TDMS Study 05053-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
BROMOFORM
NTP Experiment-Test: 05053-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/08/94
Route: GAVAGE Time: 02:48:02
Facility: TSI Mason Research
Chemical CAS #: 75-25-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund Sacrifice 10 12 11
Natural Death 14 23 19
Survivors
Terminal Sacrifice 25 13 20
Natural Death 2
Culled 1
Animals Examined Microscopically 49 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (48) (24) (49)
Lymphoid Nodule, Hyperplasia 1 (2%) 2 (4%)
Intestine Small (47) (22) (48)
Fibrosis 1 (2%)
Inflammation, Acute 1 (2%)
Mineralization 1 (5%)
Necrosis 1 (2%) 1 (5%)
Epithelium, Hyperplasia 1 (5%)
Lymphoid Nodule, Hyperplasia 16 (34%) 5 (23%) 15 (31%)
Liver (49) (50) (50)
Abscess 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Clear Cell Focus 1 (2%)
Fatty Change, Diffuse 2 (4%) 4 (8%)
Fatty Change, Focal 1 (2%) 7 (14%) 20 (40%)
Hematopoietic Cell Proliferation 32 (65%) 34 (68%) 36 (72%)
Infarct 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%)
Necrosis 5 (10%) 4 (8%) 8 (16%)
Pigmentation 3 (6%) 2 (4%)
Mesentery (16) (19) (19)
Inflammation, Acute 14 (88%) 19 (100%) 19 (100%)
Fat, Necrosis 1 (6%)
Pancreas (46) (26) (47)
Necrosis, Coagulative 1 (2%)
Acinus, Hyperplasia, Focal 1 (2%)
Stomach (47) (48) (50)
Forestomach, Acanthosis 2 (4%) 3 (6%) 2 (4%)
Forestomach, Angiectasis 1 (2%)
Forestomach, Hyperkeratosis 6 (13%) 13 (27%) 6 (12%)
Forestomach, Inflammation, Chronic Active 4 (9%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Glandular, Ectopic Tissue 1 (2%)
Glandular, Hyperplasia 1 (2%) 4 (8%) 4 (8%)
Glandular, Inflammation, Chronic Active 5 (11%) 5 (10%) 3 (6%)
Glandular, Mineralization 1 (2%)
Glandular, Necrosis 1 (2%) 3 (6%) 1 (2%)
Glandular, Pigmentation 1 (2%)
Tooth (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (48) (26) (50)
Cardiomyopathy 1 (2%) 2 (8%) 2 (4%)
Mineralization 1 (4%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (26) (46)
Accessory Adrenal Cortical Nodule 1 (2%)
Hematopoietic Cell Proliferation 9 (18%) 8 (31%) 8 (17%)
Capsule, Hyperplasia 38 (78%) 17 (65%) 38 (83%)
Medulla, Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (44) (27) (46)
Pars Distalis, Angiectasis 4 (9%) 5 (19%) 2 (4%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 16 (36%) 7 (26%) 13 (28%)
Pars Distalis, Pigmentation 1 (4%)
Pars Intermedia, Hyperplasia 1 (4%) 1 (2%)
Thyroid Gland (49) (49) (47)
Follicular Cell, Cyst 1 (2%)
Follicular Cell, Hyperplasia, Focal 4 (8%) 3 (6%) 17 (36%)
Follicular Cell, Hyperplasia, Multifocal 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (45) (36) (49)
Abscess 13 (29%) 16 (44%) 19 (39%)
Angiectasis 1 (2%)
Cyst 11 (24%) 5 (14%) 4 (8%)
Degeneration, Cystic 1 (3%)
Hemorrhage 1 (2%)
Mineralization 1 (2%) 2 (6%)
Pigmentation 1 (3%) 1 (2%)
Bilateral, Abscess 10 (22%) 15 (42%) 7 (14%)
Oviduct (1)
Inflammation, Acute 1 (100%)
Uterus (49) (39) (49)
Abscess 2 (4%) 1 (3%) 2 (4%)
Angiectasis 1 (2%) 1 (3%)
Hemorrhage 1 (2%)
Inflammation, Acute 14 (29%) 12 (31%) 12 (24%)
Necrosis 1 (2%)
Endometrium, Hyperplasia 20 (41%) 19 (49%) 22 (45%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (25) (50)
