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TDMS Study 05043-02 Pathology Tables

NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 09:53:29




       Facility:  TSI Mason Research

       Chemical CAS #:  137-09-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|             
                                           | 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  M  +  +        +  +  +  M  +  +  A  +     +  +  +|             
      Serosa, Inflammation, Suppurative    |             4                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +        +  +  M  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Angiectasis                          |       3                                                                  |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                               2                                          |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                      2                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                | 2     1                       1                 2  2  2                  |             
      Necrosis                             |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
      Serosa, Inflammation, Membranous     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +                          +  +                  |             
      Inflammation, Acute                  |             3                                                            |             
      Inflammation, Chronic                |                                                    3  2                  |             
      Fat, Necrosis                        |                                                                          |             
      Mesothelium, Inflammation, Membranous|                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                | 3                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                | 1     1        1  1                          1  1        2  2     2     2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  M  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Acanthosis                           | 3                 4           4        2  4     4        3               |             
      Inflammation, Acute, Focal           |                               2                                          |             
      Inflammation, Chronic                |                   2                                                      |             
      Ulcer                                | 3                                               3                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|             
                                           | 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Coronary Artery, Inflammation, Acute |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Capsule, Inflammation, Membranous    |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                      4                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +  +  +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  +  +  +  +  M  +        +  M  +  +  +  M  M  +     +  +  +|             
      Cyst                                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                              3                           |             
      Pars Distalis, Hyperplasia           |                               2                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic                |                                                    1                     |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +        I  +  +  +  +  +  +  +     +  +  +|             
      Cyst                                 |                      X     X                 X  X  X        X            |             
      Cyst, Multiple                       |                                           X                              |             
      Hyperplasia, Cystic, Papillary       |                                                          4               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                       4                  |             
      Bilateral, Inflammation, Suppurative |             4                                                            |             
      Follicle, Cyst                       |          X                                                               |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Endometrium, Hyperplasia, Cystic     |    2  2        3  3     3  4           4        3  3        3     2  3   |             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |                2        3                       4                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|             
                                           | 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                      4                                                   |             
      Myelofibrosis                        |                               2                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Inflammation, Acute     |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Plasma Cell             |                                                       3                  |             
      Pigmentation                         |                                                                          |             
      Serosa, Inflammation, Membranous     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |             4        4                       3                           |             
      Hyperplasia, Lymphoid                |       3                                            3                     |             
      Pigmentation                         |                                                                          |             
      Subcapsular, Inflammation, Acute     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +        +  M  +  M  +  +  +  +     M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  +  +  +  +  +  M  M        +  M  +  M  M  M  +  +     +  +  +|             
      Hyperplasia, Cystic                  |                                                                         3|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Meninges, Inflammation, Chronic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                             2            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 5| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 4| 4| 3| 3| 5| 3| 3| 3| 5| 5| 3| 2| 3| 3| 2| 2| 1| 3| 5| 3| 3| 2|             
                                           | 1| 1| 9| 0| 2| 2| 2| 6| 1| 1| 2| 3| 3| 1| 2| 2| 2| 9| 9| 0| 2| 3| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Hyperplasia, Macrophage    |                                                                          |             
      Lymphatic, Perivascular,             |                                                                          |             
          Inflammation, Acute              |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                   3                             2                        |             
      Peribronchiolar, Perivascular,       |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
      Perivascular, Inflammation, Acute    |             4                                                            |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  M  M        M  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 2     1  2  2     2        2  2        2     2  2  3  3  1               |             
      Necrosis                             |                               2                       3                  |             
      Papilla, Necrosis                    |                      3                                                   |             
      Renal Tubule, Mineralization         |                      2                                                   |             
      Renal Tubule, Regeneration           |    1  1  1           3  1  1  2           2        1  2                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +     +  +  +|             
      Serosa, Inflammation, Suppurative    |                                                                          |             
      Submucosa, Inflammation, Chronic     | 2     1           1  2                 1                    2        1   |             
      Submucosa, Ulcer, Chronic            |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|             
                                           | 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  M     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Serosa, Inflammation, Suppurative    | 4           2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +     +  +  +  +        +  +  +     +  M  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                3                                                         |             
      Clear Cell Focus                     |                               X                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  4  4                                                                  |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Inflammation, Chronic                |                                           2     2                       2|             
      Necrosis                             |                                                                      3   |             
      Serosa, Inflammation, Suppurative    | 4           3                                                            |             
      Serosa, Inflammation, Membranous     |       3                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                         +                        |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                 3                        |             
      Fat, Necrosis                        |                                                                          |             
      Mesothelium, Inflammation, Membranous|       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Inflammation, Chronic                |                                           1                              |             
      Inflammation, Suppurative            |             4                                                            |             
      Serosa, Inflammation, Suppurative    | 3                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  M     +  +|             
      Inflammation, Chronic                |             2  1  2     2                 2  2  2           1        1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Serosa, Inflammation, Suppurative    | 3                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Acanthosis                           |                                                 3     2  3               |             
      Inflammation, Acute, Focal           |                                                 3                        |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|             
                                           | 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |                                                                      1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Coronary Artery, Inflammation, Acute |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Capsule, Inflammation, Membranous    |       4                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M     +  M  +     +  M  +  M        M  M  +     M  M  M  M     +  M|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  M     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                  3                                       |             
      Pars Distalis, Hyperplasia           |                                           4                    3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Inflammation, Chronic                |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Cyst                                 |                               X                          X              X|             
      Cyst, Multiple                       |                                                                          |             
      Hyperplasia, Cystic, Papillary       |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Inflammation, Suppurative            | 4  4        2                    4                    4                  |             
      Bilateral, Inflammation, Suppurative |       4                                                                  |             
      Follicle, Cyst                       |                X  X     X                                   X            |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                           3                              |             
                                            __________________________________________________________________________|             
   Oviduct                                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Endometrium, Hyperplasia, Cystic     |                4  2     4     3           4  4  3           4  3     3  4|             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |       3     4                 2  3                    4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|             
                                           | 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  M     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |    4                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     M  +  +     +  +  +  +        +  M  +     +  +  +  +     +  +|             
      Lumbar, Hyperplasia, Plasma Cell     | 4  4                                                                     |             
      Mediastinal, Hyperplasia, Plasma Cell| 4  4                                                                     |             
      Mediastinal, Inflammation, Acute     | 2     4                                                                  |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                       2                  |             
      Renal, Hyperplasia, Lymphoid         | 2                                                                        |             
      Renal, Hyperplasia, Plasma Cell      |    4                                                  4                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     M  +  +     +  +  +  +        +  M  +     M  +  +  +     +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         |                                                 1                        |             
      Serosa, Inflammation, Membranous     |       3                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Hematopoietic Cell Proliferation     | 4  4  4                                                     3  3         |             
      Hyperplasia, Lymphoid                |                                                       2              3   |             
      Pigmentation                         |                                                                      2   |             
      Subcapsular, Inflammation, Acute     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +     M  +  +     +  M  +  M        +  +  +     M  +  M  +     M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +     +  +  +  +        +  M  M     +  M  +  M     +  +|             
      Hyperplasia, Cystic                  |                                                             3            |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Inflammation, Chronic                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Meninges, Inflammation, Chronic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 4| 4| 3| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 6| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 2| 5| 0| 5| 7| 3| 3| 5| 3| 2| 3| 3| 5| 5| 3| 3| 3| 5| 2| 7| 3| 3| 5| 2| 2|             
                                           | 1| 8| 0| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 2| 2| 3| 6| 0| 2| 2| 3| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Focal                           |                   2                                                      |             
      Alveolus, Hyperplasia, Macrophage    |                                                                          |             
      Lymphatic, Perivascular,             |                                                                          |             
          Inflammation, Acute              |             3                                                            |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Peribronchiolar, Perivascular,       |                                                                          |             
          Inflammation, Chronic            |                                                 2                        |             
      Perivascular, Inflammation, Acute    |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                2         |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Inflammation, Acute                  |             2                                                            |             
      Inflammation, Chronic                |             2     2     1                 2     1           2  1     2  1|             
      Necrosis                             |                                                                          |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Regeneration           |                   1                       3                             2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  M     +  +  +     +  +  +  +        +  +  +     +  +  +  +     +  +|             
      Serosa, Inflammation, Suppurative    |             3                                                            |             
      Submucosa, Inflammation, Chronic     |    2        3     2              2                          1        2   |             
      Submucosa, Ulcer, Chronic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5|                                            |            |
                                           | 3| 3| 3| 3| 3| 5| 3| 2| 8| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  M  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +     +  +  +  +  +  +                                             |  43        |
      Serosa, Inflammation, Suppurative    |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | M  +  +     +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     M  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  +  M  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      1  3.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      1  2.0|
      Fatty Change                         |                            2                                             |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      4  3.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      9  1.8|
      Necrosis                             |                                                                          |      1  3.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      2  3.5|
      Serosa, Inflammation, Membranous     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   7        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      3  2.7|
      Fat, Necrosis                        |                            4                                             |      1  4.0|
      Mesothelium, Inflammation, Membranous|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                      1     3                                             |      4  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +  +                                             |  49        |
      Inflammation, Chronic                |    2        2        2     2                                             |     23  1.6|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +  +                                             |  49        |
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +                                             |  49        |
