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https://ntp.niehs.nih.gov/go/2451

TDMS Study 05077-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL


NTP Experiment-Test: 05077-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: DOSED FEED                                                                                                 Time: 05:22:30




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  67774327

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           10            9           12            8           10           
    Natural Death                                                   1            1            2            3            2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           39           39           36           39           38           
    Moribund Sacrifice                                                           1                                                  
  Animals Examined Microscopically                    50           50           50           50           50           50           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (10)         (11)         (13)         (10)         (12)         
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis                                                                                                          1 (8%)      
   Intestine Large, Colon                             (50)         (11)         (12)         (13)         (11)         (12)         
      Diverticulum                                                               1 (8%)                                             
      Parasite Metazoan                                2 (4%)                                              1 (9%)                   
   Intestine Large, Rectum                            (50)         (11)         (11)         (13)         (9)          (12)         
      Parasite Metazoan                                1 (2%)                                 1 (8%)                                
   Liver                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Angiectasis                                                   1 (2%)                    4 (8%)       1 (2%)                   
      Basophilic Focus                                47 (94%)     44 (88%)     40 (80%)     37 (74%)     36 (72%)     23 (46%)     
      Clear Cell Focus                                 3 (6%)                                                                       
      Cytomegaly                                                                 1 (2%)                                             
      Degeneration, Cystic                                          2 (4%)                                 2 (4%)       3 (6%)      
      Eosinophilic Focus                               3 (6%)      19 (38%)     19 (38%)     47 (94%)     45 (90%)     45 (90%)     
      Eosinophilic Focus, Multiple                                                                         1 (2%)                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                           1 (2%)      
      Hepatodiaphragmatic Nodule                       1 (2%)       3 (6%)       2 (4%)                                 1 (2%)      
      Hyperplasia, Focal                                                         1 (2%)                                             
      Hypertrophy                                                                9 (18%)     32 (64%)     39 (78%)     40 (80%)     
      Inflammation, Chronic, Multifocal                                                      21 (42%)      8 (16%)      7 (14%)     
      Inflammation, Chronic Active                    34 (68%)     12 (24%)     19 (38%)     13 (26%)     12 (24%)      8 (16%)     
      Necrosis                                         3 (6%)                    1 (2%)       5 (10%)      5 (10%)      5 (10%)     
      Vacuolization Cytoplasmic                        3 (6%)       6 (12%)     18 (36%)     47 (94%)     43 (86%)     43 (86%)     
      Bile Duct, Cyst                                                                                      1 (2%)       1 (2%)      
      Bile Duct, Hyperplasia                          14 (28%)     18 (36%)     34 (68%)     39 (78%)     38 (76%)     44 (88%)     
      Oval Cell, Hyperplasia                                                                 12 (24%)     19 (38%)     34 (68%)     
      Periportal, Infiltration Cellular, Lymphocyte                                                        2 (4%)                   
      Subserosa, Congestion, Multifocal                                                       1 (2%)                                
   Mesentery                                          (2)          (1)          (1)          (1)          (1)          (4)          
      Inflammation, Chronic Active                     1 (50%)      1 (100%)     1 (100%)     1 (100%)     1 (100%)     3 (75%)     
   Pancreas                                           (49)         (12)         (11)         (13)         (9)          (12)         
      Ectopic Liver                                                                           1 (8%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Atrophy                                 15 (31%)      2 (17%)      3 (27%)      4 (31%)      4 (44%)      3 (25%)     
   Stomach, Forestomach                               (50)         (49)         (50)         (50)         (50)         (49)         
      Acanthosis                                       1 (2%)       2 (4%)                    3 (6%)       2 (4%)       1 (2%)      
      Diverticulum                                                               1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
      Ulcer                                                                                   1 (2%)                    1 (2%)      
      Submucosa, Foreign Body                                                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (48)         (50)         (50)         (50)         (50)         
      Hyperplasia, Focal                               1 (2%)                                 1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                                             5 (10%)      3 (6%)       6 (12%)     10 (20%)     
      Ulcer                                                                      1 (2%)       1 (2%)                    3 (6%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (11)         (12)         (14)         (11)         (12)         
      Degeneration, Chronic                           42 (84%)      3 (27%)      4 (33%)      3 (21%)      1 (9%)       1 (8%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (12)         (14)         (9)          (12)         
      Cyst                                                                                                 1 (11%)                  
      Hyperplasia                                     39 (78%)      6 (60%)      2 (17%)      3 (21%)      1 (11%)      2 (17%)     
      Hypertrophy                                     15 (30%)      1 (10%)      3 (25%)      1 (7%)                                
      Hypertrophy, Focal                                                                                                1 (8%)      
      Necrosis                                                                   2 (17%)      1 (7%)       1 (11%)      1 (8%)      
      Vacuolization Cytoplasmic                       17 (34%)      4 (40%)      3 (25%)      6 (43%)      1 (11%)      6 (50%)     
   Adrenal Gland, Medulla                             (48)         (10)         (12)         (13)         (9)          (12)         
      Hyperplasia                                      6 (13%)                   1 (8%)                                             
   Pituitary Gland                                    (50)         (34)         (27)         (29)         (28)         (27)         
      Hyperplasia                                                                             1 (3%)                                
