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https://ntp.niehs.nih.gov/go/1352

TDMS Study 05106-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          DIETHYLPHTHALATE


NTP Experiment-Test: 05106-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: SKIN APPLICATION                                                                                           Time: 20:47:31




       Facility:  Hazleton, Maryland

       Chemical CAS #:  84-66-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                  9           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12           12           17                                                  
    Natural Death                                      9           10           10                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           28           21                                                  
    Natural Death                                                                2                                                  
  Animals Examined Microscopically                    60           52           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (49)         (60)                                                
      Hyperkeratosis                                   1 (2%)       3 (6%)                                                          
   Intestine Large, Cecum                             (57)         (45)         (56)                                                
      Ulcer                                                                      1 (2%)                                             
   Intestine Large, Colon                             (58)         (47)         (58)                                                
      Edema                                                         2 (4%)       2 (3%)                                             
      Parasite Metazoan                                1 (2%)       3 (6%)       2 (3%)                                             
   Intestine Small, Duodenum                          (58)         (49)         (58)                                                
      Ulcer                                                                      1 (2%)                                             
      Mucosa, Erosion, Focal                                        1 (2%)                                                          
   Intestine Small, Ileum                             (55)         (44)         (53)                                                
      Mucosa, Atrophy                                  1 (2%)                                                                       
   Intestine Small, Jejunum                           (55)         (46)         (56)                                                
      Mucosa, Atrophy                                  1 (2%)                                                                       
   Liver                                              (59)         (52)         (60)                                                
      Angiectasis                                      1 (2%)       4 (8%)       1 (2%)                                             
      Basophilic Focus                                16 (27%)     11 (21%)      6 (10%)                                            
      Clear Cell Focus                                 2 (3%)       3 (6%)       3 (5%)                                             
      Congestion                                                    1 (2%)                                                          
      Degeneration, Fatty                             14 (24%)      5 (10%)      1 (2%)                                             
      Eosinophilic Focus                                            1 (2%)                                                          
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hepatodiaphragmatic Nodule                       8 (14%)     10 (19%)      3 (5%)                                             
      Infiltration Cellular, Focal, Histiocyte                                   1 (2%)                                             
      Inflammation, Chronic, Focal                    25 (42%)     24 (46%)     27 (45%)                                            
      Inflammation, Focal, Granulomatous               5 (8%)       1 (2%)       2 (3%)                                             
      Mitotic Alteration                                            1 (2%)                                                          
      Mixed Cell Focus                                 1 (2%)                    2 (3%)                                             
      Necrosis                                         2 (3%)       3 (6%)       2 (3%)                                             
      Necrosis, Focal                                               1 (2%)                                                          
      Pigmentation, Focal                                                        1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                          33 (56%)     28 (54%)     35 (58%)                                            
      Centrilobular, Degeneration, Fatty               3 (5%)                                                                       
      Hepatocyte, Hyperplasia                                                    1 (2%)                                             
      Midzonal, Degeneration, Fatty                    3 (5%)       1 (2%)                                                          
      Peripheral, Degeneration, Fatty                  3 (5%)       5 (10%)      2 (3%)                                             
      Periportal, Infiltration Cellular, Mixed Cell                 1 (2%)                                                          
      Subserosa, Angiectasis                                        1 (2%)                                                          
   Mesentery                                          (3)          (3)          (1)                                                 
      Hemorrhage                                                    1 (33%)                                                         
      Polyarteritis                                                              1 (100%)                                           
      Fat, Granuloma                                   2 (67%)      1 (33%)                                                         
   Pancreas                                           (59)         (50)         (60)                                                
      Cytoplasmic Alteration, Focal                                 1 (2%)       2 (3%)                                             
      Edema                                                         1 (2%)                                                          
      Fibrosis                                         1 (2%)                                                                       
      Fibrosis, Focal                                                            1 (2%)                                             
      Inflammation, Focal                                                        1 (2%)                                             
      Acinus, Atrophy                                 10 (17%)     16 (32%)     16 (27%)                                            
   Stomach, Forestomach                               (59)         (50)         (60)                                                
      Acanthosis                                      16 (27%)     13 (26%)     11 (18%)                                            
