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https://ntp.niehs.nih.gov/go/1815

TDMS Study 05053-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             BROMOFORM


NTP Experiment-Test: 05053-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: GAVAGE                                                                                                     Time: 02:48:02




       Facility:  TSI Mason Research

       Chemical CAS #:  75-25-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05053-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           12           11                                                  
    Natural Death                                     14           23           19                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           13           20                                                  
    Natural Death                                                   2                                                               
  Culled                                               1                                                                            
  Animals Examined Microscopically                    49           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (48)         (24)         (49)                                                
      Lymphoid Nodule, Hyperplasia                     1 (2%)                    2 (4%)                                             
   Intestine Small                                    (47)         (22)         (48)                                                
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Mineralization                                                1 (5%)                                                          
      Necrosis                                         1 (2%)       1 (5%)                                                          
      Epithelium, Hyperplasia                                       1 (5%)                                                          
      Lymphoid Nodule, Hyperplasia                    16 (34%)      5 (23%)     15 (31%)                                            
   Liver                                              (49)         (50)         (50)                                                
      Abscess                                          1 (2%)                                                                       
      Basophilic Focus                                 1 (2%)       1 (2%)                                                          
      Clear Cell Focus                                                           1 (2%)                                             
      Fatty Change, Diffuse                                         2 (4%)       4 (8%)                                             
      Fatty Change, Focal                              1 (2%)       7 (14%)     20 (40%)                                            
      Hematopoietic Cell Proliferation                32 (65%)     34 (68%)     36 (72%)                                            
      Infarct                                          1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         5 (10%)      4 (8%)       8 (16%)                                            
      Pigmentation                                                  3 (6%)       2 (4%)                                             
   Mesentery                                          (16)         (19)         (19)                                                
      Inflammation, Acute                             14 (88%)     19 (100%)    19 (100%)                                           
      Fat, Necrosis                                    1 (6%)                                                                       
   Pancreas                                           (46)         (26)         (47)                                                
      Necrosis, Coagulative                            1 (2%)                                                                       
      Acinus, Hyperplasia, Focal                                                 1 (2%)                                             
   Stomach                                            (47)         (48)         (50)                                                
      Forestomach, Acanthosis                          2 (4%)       3 (6%)       2 (4%)                                             
      Forestomach, Angiectasis                         1 (2%)                                                                       
      Forestomach, Hyperkeratosis                      6 (13%)     13 (27%)      6 (12%)                                            
      Forestomach, Inflammation, Chronic Active        4 (9%)       2 (4%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05053-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Glandular, Ectopic Tissue                                                  1 (2%)                                             
      Glandular, Hyperplasia                           1 (2%)       4 (8%)       4 (8%)                                             
      Glandular, Inflammation, Chronic Active          5 (11%)      5 (10%)      3 (6%)                                             
      Glandular, Mineralization                                                  1 (2%)                                             
      Glandular, Necrosis                              1 (2%)       3 (6%)       1 (2%)                                             
      Glandular, Pigmentation                                       1 (2%)                                                          
   Tooth                                                                        (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (48)         (26)         (50)                                                
      Cardiomyopathy                                   1 (2%)       2 (8%)       2 (4%)                                             
      Mineralization                                                1 (4%)       1 (2%)                                             
      Artery, Inflammation, Chronic Active                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (26)         (46)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 9 (18%)      8 (31%)      8 (17%)                                            
      Capsule, Hyperplasia                            38 (78%)     17 (65%)     38 (83%)                                            
      Medulla, Hyperplasia                             1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (44)         (27)         (46)                                                
      Pars Distalis, Angiectasis                       4 (9%)       5 (19%)      2 (4%)                                             
      Pars Distalis, Cyst                                                        1 (2%)                                             
      Pars Distalis, Hyperplasia                      16 (36%)      7 (26%)     13 (28%)                                            
      Pars Distalis, Pigmentation                                   1 (4%)                                                          
      Pars Intermedia, Hyperplasia                                  1 (4%)       1 (2%)                                             
   Thyroid Gland                                      (49)         (49)         (47)                                                
      Follicular Cell, Cyst                            1 (2%)                                                                       
      Follicular Cell, Hyperplasia, Focal              4 (8%)       3 (6%)      17 (36%)                                            
      Follicular Cell, Hyperplasia, Multifocal         1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05053-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (45)         (36)         (49)                                                
      Abscess                                         13 (29%)     16 (44%)     19 (39%)                                            