Myelofibrosis 3 (6%)
Lymph Node (44) (32) (45)
Axillary, Hyperplasia, Plasma Cell 1 (3%)
Inguinal, Hematopoietic Cell Proliferation 1 (2%)
Inguinal, Hyperplasia, Plasma Cell 1 (2%)
Lumbar, Angiectasis 1 (2%)
Lumbar, Hematopoietic Cell Proliferation 2 (6%) 1 (2%)
Lumbar, Hyperplasia, Lymphoid 1 (2%)
Lumbar, Hyperplasia, Plasma Cell 4 (13%) 3 (7%)
Lumbar, Infiltration Cellular, Plasma Cell 1 (2%)
Lumbar, Necrosis 1 (2%) 1 (3%)
Mandibular, Angiectasis 1 (2%)
Mandibular, Hematopoietic Cell Proliferation 1 (2%) 7 (22%) 5 (11%)
Mandibular, Inflammation, Acute 1 (2%)
Mediastinal, Angiectasis 1 (2%)
Mediastinal, Bacterium 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 8 (18%) 4 (13%) 7 (16%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 3 (7%) 4 (13%) 10 (22%)
Mediastinal, Infiltration Cellular, Plasma
Cell 4 (9%)
Mediastinal, Inflammation, Acute 3 (7%)
Mediastinal, Necrosis 4 (9%) 3 (9%) 5 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mesenteric, Angiectasis 7 (16%) 3 (9%) 5 (11%)
Mesenteric, Hematopoietic Cell Proliferation 16 (36%) 9 (28%) 11 (24%)
Mesenteric, Hemorrhage 1 (2%) 1 (3%)
Mesenteric, Hyperplasia, Lymphoid 1 (2%)
Mesenteric, Hyperplasia, Plasma Cell 2 (5%) 2 (6%) 2 (4%)
Mesenteric, Infiltration Cellular, Plasma
Cell 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation 2 (6%)
Renal, Angiectasis 1 (2%)
Renal, Hematopoietic Cell Proliferation 3 (7%) 4 (13%) 3 (7%)
Renal, Hyperplasia, Lymphoid 1 (2%)
Renal, Hyperplasia, Plasma Cell 2 (5%) 6 (19%) 3 (7%)
Renal, Infiltration Cellular, Plasma Cell 2 (5%)
Renal, Necrosis 1 (3%) 1 (2%)
Spleen (48) (35) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 43 (90%) 32 (91%) 48 (96%)
Hemorrhage 1 (3%)
Hyperplasia, Lymphoid 4 (8%) 5 (10%)
Necrosis 2 (4%)
Pigmentation 1 (2%)
Capsule, Fibrosis 1 (2%)
Thymus (37) (14) (35)
Atrophy 1 (3%) 1 (7%) 2 (6%)
Cyst 1 (7%)
Hyperplasia, Lymphoid 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (17) (11) (13)
Galactocele 2 (12%)
Skin (40) (25) (44)
Hyperkeratosis 1 (3%)
Necrosis 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (3%) 1 (2%)
Subcutaneous Tissue, Metaplasia, Osseous 1 (3%)
Subcutaneous Tissue, Necrosis 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (25) (50)
Joint, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 0.1 G/KG 0.2 G/KG
46 VF 46 LF 46 HF
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (25) (50)
Inflammation, Acute 1 (4%)
Thalamus, Mineralization 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (27) (50)
Abscess 1 (2%)
Bacterium 2 (4%) 4 (15%) 5 (10%)
Edema 1 (4%) 1 (2%)
Hemorrhage 6 (12%)
Inflammation, Acute 4 (8%)
Inflammation, Chronic Active 4 (8%) 4 (15%) 4 (8%)
Alveolar Epithelium, Hyperplasia 1 (2%) 3 (6%)
Pleura, Inflammation, Acute 4 (8%) 11 (41%) 9 (18%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2)
Hyperplasia 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (32) (50)
Cyst 1 (2%)
Glomerulosclerosis 1 (2%)
Inflammation, Acute 1 (2%) 3 (9%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (3%)
Inflammation, Chronic Active 7 (14%) 4 (13%) 11 (22%)
Metaplasia, Osseous 1 (2%)
Necrosis 1 (3%)
Pigmentation 1 (2%)
Cortex, Mineralization 1 (2%) 1 (3%) 2 (4%)