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Edema                                            6 (10%)      4 (8%)       6 (10%)                                            
      Hemorrhage                                       2 (3%)                    1 (2%)                                             
      Hyperkeratosis                                  14 (24%)     11 (22%)      8 (13%)                                            
      Ulcer                                            7 (12%)      4 (8%)       4 (7%)                                             
      Serosa, Inflammation, Proliferative              1 (2%)                                                                       
   Stomach, Glandular                                 (59)         (50)         (60)                                                
      Ulcer                                                         1 (2%)       2 (3%)                                             
      Mucosa, Erosion, Focal                           1 (2%)       1 (2%)       2 (3%)                                             
   Tooth                                                                        (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (2)                                                              
      Polyarteritis                                                 1 (50%)                                                         
   Heart                                              (59)         (51)         (60)                                                
      Abscess                                                                    1 (2%)                                             
      Cardiomyopathy                                  47 (80%)     34 (67%)     38 (63%)                                            
      Atrium, Thrombosis                                            2 (4%)       3 (5%)                                             
      Myocardium, Mineralization, Focal                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (50)         (60)                                                
      Angiectasis                                      1 (2%)                                                                       
      Degeneration, Fatty, Focal                      15 (25%)      8 (16%)      9 (15%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Focal                              13 (22%)     12 (24%)      8 (13%)                                            
      Hypertrophy, Focal                                                         1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
   Adrenal Gland, Medulla                             (58)         (50)         (60)                                                
      Hyperplasia, Focal                               1 (2%)       3 (6%)       5 (8%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Cytomegaly                                                    1 (2%)                                                          
      Hyperplasia                                      2 (4%)                                                                       
   Parathyroid Gland                                  (54)         (50)         (57)                                                
      Hypertrophy                                      7 (13%)      4 (8%)       2 (4%)                                             
   Pituitary Gland                                    (59)         (50)         (58)                                                
      Angiectasis                                      4 (7%)       6 (12%)      3 (5%)                                             
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                7 (12%)      7 (14%)      9 (16%)                                            
   Thyroid Gland                                      (59)         (50)         (60)                                                
      Ultimobranchial Cyst                                          1 (2%)                                                          
      C-Cell, Hyperplasia                              8 (14%)      6 (12%)      6 (10%)                                            
      Follicle, Dilatation                                          3 (6%)       4 (7%)                                             
      Follicular Cell, Hyperplasia                                               2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (2)          (2)                                                 
      Abscess                                          1 (50%)                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (53)         (39)         (50)                                                
      Cyst                                                          1 (3%)                                                          
      Ectasia                                          6 (11%)      2 (5%)       5 (10%)                                            
      Fibrosis                                         3 (6%)       1 (3%)       3 (6%)                                             
      Granuloma                                        1 (2%)                                                                       
      Hyperplasia                                                   1 (3%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (5%)                                                          
      Inflammation, Suppurative                        3 (6%)       2 (5%)       1 (2%)                                             
   Ovary                                              (59)         (50)         (60)                                                
      Atrophy                                          1 (2%)       1 (2%)       2 (3%)                                             
      Cyst                                             1 (2%)       1 (2%)       4 (7%)                                             
   Uterus                                             (59)         (50)         (60)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Dilatation                                       1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation                                                               1 (2%)                                             
      Endometrium, Atrophy                            23 (39%)     24 (48%)     15 (25%)                                            
   Vagina                                             (1)                       (1)                                                 
      Exudate                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (57)         (49)         (59)                                                
      Hypoplasia                                       1 (2%)       1 (2%)       1 (2%)                                             
   Lymph Node, Mandibular                             (59)         (50)         (60)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Spleen                                             (60)         (52)         (60)                                                
      Congestion                                                    1 (2%)                                                          
      Fibrosis                                                                   2 (3%)                                             
      Hematocyst                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                30 (50%)     26 (50%)     22 (37%)                                            
