty Change, Focal 15 (25%) 11 (18%) 14 (23%)
Hepatodiaphragmatic Nodule 4 (7%) 6 (10%) 10 (17%)
Hyperplasia 1 (2%)
Inflammation, Granulomatous 6 (10%) 24 (39%) 33 (55%)
Mixed Cell Focus 2 (3%) 5 (8%) 3 (5%)
Necrosis 3 (5%) 6 (10%) 7 (12%)
Pigmentation 3 (5%) 45 (74%) 50 (83%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 17 (28%) 4 (7%)
Mesentery (3) (9) (10)
Fat, Inflammation, Chronic Active 2 (22%) 2 (20%)
Fat, Necrosis 1 (33%) 7 (78%) 6 (60%)
Pancreas (60) (61) (59)
Fibrosis 1 (2%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 1 (2%)
Acinus, Hyperplasia 6 (10%) 4 (7%) 8 (14%)
Salivary Glands (60) (61) (60)
Inflammation, Chronic Active 1 (2%)
Stomach (60) (60) (60)
Fat, Proliferation 15 (25%) 41 (68%)
Polyp Adenomatous, Inflammation 1 (2%)
Stomach, Forestomach (60) (60) (60)
Acanthosis 11 (18%) 20 (33%) 27 (45%)
Hyperkeratosis 10 (17%) 23 (38%) 21 (35%)
Inflammation, Acute 1 (2%) 4 (7%)
Necrosis 6 (10%)
Stomach, Glandular (60) (60) (60)
Erosion 2 (3%) 11 (18%) 10 (17%)
Fibrosis 39 (65%) 51 (85%)
Hemorrhage 3 (5%) 2 (3%)
Hyperplasia 24 (40%) 23 (38%)
Hyperplasia, Adenomatous 1 (2%)
Inflammation, Acute 4 (7%) 5 (8%)
Metaplasia 36 (60%) 51 (85%)
Mineralization 7 (12%) 2 (3%)
Pigmentation 19 (32%) 24 (40%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (61) (60)
Bacterium 1 (2%)
Cardiomyopathy 23 (38%) 23 (38%) 23 (38%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (61) (60)
Degeneration 1 (2%)
Degeneration, Cystic 1 (2%)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 3 (5%) 2 (3%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Pigmentation, Ceroid 1 (2%)
Adrenal Gland, Medulla (58) (60) (59)
Hyperplasia 13 (22%) 8 (13%) 6 (10%)
Parathyroid Gland (55) (53) (51)
Hyperplasia 1 (2%)
Pituitary Gland (59) (59) (60)
Cyst 1 (2%)
Pars Distalis, Angiectasis 27 (46%) 21 (36%) 23 (38%)
Pars Distalis, Cyst 4 (7%) 4 (7%) 2 (3%)
Pars Distalis, Hyperplasia 13 (22%) 18 (31%) 24 (40%)
Pars Distalis, Pigmentation 1 (2%)
Pars Intermedia, Cyst 1 (2%) 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (60) (57) (59)
C-Cell, Hyperplasia 8 (13%) 17 (30%) 13 (22%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (56) (55) (56)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%) 1 (2%)
Ovary (58) (61) (60)
Cyst 3 (5%) 6 (10%) 1 (2%)
Degeneration, Cystic 1 (2%)
Hyperplasia, Tubular 1 (2%)
Uterus (60) (61) (60)
Cyst 2 (3%)
Decidual Reaction 1 (2%)
Hemorrhage 2 (3%) 3 (5%)
Inflammation, Acute 2 (3%)
Necrosis 1 (2%)
Prolapse 1 (2%)
Thrombosis 1 (2%)
Cervix, Hemorrhage 1 (2%)
Cervix, Inflammation, Acute 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Endometrium, Hyperplasia 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (61) (59)
Pigmentation 8 (13%) 26 (44%)
Lymph Node (60) (61) (60)
Lumbar, Degeneration, Cystic 1 (2%)
Mediastinal, Angiectasis 1 (2%)
Mediastinal, Congestion 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 12 (20%) 21 (34%) 27 (45%)
