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https://ntp.niehs.nih.gov/go/1827

TDMS Study 05053-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             BROMOFORM


NTP Experiment-Test: 05053-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: GAVAGE                                                                                                     Time: 01:01:49




       Facility:  TSI Mason Research

       Chemical CAS #:  75-25-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      3            6            2                                                  
    Moribund Sacrifice                                13           16           19                                                  
    Gavage Death                                                                 1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           28           28                                                  
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (48)         (18)         (49)                                                
      Parasite                                         5 (10%)      1 (6%)       7 (14%)                                            
      Cecum, Inflammation, Acute                                                 1 (2%)                                             
      Colon, Fibrosis                                  1 (2%)                                                                       
      Colon, Necrosis                                  1 (2%)       1 (6%)                                                          
   Intestine Small                                    (48)         (16)         (49)                                                
      Lymphoid Nodule, Mineralization                               1 (6%)                                                          
   Liver                                              (50)         (49)         (50)                                                
      Basophilic Focus                                28 (56%)     15 (31%)     13 (26%)                                            
      Clear Cell Focus                                                           1 (2%)                                             
      Cyst                                                          2 (4%)                                                          
      Eosinophilic Focus                                            2 (4%)       2 (4%)                                             
      Fatty Change, Diffuse                            8 (16%)     13 (27%)     20 (40%)                                            
      Fatty Change, Focal                             11 (22%)     26 (53%)     26 (52%)                                            
      Hepatodiaphragmatic Nodule                       3 (6%)       2 (4%)       2 (4%)                                             
      Hyperplasia, Diffuse                                                       1 (2%)                                             
      Hyperplasia, Focal                                            1 (2%)       1 (2%)                                             
      Hyperplasia, Multifocal                          1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                     9 (18%)      8 (16%)     27 (54%)                                            
      Mixed Cell Focus                                 8 (16%)     25 (51%)     28 (56%)                                            
      Necrosis                                        11 (22%)      3 (6%)       2 (4%)                                             
      Bile Duct, Hyperplasia                          17 (34%)     10 (20%)      4 (8%)                                             
   Mesentery                                          (4)          (3)          (3)                                                 
      Artery, Necrosis, Fibrinoid                                   1 (33%)                                                         
      Fat, Inflammation, Chronic Active                             1 (33%)                                                         
      Fat, Necrosis                                    4 (100%)     2 (67%)      3 (100%)                                           
   Pancreas                                           (48)         (49)         (50)                                                
      Acinus, Atrophy                                 12 (25%)      7 (14%)      3 (6%)                                             
      Acinus, Hyperplasia                              3 (6%)       2 (4%)       3 (6%)                                             
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      Artery, Necrosis, Fibrinoid                                   2 (4%)                                                          
      Artery, Pigmentation                                          1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Salivary Glands                                    (49)         (49)         (50)                                                
      Inflammation, Chronic Active                                               3 (6%)                                             
      Acinus, Hyperplasia                                                        1 (2%)                                             
      Duct, Ectasia                                                 1 (2%)       8 (16%)                                            
      Duct, Inflammation, Chronic Active                            9 (18%)     15 (30%)                                            
      Duct, Metaplasia, Squamous                                   10 (20%)     16 (32%)                                            
   Stomach                                            (50)         (26)         (50)                                                
      Forestomach, Acanthosis                          6 (12%)      7 (27%)      4 (8%)                                             
      Forestomach, Hyperkeratosis                      7 (14%)      8 (31%)      4 (8%)                                             
      Forestomach, Inflammation, Chronic Active        3 (6%)       3 (12%)      2 (4%)                                             
      Forestomach, Ulcer                               2 (4%)       4 (15%)      1 (2%)                                             
      Glandular, Abscess                                            1 (4%)                                                          
      Glandular, Hyperplasia, Lymphoid                                           1 (2%)                                             
      Glandular, Inflammation, Chronic Active                       1 (4%)       1 (2%)                                             
      Glandular, Necrosis                                           1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (16)         (50)                                                
      Cardiomyopathy                                  34 (68%)     12 (75%)     22 (44%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (18)         (50)                                                
      Necrosis                                         1 (2%)       2 (11%)                                                         
      Cortex, Hyperplasia                              1 (2%)                    3 (6%)                                             
      Medulla, Hyperplasia                             4 (8%)       3 (17%)      7 (14%)                                            
   Islets, Pancreatic                                 (48)         (49)         (50)                                                