      Acanthosis                           |                                                                          |     10  3.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5|                                            |            |
                                           | 3| 3| 3| 3| 3| 5| 3| 2| 8| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute, Focal           |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +                                             |  49        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Coronary Artery, Inflammation, Acute |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  M  +     +  +  +  +  +  +                                             |  49        |
      Capsule, Inflammation, Membranous    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  M  +     +  +  +  +  +  +                                             |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +     M  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  M  +  M  +  +                                             |  30        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  M  +                                             |  46        |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      2  3.0|
      Pars Distalis, Hyperplasia           |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                      1                                                   |      2  1.0|
      Follicular Cell, Hyperplasia         |                3                                                         |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
      Necrosis                             |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  M  +  +                                             |  48        |
      Cyst                                 | X  X  X     X     X                                                      |     14     |
      Cyst, Multiple                       |                                                                          |      1     |
      Hyperplasia, Cystic, Papillary       |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5|                                            |            |
                                           | 3| 3| 3| 3| 3| 5| 3| 2| 8| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      7  3.7|
      Bilateral, Inflammation, Suppurative |                                                                          |      2  4.0|
      Follicle, Cyst                       |                                                                          |      5     |
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         |             3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Endometrium, Hyperplasia, Cystic     | 4  3  3     3  2  3     2                                                |     30  3.1|
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      8  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +  +                                             |  47        |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      2  4.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      2  4.0|
      Mediastinal, Inflammation, Acute     |                                                                          |      2  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +                                             |  46        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Serosa, Inflammation, Membranous     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      8  3.6|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.8|
      Pigmentation                         |                                                                          |      1  2.0|
      Subcapsular, Inflammation, Acute     |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M     +  M  M  M  +  +                                             |  33        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     M  +  +  +  M  +                                             |  36        |
      Hyperplasia, Cystic                  |                3                                                         |      3  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5|                                            |            |
                                           | 3| 3| 3| 3| 3| 5| 3| 2| 8| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Meninges, Inflammation, Chronic      |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolus, Hyperplasia, Macrophage    |                4                                                         |      1  4.0|
      Lymphatic, Perivascular,             |                                                                          |            |
          Inflammation, Acute              |                                                                          |      1  3.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      2  2.5|
      Peribronchiolar, Perivascular,       |                                                                          |            |
          Inflammation, Chronic            |             3                                                            |      2  2.5|
      Perivascular, Inflammation, Acute    |                                                                          |      1  4.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  M  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +     +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                | 1  2  1     2     2                                                      |     27  1.8|
      Necrosis                             |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 0| 3| 3| 5| 5|                                            |            |
                                           | 3| 3| 3| 3| 3| 5| 3| 2| 8| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    VEHICLE                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    72VF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Papilla, Necrosis                    |                                                                          |      1  3.0|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           | 2  1  1     2           2                                                |     18  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  M     +  +  +  +  +  +                                             |  47        |
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Submucosa, Inflammation, Chronic     |             1                                                            |     14  1.6|
      Submucosa, Ulcer, Chronic            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|             
                                           | 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                      +     +                 +                           |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  M     +|             
      Lamina Propria, Pigmentation         | 1  2  1  1     1  1     1  2  1     1  1  1        1  1  1  1  1        1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +     +                 M                    +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +     +|             
      Basophilic Focus                     |                            3                             3               |             
      Fatty Change                         |                                              3                           |             
      Hematopoietic Cell Proliferation     |       2  3                 2                                             |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Inflammation, Chronic                |                                                             3            |             
      Kupffer Cell, Pigmentation           |    1              1     1     1        1  1        1  1  1  1            |             
      Serosa, Inflammation, Suppurative    |       3                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                    +                                      +      |             
      Inflammation, Suppurative            |                            3                                             |             
      Fat, Necrosis                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |                      +     +           +     +                           |             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Interlobular, Ectasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                      +     +                 M                           |             
      Inflammation, Chronic                |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +  +     +        +        +              +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +  +     +        +        +              +            |             
      Acanthosis                           |                3  3                 2        3                           |             
      Inflammation, Acute, Focal           |                                                                          |             
      Ulcer                                |                2  2                          2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                   +  +     +        +        +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                      +     +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                      +     +                 +                           |             
      Capsule, Inflammation, Suppurative   |                            3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                      +     +                 +                           |             
      Capsule, Inflammation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|             
                                           | 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                      M     +                 +                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                      +     +                 +                           |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +     +     +     +        +  +     +        +           +      |             
      Cyst                                 |                X                       X              X                  |             
      Inflammation, Suppurative            |       4  4                 4                                      4      |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                              +                           |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +                    +  +  +        +     +  +        +                  |             
      Hydrometra                           |                                                       4                  |             
      Endometrium, Hemorrhage              |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3                                   3     3  4                           |             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                      +     +                 +                           |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +           +  M     +                 +        +  +        +      |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                       2                  |             
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                            4                                             |             
      Renal, Hyperplasia, Lymphoid         |                   3                                   2                  |             
      Renal, Hyperplasia, Plasma Cell      |       4           3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +              M     +                 +           +        +      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation                         |       1                                                  1               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +                    +     +                 +                           |             
      Hematopoietic Cell Proliferation     |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|             
                                           | 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +     +                 +                           |             
      Inflammation                         |                      4                                                   |             
      Thymocyte, Necrosis                  |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                    M     +                 +                           |             
      Hyperplasia                          |                                              3                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +           +     +  +              +        +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                      +     +                 +                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Abdominal, Inflammation, Suppurative |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                      +     +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                    +     +                 +           +               |             
      Congestion                           |                      3                                                   |             
      Edema                                |                      3                                                   |             
      Inflammation, Acute, Focal           |                            2                                             |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                      M     +                 +                           |             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Turbinate, Inflammation, Chronic     |                                                                          |             
      Turbinate, Inflammation, Suppurative |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                      +     +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +     +  +        +  +  +     +     +  +  +        +|             
      Inflammation, Chronic                |                                              2              1            |             
      Metaplasia                           |                               1                                          |             
      Necrosis                             |       1                                2                       1         |             
      Fat, Inflammation, Chronic           |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 0| 7| 5| 7| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 3| 1| 5| 3| 3| 7| 3| 9| 3| 5| 3| 3| 3| 1| 5| 3| 3| 2| 3| 3| 8| 5| 9|             
                                           | 0| 0| 0| 3| 3| 0| 0| 1| 0| 2| 1| 3| 1| 0| 0| 6| 3| 1| 0| 6| 1| 1| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Dilatation             |       1                                                                  |             
      Renal Tubule, Pigmentation           |    1                                   1                    1            |             
      Renal Tubule, Regeneration           | 1  1  2        1  1           1        2  1        1     1              1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                      +     +                 +                           |             
      Submucosa, Inflammation, Chronic     |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|             
                                           | 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                   +                       +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                   M                       M        +  +  +              +|             
      Serosa, Inflammation, Suppurative    |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                   +                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                   +                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                   +                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                   M                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +     +     +  +  A     +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +     +     +  +  A     +  +  +  +     +  +  +  +|             
      Lamina Propria, Pigmentation         | 1  1  1  1     1     1  1     1     1  1        1  1  1  1     2     1  2|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                   +                       A        +  +  +              +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +     +     +  +  +     +  +  +  +     +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                         2                                                |             
      Kupffer Cell, Pigmentation           | 1  1  1        1        1     1     1  1        1     1        1  1  1  1|             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Inflammation, Suppurative            |                                                    4                     |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                   +                       +        +  +  +     +        +|             
      Atrophy                              |                                                                4         |             
      Inflammation, Chronic                |                                           1                             2|             
      Duct, Interlobular, Ectasia          |                                                                4         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                   +                       +        +  +  +              +|             
      Inflammation, Chronic                |                                           3           2  1              2|             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +     +           +     +        +  +  +     +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +     +           +     +        +  +  +     +        +|             
      Acanthosis                           |                3        4                                      4        3|             
      Inflammation, Acute, Focal           |                                                                         2|             
      Ulcer                                |                3        2                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                   +                       +        +  +  +     +        +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                   +                       +        +  +  +              +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +           +                    +  +        +  +  +              +|             
      Capsule, Inflammation, Suppurative   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                   +                    +  +        +  +  +              +|             
      Capsule, Inflammation                |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|             
                                           | 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +           +                    M  +        M  +  +              +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                   +                       +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                   +                       +        +  +  +              M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +                       +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +                       +        +  +  +              +|             
      Follicular Cell, Hyperplasia         |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +           +  +                 +  +        +  +  +              +|             
      Cyst                                 |       X              X                 X                                 |             
      Inflammation, Suppurative            |                                        4           3                     |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                    4                     |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                    +  +  +               |             