Mediastinal, Pigmentation 1 (2%) 23 (38%) 25 (42%)
Pancreatic, Angiectasis 1 (2%) 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation 1 (2%)
Pancreatic, Infiltration Cellular, Histiocyte 3 (5%) 5 (8%) 17 (28%)
Pancreatic, Pigmentation 10 (16%) 18 (30%)
Renal, Angiectasis 1 (2%)
Renal, Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mandibular (56) (59) (60)
Infiltration Cellular, Histiocyte 9 (16%) 6 (10%) 22 (37%)
Pigmentation 34 (58%) 26 (43%)
Lymph Node, Mesenteric (60) (61) (60)
Angiectasis 2 (3%)
Degeneration, Cystic 1 (2%)
Depletion Lymphoid 1 (2%)
Infiltration Cellular, Histiocyte 27 (45%) 45 (74%) 47 (78%)
Pigmentation 1 (2%) 47 (77%) 49 (82%)
Spleen (60) (60) (60)
Angiectasis 3 (5%)
Depletion Lymphoid 2 (3%) 3 (5%) 2 (3%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 33 (55%) 43 (72%) 43 (72%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 34 (57%) 28 (47%) 34 (57%)
Inflammation, Granulomatous 1 (2%)
Necrosis 2 (3%)
Pigmentation 1 (2%) 34 (57%) 33 (55%)
Pigmentation, Hemosiderin 9 (15%) 25 (42%) 36 (60%)
Capsule, Hemorrhage 1 (2%)
Capsule, Necrosis 1 (2%)
Thymus (55) (56) (58)
Cyst 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Depletion Lymphoid 1 (2%) 1 (2%)
Pigmentation 5 (9%) 34 (61%) 41 (71%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (56) (56) (49)
Galactocele 21 (38%) 12 (21%) 7 (14%)
Acinus, Hyperplasia 1 (2%)
Skin (60) (61) (58)
Abscess 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (61) (60)
Hyperplasia 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (61) (60)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (61) (60)
Atelectasis 3 (5%) 5 (8%) 5 (8%)
Bacterium 1 (2%)
Congestion 3 (5%) 4 (7%) 3 (5%)
Edema 3 (5%) 5 (8%) 6 (10%)
Hemorrhage 2 (3%) 7 (11%) 3 (5%)
Infiltration Cellular, Histiocyte 22 (37%) 48 (79%) 46 (77%)
Inflammation, Acute 2 (3%) 4 (7%) 9 (15%)
Inflammation, Granulomatous 3 (5%) 8 (13%)
Metaplasia, Osseous 1 (2%)
Pigmentation 1 (2%) 23 (38%) 35 (58%)
Pigmentation, Cholesterol 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 4 (7%)
Nose (60) (61) (60)
Fungus 1 (2%) 2 (3%) 1 (2%)
Hemorrhage 2 (3%)
Inflammation, Acute 7 (12%) 13 (21%) 15 (25%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 0.025 G/ 0.05 G/K
79 VF KG 79 LF G 79 HF
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Submucosa, Glands, Hyperplasia 1 (2%)
Trachea (60) (59) (60)
Erosion 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (6)
Inflammation, Acute 1 (17%)
Canal, Abscess 1 (100%) 2 (33%)
Eye (5) (11) (18)
Hemorrhage 1 (6%)
Inflammation, Acute 1 (9%) 1 (6%)
Synechia 2 (40%) 1 (9%) 3 (17%)
Lens, Cataract 1 (20%) 5 (45%) 4 (22%)
Retina, Atrophy 3 (60%) 2 (11%)
Harderian Gland (4) (8) (14)
Pigmentation 1 (13%) 5 (36%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (61) (60)
Bacterium 1 (2%)
Cyst 1 (2%)
Inflammation, Chronic Active 1 (2%)
Nephropathy 32 (53%) 26 (43%) 35 (58%)
Cortex, Mineralization 4 (7%) 4 (7%) 2 (3%)