      Ectopic Tissue                                                1 (2%)                                                          
   Parathyroid Gland                                  (21)         (16)         (20)                                                
      Hyperplasia                                                   1 (6%)                                                          
   Pituitary Gland                                    (48)         (46)         (48)                                                
      Pars Distalis, Angiectasis                      27 (56%)     11 (24%)      9 (19%)                                            
      Pars Distalis, Cyst                              6 (13%)      8 (17%)      2 (4%)                                             
      Pars Distalis, Hyperplasia                       9 (19%)     15 (33%)      7 (15%)                                            
      Pars Intermedia, Cyst                                                      1 (2%)                                             
      Pars Intermedia, Hyperplasia                     2 (4%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (47)         (49)                                                
      Necrosis                                                      1 (2%)                                                          
      C-Cell, Hyperplasia                              9 (18%)      7 (15%)      3 (6%)                                             
      Follicular Cell, Cyst                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (34)         (9)          (39)                                                
      Inflammation, Chronic Active                     2 (6%)       1 (11%)      2 (5%)                                             
      Necrosis                                         2 (6%)                    3 (8%)                                             
   Ovary                                              (50)         (20)         (50)                                                
      Cyst                                             5 (10%)      2 (10%)      3 (6%)                                             
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                                      1 (5%)                                                          
      Interstitium, Hyperplasia                        1 (2%)                                                                       
   Uterus                                             (49)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Decidual Reaction                                             1 (2%)                                                          
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    2 (4%)                                             
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (47)         (49)                                                
      Lumbar, Pigmentation                                          1 (2%)                                                          
      Mandibular, Hematopoietic Cell Proliferation                               1 (2%)                                             
      Mandibular, Infiltration Cellular, Plasma                                                                                     
          Cell                                                      1 (2%)       3 (6%)                                             
      Mandibular, Pigmentation                                                   1 (2%)                                             
      Mediastinal, Congestion                                                    1 (2%)                                             
      Mediastinal, Infiltration Cellular, Mast Cell                              1 (2%)                                             
      Mediastinal, Pigmentation                        2 (4%)       2 (4%)       6 (12%)                                            
      Mesenteric, Depletion Lymphoid                                1 (2%)       2 (4%)                                             
      Mesenteric, Infiltration Cellular, Mast Cell                               1 (2%)                                             
      Mesenteric, Pigmentation                                                   1 (2%)                                             
      Pancreatic, Infiltration Cellular, Mast Cell                               1 (2%)                                             
      Pancreatic, Infiltration Cellular, Plasma                                                                                     
          Cell                                                      2 (4%)                                                          
      Pancreatic, Pigmentation                                                   1 (2%)                                             
   Spleen                                             (49)         (28)         (50)                                                
      Depletion Lymphoid                               1 (2%)       2 (7%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                35 (71%)     17 (61%)     39 (78%)                                            
      Hemorrhage                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Necrosis                                         1 (2%)       1 (4%)                                                          
      Pigmentation                                     7 (14%)      6 (21%)     29 (58%)                                            
   Thymus                                             (48)         (14)         (48)                                                
      Infiltration Cellular, Lymphocyte                             1 (7%)       1 (2%)                                             
      Epithelial Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (42)         (39)                                                
      Galactocele                                     25 (57%)      4 (10%)      1 (3%)                                             
      Necrosis                                                      1 (2%)                                                          
   Skin                                               (50)         (46)         (50)                                                
      Hyperkeratosis                                                1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (17)         (50)                                                
      Brain Stem, Hemorrhage                           2 (4%)                                                                       
      Cerebellum, Hemorrhage                           2 (4%)                    1 (2%)                                             
      Cerebellum, Inflammation, Chronic Active                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (32)         (50)                                                
      Infiltration Cellular, Histiocyte               11 (22%)      8 (25%)     16 (32%)                                            
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                     4 (8%)       4 (13%)      4 (8%)                                             
      Inflammation, Granulomatous                                   1 (3%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (3%)                                                          
      Bronchus, Metaplasia, Squamous                                             1 (2%)                                             