      Inflammation, Suppurative            |                                                    3                     |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +              +           +        +  +     +  +  +  +     +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Endometrium, Hemorrhage              |                                                 3                        |             
      Endometrium, Hyperplasia, Cystic     |    3                          2        3  4              3     3  4  4   |             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                   +                       +        +  +  +              +|             
      Myeloid Cell, Hyperplasia            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +        +  +     +              +  +     +  +  +  +     +  +     +|             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                4                                                         |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |                                                          3               |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                4                                                         |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +           +                    +  +     +  +  +  +     +  +     +|             
      Hyperplasia, Plasma Cell             |                                        4                                 |             
      Inflammation, Suppurative            |                                        2                                 |             
      Pigmentation                         |       1                                                           1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +     +  +     +           +  +  +     +  +  +  +     +        +|             
      Hematopoietic Cell Proliferation     |                4                    4  4        4  3     2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|             
                                           | 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                     4                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |                   M     +                 M        M  +  +              +|             
      Inflammation                         |                                                                          |             
      Thymocyte, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                   +                       +        M  M  +           +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +        M     +  +                    +  +     +  +  +  +              +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +                       +        +  +  +              +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
      Abdominal, Inflammation, Suppurative |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                   +                       +        +  +  +              +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                   +  +                 +  +     +  +  +  +              +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                      3                                                   |             
      Pleura, Inflammation, Suppurative    |                                        3                                 |             
                                            __________________________________________________________________________|             
   Nose                                    |                   +                       +        +  +  +              +|             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Turbinate, Inflammation, Chronic     |                                                          2               |             
      Turbinate, Inflammation, Suppurative |                                                          2               |             
                                            __________________________________________________________________________|             
   Trachea                                 |                   +                       +        +  +  +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +        +  +  +  +     +     +  +  +        +  +  +           +  +|             
      Inflammation, Chronic                |                1                          2        1  3                 2|             
      Metaplasia                           |                         2                             1                  |             
      Necrosis                             |                               2                                          |             
      Fat, Inflammation, Chronic           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 6| 2| 7| 7| 4| 7| 4| 7| 7| 6| 4| 7| 4| 3| 3| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 3| 3| 3| 5| 6| 5| 3| 3| 5| 3| 5| 3| 0| 1| 5| 3| 7| 3| 3| 5| 3| 3| 3| 3|             
                                           | 4| 1| 1| 1| 3| 0| 6| 1| 1| 3| 1| 3| 1| 0| 9| 3| 1| 1| 0| 7| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .019  G/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Pigmentation           |                               1                                          |             
      Renal Tubule, Regeneration           |    1  1        1     1  1     2     2                 1              1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                   +                       M        +  +  M              +|             
      Submucosa, Inflammation, Chronic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 7| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1|                                            |            |
                                           | 1| 0| 1| 1| 1| 1| 1| 3| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                    +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +                    +  +                                             |  10        |
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +                    +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +                                             |  48        |
      Lamina Propria, Pigmentation         | 1  1  1  1  1  2  1     1  2                                             |     44  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +                    +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +     +  +                                             |  50        |
      Basophilic Focus                     |                2                                                         |      3  2.7|
      Fatty Change                         |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |       2                                                                  |      5  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Kupffer Cell, Pigmentation           |    1  1  1  1  1  1     1                                                |     31  1.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Suppurative            |                                                                          |      2  3.5|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                    +  +                                             |  14        |
      Atrophy                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Duct, Interlobular, Ectasia          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                    +  +                                             |  11        |
      Inflammation, Chronic                |    2                    2                                                |      7  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +                    +  +                                             |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +                    +  +                                             |  20        |
      Acanthosis                           |                         4                                                |      9  3.2|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +                    +  +                                             |  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +                    +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 7| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1|                                            |            |
                                           | 1| 0| 1| 1| 1| 1| 1| 3| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                    +  +                                             |  14        |
      Capsule, Inflammation, Suppurative   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +                    +  +                                             |  13        |
      Capsule, Inflammation                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +                    +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                    +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +                    +  M                                             |   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +              M  +                                             |  13        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +                    +  +                                             |  13        |
      Follicular Cell, Hyperplasia         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +     +     +        +  +                                             |  25        |
      Cyst                                 |          X     X                                                         |      8     |
      Inflammation, Suppurative            |                                                                          |      6  3.8|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |    +                       +                                             |   6        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +                 +  +                                             |  26        |
      Hydrometra                           |                                                                          |      1  4.0|
      Endometrium, Hemorrhage              |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 3     4                 2                                                |     15  3.2|
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +                    +  +                                             |  12        |
      Myeloid Cell, Hyperplasia            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +           +     +  +                                             |  27        |
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                                                                          |      1  4.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  2.0|
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |      1  3.0|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 7| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1|                                            |            |
                                           | 1| 0| 1| 1| 1| 1| 1| 3| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Proliferation                    |                                                                          |      1  4.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  2.5|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +           +     +  +                                             |  23        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +     +     +     +  +                                             |  24        |
      Hematopoietic Cell Proliferation     |       4                 4                                                |      9  3.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +                    +  +                                             |  10        |
      Inflammation                         |                                                                          |      1  4.0|
      Thymocyte, Necrosis                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M                    +  +                                             |  10        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  M  +  +  +        +  +                                             |  31        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                    +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Inflammation, Suppurative |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +                    +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +     +        +  +                                             |  20        |
      Congestion                           |                                                                          |      1  3.0|
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                         2                                                |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Pleura, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +                    +  +                                             |  11        |
      Inflammation, Suppurative            |    3                       3                                             |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 7| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 5| 2| 1|                                            |            |
                                           | 1| 0| 1| 1| 1| 1| 1| 3| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    .019  G/                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    KG 72LF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Chronic        |    4                                                                     |      1  4.0|
      Turbinate, Inflammation, Chronic     |                                                                          |      1  2.0|
      Turbinate, Inflammation, Suppurative |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                    +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +     +  +                                             |  39        |
      Inflammation, Chronic                |    2                    2  1                                             |     10  1.7|
      Metaplasia                           |                                                                          |      3  1.3|
      Necrosis                             | 1                                                                        |      5  1.4|
      Fat, Inflammation, Chronic           |                                                                          |      1  2.0|
      Renal Tubule, Dilatation             |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                                                          |      4  1.0|
      Renal Tubule, Regeneration           |          2     1  1     1                                                |     24  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +                    +  +                                             |  10        |
      Submucosa, Inflammation, Chronic     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|             
                                           | 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     M  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +  +  +     +  +  +     +     +  +  +     M  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     M  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Lamina Propria, Congestion, Diffuse  |                                                                          |             
      Lamina Propria, Pigmentation         | 3  3  2        3  1  2     2  2  2     3     2  2  3     2  1     2  2  2|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Lamina Propria, Congestion, Diffuse  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Abscess, Single                      |                               3                                          |             
      Angiectasis                          |                                              3                           |             
      Clear Cell Focus                     |                                              X                           |             
      Fatty Change                         |                                                          4               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |                               2                                   2     2|             
      Necrosis                             |                            2                                             |             
      Kupffer Cell, Pigmentation           | 2  2  2     2  2  2  3     2  2  4     2     2  3  4     1  2     2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Fat, Necrosis                        |                                                 4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Inflammation, Chronic                |                                                 3                        |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                                                 X                        |             
      Interlobular, Inflammation, Acute    |                                                                          |             
      Serosa, Interlobular, Inflammation,  |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +     +  +  +     +     +  +  +     M  +     +  +  +|             
      Inflammation, Chronic                |                2  2                                               1  2   |             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Necrotizing                      |                                                                         4|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Acanthosis                           | 2     3                                                                  |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|             
                                           | 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Myocardium, Inflammation, Acute      |                                                                          |             
      Pericardium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +     +  +  +  +     +  +  +     +     +  +  +     +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +     +  M  M  M     +  +  +     M     +  +  +     M  M     +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +     +  M  +     +     +  +  +     +  +     +  M  M|             
      Pars Distalis, Hyperplasia, Focal    |                                              2                           |             
      Pars Distalis, Hyperplasia           |                3                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Cyst                                 | X              X                                                        X|             
      Inflammation, Chronic                |                                                                         2|             
      Inflammation, Suppurative            |                                                                          |             
      Bilateral, Inflammation, Suppurative |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                 3                        |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Suppurative                     |                                                                          |             
      Periovarian Tissue, Necrosis         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                               +  +                                   +   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Hydrometra                           |    4           4                                            3            |             
      Endometrium, Hyperplasia, Cystic     |             3     2  4        3        2     3                    4     3|             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|             
                                           | 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Muscularis, Inflammation, Suppurative|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Myelofibrosis                        |             3              2                                             |             