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infarct                                                       1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)                                                          
      Pigmentation, Hemosiderin                       24 (40%)     21 (40%)     27 (45%)                                            
      Capsule, Hyperplasia                                                       1 (2%)                                             
   Thymus                                             (53)         (43)         (52)                                                
      Congestion                                                    1 (2%)                                                          
      Cyst                                             2 (4%)       1 (2%)       1 (2%)                                             
      Depletion Lymphoid                               2 (4%)       2 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (49)         (60)                                                
      Hyperplasia                                      9 (15%)      9 (18%)      9 (15%)                                            
      Hyperplasia, Cystic                              7 (12%)      1 (2%)       5 (8%)                                             
      Lactation                                       44 (75%)     42 (86%)     43 (72%)                                            
   Skin                                               (59)         (49)         (60)                                                
      Other, Acanthosis                                2 (3%)                    1 (2%)                                             
      Other, Hyperkeratosis                                                      1 (2%)                                             
      Other, Inflammation, Chronic                                  1 (2%)                                                          
   Skin, Control                                      (59)         (49)         (60)                                                
      Acanthosis                                       3 (5%)                                                                       
   Skin, Site of Application-No Mass                  (59)         (49)         (60)                                                
      Acanthosis                                       8 (14%)     18 (37%)     23 (38%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (57)         (49)         (60)                                                
      Fibrous Osteodystrophy                           1 (2%)                    1 (2%)                                             
      Hyperostosis                                     1 (2%)                    1 (2%)                                             
      Osteopetrosis                                                 2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (50)         (60)                                                
      Compression                                      7 (12%)      5 (10%)      9 (15%)                                            
      Hemorrhage, Focal                                             1 (2%)                                                          
      Hydrocephalus                                                 1 (2%)                                                          
      Cerebrum, Compression                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (50)         (60)                                                
      Atelectasis                                                                1 (2%)                                             
      Atelectasis, Focal                               1 (2%)                                                                       
      Congestion                                      18 (31%)     15 (30%)     14 (23%)                                            
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Histiocyte                2 (3%)       1 (2%)       2 (3%)                                             
      Inflammation, Chronic                            8 (14%)      7 (14%)      4 (7%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    1 (2%)                                             
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)                                                                       
   Nose                                               (60)         (50)         (60)                                                
      Exudate                                                                    1 (2%)                                             
      Foreign Body                                                  1 (2%)       4 (7%)                                             
      Fungus                                           3 (5%)                    1 (2%)                                             
      Inflammation, Chronic                           10 (17%)     18 (36%)     16 (27%)                                            
      Inflammation, Suppurative                        3 (5%)       2 (4%)       2 (3%)                                             
      Nares, Ulcer                                     1 (2%)                                                                       
      Nasolacrimal Duct, Exudate                       2 (3%)                                                                       
      Nasolacrimal Duct, Inflammation, Suppurative                  4 (8%)       2 (3%)                                             
   Trachea                                            (59)         (50)         (60)                                                
      Glands, Dilatation                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (47)         (44)         (39)                                                
      Cataract                                        47 (100%)    44 (100%)    39 (100%)                                           
      Hemorrhage                                       5 (11%)                   2 (5%)                                             
      Inflammation                                     1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0UL/RAT      100UL        300UL                                                  
                                                   UF           RAT LF       RAT HF                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Phthisis Bulbi                                                1 (2%)                                                          
      Cornea, Hyperplasia, Focal, Squamous                          1 (2%)                                                          
      Cornea, Inflammation                             2 (4%)       4 (9%)       3 (8%)                                             
      Retina, Atrophy                                 41 (87%)     38 (86%)     32 (82%)                                            
      Retrobulbar, Hemorrhage                          1 (2%)                                                                       
   Zymbal's Gland                                     (1)          (1)          (1)                                                 
      Abscess                                                       1 (100%)                                                        
      Cyst                                             1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (51)         (60)                                                