      Angiectasis                                                                1 (2%)                                             
      Cyst                                            11 (24%)      5 (14%)      4 (8%)                                             
      Degeneration, Cystic                                          1 (3%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Mineralization                                   1 (2%)       2 (6%)                                                          
      Pigmentation                                                  1 (3%)       1 (2%)                                             
      Bilateral, Abscess                              10 (22%)     15 (42%)      7 (14%)                                            
   Oviduct                                            (1)                                                                           
      Inflammation, Acute                              1 (100%)                                                                     
   Uterus                                             (49)         (39)         (49)                                                
      Abscess                                          2 (4%)       1 (3%)       2 (4%)                                             
      Angiectasis                                      1 (2%)       1 (3%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                             14 (29%)     12 (31%)     12 (24%)                                            
      Necrosis                                         1 (2%)                                                                       
      Endometrium, Hyperplasia                        20 (41%)     19 (49%)     22 (45%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (25)         (50)                                                
      Myelofibrosis                                    3 (6%)                                                                       
   Lymph Node                                         (44)         (32)         (45)                                                
      Axillary, Hyperplasia, Plasma Cell                            1 (3%)                                                          
      Inguinal, Hematopoietic Cell Proliferation       1 (2%)                                                                       
      Inguinal, Hyperplasia, Plasma Cell               1 (2%)                                                                       
      Lumbar, Angiectasis                                                        1 (2%)                                             
      Lumbar, Hematopoietic Cell Proliferation                      2 (6%)       1 (2%)                                             
      Lumbar, Hyperplasia, Lymphoid                    1 (2%)                                                                       
      Lumbar, Hyperplasia, Plasma Cell                              4 (13%)      3 (7%)                                             
      Lumbar, Infiltration Cellular, Plasma Cell       1 (2%)                                                                       
      Lumbar, Necrosis                                 1 (2%)       1 (3%)                                                          
      Mandibular, Angiectasis                                                    1 (2%)                                             
      Mandibular, Hematopoietic Cell Proliferation     1 (2%)       7 (22%)      5 (11%)                                            
      Mandibular, Inflammation, Acute                  1 (2%)                                                                       
      Mediastinal, Angiectasis                         1 (2%)                                                                       
      Mediastinal, Bacterium                           1 (2%)                                                                       
      Mediastinal, Hematopoietic Cell Proliferation    8 (18%)      4 (13%)      7 (16%)                                            
      Mediastinal, Hemorrhage                                                    1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell            3 (7%)       4 (13%)     10 (22%)                                            
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                         4 (9%)                                                                       
      Mediastinal, Inflammation, Acute                 3 (7%)                                                                       
      Mediastinal, Necrosis                            4 (9%)       3 (9%)       5 (11%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05053-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mesenteric, Angiectasis                          7 (16%)      3 (9%)       5 (11%)                                            
      Mesenteric, Hematopoietic Cell Proliferation    16 (36%)      9 (28%)     11 (24%)                                            
      Mesenteric, Hemorrhage                           1 (2%)       1 (3%)                                                          
      Mesenteric, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Mesenteric, Hyperplasia, Plasma Cell             2 (5%)       2 (6%)       2 (4%)                                             
      Mesenteric, Infiltration Cellular, Plasma                                                                                     
          Cell                                         1 (2%)                                                                       
      Pancreatic, Hematopoietic Cell Proliferation                  2 (6%)                                                          
      Renal, Angiectasis                               1 (2%)                                                                       
      Renal, Hematopoietic Cell Proliferation          3 (7%)       4 (13%)      3 (7%)                                             
      Renal, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Renal, Hyperplasia, Plasma Cell                  2 (5%)       6 (19%)      3 (7%)                                             
      Renal, Infiltration Cellular, Plasma Cell        2 (5%)                                                                       
      Renal, Necrosis                                               1 (3%)       1 (2%)                                             
   Spleen                                             (48)         (35)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hematopoietic Cell Proliferation                43 (90%)     32 (91%)     48 (96%)                                            
      Hemorrhage                                                    1 (3%)                                                          
      Hyperplasia, Lymphoid                            4 (8%)                    5 (10%)                                            
      Necrosis                                         2 (4%)                                                                       
      Pigmentation                                     1 (2%)                                                                       
      Capsule, Fibrosis                                                          1 (2%)                                             
   Thymus                                             (37)         (14)         (35)                                                
      Atrophy                                          1 (3%)       1 (7%)       2 (6%)                                             
      Cyst                                                          1 (7%)                                                          
      Hyperplasia, Lymphoid                                                      1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (17)         (11)         (13)                                                
      Galactocele                                      2 (12%)                                                                      