   Nose                                               (48)         (12)         (46)                                                
      Hemorrhage                                                    1 (8%)                                                          
      Inflammation, Chronic Active                                  2 (17%)      2 (4%)                                             
      Metaplasia, Squamous                                                       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)                    1 (2%)                                             
   Trachea                                            (50)         (47)         (50)                                                
      Inflammation, Acute                                                        2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VF         46 LF        46 HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic Active                                               3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (3)          (4)                                                 
      Inflammation, Acute                                                        1 (25%)                                            
      Synechia                                                                   1 (25%)                                            
      Lens, Cataract                                                2 (67%)      2 (50%)                                            
      Lens, Inflammation, Acute                                                  1 (25%)                                            
      Lens, Synechia                                                2 (67%)                                                         
   Harderian Gland                                    (1)                       (4)                                                 
      Abscess                                                                    3 (75%)                                            
      Duct, Metaplasia, Squamous                                                 1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                                          1 (2%)       1 (2%)                                             
      Necrosis                                                                   2 (4%)                                             
      Nephropathy                                     40 (80%)     41 (82%)     46 (92%)                                            
      Transitional Epithelium, Hyperplasia                          2 (4%)       1 (2%)                                             
      Transitional Epithelium, Metaplasia, Osseous                               1 (2%)                                             
      Transitional Epithelium, Mineralization                                    1 (2%)                                             
   Urinary Bladder                                    (45)         (14)         (46)                                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      Mineralization                                                2 (14%)                                                         
      Necrosis                                         1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia                          1 (7%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      9            3            6                                                  
    Moribund Sacrifice                                 7           17           33                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           30           11                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (50)         (50)                                                
      Abscess                                          1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Parasite                                         2 (4%)       5 (10%)      5 (10%)                                            
      Cecum, Inflammation, Chronic Active              1 (2%)                                                                       
      Colon, Erosion                                                             1 (2%)                                             
      Colon, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Lymphoid Nodule, Hyperplasia                                  1 (2%)       1 (2%)                                             
   Intestine Small                                    (49)         (50)         (50)                                                
      Ileum, Fibrosis                                                            1 (2%)                                             
      Ileum, Necrosis                                                            1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                28 (56%)     20 (40%)     24 (48%)                                            
      Clear Cell Focus                                              2 (4%)                                                          
      Degeneration, Cystic                                          1 (2%)                                                          
      Eosinophilic Focus                               1 (2%)       9 (18%)      4 (8%)                                             
      Fatty Change, Diffuse                            5 (10%)     13 (26%)     27 (54%)                                            
      Fatty Change, Focal                             18 (36%)     36 (72%)     23 (46%)                                            
      Focal Cellular Change                                         1 (2%)                                                          
      Hepatodiaphragmatic Nodule                                    1 (2%)                                                          
      Hyperplasia, Focal                               2 (4%)       1 (2%)                                                          
      Hyperplasia, Multifocal                          2 (4%)       2 (4%)                                                          
      Inflammation, Chronic Active                                 29 (58%)     23 (46%)                                            
      Mixed Cell Focus                                10 (20%)     11 (22%)      8 (16%)                                            
      Necrosis                                         7 (14%)      3 (6%)      20 (40%)                                            
      Bile Duct, Hyperplasia                          39 (78%)     37 (74%)     22 (44%)                                            
   Mesentery                                          (4)          (4)          (3)                                                 
      Artery, Necrosis, Fibrinoid                      1 (25%)                                                                      
      Fat, Inflammation, Chronic Active                1 (25%)      1 (25%)                                                         
      Fat, Necrosis                                    2 (50%)      3 (75%)      1 (33%)                                            
   Pancreas                                           (50)         (50)         (50)                                                
      Acinus, Atrophy                                  6 (12%)      9 (18%)      3 (6%)                                             
      Acinus, Hyperplasia                              4 (8%)       2 (4%)       3 (6%)                                             
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Thrombosis                                                         1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (48)                                                