      Pars Distalis, Cyst                             20 (40%)      9 (26%)      1 (4%)       5 (17%)      8 (29%)      3 (11%)     
      Pars Distalis, Hyperplasia                      13 (26%)      7 (21%)      6 (22%)      3 (10%)      6 (21%)      8 (30%)     
   Thyroid Gland                                      (50)         (12)         (15)         (14)         (10)         (13)         
      Atrophy                                                                                              1 (10%)                  
      Infiltration Cellular, Lymphocyte                                                                    1 (10%)                  
      C-Cell, Hyperplasia                             50 (100%)    11 (92%)     12 (80%)     12 (86%)     10 (100%)    12 (92%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (15)         (12)         (16)         (10)         (13)         
      Hyperplasia                                                   1 (7%)       1 (8%)       1 (6%)                    1 (8%)      
      Inflammation, Chronic Active                    24 (48%)     13 (87%)     10 (83%)      6 (38%)      3 (30%)      5 (38%)     
      Duct, Dilatation                                19 (38%)                   3 (25%)      8 (50%)      3 (30%)      4 (31%)     
   Ovary                                              (50)         (23)         (19)         (22)         (14)         (20)         
      Infiltration Cellular, Lymphocyte                3 (6%)                                                                       
      Follicle, Cyst                                   3 (6%)       1 (4%)                                              1 (5%)      
      Periovarian Tissue, Cyst                         9 (18%)     11 (48%)      8 (42%)      9 (41%)      3 (21%)      8 (40%)     
   Uterus                                             (50)         (17)         (18)         (18)         (21)         (20)         
      Dilatation                                       7 (14%)                   1 (6%)       1 (6%)                                
      Fibrosis                                                                   1 (6%)                                             
      Hemorrhage                                                                                           2 (10%)                  
      Inflammation, Acute                                                                                  1 (5%)                   
      Necrosis                                                                                             1 (5%)                   
      Cervix, Cyst                                     1 (2%)                    2 (11%)                                3 (15%)     
      Endometrium, Hyperplasia, Cystic, Glandular                   4 (24%)      4 (22%)      1 (6%)       7 (33%)      6 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (11)         (11)         (14)         (12)         (12)         
      Mandibular, Hyperplasia                          1 (2%)                                                                       
      Mandibular, Necrosis                                                                                              1 (8%)      
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (2%)                                                                       
   Lymph Node, Mesenteric                             (4)          (2)          (3)          (1)          (1)          (3)          
      Angiectasis                                                                                          1 (100%)                 
      Cyst                                                          1 (50%)                                                         
      Hyperplasia, Lymphoid                            1 (25%)                                                                      
      Infiltration Cellular, Histiocyte                1 (25%)                                                                      
      Sinus, Ectasia                                   2 (50%)                                                                      
   Spleen                                             (50)         (50)         (50)         (50)         (49)         (49)         
      Depletion Lymphoid                                                         1 (2%)                    1 (2%)                   
      Fibrosis                                                                                1 (2%)       1 (2%)       2 (4%)      
      Hematopoietic Cell Proliferation                                           1 (2%)       1 (2%)       1 (2%)                   
      Necrosis                                                                                                          1 (2%)      
      Capsule, Hemorrhage                                                                                  1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (16)         (13)         (21)         (16)         (11)         
      Hyperplasia, Cystic                             46 (96%)     10 (63%)     10 (77%)     13 (62%)     10 (63%)      9 (82%)     
   Skin                                               (50)         (11)         (12)         (13)         (11)         (14)         
      Subcutaneous Tissue, Lip, Foreign Body                                     1 (8%)                                             
      Subcutaneous Tissue, Lip, Inflammation,                                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
          Chronic Active                                                         1 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (11)         (11)         (14)         (11)         (12)         
      Cranium, Fracture                                                          1 (9%)                                             
      Femur, Hyperostosis                                                        1 (9%)                    1 (9%)       2 (17%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (11)         (14)         (10)         (12)         
      Compression                                      7 (14%)      3 (27%)      3 (27%)      3 (21%)      3 (30%)      1 (8%)      
      Hemorrhage                                                                 1 (9%)                                             
      Hydrocephalus                                                 3 (27%)      3 (27%)      3 (21%)      3 (30%)      1 (8%)      
      Necrosis                                         1 (2%)                                                                       
   Spinal Cord                                        (2)          (2)                       (1)          (1)          (1)          
      Nerve, Demyelination                             2 (100%)     2 (100%)                  1 (100%)     1 (100%)     1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (11)         (11)         (14)         (9)          (11)         
      Interstitium, Inflammation, Chronic Active                                              1 (7%)                    1 (9%)      
   Nose                                               (50)         (11)         (11)         (13)         (10)         (12)         
      Mucosa, Inflammation, Chronic Active                                                    1 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (3)          (2)          (4)          (3)          (5)          
      Choroid, Hemorrhage                                           1 (33%)                                                         
      Lens, Cataract                                   4 (100%)     2 (67%)      1 (50%)      4 (100%)     3 (100%)     5 (100%)    
      Retina, Atrophy                                  4 (100%)     2 (67%)      1 (50%)      4 (100%)     3 (100%)     5 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (11)         (11)         (14)         (11)         (12)         