      Myeloid Cell, Hyperplasia            |                               4                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     M  +  +|             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |                               3                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Pancreatic, Pigmentation             |                4                                2  1                     |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  M  +  +     +  M  +     +     +  +  +     +  +     M  +  +|             
      Congestion                           |             4                                                            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |       1     2                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                                                 4                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Metaplasia                           |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  M  M     +  +  +     +     +  +  +     A  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  M  M  M     +  +  +     +     M  +  +     +  M     M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +     +  +  +     +     M  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Joint, Tarsal, Hyperostosis          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Cerebellum, Abscess, Multiple        |                               4                                          |             
      Meninges, Inflammation, Acute        |                                                                          |             
      Meninges, Inflammation, Chronic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic                | 2                                                                        |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 4| 5| 3| 4| 4| 7| 4| 7| 5| 5| 4| 2| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 4| 4| 5| 3| 5| 3| 9| 1| 5| 4| 3| 5| 3| 1| 3|             
                                           | 0| 0| 0| 3| 0| 0| 0| 0| 3| 1| 0| 3| 3| 0| 3| 0| 2| 6| 3| 5| 0| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Pleura, Inflammation, Chronic        |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +     +  +  +     +     +  +  +     M  +     +  +  M|             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Inflammation, Chronic        |       2                                            3                     |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                  1                                       |             
      Turbinate, Inflammation, Chronic     |                               2                                          |             
      Turbinate, Inflammation, Suppurative |                                                 2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +     +  +  +     +     +  +  +     +  +     +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    2  3     2  2     2     3  2  2     2     2  2  1              2     2|             
      Metaplasia                           |                                                                          |             
      Necrosis                             |       3           2        3                                             |             
      Cortex, Abscess, Single              |                               3                                          |             
      Papilla, Mineralization              |       2     1  1                                                         |             
      Renal Tubule, Dilatation             |    2                                                                     |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization         |                                                          2               |             
      Renal Tubule, Necrosis               |             2                                                            |             
      Renal Tubule, Pigmentation           | 1  1  2     2  1  2  1     4  2  3     1     1  2  2     2  2     1  1  2|             
      Renal Tubule, Regeneration           | 1  1  2     2  1  2  1     3  1  3     1     2  2  2        2        1  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +     +  M  +     +     +  +  +     +  +     +  M  +|             
      Artery, Serosa, Inflammation, Chronic|                                                                         4|             
      Submucosa, Inflammation, Chronic     |    2              2              2           2                    2     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|             
                                           | 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .038  G/                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +     +  +     +  M  +     +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Lamina Propria, Congestion, Diffuse  |          4                                                               |             
      Lamina Propria, Pigmentation         | 2     2  2  1  2  2  2  2  2  2  2     3  3     2  2  2     2  1  2  2  2|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Lamina Propria, Congestion, Diffuse  |          4                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Abscess, Single                      |                                                                          |             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                   3     4  3     2                             3         |             
      Inflammation, Chronic                | 1           2                    2                                       |             
      Necrosis                             |                                                                          |             
      Kupffer Cell, Pigmentation           | 1  2  2  1  2  2  3  3  2  3  2  2     3  2     2  2  2     3  2  3  3  3|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +        +                                             |             
      Inflammation, Chronic                |                   3                                                      |             
      Inflammation, Chronic Active         |             3                                                            |             
      Inflammation, Suppurative            |                            2                                             |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                |             3                          1                             2   |             
      Acinus, Atrophy                      |                                                 3                        |             
      Duct, Cyst                           |                                                                          |             
      Interlobular, Inflammation, Acute    |          3                                                               |             
      Serosa, Interlobular, Inflammation,  |                                                                          |             
           Suppurative                     |                            2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Inflammation, Chronic                | 2           2  1  2        1  2  2     2              2                 1|             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Necrotizing                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Acanthosis                           |             3     4  3  4                             4     4     4      |             
      Inflammation, Acute, Focal           |             2                                                     4      |             
      Inflammation, Chronic                |                   3     1                                                |             
      Ulcer                                |                                                       2     2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|             
                                           | 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .038  G/                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Myocardium, Inflammation, Acute      |          4                                                               |             
      Pericardium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Congestion                           |                                                       4                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  M  M  M  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  M  +  +  +  M  M     +  +     +  +  M     +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  M  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 2              2     3                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | M  M  M  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  M|             
      Cyst                                 |                                                       X        X         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                   4     4  4                    4                 4      |             
      Bilateral, Inflammation, Suppurative |          4                                                           4   |             
      Follicle, Cyst                       |                                           X                              |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                               3                       4                  |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Suppurative                     |                            3                                             |             
      Periovarian Tissue, Necrosis         |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |       +  +                                +                 +           +|             
      Inflammation, Suppurative            |                                                                         3|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  M  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 4              2              3  3     3              4        3  3     3|             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |          3        4     3     4                                2  3  4  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|             
                                           | 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .038  G/                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Muscularis, Inflammation, Suppurative|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Myelofibrosis                        |             2                                                            |             
      Myeloid Cell, Hyperplasia            |    4  4                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Lumbar, Hyperplasia, Plasma Cell     |                         4                                            4   |             
      Mandibular, Hyperplasia, Plasma Cell |    4                                                                     |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                      4   |             
      Pancreatic, Pigmentation             |             3                                                            |             
      Renal, Hyperplasia, Lymphoid         |                                  4                                       |             
      Renal, Hyperplasia, Plasma Cell      |                                                                      4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                  3                                       |             
      Pigmentation                         |       1  1                                3                       2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3  4  4        4     4  4              3                    3  4  4   |             
      Hyperplasia, Lymphoid                |                      3           3              4                        |             
      Metaplasia                           |                      2                                                   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  +  +  +  +  +  +  +     +  +     M  +  +     +  +  M  M  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  M  +  +  +  +  +  +  +     +  +     +  +  +     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Cerebellum, Abscess, Multiple        |                                                                          |             
      Meninges, Inflammation, Acute        |          4                                                               |             
      Meninges, Inflammation, Chronic      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 3| 3| 7| 7| 6| 7| 6| 6| 7| 6| 4| 7| 4| 4| 6| 2| 7| 4| 4| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 8| 2| 2| 3| 3| 5| 3| 6| 1| 3| 6| 5| 3| 7| 5| 8| 8| 3| 5| 3| 3| 3| 6| 6|             
                                           | 0| 8| 7| 7| 0| 0| 9| 0| 2| 4| 0| 2| 3| 0| 9| 3| 8| 8| 0| 3| 0| 0| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    .038  G/                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Pleura, Inflammation, Chronic        |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                      3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  M  +  M  +  +     +  +     +  +  +     +  +  +  +  +|             
      Inflammation, Suppurative            |       3                                                                  |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Mucosa, Inflammation, Suppurative    |    2  2                                   3        3                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Turbinate, Inflammation, Chronic     |                                                                          |             
      Turbinate, Inflammation, Suppurative |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Amyloid Deposition                   |                                                 4                        |             
      Inflammation, Acute                  |          3                                                               |             
      Inflammation, Chronic                | 2  4  2     1  1  3     3     2  2     2  2           2     1     2  2   |             
      Metaplasia                           |                                  2                                       |             
      Necrosis                             |    3        2                                                            |             
      Cortex, Abscess, Single              |                                                                          |             
      Papilla, Mineralization              |                                                                          |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                 4                        |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           | 1  2  2  1  1  1  2  1  1  1  2  2     2  2     2  2  1     3  1  2  1  2|             
      Renal Tubule, Regeneration           | 1  3  1     1  2  3  1  1  1  1  1     1        3     1     2  1  2  1  1|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +     +  +     +  +  +     +  +  +  +  +|             
      Artery, Serosa, Inflammation, Chronic|                                                                          |             
      Submucosa, Inflammation, Chronic     | 1  3     2  2                 2                    2        2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 3| 0| 0| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A     +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +     +  +  M  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M     +  +  +  +                                             |  48        |
      Lamina Propria, Congestion, Diffuse  |                                                                          |      1  4.0|
      Lamina Propria, Pigmentation         | 2  2  2  2        2  2  2  2                                             |     47  2.1|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +                                             |  50        |
      Lamina Propria, Congestion, Diffuse  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +                                             |  50        |
      Abscess, Single                      |                                                                          |      1  3.0|
      Angiectasis                          |                                                                          |      1  3.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Fatty Change                         |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |      5  3.0|
      Inflammation, Chronic                |                   2     2                                                |      8  1.9|
      Necrosis                             |                                                                          |      1  2.0|
      Kupffer Cell, Pigmentation           | 2  2  3  2  2     2  2  3  2                                             |     50  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M     +  +  +  +                                             |  49        |
      Inflammation, Chronic                |       2           1                                                      |      6  2.0|
      Acinus, Atrophy                      |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                                          |      1     |
      Interlobular, Inflammation, Acute    |                                                                          |      1  3.0|
      Serosa, Interlobular, Inflammation,  |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +                                             |  49        |
      Inflammation, Chronic                |    2  2     2        2                                                   |     18  1.8|
      Artery, Inflammation, Chronic,       |                                                                          |            |
          Necrotizing                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 3| 0| 0| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +                                             |  50        |
      Acanthosis                           | 4     4                    3                                             |     12  3.5|
      Inflammation, Acute, Focal           |                                                                          |      2  3.0|
      Inflammation, Chronic                | 3                                                                        |      3  2.3|
      Ulcer                                |                            3                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +                                             |  50        |
      Artery, Inflammation, Chronic        |                   3                                                      |      1  3.0|
      Myocardium, Inflammation, Acute      |                                                                          |      1  4.0|
      Pericardium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +  +     +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M     +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +     +  M  M  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  I  +  M  +     +  +  +  +                                             |  44        |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +                                             |  50        |
      Follicular Cell, Hyperplasia         |                      2                                                   |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M  +     M  +  +  +                                             |  44        |
      Cyst                                 |       X                                                                  |      6     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      5  4.0|