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Atrophy, Focal                                   1 (2%)                                                                       
      Fibrosis                                                      1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                                  2 (4%)       3 (6%)                                             
      Duct, Ectasia                                                 5 (10%)                                                         
      Duct, Inflammation, Chronic Active                           14 (28%)     22 (46%)                                            
      Duct, Metaplasia, Squamous                                   15 (30%)     31 (65%)                                            
   Stomach                                            (49)         (50)         (50)                                                
      Forestomach, Acanthosis                          1 (2%)       1 (2%)                                                          
      Forestomach, Fibrosis                                         2 (4%)                                                          
      Forestomach, Hyperkeratosis                      6 (12%)      8 (16%)      4 (8%)                                             
      Forestomach, Hyperplasia, Basal Cell                                       3 (6%)                                             
      Forestomach, Inflammation, Chronic Active        4 (8%)       4 (8%)      10 (20%)                                            
      Forestomach, Necrosis                            3 (6%)                                                                       
      Forestomach, Ulcer                               1 (2%)       5 (10%)     10 (20%)                                            
      Glandular, Necrosis                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  42 (84%)     39 (78%)     23 (46%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (48)         (50)         (50)                                                
      Cyst                                                          2 (4%)                                                          
      Thrombosis                                       1 (2%)                                                                       
      Cortex, Hyperplasia                              3 (6%)       1 (2%)                                                          
      Cortex, Hypertrophy, Focal                                                 1 (2%)                                             
      Cortex, Necrosis                                 1 (2%)       1 (2%)       1 (2%)                                             
      Medulla, Hyperplasia                            21 (44%)     16 (32%)      6 (12%)                                            
   Islets, Pancreatic                                 (48)         (50)         (50)                                                
      Hyperplasia                                      2 (4%)       3 (6%)       2 (4%)                                             
   Pituitary Gland                                    (50)         (48)         (45)                                                
      Pars Distalis, Angiectasis                      11 (22%)     12 (25%)      1 (2%)                                             
      Pars Distalis, Cyst                              2 (4%)       2 (4%)                                                          
      Pars Distalis, Hyperplasia                       9 (18%)     26 (54%)     15 (33%)                                            
      Pars Intermedia, Hyperplasia                     2 (4%)                                                                       
      Pars Nervosa, Cyst                               1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (49)         (49)         (47)                                                
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      C-Cell, Hyperplasia                              3 (6%)       3 (6%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Capsule, Necrosis, Fibrinoid                     1 (2%)                                                                       
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (45)         (49)         (41)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
   Preputial Gland                                    (41)         (38)         (34)                                                
      Fibrosis                                         2 (5%)                                                                       
      Inflammation, Chronic Active                     7 (17%)     11 (29%)     10 (29%)                                            
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         7 (17%)      3 (8%)       7 (21%)                                            
   Prostate                                           (49)         (46)         (50)                                                
      Fibrosis                                         2 (4%)       4 (9%)       5 (10%)                                            
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                    16 (33%)     17 (37%)     19 (38%)                                            
      Metaplasia, Squamous                             2 (4%)       6 (13%)     12 (24%)                                            
      Mineralization                                                1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)       2 (4%)       3 (6%)                                             
   Seminal Vesicle                                    (50)         (48)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Inflammation                                                               1 (2%)                                             
   Testes                                             (50)         (50)         (50)                                                
      Spermatocele                                                  1 (2%)       1 (2%)                                             
      Interstitial Cell, Hyperplasia                  37 (74%)     39 (78%)     39 (78%)                                            
      Seminiferous Tubule, Atrophy                    40 (80%)     38 (76%)     33 (66%)                                            
      Seminiferous Tubule, Giant Cell                               6 (12%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (48)         (49)                                                
      Lumbar, Pigmentation                             1 (2%)                    1 (2%)                                             
      Mandibular, Infiltration Cellular, Plasma                                                                                     
          Cell                                                      4 (8%)                                                          
      Mandibular, Necrosis                                          1 (2%)                                                          
      Mediastinal, Angiectasis                         2 (4%)                    3 (6%)                                             
      Mediastinal, Congestion                                       1 (2%)       1 (2%)                                             
      Mediastinal, Depletion Lymphoid                               1 (2%)       1 (2%)                                             