Glomerulus, Inflammation, Acute 5 (10%) 6 (19%) 5 (10%)
Papilla, Mineralization 5 (10%) 3 (6%)
Papilla, Necrosis 1 (2%) 2 (6%) 1 (2%)
Renal Tubule, Casts 1 (2%)
Renal Tubule, Regeneration 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Natural Death 4 7 10
Moribund Sacrifice 5 6 4
Survivors
Terminal Sacrifice 41 37 36
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (6) (30)
Inflammation, Chronic Active 2 (4%) 1 (3%)
Intestine Large (50) (7) (48)
Circumanal Gland, Inflammation, Acute 1 (14%)
Lymphoid Nodule, Hyperplasia 2 (4%) 1 (14%) 5 (10%)
Intestine Small (50) (6) (46)
Hyperplasia, Lymphoid 1 (2%)
Duodenum, Fibrosis 1 (17%)
Duodenum, Hyperplasia 1 (17%)
Duodenum, Inflammation, Chronic Active 1 (17%)
Duodenum, Necrosis 1 (17%)
Ileum, Epithelium, Hyperplasia 1 (2%)
Lymphoid Nodule, Hyperplasia 26 (52%) 21 (46%)
Lymphoid Nodule, Necrosis 1 (2%)
Liver (50) (50) (49)
Basophilic Focus 2 (4%) 2 (4%)
Cyst 1 (2%)
Fatty Change, Diffuse 1 (2%)
Fatty Change, Focal 7 (14%) 5 (10%) 7 (14%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 20 (40%) 5 (10%) 14 (29%)
Hemorrhage 1 (2%) 1 (2%)
Infarct 1 (2%)
Mineralization 3 (6%) 3 (6%) 3 (6%)
Necrosis 10 (20%) 8 (16%) 12 (24%)
Pigmentation 1 (2%)
Regeneration 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Mesentery (2) (1)
Abscess 1 (100%)
Fat, Necrosis 1 (50%)
Pancreas (49) (9) (48)
Acinus, Atrophy 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Hyperplasia 2 (4%) 1 (2%)
Stomach (50) (50) (49)
Hyperplasia, Glandular 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Forestomach, Acanthosis 4 (8%) 3 (6%) 6 (12%)
Forestomach, Cyst Epithelial Inclusion,
Multiple 1 (2%)
Forestomach, Fibrosis 1 (2%) 1 (2%)
Forestomach, Hyperkeratosis 5 (10%) 5 (10%) 7 (14%)
Forestomach, Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%)
Forestomach, Mineralization 1 (2%)
Forestomach, Ulcer 2 (4%) 2 (4%) 2 (4%)
Glandular, Cyst 1 (2%)
Glandular, Dysplasia 1 (2%)
Glandular, Hyperplasia 4 (8%) 6 (12%)
Glandular, Inflammation, Chronic Active 4 (8%) 6 (12%) 8 (16%)
Glandular, Mineralization 1 (2%)
Tooth (1)
Developmental Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (6) (48)
Cardiomyopathy 2 (4%)
Mineralization 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Pericardium, Inflammation, Acute 1 (17%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (9) (49)
Capsule, Hyperplasia 31 (63%) 6 (67%) 30 (61%)
Cortex, Hyperplasia 1 (2%) 2 (4%)
Cortex, Hypertrophy 1 (11%) 2 (4%)
Cortex, Hypertrophy, Diffuse 1 (2%)
Cortex, Hypertrophy, Focal 1 (2%)
Medulla, Hyperplasia 8 (16%) 1 (11%) 4 (8%)
Islets, Pancreatic (49) (9) (48)
Hyperplasia 1 (2%)
Pituitary Gland (45) (6) (40)
Pars Distalis, Cyst 2 (4%) 1 (17%) 1 (3%)
Pars Distalis, Hyperplasia 3 (7%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (48) (6) (46)
Follicle, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicular Cell, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (47) (7) (47)
Abscess 1 (14%)
Preputial Gland (7) (9) (10)
Cyst 3 (33%)
Dilatation 1 (14%)
Inflammation, Chronic Active 5 (71%) 2 (22%) 5 (50%)
Necrosis 1 (14%) 3 (33%) 5 (50%)
Prostate (46) (6) (45)
Hemorrhage 1 (17%)
Inflammation, Chronic Active 1 (2%) 1 (17%) 2 (4%)
Necrosis 1 (17%)