      Hydronephrosis                                   1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)       2 (3%)                                             
      Nephropathy                                     52 (87%)     46 (90%)     55 (92%)                                            
      Collecting Tubule, Casts                                      1 (2%)                                                          
      Cortex, Mineralization, Focal                    3 (5%)                    2 (3%)                                             
      Medulla, Necrosis                                                          1 (2%)                                             
      Pelvis, Dilatation                               3 (5%)       3 (6%)                                                          
      Pelvis, Epithelium, Hyperplasia                 22 (37%)     23 (45%)     26 (43%)                                            
      Pelvis, Epithelium, Mineralization              14 (23%)     16 (31%)     13 (22%)                                            
      Pelvis, Epithelium, Mineralization, Focal        3 (5%)                    4 (7%)                                             
      Perirenal Tissue, Inflammation, Suppurative      1 (2%)       1 (2%)                                                          
      Proximal Convoluted Renal Tubule, Necrosis       1 (2%)       1 (2%)       2 (3%)                                             
      Proximal Convoluted Renal Tubule,                                                                                             
          Pigmentation                                 1 (2%)       2 (4%)                                                          
      Renal Tubule, Mineralization                     2 (3%)       2 (4%)       2 (3%)                                             
      Renal Tubule, Necrosis                                        1 (2%)                                                          
   Urinary Bladder                                    (57)         (47)         (59)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Lumen, Hemorrhage                                             1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10            9                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                31           38           26                                                  
    Natural Death                                     15            6           19                                                  
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                                                                            
    Terminal Sacrifice                                 3            6            6                                                  
  Animals Examined Microscopically                    60           56           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (49)         (59)                                                
      Hyperkeratosis                                   4 (7%)       3 (6%)       4 (7%)                                             
      Necrosis                                         1 (2%)                                                                       
   Intestine Large, Cecum                             (50)         (47)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Edema                                            1 (2%)                    1 (2%)                                             
      Ulcer                                                                      3 (6%)                                             
      Serosa, Necrosis, Focal                          1 (2%)                                                                       
   Intestine Large, Colon                             (51)         (47)         (53)                                                
      Edema                                            1 (2%)                    2 (4%)                                             
      Parasite Metazoan                                3 (6%)       1 (2%)       1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Muscularis, Degeneration, Focal                  1 (2%)                                                                       
      Muscularis, Necrosis, Focal                                   1 (2%)                                                          
      Serosa, Necrosis, Focal                          1 (2%)                                                                       
   Intestine Small, Duodenum                          (57)         (49)         (56)                                                
      Ulcer                                                                      1 (2%)                                             
      Mucosa, Erosion, Focal                           3 (5%)       2 (4%)                                                          
   Intestine Small, Ileum                             (54)         (46)         (49)                                                
      Hemorrhage, Focal                                1 (2%)                                                                       
      Mucosa, Necrosis                                 1 (2%)                                                                       
   Intestine Small, Jejunum                           (52)         (46)         (49)                                                
      Intussusception                                  1 (2%)                                                                       
   Liver                                              (60)         (50)         (60)                                                
      Angiectasis                                                   1 (2%)                                                          
      Basophilic Focus                                 1 (2%)                                                                       
      Clear Cell Focus                                 4 (7%)                    1 (2%)                                             
      Degeneration, Cystic, Focal                      2 (3%)       3 (6%)       2 (3%)                                             
      Degeneration, Fatty                             19 (32%)      5 (10%)      2 (3%)                                             
      Degeneration, Fatty, Focal                       1 (2%)                    1 (2%)                                             
      Eosinophilic Focus                               2 (3%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fibrosis, Focal                                                            2 (3%)                                             
      Focal Cellular Change                            1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hepatodiaphragmatic Nodule                       2 (3%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Focal                     9 (15%)     11 (22%)     12 (20%)                                            
      Inflammation, Focal, Granulomatous               8 (13%)                   7 (12%)                                            
      Necrosis                                         1 (2%)       3 (6%)       6 (10%)                                            
      Bile Duct, Hyperplasia                          53 (88%)     42 (84%)     47 (78%)                                            
      Centrilobular, Degeneration, Fatty               1 (2%)       2 (4%)       1 (2%)                                             