      Hydronephrosis                                                1 (9%)                                                          
      Nephropathy, Chronic                            25 (51%)      7 (64%)      8 (73%)     11 (79%)      8 (73%)      8 (67%)     
      Cortex, Infarct                                                                         1 (7%)                                
      Renal Tubule, Mineralization                     3 (6%)                                 2 (14%)                               
   Urinary Bladder                                    (50)         (11)         (11)         (14)         (10)         (12)         
      Calculus Micro Observation Only                                                                                   1 (8%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Mucosa, Hyperplasia, Papillary                                1 (9%)                                              1 (8%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      5            2                                                               
    Moribund Sacrifice                                10           15                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32                                                               
    Natural Death                                      1            1                                                               
  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (50)                                                             
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Large, Rectum                            (47)         (49)                                                             
      Parasite Metazoan                                6 (13%)      1 (2%)                                                          
   Liver                                              (50)         (50)                                                             
      Basophilic Focus                                11 (22%)     13 (26%)                                                         
      Cytomegaly                                                    1 (2%)                                                          
      Eosinophilic Focus                              48 (96%)     47 (94%)                                                         
      Hypertrophy                                     17 (34%)      6 (12%)                                                         
      Inflammation, Chronic, Multifocal               31 (62%)     22 (44%)                                                         
      Inflammation, Chronic Active                     3 (6%)       2 (4%)                                                          
      Inflammation, Multifocal                                      1 (2%)                                                          
      Necrosis                                         1 (2%)       3 (6%)                                                          
      Thrombosis                                                    1 (2%)                                                          
      Vacuolization Cytoplasmic                       50 (100%)    40 (80%)                                                         
      Bile Duct, Cyst                                  2 (4%)       5 (10%)                                                         
      Bile Duct, Fibrosis                              3 (6%)      19 (38%)                                                         
      Bile Duct, Hyperplasia                          50 (100%)    15 (30%)                                                         
      Bile Duct, Metaplasia                            1 (2%)                                                                       
      Oval Cell, Hyperplasia                          42 (84%)     44 (88%)                                                         
   Pancreas                                           (50)         (50)                                                             
      Focal Cellular Change, Multiple                               1 (2%)                                                          
      Acinus, Atrophy                                 29 (58%)     25 (50%)                                                         
      Perivascular, Inflammation, Chronic Active       1 (2%)                                                                       
   Salivary Glands                                    (49)         (49)                                                             
      Cytomegaly, Focal                                1 (2%)                                                                       
      Acinus, Atrophy                                  1 (2%)       2 (4%)                                                          
   Stomach, Forestomach                               (48)         (50)                                                             
      Acanthosis                                                    5 (10%)                                                         
      Inflammation, Chronic Active                     1 (2%)       3 (6%)                                                          
      Ulcer                                            1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (49)         (50)                                                             
      Dysplasia, Focal                                              1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)                                                             
      Degeneration, Chronic                           21 (43%)     11 (22%)                                                         
      Myocardium, Inflammation, Chronic Active         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Cyst                                                          2 (4%)                                                          
      Hyperplasia                                     19 (38%)     21 (42%)                                                         
      Hypertrophy                                      9 (18%)      9 (18%)                                                         
      Vacuolization Cytoplasmic                       18 (36%)     25 (50%)                                                         
   Adrenal Gland, Medulla                             (49)         (49)                                                             
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (46)         (49)                                                             
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)                                                             
      Pars Distalis, Cyst                              1 (2%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia                      13 (26%)     13 (26%)                                                         
   Thyroid Gland                                      (48)         (48)                                                             
      C-Cell, Hyperplasia                             43 (90%)     47 (98%)                                                         
      Follicle, Cyst                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (46)                                                             
      Inflammation, Chronic Active                    22 (47%)     13 (28%)                                                         
      Duct, Dilatation                                26 (55%)     23 (50%)                                                         
   Ovary                                              (48)         (49)                                                             
      Follicle, Cyst                                   1 (2%)                                                                       
      Periovarian Tissue, Cyst                        11 (23%)      9 (18%)                                                         