      Bilateral, Inflammation, Suppurative |                                                                          |      2  4.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         |                                                                          |      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 3| 0| 0| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Periovarian Tissue, Necrosis         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |             +                                                            |   9        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +                                             |  49        |
      Hydrometra                           |                                                                          |      3  3.7|
      Endometrium, Hyperplasia, Cystic     | 4  4     2        3  3     4                                             |     23  3.1|
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      9  3.2|
      Muscularis, Inflammation, Suppurative|                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +                                             |  50        |
      Myelofibrosis                        | 2                                                                        |      4  2.3|
      Myeloid Cell, Hyperplasia            |                                                                          |      3  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +                                             |  49        |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      2  4.0|
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |      2  3.5|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  4.0|
      Pancreatic, Pigmentation             |                            4                                             |      5  2.8|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +                                             |  46        |
      Congestion                           |          2                                                               |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation                         |    3     3                                                               |      8  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |       3              3                                                   |     13  3.6|
      Hyperplasia, Lymphoid                |                                                                          |      3  3.3|
      Metaplasia                           |                                                                          |      1  2.0|
      Pigmentation                         | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  M     +  +  +  +                                             |  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +     +  M  +  M                                             |  37        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 3| 0| 0| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +                                             |  50        |
      Joint, Tarsal, Hyperostosis          |                      X                                                   |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +                                             |  50        |
      Cerebellum, Abscess, Multiple        |                                                                          |      1  4.0|
      Meninges, Inflammation, Acute        |                                                                          |      1  4.0|
      Meninges, Inflammation, Chronic      |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +                                             |  50        |
      Congestion                           |             3                                                            |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Pleura, Inflammation, Chronic        |                            2                                             |      1  2.0|
      Pleura, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +                                             |  46        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mucosa, Inflammation, Chronic        |                                                                          |      2  2.5|
      Mucosa, Inflammation, Suppurative    |                         3                                                |      5  2.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
      Turbinate, Inflammation, Chronic     |                                                                          |      1  2.0|
      Turbinate, Inflammation, Suppurative |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +                                             |  50        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |    1  2  2        2  2     2                                             |     35  2.0|
      Metaplasia                           |                                                                          |      1  2.0|
      Necrosis                             |    2     1           2                                                   |      8  2.3|
      Cortex, Abscess, Single              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 5| 3| 3| 6| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 3| 0| 0| 7| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    .038  G/                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    KG 72HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Papilla, Mineralization              |                                                                          |      3  1.3|
      Renal Tubule, Dilatation             |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  4.0|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           | 1  1  1  2  2     1  2  2  2                                             |     50  1.6|
      Renal Tubule, Regeneration           |    1     2  2        2  1  1                                             |     42  1.6|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +                                             |  47        |
      Artery, Serosa, Inflammation, Chronic|                                                                          |      1  4.0|
      Submucosa, Inflammation, Chronic     |       2                    2                                             |     15  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|             
                                           | 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  A  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  A  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Fatty Change                         |                                           4     2                        |             
      Inflammation, Chronic                |                                                             1            |             
      Necrosis                             |                                           2  1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +     +                     |             
      Fat, Necrosis, Focal                 |                                                    4                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic                |                               2                                          |             
      Acinus, Atrophy                      |                      2                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic                | 1  1           2  2  1  2     2           2     2  2  2     2     1      |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Acanthosis                           |                                           2                              |             
      Inflammation, Acute                  |                                           1                              |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Hyperplasia                          |    3                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|             
                                           | 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  M  M  M  +  +  +  +  +     +  +  +  M  M  M     M  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  M  +     +  +  +  +  M  +     +  +  +  M   |             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M     +  +  +  +   |             
      Follicle, Hyperplasia                |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |       4  2                                   4                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Suppurative            |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Interstitial Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Myelofibrosis                        |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +     +  +  +  M   |             
      Lumbar, Hyperplasia, Plasma Cell     |                                              4                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +     +  +  +  M   |             
      Congestion                           |                                  3                          3            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           4  3                 4         |             
      Hyperplasia, Lymphoid                |                               4                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  M  +  +  +  M  M  +     +  +  +  M  +  M     +  M  +  +   |             
      Necrosis                             |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|             
                                           | 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M  M     M  +  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Dermis, Subcutaneous Tissue, Fibrosis|    4                                                                     |             
      Prepuce, Hyperkeratosis              |             3                                                            |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
      Prepuce, Necrosis, Focal             |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Joint, Tarsal, Hyperostosis          | X                             X        X                             X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Congestion                           |       2                                                                  |             
      Hemorrhage                           |                   3                                                      |             
      Alveolar Epithelium, Hyperplasia     |                3  2                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  +  +  +  +     M  +  +  +  +  +     +  +  +  M   |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Inflammation, Chronic                |    2  2        2  3  2  1  1  2  2     2              1     2  2  2  2   |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |                                                                          |             
      Cortex, Inflammation, Suppurative    |                                                                          |             
      Papilla, Necrosis                    |       4                                                                  |             
      Renal Tubule, Dilatation             |                   1                                                      |             
      Renal Tubule, Mineralization         |       3                                                                  |             
      Renal Tubule, Regeneration           |             1  1  1  1  1     1  1     1        2  1  1     1  1  1  1   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 3| 5| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 6| 1| 7| 7| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 0| 2| 3| 8| 3| 3| 3| 3| 4| 3| 3| 6| 6| 7| 4| 3| 3| 3| 6| 3| 1| 3| 3| 6|             
                                           | 6| 2| 8| 7| 3| 6| 6| 6| 6| 3| 6| 6| 1| 9| 0| 7| 6| 6| 9| 1| 6| 9| 6| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mucosa, Lumen, Inflammation,         |                                                                          |             
          Suppurative                      |                                              4                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +   |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Necrosis                     |                                                                          |             
      Serosa, Inflammation, Acute          |                                              3                           |             
      Submucosa, Hemorrhage                |                                                                          |             
      Submucosa, Inflammation, Chronic     |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|             
                                           | 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     M  +  +  +  +  +  +  +  +  +  +  +     +     +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +  +  +  +  +  +     +     A  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +  +  +  M     +     A  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     A  +  A  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  M  +  +  +  +  +  +     +     A  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  A  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  A  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     A  +  A  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +  +  +  +  +  +     +     A  +  A  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   3      |             
      Fatty Change                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |          4                                         4                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   1                                                      |             
      Acinus, Atrophy                      |          2                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1     1  1     1  2        2  1     2  1     2                 1     2   |             
      Inflammation, Suppurative            |                                                       4                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Acanthosis                           |       4                    3                                   2         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X                                                      |             
      Hypertrophy                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|             
                                           | 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  M  +  M  +  +  +  M  +  +  +  M     +     +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     M  +  M  +  +  +  +  +  +  +  +  +     +     +  +  +  M  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Follicle, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                       +                  |             
      Inflammation, Suppurative            |                                                       4                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +        +                             +                    +|             
      Duct, Ectasia                        |                      4                             4                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                       4                  |             
      Inflammation, Chronic                |             3                                                            |             
      Inflammation, Suppurative            |                                                          3              2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  M  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             4                                                            |             
      Interstitial Cell, Hyperplasia       | 2                                                                        |             
      Interstitial Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |             3                                                            |             
      Seminiferous Tubule, Degeneration    |                                                                      3   |             
      Seminiferous Tubule, Mineralization  |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +  +  +  M  +  +     +     +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  M  +  +  +  +  +     +     +  M  M  +  +  +  +  +|             
      Lumbar, Hyperplasia, Plasma Cell     |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  M  +  +  +  +  +     +     +  M  M  +  +  +  +  +|             
      Congestion                           | 3        4                                                     4         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   3      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     M  M  +  +  M  M  +  M  +  +  +  +     +     +  M  M  M  +  M  +  M|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|             
                                           | 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M  M  M  M  M  M  M  M  M  M  M     M     M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                         2|             
      Dermis, Subcutaneous Tissue, Fibrosis|                                                                          |             
      Prepuce, Hyperkeratosis              |                                                                          |             
      Prepuce, Inflammation, Suppurative   |             4                                         4                  |             
      Prepuce, Necrosis, Focal             |                                                       4                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          |                   X                                            X     X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         4|             
      Hemorrhage                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     M  +  +  +  +  +  +  +  M  +  +  +     +     M  M  +  +  +  +  +  +|             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1              1  2                 1  1                    1     1  2   |             
      Metaplasia, Osseous                  |                2                                                         |             
      Nephropathy                          |                                                                          |             
      Cortex, Inflammation, Suppurative    |                                                          3               |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Mineralization         |                                                                         3|             
      Renal Tubule, Regeneration           |       2  1     1  1     2  1  1  1  1                       1  1  1  1   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 2| 7| 7| 6| 4| 4| 7| 7| 7| 6| 4| 6| 4| 5| 2| 1| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 3| 6| 3| 3| 1| 3| 3| 2| 8| 6| 3| 3| 3| 0| 6| 8| 6| 6| 0| 5| 3| 3| 3| 3| 1|             
                                           | 6| 1| 6| 6| 4| 6| 6| 1| 3| 9| 6| 9| 9| 7| 1| 5| 1| 3| 4| 7| 6| 6| 6| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mucosa, Lumen, Inflammation,         |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  M  +  +  +  +  +  +  +  +  +     +     +  +  A  M  +  +  +  +|             
      Mucosa, Inflammation, Acute          |                                                       3                  |             
      Mucosa, Necrosis                     |                                                       4                  |             
      Serosa, Inflammation, Acute          |                                                                          |             
      Submucosa, Hemorrhage                |                                                                         4|             