Papilla, Mineralization 5 (8%) 10 (16%) 6 (10%)
Pelvis, Mineralization 2 (3%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Pigmentation 35 (58%) 32 (52%) 40 (67%)
Urinary Bladder (60) (58) (60)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 80 80 80
Scheduled Sacrifice 10 10 10
Early Deaths
Dead 11 15 17
Moribund 8 14 17
Accident 1 2
Survivors
Terminal Sacrifice 41 30 24
Aborted 10 10 10
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (54) (54) (55)
Pigmentation 1 (2%)
Intestine Large, Colon (56) (54) (57)
Parasite 4 (7%) 2 (4%) 4 (7%)
Pigmentation 1 (2%)
Intestine Large, Rectum (54) (55) (54)
Parasite 5 (9%) 1 (2%)
Intestine Small, Duodenum (59) (54) (53)
Pigmentation 23 (43%) 36 (68%)
Intestine Small, Ileum (55) (52) (57)
Pigmentation 3 (5%)
Lymphoid Tissue, Hyperplasia 1 (2%)
Intestine Small, Jejunum (53) (53) (51)
Pigmentation 1 (2%) 14 (27%)
Lymphoid Tissue, Hyperplasia 1 (2%)
Liver (60) (59) (60)
Angiectasis 1 (2%)
Basophilic Focus 46 (77%) 36 (61%) 40 (67%)
Clear Cell Focus 16 (27%) 14 (24%) 14 (23%)
Congestion 1 (2%)
Cyst 1 (2%)
Degeneration, Cystic 1 (2%) 3 (5%) 4 (7%)
Eosinophilic Focus 4 (7%) 7 (12%) 14 (23%)
Fatty Change, Diffuse 5 (8%) 6 (10%)
Fatty Change, Focal 9 (15%) 19 (32%) 19 (32%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 4 (7%) 5 (8%) 2 (3%)
Infarct 1 (2%) 1 (2%)
Inflammation, Granulomatous 16 (27%) 14 (23%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mixed Cell Focus 1 (2%) 1 (2%) 8 (13%)
Necrosis 2 (3%) 1 (2%) 5 (8%)
Pigmentation 1 (2%) 39 (66%) 41 (68%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 30 (50%) 15 (25%) 11 (18%)
Mesentery (6) (4) (5)
Fibrosis 1 (25%)
Artery, Necrosis, Fibrinoid 1 (17%) 1 (20%)
Fat, Hemorrhage 1 (20%)
Fat, Inflammation, Chronic Active 1 (17%) 2 (50%)
Fat, Mineralization 1 (17%)
Fat, Necrosis 3 (50%) 1 (25%) 3 (60%)
Pancreas (59) (56) (59)
Hyperplasia 1 (2%) 1 (2%)
Acinus, Focal Cellular Change 1 (2%)
Acinus, Hyperplasia 14 (24%) 20 (36%) 16 (27%)
Artery, Inflammation, Chronic Active 3 (5%) 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Salivary Glands (60) (59) (59)
Necrosis 1 (2%)
Stomach (59) (59) (60)
Artery, Necrosis, Fibrinoid 1 (2%)
Fat, Proliferation 2 (3%) 14 (23%)
Stomach, Forestomach (57) (59) (59)
Acanthosis 8 (14%) 25 (42%) 26 (44%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis 5 (9%) 13 (22%) 17 (29%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (3%) 1 (2%)
Necrosis 2 (4%) 1 (2%)
Pigmentation 1 (2%)
Stomach, Glandular (58) (59) (58)
Erosion 1 (2%) 9 (15%) 13 (22%)
Fibrosis 30 (51%) 37 (64%)
Hemorrhage 2 (3%) 5 (9%)
Hyperplasia 10 (17%) 24 (41%)
Hyperplasia, Adenomatous 2 (3%)
Inflammation, Acute 9 (15%) 10 (17%)
Metaplasia 26 (44%) 36 (62%)
Mineralization 2 (3%) 1 (2%)
Pigmentation 8 (14%) 19 (33%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60)
Bacterium 1 (2%)
Cardiomyopathy 50 (83%) 52 (87%) 43 (72%)
Mineralization 1 (2%)