   Skin                                               (40)         (25)         (44)                                                
      Hyperkeratosis                                   1 (3%)                                                                       
      Necrosis                                                                   1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (3%)                    1 (2%)                                             
      Subcutaneous Tissue, Metaplasia, Osseous         1 (3%)                                                                       
      Subcutaneous Tissue, Necrosis                                 1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (25)         (50)                                                
      Joint, Hyperostosis                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05053-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (25)         (50)                                                
      Inflammation, Acute                                           1 (4%)                                                          
      Thalamus, Mineralization                         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (27)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Bacterium                                        2 (4%)       4 (15%)      5 (10%)                                            
      Edema                                                         1 (4%)       1 (2%)                                             
      Hemorrhage                                                                 6 (12%)                                            
      Inflammation, Acute                              4 (8%)                                                                       
      Inflammation, Chronic Active                     4 (8%)       4 (15%)      4 (8%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    3 (6%)                                             
      Pleura, Inflammation, Acute                      4 (8%)      11 (41%)      9 (18%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (2)                                                              
      Hyperplasia                                                   1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (32)         (50)                                                
      Cyst                                                                       1 (2%)                                             
      Glomerulosclerosis                                                         1 (2%)                                             
      Inflammation, Acute                              1 (2%)       3 (9%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       1 (3%)                                                          
      Inflammation, Chronic Active                     7 (14%)      4 (13%)     11 (22%)                                            
      Metaplasia, Osseous                              1 (2%)                                                                       
      Necrosis                                                      1 (3%)                                                          
      Pigmentation                                                               1 (2%)                                             
      Cortex, Mineralization                           1 (2%)       1 (3%)       2 (4%)                                             
      Glomerulus, Inflammation, Acute                  5 (10%)      6 (19%)      5 (10%)                                            
      Papilla, Mineralization                          5 (10%)                   3 (6%)                                             
      Papilla, Necrosis                                1 (2%)       2 (6%)       1 (2%)                                             
      Renal Tubule, Casts                                                        1 (2%)                                             
      Renal Tubule, Regeneration                                                 2 (4%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05053-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .05 G/KG     0.1 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      4            7           10                                                  
    Moribund Sacrifice                                 5            6            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           37           36                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (6)          (30)                                                
      Inflammation, Chronic Active                     2 (4%)                    1 (3%)                                             
   Intestine Large                                    (50)         (7)          (48)                                                
      Circumanal Gland, Inflammation, Acute                         1 (14%)                                                         
      Lymphoid Nodule, Hyperplasia                     2 (4%)       1 (14%)      5 (10%)                                            
   Intestine Small                                    (50)         (6)          (46)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Duodenum, Fibrosis                                            1 (17%)                                                         
      Duodenum, Hyperplasia                                         1 (17%)                                                         
      Duodenum, Inflammation, Chronic Active                        1 (17%)                                                         
      Duodenum, Necrosis                                            1 (17%)                                                         
      Ileum, Epithelium, Hyperplasia                   1 (2%)                                                                       
      Lymphoid Nodule, Hyperplasia                    26 (52%)                  21 (46%)                                            
      Lymphoid Nodule, Necrosis                                                  1 (2%)                                             
   Liver                                              (50)         (50)         (49)                                                
      Basophilic Focus                                 2 (4%)       2 (4%)                                                          
      Cyst                                                          1 (2%)                                                          
      Fatty Change, Diffuse                                         1 (2%)                                                          
      Fatty Change, Focal                              7 (14%)      5 (10%)      7 (14%)                                            
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                20 (40%)      5 (10%)     14 (29%)                                            
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Mineralization                                   3 (6%)       3 (6%)       3 (6%)                                             
      Necrosis                                        10 (20%)      8 (16%)     12 (24%)                                            
      Pigmentation                                     1 (2%)                                                                       
      Regeneration                                                  1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
      Bile Duct, Hyperplasia                                                     1 (2%)                                             
   Mesentery                                          (2)          (1)                                                              
      Abscess                                                       1 (100%)                                                        
      Fat, Necrosis                                    1 (50%)                                                                      