      Rete Ovarii, Hyperplasia                         1 (2%)                                                                       
   Oviduct                                                         (1)                                                              
      Dilatation                                                    1 (100%)                                                        
   Uterus                                             (49)         (50)                                                             
      Dilatation                                                    1 (2%)                                                          
      Cervix, Cyst                                                  2 (4%)                                                          
      Cervix, Mucosa, Hyperplasia, Squamous                         1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic, Glandular     12 (24%)     11 (22%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (49)         (47)                                                             
      Mandibular, Angiectasis                          1 (2%)                                                                       
      Mandibular, Infiltration Cellular, Plasma                                                                                     
          Cell                                                      1 (2%)                                                          
      Mediastinal, Angiectasis                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (5)                                                                           
      Angiectasis                                      1 (20%)                                                                      
   Spleen                                             (50)         (50)                                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (48)                                                             
      Hyperplasia, Cystic                             47 (96%)     43 (90%)                                                         
   Skin                                               (49)         (50)                                                             
      Acanthosis                                       1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)                                                             
      Femur, Hyperostosis                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)                                                             
      Compression                                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (47)         (50)                                                             
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      Metaplasia, Focal, Osseous                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                                                       
      Interstitium, Inflammation, Chronic Active       1 (2%)                                                                       
   Nose                                               (48)         (50)                                                             
      Mucosa, Inflammation, Chronic Active             4 (8%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (5)                                                              
      Lens, Cataract                                   1 (50%)      4 (80%)                                                         
      Retina, Atrophy                                  1 (50%)      4 (80%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Nephropathy, Chronic                            37 (74%)     42 (84%)                                                         
      Renal Tubule, Inflammation, Acute, Multifocal                 1 (2%)                                                          
      Renal Tubule, Mineralization                     2 (4%)                                                                       
   Urinary Bladder                                    (49)         (50)                                                             
      Hemorrhage                                                    1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Natural Death                                      5            4            1            6            5            4           
    Moribund Sacrifice                                16           16           15           21           25           26           
  Survivors                                                                                                                         
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                29           29           34           22           19           19           
    Moribund Sacrifice                                                                        1            1            1           
  Animals Examined Microscopically                    50           50           50           50           50           50           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (20)         (16)         (26)         (30)         (29)         
      Dilatation                                                    1 (5%)                    1 (4%)                                
      Inflammation, Chronic Active                                                                         1 (3%)                   
      Ulcer                                                                                                1 (3%)                   
   Intestine Large, Colon                             (49)         (21)         (16)         (27)         (31)         (30)         
      Dilatation                                                    1 (5%)                                                          
      Parasite Metazoan                                3 (6%)       1 (5%)                                 1 (3%)                   
   Intestine Large, Rectum                            (49)         (21)         (16)         (27)         (30)         (30)         
      Parasite Metazoan                                3 (6%)                    1 (6%)       1 (4%)       2 (7%)                   
   Intestine Small, Duodenum                          (48)         (21)         (16)         (27)         (31)         (30)         
      Ulcer                                                                                                             1 (3%)      
   Intestine Small, Ileum                             (49)         (19)         (16)         (28)         (29)         (29)         
      Parasite Metazoan                                                                                                 1 (3%)      
   Liver                                              (50)         (50)         (50)         (49)         (50)         (50)         
      Angiectasis                                                   4 (8%)       1 (2%)                                             
      Basophilic Focus                                27 (54%)     19 (38%)     36 (72%)     28 (57%)      8 (16%)     15 (30%)     
      Clear Cell Focus                                 1 (2%)       1 (2%)       1 (2%)                                 1 (2%)      
      Congestion                                                                 1 (2%)                                             
      Degeneration, Cystic                            18 (36%)     12 (24%)     12 (24%)      5 (10%)      3 (6%)       7 (14%)     
      Eosinophilic Focus                              18 (36%)     29 (58%)     40 (80%)     44 (90%)     42 (84%)     47 (94%)     
      Hepatodiaphragmatic Nodule                                    4 (8%)       1 (2%)                                             
      Hyperplasia, Focal                               2 (4%)       1 (2%)                                                          
      Hyperplasia, Multifocal                          2 (4%)                                                                       