      Submucosa, Inflammation, Chronic     |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 6| 1| 1| 9| 1| 1| 6| 6| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +        +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +        +        +  +  +  M                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +        +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +        +        +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +        +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +        +        +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +        +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +        +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +        +        +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +        +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Fatty Change                         |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis, Focal                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +        +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                         2                                                |      3  1.7|
      Acinus, Atrophy                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +        +        +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                         1                                                |     26  1.5|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +        +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +        +  +  +  +                                             |  50        |
      Acanthosis                           |                                                                          |      4  2.8|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                                                   |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +        +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +        M        +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +        M        +  +  +  +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 6| 1| 1| 9| 1| 1| 6| 6| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      1     |
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +        M        +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +        +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +        +  M  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        I        +  +  M  +                                             |  41        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +        +  +  +  +                                             |  49        |
      Follicle, Hyperplasia                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +        +        +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   4        |
      Duct, Ectasia                        |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +        +        +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      5  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +        +        +  +  +  +                                             |  49        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +        +        +  +  +  +                                             |  50        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Interstitial Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Seminiferous Tubule, Degeneration    |                         2                                                |      2  2.5|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +        +  +  +  +                                             |  49        |
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +        +  +  +  M                                             |  44        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 6| 1| 1| 9| 1| 1| 6| 6| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +        +  +  +  M                                             |  44        |
      Congestion                           | 4                                                                        |      6  3.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +        +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M        +        M  +  +  M                                             |  29        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M        M        M  M  M  M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +        +  +  +  +                                             |  49        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Dermis, Subcutaneous Tissue, Fibrosis|                                                                          |      1  4.0|
      Prepuce, Hyperkeratosis              |                                                                          |      1  3.0|
      Prepuce, Inflammation, Suppurative   |                                                                          |      2  4.0|
      Prepuce, Necrosis, Focal             |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +        +  +  +  +                                             |  50        |
      Joint, Tarsal, Hyperostosis          |                                                                          |      7     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +        +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +        +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +        M        +  +  +  +                                             |  42        |
      Mucosa, Inflammation, Suppurative    |                      3                                                   |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +        +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 7| 4| 4| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 3| 6| 6| 3| 3| 3| 3|                                            |            |
                                           | 6| 1| 1| 9| 1| 1| 6| 6| 6| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    72VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +        +  +  +  +                                             |  50        |
      Inflammation, Chronic                | 1                    1  2                                                |     26  1.6|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Nephropathy                          |                            3                                             |      1  3.0|
      Cortex, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Papilla, Necrosis                    |                                                                          |      1  4.0|
      Renal Tubule, Dilatation             |                                                                          |      1  1.0|
      Renal Tubule, Mineralization         |                                                                          |      2  3.0|
      Renal Tubule, Regeneration           | 1        1        1  1  1  2                                             |     34  1.1|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Mucosa, Lumen, Inflammation,         |                                                                          |            |
          Suppurative                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +        +  +  +  +                                             |  47        |
      Mucosa, Inflammation, Acute          |                                                                          |      1  3.0|
      Mucosa, Necrosis                     |                                                                          |      1  4.0|
      Serosa, Inflammation, Acute          |                                                                          |      1  3.0|
      Submucosa, Hemorrhage                |                                                                          |      1  4.0|
      Submucosa, Inflammation, Chronic     |                            2                                             |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 5| 1| 7| 7| 7| 6| 4| 4| 7| 7| 7| 0| 4| 7| 7| 5| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 1| 0| 7| 1| 0| 3| 3| 3| 2| 6| 6| 3| 3| 3| 9| 6| 3| 3| 9| 3|             
                                           | 5| 5| 5| 5| 9| 7| 2| 1| 8| 2| 5| 5| 5| 4| 1| 1| 5| 5| 5| 8| 1| 5| 5| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +  +  +  +           M                 +           +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +  +  M  +           +                 +           +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  M  +  +  +           +                 +           +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +|             
      Lamina Propria, Pigmentation         | 1  2  1  1  1  1  1  1  2  2  1  1  1  1        1  1  1  1     1  2  1  1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +  M  A  +           +              +  +           +  +|             
      Peyer's Patch, Hyperplasia,          |                                                                          |             
          Neutrophil                       |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +|             
      Angiectasis                          |                      4                                                   |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |          2                                            2                  |             
      Kupffer Cell, Pigmentation           | 1  1     1  1  1  1  1  1  1  1  1  1  1        1  1  1        1  1  1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                  +      |             
      Necrosis, Multifocal                 |                                                                   4      |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +  +  +  +           +                 +           +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +  +  +  +           +                 +           +  +|             
      Inflammation, Chronic                |                1  2                    1                             3   |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +  +  +  +  +  +  +           +                 +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +  +  +  +  +  +  +           +                 +        +  +  +|             
      Acanthosis                           |          2  4                                                     4  2   |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +  +  +  +  +  +           +                 +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +  +  +  +           +                 +           +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +  +  +  +           +                 +           +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +  M  M           +                 M           +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 5| 1| 7| 7| 7| 6| 4| 4| 7| 7| 7| 0| 4| 7| 7| 5| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 1| 0| 7| 1| 0| 3| 3| 3| 2| 6| 6| 3| 3| 3| 9| 6| 3| 3| 9| 3|             
                                           | 5| 5| 5| 5| 9| 7| 2| 1| 8| 2| 5| 5| 5| 4| 1| 1| 5| 5| 5| 8| 1| 5| 5| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +  +  +  +           +                 +           +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +  +  +           +                 +           +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +  +  +  M  +           +                 +        +  +  +|             
      Inflammation, Focal, Granulomatous   |                                                                   3      |             
                                            __________________________________________________________________________|             
   Penis                                   |                         +  +                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                         4                                                |             
      Necrosis                             |                            4                                             |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +  +        +                                               +|             
      Inflammation, Chronic                |             3                                                            |             
      Inflammation, Suppurative            |                4                                                        4|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                +  +  +  +  +           +                 +           +  +|             
      Inflammation, Acute                  |                                                                         2|             
      Inflammation, Suppurative            |                         3  4                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +  +  +  +  +           +                 +        +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  |                +  +  +  +  +           +                 +        +  +  +|             
      Seminiferous Tubule, Degeneration    |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +  +  +  +           +                 +           +  +|             
      Myeloid Cell, Hyperplasia            |                            4                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +  +  +  +  M  +  +  +     +        +     +  +     +  +  +  +|             
      Lumbar, Hyperplasia, Plasma Cell     |                            3                                             |             
      Mediastinal, Hyperplasia, Lymphoid   |                               4                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +              +  +  +  M  +  +  +     +        +     +  +     +  +  +  +|             
      Congestion                           | 2                             2  3              2              3  4  4   |             
      Hematopoietic Cell Proliferation     |                                                       4                  |             
      Pigmentation                         |                                  1                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +  +  +        +              +  +           +  +|             
      Hematopoietic Cell Proliferation     |                            4           3              4                  |             
      Hyperplasia, Lymphoid                |                               3                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +  +  M  +           +                 M           +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                         M  M           M                 M              M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +        +  +  +  +  +     +     +                 +        +  +  +|             
      Inflammation, Chronic                |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 5| 1| 7| 7| 7| 6| 4| 4| 7| 7| 7| 0| 4| 7| 7| 5| 2|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 1| 0| 7| 1| 0| 3| 3| 3| 2| 6| 6| 3| 3| 3| 9| 6| 3| 3| 9| 3|             
                                           | 5| 5| 5| 5| 9| 7| 2| 1| 8| 2| 5| 5| 5| 4| 1| 1| 5| 5| 5| 8| 1| 5| 5| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Parakeratosis, Multifocal            |                   2                                                      |             
      Ulcer, Multiple                      |                                                                          |             
      Dermis, Fibrosis                     |                   4                                                      |             
      Dermis, Inflammation, Chronic        |                                                                          |             
      Prepuce, Inflammation, Suppurative   |                         4  4                                             |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +  +  +  +     +     +           +     +              +|             
      Hyperostosis                         |                                        X                                 |             
      Joint, Tarsal, Hyperostosis          |                X  X  X  X        X                 X                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +  +  +  +           +                 +           +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +     +  +  +  +  +  +        +  +                 +     +     +  +|             
      Congestion                           |                                                          3               |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +  +  M  +           +                 +           M  M|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +  +  +  +           +                 +           +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Cataract                             |          3                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +|             
      Inflammation, Chronic                | 2        2     1  1  1                 1        1                 2      |             
      Necrosis                             |                                                    2  1        1  1  1   |             
      Pelvis, Inflammation, Acute          |                            2                                             |             
      Renal Tubule, Calculus Micro         |                                                                          |             
          Observation Only                 |                         2                                                |             
      Renal Tubule, Dilatation             |                   1                 1                             1      |             
      Renal Tubule, Pigmentation           |                   1                 1                          1  1      |             
      Renal Tubule, Regeneration           | 1  1  1  1  2                 1  1  1           2  1  1           2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +  +  +  +           +                 +           +  +|             
      Mucosa, Inflammation, Subacute       |                            4                                             |             
      Mucosa, Necrosis                     |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 4| 4| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 6| 6| 6| 7| 2| 3| 3| 1| 8| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3|             
                                           | 5| 5| 4| 4| 4| 7| 1| 1| 1| 0| 1| 5| 5| 3| 3| 5| 5| 5| 5| 7| 6| 5| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .019  G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +           +           M  +              +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  M  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  M  +  +     +  +|             
      Lamina Propria, Pigmentation         | 1  1  1  1  1  1              2  1  2  1  1  1  1  1  1     1  2     1  1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +           +           +  +              M               |             
      Peyer's Patch, Hyperplasia,          |                                                                          |             
          Neutrophil                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +           +           +  +              M               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +           +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                             X            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Kupffer Cell, Pigmentation           | 1  1  1  1  1              1     1  1  1  1     1  1  1  1  1  1     1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Necrosis, Multifocal                 |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                4         |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +           +           +  +              +               |             
      Inflammation, Chronic                |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +           +           +  +              +               |             
      Inflammation, Chronic                |                            2           2  2                              |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +           +           +           +  +           +  +  +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +           +           +           +  +           +  +  +        +   |             