   Pancreas                                           (49)         (9)          (48)                                                
      Acinus, Atrophy                                  1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05053-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .05 G/KG     0.1 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Hyperplasia                              2 (4%)                    1 (2%)                                             
   Stomach                                            (50)         (50)         (49)                                                
      Hyperplasia, Glandular                           1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Forestomach, Acanthosis                          4 (8%)       3 (6%)       6 (12%)                                            
      Forestomach, Cyst Epithelial Inclusion,                                                                                       
          Multiple                                                               1 (2%)                                             
      Forestomach, Fibrosis                            1 (2%)       1 (2%)                                                          
      Forestomach, Hyperkeratosis                      5 (10%)      5 (10%)      7 (14%)                                            
      Forestomach, Inflammation, Chronic Active        1 (2%)       2 (4%)       2 (4%)                                             
      Forestomach, Mineralization                                   1 (2%)                                                          
      Forestomach, Ulcer                               2 (4%)       2 (4%)       2 (4%)                                             
      Glandular, Cyst                                                            1 (2%)                                             
      Glandular, Dysplasia                                                       1 (2%)                                             
      Glandular, Hyperplasia                                        4 (8%)       6 (12%)                                            
      Glandular, Inflammation, Chronic Active          4 (8%)       6 (12%)      8 (16%)                                            
      Glandular, Mineralization                        1 (2%)                                                                       
   Tooth                                                                        (1)                                                 
      Developmental Malformation                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (6)          (48)                                                
      Cardiomyopathy                                   2 (4%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Artery, Inflammation, Chronic Active                                       1 (2%)                                             
      Pericardium, Inflammation, Acute                              1 (17%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (9)          (49)                                                
      Capsule, Hyperplasia                            31 (63%)      6 (67%)     30 (61%)                                            
      Cortex, Hyperplasia                              1 (2%)                    2 (4%)                                             
      Cortex, Hypertrophy                                           1 (11%)      2 (4%)                                             
      Cortex, Hypertrophy, Diffuse                                               1 (2%)                                             
      Cortex, Hypertrophy, Focal                       1 (2%)                                                                       
      Medulla, Hyperplasia                             8 (16%)      1 (11%)      4 (8%)                                             
   Islets, Pancreatic                                 (49)         (9)          (48)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (45)         (6)          (40)                                                
      Pars Distalis, Cyst                              2 (4%)       1 (17%)      1 (3%)                                             
      Pars Distalis, Hyperplasia                       3 (7%)                                                                       
      Pars Intermedia, Cyst                            1 (2%)                                                                       
   Thyroid Gland                                      (48)         (6)          (46)                                                
      Follicle, Cyst                                   1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05053-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .05 G/KG     0.1 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia, Focal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (47)         (7)          (47)                                                
      Abscess                                                       1 (14%)                                                         
   Preputial Gland                                    (7)          (9)          (10)                                                
      Cyst                                                          3 (33%)                                                         
      Dilatation                                       1 (14%)                                                                      
      Inflammation, Chronic Active                     5 (71%)      2 (22%)      5 (50%)                                            
      Necrosis                                         1 (14%)      3 (33%)      5 (50%)                                            
   Prostate                                           (46)         (6)          (45)                                                
      Hemorrhage                                                    1 (17%)                                                         
      Inflammation, Chronic Active                     1 (2%)       1 (17%)      2 (4%)                                             
      Necrosis                                                      1 (17%)                                                         
   Seminal Vesicle                                    (49)         (10)         (48)                                                
      Inflammation, Chronic Active                     1 (2%)       1 (10%)                                                         
   Testes                                             (50)         (9)          (48)                                                
      Spermatocele                                                  1 (11%)                                                         
      Seminiferous Tubule, Atrophy                     7 (14%)      1 (11%)      6 (13%)                                            
      Seminiferous Tubule, Mineralization              1 (2%)       1 (11%)      3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (47)         (15)         (43)                                                
      Lumbar, Angiectasis                                                        1 (2%)                                             
      Lumbar, Hematopoietic Cell Proliferation                                   1 (2%)                                             
      Lumbar, Hyperplasia, Plasma Cell                 1 (2%)       1 (7%)                                                          
      Mandibular, Infiltration Cellular, Plasma                                                                                     
          Cell                                                                   1 (2%)                                             
      Mesenteric, Angiectasis                         22 (47%)     10 (67%)     14 (33%)                                            
      Mesenteric, Hematopoietic Cell Proliferation    15 (32%)     10 (67%)     10 (23%)                                            