      Hypertrophy                                                   3 (6%)      34 (68%)     27 (55%)     29 (58%)     27 (54%)     
      Infarct                                                       1 (2%)                                                          
      Inflammation, Chronic                                         4 (8%)                                              2 (4%)      
      Inflammation, Chronic, Multifocal                             1 (2%)      13 (26%)      6 (12%)      4 (8%)       4 (8%)      
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       1 (2%)       1 (2%)                   
      Necrosis                                                      2 (4%)       4 (8%)       1 (2%)       2 (4%)       1 (2%)      
      Vacuolization Cytoplasmic                        5 (10%)     18 (36%)     42 (84%)     28 (57%)     28 (56%)     32 (64%)     
      Bile Duct, Hyperplasia                          48 (96%)     45 (90%)     49 (98%)     48 (98%)     47 (94%)     49 (98%)     
      Centrilobular, Degeneration                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Necrosis                                       1 (2%)                                                          
      Oval Cell, Hyperplasia                                        2 (4%)       4 (8%)      11 (22%)     13 (26%)     23 (46%)     
      Portal Vein, Thrombosis                                                    1 (2%)                                             
   Mesentery                                                       (6)                       (3)          (1)          (2)          
      Inflammation, Chronic Active                                  1 (17%)                   1 (33%)                               
      Artery, Inflammation, Chronic Active                                                    2 (67%)                               
   Pancreas                                           (49)         (21)         (16)         (27)         (32)         (31)         
      Fibrosis                                                                   1 (6%)                                             
      Inflammation, Chronic Active                                               1 (6%)                                             
      Necrosis                                                                                                          1 (3%)      
      Acinus, Atrophy                                 23 (47%)      7 (33%)      8 (50%)     13 (48%)     12 (38%)     16 (52%)     
      Acinus, Cytomegaly, Focal                                                               1 (4%)                                
      Acinus, Hyperplasia                              2 (4%)                                              1 (3%)                   
      Duct, Hyperplasia                                                                       1 (4%)                                
   Stomach, Forestomach                               (50)         (49)         (48)         (49)         (50)         (50)         
      Acanthosis                                                    4 (8%)       3 (6%)       7 (14%)      7 (14%)      8 (16%)     
      Cyst Epithelial Inclusion                        1 (2%)                                 1 (2%)                                
      Erosion                                                                                                           1 (2%)      
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic                                                                                1 (2%)       1 (2%)      
      Inflammation, Chronic Active                                  1 (2%)       2 (4%)       6 (12%)      5 (10%)      5 (10%)     
      Mineralization                                                                                       1 (2%)                   
      Ulcer                                                         1 (2%)                    5 (10%)      3 (6%)       4 (8%)      
   Stomach, Glandular                                 (50)         (48)         (48)         (48)         (50)         (49)         
      Dysplasia                                                                                            1 (2%)                   
      Hyperplasia, Focal                                                                                                1 (2%)      
      Inflammation, Chronic Active                                  1 (2%)                                 1 (2%)                   
      Mineralization                                                                                       1 (2%)       1 (2%)      
      Ulcer                                                         1 (2%)                    1 (2%)                    1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (21)         (16)         (27)         (31)         (31)         
      Degeneration, Chronic                           50 (100%)    12 (57%)      9 (56%)     23 (85%)     22 (71%)     23 (74%)     
      Thrombosis                                                    1 (5%)       1 (6%)                                 1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (21)         (15)         (28)         (31)         (30)         
      Atrophy                                                                                                           1 (3%)      
      Degeneration, Cystic                                                                                 1 (3%)       1 (3%)      
      Hyperplasia                                     19 (38%)      4 (19%)      4 (27%)      9 (32%)      5 (16%)      4 (13%)     
      Hypertrophy                                      8 (16%)      1 (5%)                    1 (4%)                    2 (7%)      
      Necrosis                                                                   1 (7%)                    1 (3%)                   
      Vacuolization Cytoplasmic                       11 (22%)     10 (48%)      7 (47%)      6 (21%)     15 (48%)     14 (47%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Gland, Medulla                             (49)         (22)         (16)         (29)         (32)         (30)         
      Hyperplasia                                     13 (27%)      3 (14%)      1 (6%)       6 (21%)      1 (3%)       3 (10%)     
   Islets, Pancreatic                                 (49)         (21)         (16)         (27)         (31)         (30)         
      Hyperplasia                                      1 (2%)                                                           1 (3%)      
      Necrosis                                                                                                          1 (3%)      
   Parathyroid Gland                                  (43)         (21)         (16)         (27)         (31)         (29)         
      Hyperplasia                                                                                                       1 (3%)      
   Pituitary Gland                                    (50)         (27)         (22)         (32)         (30)         (34)         
      Pars Distalis, Cyst                              3 (6%)       3 (11%)      1 (5%)                    2 (7%)       1 (3%)      
      Pars Distalis, Hemorrhage                                                                                         1 (3%)      
      Pars Distalis, Hyperplasia                       9 (18%)      5 (19%)      1 (5%)       8 (25%)      6 (20%)      8 (24%)     
      Pars Intermedia, Hyperplasia, Glandular                       1 (4%)                                                          
   Thyroid Gland                                      (49)         (23)         (17)         (28)         (31)         (30)         
      C-Cell, Hyperplasia                             48 (98%)     20 (87%)     16 (94%)     28 (100%)    30 (97%)     29 (97%)     