      Acanthosis                           |    3                                      3           2     4            |             
      Cyst                                 |                                        X                                 |             
      Inflammation, Chronic                |                                                       1                  |             
      Ulcer                                |    3                                                        3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +           +           +           +  +              +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +           +           +  +              +               |             
      Hyperplasia                          |                1                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                M           +           M  +              M               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 4| 4| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 6| 6| 6| 7| 2| 3| 3| 1| 8| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3|             
                                           | 5| 5| 4| 4| 4| 7| 1| 1| 1| 0| 1| 5| 5| 3| 3| 5| 5| 5| 5| 7| 6| 5| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .019  G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +           +           +  +              +               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                +           +           +  +              +               |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                               +                                          |             
      Inflammation, Chronic Active         |                               2                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                        +                    +           +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                        3                                 |             
      Duct, Ectasia                        |                                                             4           4|             
                                            __________________________________________________________________________|             
   Prostate                                |                +           +           +  +              +               |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +        +           +  +        +  +              +               |             
                                            __________________________________________________________________________|             
   Testes                                  |                +           +           +  +              +               |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +           +           +  +              +               |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +           +  +  +  +  +  +  +  +        +  +  +         |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Pigmentation             | 1                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +           +     +  +  +  +  +  +        +  +  +         |             
      Congestion                           |    4     3  2  3           3     3  4        2  4           3  2         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation                         |       1     1                             1                              |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +           +  +        +  +              +               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                           M                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +           +           +     +     +  +  +  +        +  +        +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 4| 4| 4| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 6| 6| 6| 7| 2| 3| 3| 1| 8| 3| 3| 3| 3| 0| 3| 3| 6| 3| 3|             
                                           | 5| 5| 4| 4| 4| 7| 1| 1| 1| 0| 1| 5| 5| 3| 3| 5| 5| 5| 5| 7| 6| 5| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .019  G/                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Parakeratosis, Multifocal            |                                                                          |             
      Ulcer, Multiple                      |                                                          3               |             
      Dermis, Fibrosis                     |                                                                          |             
      Dermis, Inflammation, Chronic        |                                              2                           |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +  +           +        +     +  +     +                     |             
      Hyperostosis                         |                                                                          |             
      Joint, Tarsal, Hyperostosis          |             X  X           X        X        X     X                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +           +           +  +              +               |             
      Congestion                           |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                          3               |             
                                            __________________________________________________________________________|             
   Nose                                    |                +           M           +  +              +               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +           +           +  +              +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +           +  +  +  +  +  +  +  +  +     +  +  +     +  +|             
      Inflammation, Chronic                |    4  4        2           2                             2           1  1|             
      Necrosis                             |    3  3                                   1                    1        1|             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Calculus Micro         |                                                                          |             
          Observation Only                 |                                                                          |             
      Renal Tubule, Dilatation             |             1                 1  1  1  1  1  1  1              1         |             
      Renal Tubule, Pigmentation           |       1     1                       1                          1         |             
      Renal Tubule, Regeneration           |    2  3  1  1  1                 1  1  2  3  2  1  1     2  1  2     1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +           +           +  +              +               |             
      Mucosa, Inflammation, Subacute       |                                                                          |             
      Mucosa, Necrosis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6|                                            |            |
                                           | 9| 1| 5| 1| 5| 5| 5| 5| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +     +  +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +     +  +  +  +  +                                                |  49        |
      Lamina Propria, Pigmentation         | 2     1     1  1  1  1  1                                                |     48  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  13        |
      Peyer's Patch, Hyperplasia,          |                                                                          |            |
          Neutrophil                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +  +  +  +  +                                                |  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 4                                                                        |      1  4.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Kupffer Cell, Pigmentation           | 1     1     1  1  1  1  1                                                |     44  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Necrosis, Multifocal                 |                                                                          |      1  4.0|
      Fat, Necrosis, Focal                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                    +                                                   |  16        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  15        |
      Inflammation, Chronic                |                                                                          |      7  1.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                 +                                                      |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                 +                                                      |  23        |
      Acanthosis                           | 3                 4                                                      |     10  3.1|
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic                | 3                 2                                                      |      3  2.0|
      Ulcer                                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                 +                                                      |  22        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                                                                        |  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6|                                            |            |
                                           | 9| 1| 5| 1| 5| 5| 5| 5| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                                                                        |  15        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  15        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                                                        |  15        |
      Inflammation, Focal, Granulomatous   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   3        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M                       +                                                |   8        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      3  3.7|
      Duct, Ectasia                        |                         3                                                |      3  3.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                                                        |  15        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |  19        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                                                        |  16        |
      Seminiferous Tubule, Degeneration    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  15        |
      Myeloid Cell, Hyperplasia            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +        +                                                   |  36        |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  4.0|
      Pancreatic, Pigmentation             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +           +                                                            |  32        |
      Congestion                           |                                                                          |     18  2.9|
      Hematopoietic Cell Proliferation     | 3                                                                        |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6|                                            |            |
                                           | 9| 1| 5| 1| 5| 5| 5| 5| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         |             1                                                            |      5  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                    +                                                   |  19        |
      Hematopoietic Cell Proliferation     | 3                                                                        |      4  3.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                                                                        |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M                                                                        |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +        +                                                         |  29        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Parakeratosis, Multifocal            |                                                                          |      1  2.0|
      Ulcer, Multiple                      |                                                                          |      1  3.0|
      Dermis, Fibrosis                     |                                                                          |      1  4.0|
      Dermis, Inflammation, Chronic        |                                                                          |      1  2.0|
      Prepuce, Inflammation, Suppurative   |                                                                          |      2  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +              +                                                         |  19        |
      Hyperostosis                         |                                                                          |      1     |
      Joint, Tarsal, Hyperostosis          | X              X                                                         |     14     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  15        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  19        |
      Congestion                           |                                                                          |      1  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  11        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 4| 7| 7| 7| 7| 7| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 3| 6| 3| 3| 3| 3| 3| 6|                                            |            |
                                           | 9| 1| 5| 1| 5| 5| 5| 5| 4| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    .019  G/                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    KG 72LM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +  +  +  +  +                                                |  48        |
      Inflammation, Chronic                |       1                                                                  |     16  1.8|
      Necrosis                             |       1        1                                                         |     12  1.4|
      Pelvis, Inflammation, Acute          |                                                                          |      1  2.0|
      Renal Tubule, Calculus Micro         |                                                                          |            |
          Observation Only                 |                                                                          |      1  2.0|
      Renal Tubule, Dilatation             |                1  1     2                                                |     15  1.1|
      Renal Tubule, Pigmentation           |                                                                          |      8  1.0|
      Renal Tubule, Regeneration           |       2     1  1  1     1                                                |     34  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  15        |
      Mucosa, Inflammation, Subacute       |                                                                          |      1  4.0|
      Mucosa, Necrosis                     |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  M     +  M  +     M     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +     +  +  +  +  +  +  +  +     +  +  M     +     +  +  +  +  +|             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  M  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  M  +  +  +  +     +  +  +     +     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     M  +  +  +  +|             
      Lamina Propria, Pigmentation         | 2  2  2  2     1  2  2  2  2  2  2  2     2  2  3     3        1  2  2  1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  M  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                4         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Fatty Change                         | 3                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |    2                                2                                    |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             | 3                                                     4                  |             
      Kupffer Cell, Pigmentation           | 1  2  1  1     1  2  2  2  2  2  2  2     1  1  2           2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                |       1                                                                  |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hypertrophy, Focal           |                                           3                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                | 1  3  3  1        2  1           1  2     2  2  2              2     2   |             
      Acinus, Atrophy, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Acanthosis                           |                4  4  4     3        3           4     3        3         |             
      Inflammation, Acute                  |                3                                      1     2  1         |             
      Inflammation, Chronic                |                                                 2                        |             
      Inflammation, Focal                  |                      3                                                   |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                            2        3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Pulp, Inflammation, Necrotizing      |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  M  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  M  +  +  +  M     +  M  M     +     M  M  +  +  M|             
      Cyst, Multiple                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Pars Intermedia, Hyperplasia, Focal  |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |          2     2                                3                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +                                   +|             
      Inflammation, Chronic                |                                     2                                    |             
      Inflammation, Suppurative            |                                                                         4|             
      Duct, Ectasia                        |                                     4                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  M     +  +  +  +  +  M  +  +     +  +  +     +     +  +  +  M  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Myelofibrosis                        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  M  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Pancreatic, Pigmentation             |    2                                      1                             2|             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  M  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Congestion                           |    2                       3  4              3                 2        3|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         | 2     2           2           1     1        1                       1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4                                                     4                  |             
      Hyperplasia, Lymphoid                |    3                                                                     |             
      Pigmentation                         |                                                             1            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +     +  +  +  +  M  +  M  +     +  +  M     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M     M  M  M  M  M  M  M  M     M  M  M     M     M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Ulcer, Multiple                      |                                                                          |             