Seminal Vesicle (49) (10) (48)
Inflammation, Chronic Active 1 (2%) 1 (10%)
Testes (50) (9) (48)
Spermatocele 1 (11%)
Seminiferous Tubule, Atrophy 7 (14%) 1 (11%) 6 (13%)
Seminiferous Tubule, Mineralization 1 (2%) 1 (11%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (47) (15) (43)
Lumbar, Angiectasis 1 (2%)
Lumbar, Hematopoietic Cell Proliferation 1 (2%)
Lumbar, Hyperplasia, Plasma Cell 1 (2%) 1 (7%)
Mandibular, Infiltration Cellular, Plasma
Cell 1 (2%)
Mesenteric, Angiectasis 22 (47%) 10 (67%) 14 (33%)
Mesenteric, Hematopoietic Cell Proliferation 15 (32%) 10 (67%) 10 (23%)
Mesenteric, Necrosis 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation 1 (7%)
Renal, Necrosis 1 (2%)
Thoracic, Angiectasis 1 (2%)
Thoracic, Necrosis 1 (2%)
Spleen (50) (18) (49)
Angiectasis 2 (4%) 1 (6%)
Atrophy 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 40 (80%) 15 (83%) 38 (78%)
Hyperplasia, Lymphoid 3 (6%) 1 (2%)
Hyperplasia, Mast Cell 1 (6%)
Thymus (35) (6) (30)
Atrophy 3 (9%) 2 (33%)
Hyperplasia, Lymphoid 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (48) (23) (49)
Bacterium 1 (2%) 3 (13%) 2 (4%)
Hemorrhage 1 (4%) 1 (2%)
Hyperplasia, Basal Cell 1 (4%)
Inflammation, Acute 1 (4%)
Inflammation, Chronic Active 2 (9%)
Necrosis 4 (8%) 8 (35%) 8 (16%)
Prepuce, Acanthosis 1 (2%)
Prepuce, Inflammation, Chronic Active 1 (4%) 1 (2%)
Prepuce, Necrosis 2 (4%)
Sebaceous Gland, Hyperplasia 1 (4%)
Subcutaneous Tissue, Fibrosis 3 (13%) 2 (4%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (4%)
Subcutaneous Tissue, Metaplasia, Osseous 1 (2%)
Subcutaneous Tissue, Necrosis 1 (2%) 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (49)
Joint, Tarsal, Hyperostosis 35 (70%) 40 (82%) 27 (55%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (6) (48)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Thalamus, Mineralization 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05053-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BROMOFORM Date: 09/08/94
Route: GAVAGE Time: 02:48:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .05 G/KG 0.1 G/KG
46 VM 46 LM 46 HM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49)
Abscess 1 (2%)
Embolus Tumor 1 (2%)
Fungus 1 (2%)
Hemorrhage 7 (14%) 4 (8%) 7 (14%)
Infiltration Cellular, Histiocyte 2 (4%) 2 (4%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 2 (4%) 1 (2%)
Bronchiole, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (2) (3)
Abscess 1 (33%)
Fibrosis 1 (33%)
Fungus 1 (33%)
Inflammation, Chronic Active 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (20) (49)
Abscess 1 (2%)
Cyst 4 (8%) 1 (5%)
Embolus Tumor 1 (2%)
Inflammation, Chronic Active 3 (6%) 4 (20%) 2 (4%)
Cortex, Mineralization 19 (38%) 2 (10%) 10 (20%)
Papilla, Mineralization 1 (2%) 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Casts 5 (10%) 1 (5%) 4 (8%)
Renal Tubule, Degeneration 1 (2%) 1 (2%)
Renal Tubule, Regeneration 18 (36%) 4 (20%) 8 (16%)
Urinary Bladder (48) (7) (47)
Angiectasis 1 (14%)
Calculus Micro Observation Only 2 (4%)
Inflammation, Acute 1 (14%)
Inflammation, Chronic 1 (14%)
Inflammation, Chronic Active 1 (2%) 1 (14%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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