      Follicle, Cyst                                                             1 (6%)                                 1 (3%)      
      Follicular Cell, Hyperplasia                                                                                      1 (3%)      
      Follicular Cell, Hypertrophy                     2 (4%)                    1 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (20)         (16)         (28)         (30)         (30)         
      Inflammation, Chronic Active                                                                                      2 (7%)      
   Preputial Gland                                    (47)         (25)         (20)         (32)         (34)         (32)         
      Hyperplasia                                      3 (6%)       1 (4%)                                                          
      Inflammation, Chronic Active                    37 (79%)     15 (60%)     14 (70%)     27 (84%)     23 (68%)     25 (78%)     
      Duct, Dilatation                                 1 (2%)       3 (12%)                   2 (6%)       1 (3%)       1 (3%)      
      Duct, Hyperplasia, Squamous                                                                          3 (9%)                   
   Prostate                                           (50)         (21)         (16)         (28)         (30)         (31)         
      Inflammation, Acute                                                                                  1 (3%)                   
      Inflammation, Chronic Active                    11 (22%)      4 (19%)      2 (13%)      8 (29%)      5 (17%)     10 (32%)     
      Metaplasia, Squamous                            11 (22%)                                             1 (3%)       3 (10%)     
   Seminal Vesicle                                                 (2)          (3)                       (1)          (1)          
      Dilatation                                                    1 (50%)      2 (67%)                   1 (100%)                 
      Epithelium, Hyperplasia                                       1 (50%)                                                         
   Testes                                             (50)         (49)         (50)         (50)         (50)         (50)         
      Interstitial Cell, Hyperplasia                   8 (16%)      3 (6%)       1 (2%)       3 (6%)       9 (18%)      4 (8%)      
      Seminiferous Tubule, Atrophy                     3 (6%)       2 (4%)       5 (10%)                   1 (2%)       3 (6%)      
      Seminiferous Tubule, Mineralization              1 (2%)                    3 (6%)                                 2 (4%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (21)         (15)         (27)         (31)         (30)         
      Femoral, Atrophy                                                           1 (7%)                                             
      Femoral, Hyperplasia, Reticulum Cell             1 (2%)                                                                       
      Femoral, Myelofibrosis                                                                                            1 (3%)      
   Lymph Node                                         (50)         (23)         (18)         (27)         (33)         (31)         
      Mandibular, Hemorrhage                           1 (2%)                                                                       
      Mandibular, Hyperplasia, Lymphoid                                                                                 3 (10%)     
      Mediastinal, Congestion                                                                                           1 (3%)      
      Mediastinal, Hemorrhage                                                    1 (6%)                                             
      Mediastinal, Hyperplasia, Macrophage                          1 (4%)                                                          
   Lymph Node, Mesenteric                             (2)          (3)          (2)          (9)          (8)          (4)          
      Angiectasis                                                                             1 (11%)                               
   Spleen                                             (50)         (50)         (49)         (49)         (50)         (50)         
      Depletion Lymphoid                                                         1 (2%)                                             
      Fibrosis                                         1 (2%)       2 (4%)       6 (12%)      4 (8%)       2 (4%)                   
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                                                         1 (2%)                   
      Necrosis                                                                   1 (2%)       2 (4%)                                
      Thrombosis                                                                              1 (2%)                                
      Capsule, Cyst                                                                                                     1 (2%)      
      Capsule, Hemorrhage                                           1 (2%)                                                          
   Thymus                                             (47)         (17)         (15)         (22)         (24)         (27)         
      Depletion Lymphoid                                                                                                1 (4%)      
      Inflammation, Chronic Active                                               1 (7%)                                             
      Necrosis                                                                   1 (7%)                                 1 (4%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (14)         (14)         (23)         (20)         (18)         
      Hyperplasia, Cystic                             38 (97%)     14 (100%)    12 (86%)     19 (83%)     20 (100%)    18 (100%)    
   Skin                                               (50)         (26)         (22)         (31)         (32)         (32)         
      Acanthosis                                                                              1 (3%)                                
      Necrosis                                         1 (2%)                                                                       
      Face, Cyst Epithelial Inclusion                               1 (4%)                                                          
      Subcutaneous Tissue, Fibrosis                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (21)         (16)         (29)         (31)         (31)         
      Compression                                      3 (6%)                    2 (13%)                   1 (3%)       4 (13%)     
      Gliosis                                                       1 (5%)                                                          
      Hemorrhage                                       1 (2%)       2 (10%)                   4 (14%)      2 (6%)       1 (3%)      
      Hydrocephalus                                                              2 (13%)                   2 (6%)       4 (13%)     
   Spinal Cord                                        (2)          (1)          (1)                                                 
      Hemorrhage                                                    1 (100%)                                                        
      Nerve, Demyelination                             2 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (21)         (17)         (28)         (32)         (31)         
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (5%)                    1 (4%)                    1 (3%)      
      Interstitium, Inflammation, Chronic Active       3 (6%)       2 (10%)                                1 (3%)                   
   Nose                                               (50)         (21)         (16)         (27)         (31)         (30)         