      Mediastinal, Hemorrhage                          1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Pigmentation                        2 (4%)                   12 (24%)                                            
      Mesenteric, Angiectasis                          1 (2%)                                                                       
      Mesenteric, Infiltration Cellular, Mast Cell                               2 (4%)                                             
      Pancreatic, Angiectasis                          1 (2%)                                                                       
      Pancreatic, Pigmentation                                                   1 (2%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Cyst                                                          1 (2%)                                                          
      Depletion Lymphoid                                                         4 (8%)                                             
      Fibrosis                                                      2 (4%)                                                          
      Hematopoietic Cell Proliferation                30 (60%)     36 (72%)     35 (70%)                                            
      Infarct                                                                    1 (2%)                                             
      Pigmentation                                     1 (2%)       2 (4%)                                                          
   Thymus                                             (47)         (46)         (41)                                                
      Epithelial Cell, Hyperplasia                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (20)         (15)         (19)                                                
      Galactocele                                      1 (5%)                                                                       
   Skin                                               (49)         (49)         (50)                                                
      Acanthosis                                       1 (2%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hyperkeratosis                                   2 (4%)       1 (2%)                                                          
      Inflammation, Chronic Active                                  3 (6%)                                                          
      Necrosis                                         2 (4%)                    2 (4%)                                             
      Subcutaneous Tissue, Necrosis                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
      Joint, Tarsal, Hyperostosis                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Hemorrhage                                                    2 (4%)                                                          
      Artery, Thrombosis                                            1 (2%)                                                          
      Brain Stem, Vacuolization Cytoplasmic                                      2 (4%)                                             
      White Matter, Cerebrum, Vacuolization                                                                                         
          Cytoplasmic                                                            2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Bronchiectasis                                   1 (2%)                    1 (2%)                                             
      Edema                                            2 (4%)       3 (6%)                                                          
      Infiltration Cellular, Histiocyte                8 (16%)      9 (18%)     13 (26%)                                            
      Inflammation, Acute                              1 (2%)                    2 (4%)                                             
      Inflammation, Chronic Active                     1 (2%)       7 (14%)     15 (30%)                                            
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mineralization                                                1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (6%)       6 (12%)      4 (8%)                                             
      Bronchiole, Inflammation, Acute                                            3 (6%)                                             
      Bronchus, Metaplasia, Squamous                                             1 (2%)                                             
   Nose                                               (45)         (46)         (38)                                                
      Inflammation, Chronic Active                     1 (2%)       3 (7%)       4 (11%)                                            
      Metaplasia, Squamous                                                       1 (3%)                                             
      Nasolacrimal Duct, Inflammation                                            1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (3)          (2)                                                 
      Hyperplasia                                                   1 (33%)                                                         
      Inflammation, Chronic Active                                               1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                             1 (2%)       1 (2%)       1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Fibrosis, Focal                                               1 (2%)                                                          
      Hydronephrosis                                   1 (2%)                    1 (2%)                                             
      Necrosis                                                                   2 (4%)                                             
      Nephropathy                                     46 (92%)     50 (100%)    45 (90%)                                            
      Artery, Necrosis, Fibrinoid                                                1 (2%)                                             
      Pelvis, Inflammation, Acute                                                1 (2%)                                             
      Renal Tubule, Degeneration                                                 1 (2%)                                             
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
   Urinary Bladder                                    (48)         (49)         (50)                                                
      Hemorrhage                                       3 (6%)                    2 (4%)                                             
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       2 (4%)                                             
      Necrosis                                         1 (2%)                    3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05053-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             BROMOFORM                                         Date: 09/08/94  
Route: GAVAGE                                                                                                     Time: 01:01:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0.1 G/KG     0.2 G/KG                                               
                                                   46 VM         46 LM        46 HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia             1 (2%)                    3 (6%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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