Pigmentation 2 (3%)
Thrombosis 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (60)
Hyperplasia 2 (3%) 3 (5%) 3 (5%)
Infarct 1 (2%)
Adrenal Gland, Medulla (60) (60) (59)
Hyperplasia 25 (42%) 18 (30%) 13 (22%)
Islets, Pancreatic (58) (56) (59)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Parathyroid Gland (56) (54) (51)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (56) (59) (56)
Cyst 1 (2%)
Pars Distalis, Angiectasis 18 (32%) 15 (25%) 11 (20%)
Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 14 (25%) 11 (19%) 13 (23%)
Pars Distalis, Pigmentation 1 (2%)
Pars Intermedia, Cyst 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Rathke's Cleft, Cyst 1 (2%)
Thyroid Gland (60) (55) (58)
C-Cell, Hyperplasia 6 (10%) 5 (9%) 10 (17%)
Follicular Cell, Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (58) (60)
Spermatocele 1 (2%)
Preputial Gland (56) (59) (56)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Necrosis 4 (7%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Prostate (59) (57) (60)
Abscess 1 (2%)
Epithelium, Hyperplasia 12 (20%) 4 (7%) 7 (12%)
Seminal Vesicle (60) (59) (60)
Epithelium, Hyperplasia 1 (2%)
Testes (60) (60) (60)
Atrophy 1 (2%)
Infarct 1 (2%)
Interstitial Cell, Hyperplasia 26 (43%) 26 (43%) 32 (53%)
Seminiferous Tubule, Atrophy 29 (48%) 34 (57%) 36 (60%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (58) (60)
Pigmentation 20 (34%) 37 (62%)
Lymph Node (60) (59) (60)
Axillary, Angiectasis 1 (2%)
Axillary, Infiltration Cellular, Histiocyte 1 (2%)
Lumbar, Infiltration Cellular, Histiocyte 1 (2%)
Lumbar, Pigmentation 1 (2%)
Mediastinal, Angiectasis 1 (2%)
Mediastinal, Degeneration, Cystic 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 8 (13%) 5 (8%) 30 (50%)
Mediastinal, Pigmentation 6 (10%) 20 (34%) 25 (42%)
Pancreatic, Infiltration Cellular, Plasma
Cell 1 (2%)
Pancreatic, Infiltration Cellular, Histiocyte 3 (5%) 6 (10%) 5 (8%)
Pancreatic, Pigmentation 7 (12%) 2 (3%)
Renal, Angiectasis 1 (2%)
Renal, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Renal, Pigmentation 1 (2%) 1 (2%)
Lymph Node, Mandibular (58) (56) (56)
Bacterium 1 (2%)
Degeneration 1 (2%)
Degeneration, Cystic 5 (9%) 1 (2%) 3 (5%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 2 (3%) 3 (5%) 20 (36%)
Pigmentation 2 (3%) 28 (50%) 17 (30%)
Lymph Node, Mesenteric (59) (54) (58)
Bacterium 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%) 2 (4%) 3 (5%)
Infiltration Cellular, Histiocyte 26 (44%) 40 (74%) 45 (78%)
Mineralization 3 (5%)
Pigmentation 9 (15%) 42 (78%) 44 (76%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (58) (56) (59)
Angiectasis 1 (2%)
Depletion Lymphoid 2 (3%) 5 (9%) 6 (10%)
Fibrosis 3 (5%) 3 (5%) 2 (3%)
Hematopoietic Cell Proliferation 24 (41%) 35 (63%) 28 (47%)
Hemorrhage 1 (2%) 2 (3%)
Infiltration Cellular, Histiocyte 15 (26%) 24 (43%) 33 (56%)
Inflammation, Granulomatous 1 (2%)
Necrosis 1 (2%)