      Foreign Body                                                                                         1 (3%)                   
      Mucosa, Inflammation, Acute                                                                          1 (3%)                   
      Mucosa, Inflammation, Chronic Active             1 (2%)       1 (5%)       1 (6%)                    2 (6%)       1 (3%)      
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (4)          (7)          (4)          (3)          
      Cornea, Inflammation, Chronic Active                                                                              1 (33%)     
      Lens, Cataract                                                1 (100%)     2 (50%)      7 (100%)     4 (100%)     2 (67%)     
      Retina, Atrophy                                               1 (100%)     3 (75%)      7 (100%)     4 (100%)     2 (67%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (24)         (20)         (32)         (32)         (37)         
      Hydronephrosis                                   1 (2%)       2 (8%)                                                          
      Nephropathy, Chronic                            50 (100%)    23 (96%)     19 (95%)     32 (100%)    32 (100%)    36 (97%)     
      Cortex, Cyst                                                  1 (4%)       1 (5%)       2 (6%)       1 (3%)       1 (3%)      
   Urinary Bladder                                    (49)         (20)         (17)         (27)         (31)         (30)         
      Calculus Micro Observation Only                                            1 (6%)                                             
      Hemorrhage                                       1 (2%)       1 (5%)                                              1 (3%)      
      Inflammation, Acute                                                                                  1 (3%)                   
      Mucosa, Hyperplasia                                                                                               1 (3%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        3 PPM        10 PPM       10 PPM       10 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Mucosa, Ulcer                                    1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           24                                                               
    Natural Death                                      3            7                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1            1                                                               
    Terminal Sacrifice                                23           18                                                               
  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (47)                                                             
      Parasite Metazoan                                2 (4%)                                                                       
   Intestine Large, Rectum                            (48)         (46)                                                             
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Small, Duodenum                          (48)         (48)                                                             
      Ulcer                                                         1 (2%)                                                          
   Liver                                              (50)         (50)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                 8 (16%)      5 (10%)                                                         
      Clear Cell Focus                                 1 (2%)       1 (2%)                                                          
      Congestion                                                    1 (2%)                                                          
      Degeneration, Cystic                             1 (2%)       3 (6%)                                                          
      Eosinophilic Focus                              46 (92%)     46 (92%)                                                         
      Fibrosis                                                      2 (4%)                                                          
      Hypertrophy                                     17 (34%)     15 (30%)                                                         
      Infarct                                                       2 (4%)                                                          
      Inflammation, Chronic, Multifocal                4 (8%)       5 (10%)                                                         
      Metaplasia                                       1 (2%)       1 (2%)                                                          
      Necrosis                                         1 (2%)       4 (8%)                                                          
      Vacuolization Cytoplasmic                       34 (68%)     37 (74%)                                                         
      Bile Duct, Cyst                                               1 (2%)                                                          
      Bile Duct, Hyperplasia                          49 (98%)     49 (98%)                                                         
      Oval Cell, Hyperplasia                          37 (74%)     41 (82%)                                                         
      Serosa, Fibrosis                                              1 (2%)                                                          
   Pancreas                                           (49)         (50)                                                             
      Acinus, Atrophy                                 35 (71%)     29 (58%)                                                         
      Acinus, Cytomegaly                               1 (2%)                                                                       
      Acinus, Hyperplasia                              2 (4%)       1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)                                                             
      Acanthosis                                      11 (22%)      6 (12%)                                                         
      Acanthosis, Focal                                1 (2%)                                                                       
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Erosion                                                       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                     9 (18%)      3 (6%)                                                          
      Ulcer                                            6 (12%)      2 (4%)                                                          
   Stomach, Glandular                                 (50)         (49)                                                             
      Erosion                                                       1 (2%)                                                          
      Hyperplasia, Focal                               1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                                         3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)                                                             
      Degeneration, Chronic                           40 (80%)     34 (69%)                                                         
      Atrium, Thrombosis                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)                                                             
      Capsule, Spindle Cell, Hyperplasia                            1 (2%)                                                          
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Hyperplasia                                     17 (34%)     13 (26%)                                                         