      Dermis, Fibrosis                     |                   3                                                      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Joint, Tarsal, Hyperostosis          | X     X           X                             X                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Peribronchiolar, Perivascular,       |                                                                          |             
          Inflammation, Chronic            |    3                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M     +  +  +  +  M  +  +  +     +  M  +     M     M  +  +  +  +|             
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |             
          Squamous                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                | 2  2  2  3        2  2     2  2  2  2     3  3  2           2  2  2  2  2|             
      Metaplasia                           |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 4| 5| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 2| 2| 6| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 6| 7| 6| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 1| 3| 3| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 1| 9| 1| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |    1  2  2           2  2  2  2  1  2     2  2  2     2     1  1        1|             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Dilatation             | 2  2  2  3     1  2  1  1  3  2  2  3     3  3  2     3     2  2  2  1  2|             
      Renal Tubule, Hyperplasia            |                   2           1                                   2      |             
      Renal Tubule, Mineralization         |                            2                                      2     1|             
      Renal Tubule, Pigmentation           | 1  2  2  2     1  1  1  1  2  1  2  2     2  2        3     2  1  2  1  2|             
      Renal Tubule, Regeneration           | 2  2  3  3        2  2  2  3  2  2  3     3  3  2     3     2  2  2  1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +     +  +  +  +  +|             
      Concretion                           |                                                       3                  |             
      Serosa, Inflammation                 |                                                                          |             
      Submucosa, Inflammation, Chronic     |                      2                       1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|             
                                           | 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .038  G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  M  +  +  +  +     +  M  M  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +  +  +  +     M  +  +  M  M  +     +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Acute          |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +     +  +  +  +  +  M     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Lamina Propria, Pigmentation         | 1     2  2  1  2  1  1  2     2  2  1  2     1     1  2  2  1  2  2  3  3|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +     +  +  +  +  A  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     3                                    |             
      Inflammation, Chronic                |                                                       2                  |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Kupffer Cell, Pigmentation           | 2     1  2  1  2  2  1  2     2  2  3  1     2     2  2  3  2  2  2  2  4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                                          3        2      |             
      Acinus, Hypertrophy, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2     2  2  1  2           1     1     1           2  1  2     1  2|             
      Acinus, Atrophy, Focal               |                         3                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Acanthosis                           |       3        3                                   4                    4|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                2                                   3                    2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                      3                                                   |             
      Pulp, Inflammation, Necrotizing      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|             
                                           | 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .038  G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic        |                                                          4               |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  +  M  +  +  M  +     M  +  M  +  +  +     +  M  M  +  +  M  M  M|             
      Cyst, Multiple                       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  M  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +              +     +                                    |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                     4                                    |             
      Duct, Ectasia                        |                4                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                          2               |             
      Inflammation, Suppurative            |                                           3                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                         +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Pancreatic, Pigmentation             |                3                                                     4   |             
      Renal, Hyperplasia, Histiocytic      |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Congestion                           |       3  2           3        2  2                             4     3   |             
      Hyperplasia, Lymphoid                |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|             
                                           | 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .038  G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         | 1                    1           1                          2  1        3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                         4                    4                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M     +  +  +  M  +  M  +     M  +  M  +  A  M     M  +  M  +  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M  M  M  M  M  M     M  M  M  M  M  M     M  +  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Ulcer, Multiple                      |                                                                          |             
      Dermis, Fibrosis                     |                                                       4                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperostosis                         |             X                                                            |             
      Joint, Tarsal, Hyperostosis          | X     X  X                          X                       X  X  X      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Congestion                           |                                           2                              |             
      Peribronchiolar, Perivascular,       |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  M  +  +  M     +  M  +  +  I  +     +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |             
          Squamous                         |                   3                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  M  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2  2  2  2  1           2  2     2              2  2  1     2  2  2|             
      Metaplasia                           |                                                                          |             
      Metaplasia, Osseous                  |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 1| 7| 4| 7| 6| 3| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 0| 3| 3| 3| 6| 6| 3| 3| 3| 2| 3| 3| 6| 3| 0| 7| 3| 3| 3| 3| 3|             
                                           | 3| 1| 3| 3| 6| 3| 3| 3| 8| 1| 3| 3| 3| 1| 6| 3| 1| 3| 3| 8| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    .038  G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |       1  1     1  2  1  2     2  1     1     2                       1   |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Dilatation             | 2     2  1  1  3  2  2  2     3  2  2  1     2     2  1     2     2  3  2|             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization         |       1                                   4           2                 2|             
      Renal Tubule, Pigmentation           | 2     1  1  1  1  1  2  1     3  2  2  1     1     1  1  1  1  1  1  1  4|             
      Renal Tubule, Regeneration           | 2     2  2  2  1  2  2  1     3  2  1  1     3     2  1  1  1  1  1  3  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Serosa, Inflammation                 |                                           2                              |             
      Submucosa, Inflammation, Chronic     |                                  2                                2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 4| 6| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5|                                            |            |
                                           | 3| 3| 3| 0| 1| 1| 4| 1| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +        +     +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +        +     A  +                                             |  44        |
      Serosa, Inflammation, Acute          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +        +     A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +        +     A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +        +     A  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +        +     A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +        +     A  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +        +     A  +                                             |  48        |
      Lamina Propria, Pigmentation         | 2  2  4  1        1        2                                             |     47  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +        +     A  +                                             |  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +        +     A  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +        +     +  +                                             |  50        |
      Fatty Change                         |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      3  2.0|
      Mixed Cell Focus                     |       X                                                                  |      1     |
      Necrosis                             |       1                                                                  |      3  2.7|
      Kupffer Cell, Pigmentation           | 2  2  2  4        2        3                                             |     47  1.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +        +     +  +                                             |  50        |
      Inflammation, Chronic                |       1                                                                  |      2  1.0|
      Acinus, Atrophy                      |                                                                          |      2  2.5|
      Acinus, Hypertrophy, Focal           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +        +     +  +                                             |  50        |
      Inflammation, Chronic                | 2  2  1  2        1                                                      |     31  1.7|
      Acinus, Atrophy, Focal               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +        +     +  +                                             |  50        |
      Acanthosis                           |          3                                                               |     13  3.5|
      Inflammation, Acute                  |          2                                                               |      5  1.8|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Focal                  |                                                                          |      1  3.0|
      Mineralization                       |          2                                                               |      1  2.0|
      Ulcer                                |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +        +     +  +                                             |  50        |
      Pigmentation                         |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 4| 6| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5|                                            |            |
                                           | 3| 3| 3| 0| 1| 1| 4| 1| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
      Pulp, Inflammation, Necrotizing      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +        +     +  +                                             |  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +        +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +        +     +  +                                             |  50        |
      Hyperplasia                          |       3                                                                  |      3  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +        +     +  +                                             |  33        |
      Cyst, Multiple                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +        +     +  +                                             |  50        |
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +        +     +  +                                             |  49        |
      Follicular Cell, Hyperplasia         |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +        +     +  +                                             |  50        |
      Inflammation, Chronic                |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |   6        |
      Inflammation, Chronic                | 4                                                                        |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
      Duct, Ectasia                        |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +        +     +  +                                             |  46        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +        +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +        +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 4| 6| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5|                                            |            |
                                           | 3| 3| 3| 0| 1| 1| 4| 1| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +        +     +  +                                             |  50        |
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +        +     +  +                                             |  49        |
      Pancreatic, Pigmentation             |                   4        3                                             |      7  2.7|
      Renal, Hyperplasia, Histiocytic      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +        +     +  +                                             |  49        |
      Congestion                           | 4  4                    4                                                |     16  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Pigmentation                         |       1                 2  1                                             |     17  1.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +        +     +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |                            4                                             |      5  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation                         |          4                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +        M     M  +                                             |  31        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M        M     M  M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +        +     +  +                                             |  50        |
      Ulcer, Multiple                      |                   4                                                      |      1  4.0|
      Dermis, Fibrosis                     |                                                                          |      2  3.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +        +     +  +                                             |  50        |
      Hyperostosis                         |                                                                          |      1     |
      Joint, Tarsal, Hyperostosis          |    X                                                                     |     12     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +        +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +        +     +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Peribronchiolar, Perivascular,       |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05043-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 2,4-DIAMINOPHENOL DIHYDROCHLORIDE                             Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 09:53:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 4| 4| 6| 4| 6| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 1| 7| 6| 6| 9| 6| 5| 5|                                            |            |
                                           | 3| 3| 3| 0| 1| 1| 4| 1| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    .038  G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    KG 72HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  M  +        +     +  +                                             |  39        |
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |            |
          Squamous                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +        +     +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +        +     +  +                                             |  50        |
      Inflammation, Chronic                | 2  1  2  2        1     2                                                |     38  2.0|
      Metaplasia                           |    2                                                                     |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Necrosis                             |          2        2     2                                                |     30  1.6|
      Papilla, Necrosis                    |                         2                                                |      1  2.0|
      Renal Tubule, Dilatation             | 1  4     2        1     2  1                                             |     46  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      3  1.7|
      Renal Tubule, Mineralization         |                         3                                                |      8  2.1|
      Renal Tubule, Pigmentation           |    2  1  3        1     1  1                                             |     47  1.5|
      Renal Tubule, Regeneration           | 2  1  1  2        2     2  2                                             |     48  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +        +     +  +                                             |  50        |
      Concretion                           |                                                                          |      1  3.0|
      Serosa, Inflammation                 |                                                                          |      1  2.0|
      Submucosa, Inflammation, Chronic     | 1  1                                                                     |      6  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
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