Pigmentation 33 (59%) 32 (54%)
Pigmentation, Hemosiderin 9 (16%) 35 (63%) 37 (63%)
Thrombosis 1 (2%)
Capsule, Cyst 1 (2%)
Thymus (55) (50) (52)
Cyst 1 (2%)
Depletion Lymphoid 5 (10%) 7 (13%)
Ectopic Parathyroid Gland 1 (2%)
Hemorrhage 1 (2%)
Pigmentation 25 (50%) 31 (60%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (36) (41)
Galactocele 4 (10%) 1 (3%) 1 (2%)
Skin (58) (60) (59)
Cyst Epithelial Inclusion 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Osseous 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60)
Costochondral Junction, Fibrosis 1 (2%)
Costochondral Junction, Inflammation,
Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (59) (60)
Bacterium 1 (2%)
Metaplasia, Osseous 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60)
Atelectasis 10 (17%) 14 (23%)
Bacterium 1 (2%)
Congestion 6 (10%) 5 (8%) 6 (10%)
Edema 9 (15%) 11 (18%)
Fibrosis 1 (2%)
Hemorrhage 4 (7%) 3 (5%) 8 (13%)
Infiltration Cellular, Histiocyte 9 (15%) 46 (77%) 49 (82%)
Inflammation, Acute 1 (2%) 13 (22%) 10 (17%)
Inflammation, Granulomatous 10 (17%) 20 (33%)
Mineralization 3 (5%)
Necrosis 1 (2%)
Pigmentation 34 (57%) 50 (83%)
Pigmentation, Cholesterol 3 (5%) 5 (8%)
Alveolar Epithelium, Hyperplasia 4 (7%) 6 (10%) 5 (8%)
Artery, Mediastinum, Necrosis, Fibrinoid 1 (2%)
Bronchiole, Hyperplasia 1 (2%)
Bronchiole, Epithelium, Metaplasia, Squamous 1 (2%)
Bronchus, Inflammation, Chronic 1 (2%)
Nose (59) (60) (56)
Erosion 1 (2%)
Fungus 1 (2%) 6 (10%) 8 (14%)
Inflammation, Acute 8 (14%) 18 (30%) 22 (39%)
Trachea (60) (58) (60)
Erosion 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%) 3 (5%)
Metaplasia, Squamous 3 (5%)
Pigmentation 1 (2%)
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SPECIAL SENSES SYSTEM
Ear (1) (3) (1)
Canal, Inflammation, Acute 2 (67%)
Eye (6) (13) (9)
Hemorrhage 1 (8%)
Inflammation, Acute 1 (8%)
Lens, Cataract 1 (17%) 6 (46%) 1 (11%)
Retina, Atrophy 1 (8%) 1 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05047-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TITANOCENE DICHLORIDE Date: 09/06/94
Route: GAVAGE Time: 21:41:21
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 0.025 G/ 0.05 G/K
79VM KG 79 LM G 79 HM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Harderian Gland (6) (10) (7)
Inflammation, Chronic Active 1 (14%)
Pigmentation 1 (10%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60)
Abscess 1 (2%)
Bacterium 1 (2%)
Cyst 1 (2%)
Nephropathy 56 (93%) 39 (65%) 34 (57%)
Pigmentation 2 (3%)
Artery, Necrosis, Fibrinoid 1 (2%)
Cortex, Mineralization 1 (2%) 3 (5%) 1 (2%)
Papilla, Mineralization 6 (10%) 15 (25%) 10 (17%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 24 (40%) 20 (33%) 29 (48%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (60) (55) (56)
Calculus Gross Observation 1 (2%) 1 (2%)
Calculus Micro Observation Only 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
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