      Hypertrophy                                      7 (14%)      2 (4%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                       10 (20%)     15 (30%)                                                         
      Capsule, Ectopic Tissue                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (50)                                                             
      Hyperplasia                                      4 (8%)       5 (10%)                                                         
   Islets, Pancreatic                                 (49)         (50)                                                             
      Hyperplasia                                                   4 (8%)                                                          
   Parathyroid Gland                                  (49)         (47)                                                             
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      2 (4%)                                                                       
      Hypertrophy                                      1 (2%)                                                                       
   Pituitary Gland                                    (48)         (49)                                                             
      Pars Distalis, Hyperplasia                      10 (21%)     10 (20%)                                                         
      Pars Distalis, Vacuolization Cytoplasmic         1 (2%)                                                                       
   Thyroid Gland                                      (49)         (49)                                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      C-Cell, Hyperplasia                             47 (96%)     48 (98%)                                                         
      Follicle, Cyst                                                1 (2%)                                                          
      Follicle, Hyperplasia, Cystic                                 1 (2%)                                                          
      Follicular Cell, Cytoplasmic Alteration          1 (2%)                                                                       
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
      Follicular Cell, Hypertrophy                     1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)                                                             
      Inflammation, Chronic Active                     3 (6%)       3 (6%)                                                          
   Preputial Gland                                    (44)         (49)                                                             
      Inflammation, Chronic Active                    34 (77%)     36 (73%)                                                         
      Duct, Dilatation                                 3 (7%)       6 (12%)                                                         
      Duct, Hyperplasia, Squamous                      2 (5%)                                                                       
   Prostate                                           (49)         (50)                                                             
      Dilatation                                       1 (2%)                                                                       
      Inflammation, Chronic Active                     7 (14%)     10 (20%)                                                         
      Metaplasia, Squamous                             3 (6%)       8 (16%)                                                         
   Testes                                             (50)         (50)                                                             
      Interstitial Cell, Hyperplasia                   7 (14%)     12 (24%)                                                         
      Seminiferous Tubule, Atrophy                     6 (12%)     11 (22%)                                                         
      Seminiferous Tubule, Mineralization              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
      Femoral, Hyperplasia, Neutrophil                              1 (2%)                                                          
   Lymph Node                                         (49)         (49)                                                             
      Mandibular, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Mandibular, Inflammation, Chronic, Multifocal    1 (2%)                                                                       
      Sinus, Mandibular, Ectasia                                    1 (2%)                                                          
   Spleen                                             (50)         (50)                                                             
      Fibrosis                                        10 (20%)      6 (12%)                                                         
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Thrombosis, Multiple                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (30)                                                             
      Hyperplasia, Cystic                             37 (95%)     30 (100%)                                                        
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05077-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                              FIREMASTER FF-1 POLYBROMINATED BIPHENYL                          Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 05:22:30  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     30 PPM       30 PPM                                                              
                                                    0-10         10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Compression                                                   1 (2%)                                                          
      Hydrocephalus                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)                                                             
      Alveolar Epithelium, Hyperplasia                 4 (8%)       2 (4%)                                                          
      Bronchiole, Epithelium, Hyperplasia                           1 (2%)                                                          
      Interstitium, Inflammation, Chronic Active       2 (4%)       1 (2%)                                                          
   Nose                                               (49)         (50)                                                             
      Hemorrhage, Subacute                                          1 (2%)                                                          
      Mucosa, Inflammation, Chronic Active             3 (6%)       5 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (4)                                                              
      Cornea, Inflammation, Chronic Active             1 (20%)                                                                      
      Lens, Cataract                                   3 (60%)      1 (25%)                                                         
      Retina, Atrophy                                  3 (60%)      1 (25%)                                                         
   Harderian Gland                                                 (1)                                                              
      Acinus, Atrophy                                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
      Nephropathy, Chronic                            50 (100%)    50 (100%)                                                        
      Cortex, Cyst                                     1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (48)         (50)                                                             
      Mucosa, Hyperplasia                                           1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
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