      Mesenteric, Necrosis                             1 (2%)                                                                       
      Pancreatic, Hematopoietic Cell Proliferation                  1 (7%)                                                          
      Renal, Necrosis                                  1 (2%)                                                                       
      Thoracic, Angiectasis                            1 (2%)                                                                       
      Thoracic, Necrosis                               1 (2%)                                                                       
   Spleen                                             (50)         (18)         (49)                                                
      Angiectasis                                      2 (4%)       1 (6%)                                                          
      Atrophy                                          1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05053-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .05 G/KG     0.1 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                40 (80%)     15 (83%)     38 (78%)                                            
      Hyperplasia, Lymphoid                            3 (6%)                    1 (2%)                                             
      Hyperplasia, Mast Cell                                        1 (6%)                                                          
   Thymus                                             (35)         (6)          (30)                                                
      Atrophy                                          3 (9%)       2 (33%)                                                         
      Hyperplasia, Lymphoid                                                      1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (23)         (49)                                                
      Bacterium                                        1 (2%)       3 (13%)      2 (4%)                                             
      Hemorrhage                                                    1 (4%)       1 (2%)                                             
      Hyperplasia, Basal Cell                                       1 (4%)                                                          
      Inflammation, Acute                                           1 (4%)                                                          
      Inflammation, Chronic Active                                  2 (9%)                                                          
      Necrosis                                         4 (8%)       8 (35%)      8 (16%)                                            
      Prepuce, Acanthosis                                                        1 (2%)                                             
      Prepuce, Inflammation, Chronic Active                         1 (4%)       1 (2%)                                             
      Prepuce, Necrosis                                                          2 (4%)                                             
      Sebaceous Gland, Hyperplasia                                  1 (4%)                                                          
      Subcutaneous Tissue, Fibrosis                                 3 (13%)      2 (4%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                    1 (4%)                                                          
      Subcutaneous Tissue, Metaplasia, Osseous         1 (2%)                                                                       
      Subcutaneous Tissue, Necrosis                    1 (2%)       1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (49)                                                
      Joint, Tarsal, Hyperostosis                     35 (70%)     40 (82%)     27 (55%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (6)          (48)                                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Thalamus, Mineralization                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05053-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 02:48:02  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      .05 G/KG     0.1 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Abscess                                                                    1 (2%)                                             
      Embolus Tumor                                    1 (2%)                                                                       
      Fungus                                                                     1 (2%)                                             
      Hemorrhage                                       7 (14%)      4 (8%)       7 (14%)                                            
      Infiltration Cellular, Histiocyte                2 (4%)       2 (4%)                                                          
      Inflammation, Chronic Active                                  2 (4%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (6%)       2 (4%)       1 (2%)                                             
      Bronchiole, Inflammation, Acute                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (2)          (3)                                                 
      Abscess                                                                    1 (33%)                                            
      Fibrosis                                                                   1 (33%)                                            
      Fungus                                                                     1 (33%)                                            
      Inflammation, Chronic Active                                               1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (20)         (49)                                                
      Abscess                                                                    1 (2%)                                             
      Cyst                                             4 (8%)       1 (5%)                                                          
      Embolus Tumor                                    1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (6%)       4 (20%)      2 (4%)                                             
      Cortex, Mineralization                          19 (38%)      2 (10%)     10 (20%)                                            
      Papilla, Mineralization                          1 (2%)                    1 (2%)                                             
      Papilla, Necrosis                                                          1 (2%)                                             
      Renal Tubule, Casts                              5 (10%)      1 (5%)       4 (8%)                                             
      Renal Tubule, Degeneration                       1 (2%)                    1 (2%)                                             
      Renal Tubule, Regeneration                      18 (36%)      4 (20%)      8 (16%)                                            
   Urinary Bladder                                    (48)         (7)          (47)                                                
      Angiectasis                                                   1 (14%)                                                         
      Calculus Micro Observation Only                  2 (4%)                                                                       
      Inflammation, Acute                                           1 (14%)                                                         
      Inflammation, Chronic                                         1 (14%)                                                         
      Inflammation, Chronic Active                     1 (2%)       1 (14%)                                                         
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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