      Hepatocyte, Atrophy                              1 (2%)                                                                       
      Hepatocyte, Hyperplasia, Focal                   2 (3%)                                                                       
      Midzonal, Degeneration, Fatty                    2 (3%)                    1 (2%)                                             
      Peripheral, Degeneration, Fatty                  4 (7%)       1 (2%)       1 (2%)                                             
      Serosa, Inflammation, Necrotizing                                          1 (2%)                                             
   Mesentery                                          (4)          (3)          (1)                                                 
      Fat, Granuloma                                   2 (50%)      2 (67%)      1 (100%)                                           
   Pancreas                                           (60)         (50)         (59)                                                
      Accessory Spleen                                 1 (2%)                                                                       
      Cytoplasmic Alteration, Focal                    1 (2%)       1 (2%)       1 (2%)                                             
      Edema                                                                      2 (3%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Acinus, Atrophy                                 17 (28%)     17 (34%)     26 (44%)                                            
      Acinus, Hyperplasia, Focal                       1 (2%)                                                                       
      Interlobular, Inflammation, Chronic                           1 (2%)                                                          
   Salivary Glands                                    (58)         (50)         (59)                                                
      Concretion                                                                 1 (2%)                                             
   Stomach                                            (59)         (50)         (59)                                                
      Muscularis, Necrosis                                                       1 (2%)                                             
      Muscularis, Necrosis, Focal                      2 (3%)       3 (6%)       1 (2%)                                             
      Serosa, Inflammation, Necrotizing                             1 (2%)                                                          
      Serosa, Inflammation, Suppurative                                          1 (2%)                                             
      Serosa, Necrosis, Focal                                       1 (2%)                                                          
   Stomach, Forestomach                               (59)         (50)         (59)                                                
      Acanthosis                                      25 (42%)     21 (42%)     24 (41%)                                            
      Edema                                           13 (22%)      9 (18%)     10 (17%)                                            
      Hyperkeratosis                                  25 (42%)     20 (40%)     24 (41%)                                            
      Ulcer                                           13 (22%)     13 (26%)      8 (14%)                                            
      Muscularis, Necrosis                             2 (3%)                                                                       
      Serosa, Inflammation, Suppurative                             1 (2%)                                                          
      Serosa, Inflammation, Proliferative                           1 (2%)                                                          
      Serosa, Necrosis, Focal                          1 (2%)                                                                       
   Stomach, Glandular                                 (59)         (50)         (58)                                                
      Dilatation                                       1 (2%)                                                                       
      Fibrosis                                                      1 (2%)                                                          
      Foreign Body                                     1 (2%)                                                                       
      Epithelium, Degeneration                                      1 (2%)                                                          
      Epithelium, Hyperplasia                                       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mucosa, Degeneration                            11 (19%)      5 (10%)      4 (7%)                                             
      Mucosa, Erosion, Focal                           1 (2%)       2 (4%)       1 (2%)                                             
      Muscularis, Necrosis, Focal                      1 (2%)                                                                       
   Tooth                                                           (1)                                                              
      Inflammation, Suppurative                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (13)         (8)          (2)                                                 
      Degeneration                                    13 (100%)     7 (88%)      2 (100%)                                           
   Heart                                              (60)         (50)         (59)                                                
      Abscess                                          1 (2%)                                                                       
      Cardiomyopathy                                  53 (88%)     44 (88%)     52 (88%)                                            
      Atrium, Dilatation                               1 (2%)                                                                       
      Atrium, Thrombosis                               6 (10%)      5 (10%)      3 (5%)                                             
      Myocardium, Necrosis                             1 (2%)                                                                       
      Myocardium, Necrosis, Focal                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (50)         (59)                                                
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Cytoplasmic Alteration, Focal                                 1 (2%)                                                          
      Degeneration                                     7 (12%)      3 (6%)       1 (2%)                                             
      Degeneration, Fatty, Focal                      21 (36%)     21 (42%)     15 (25%)                                            
      Hyperplasia, Focal                               6 (10%)      9 (18%)      8 (14%)                                            
      Hypertrophy, Focal                                                         1 (2%)                                             
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
   Adrenal Gland, Medulla                             (59)         (50)         (57)                                                
      Hyperplasia, Focal                              21 (36%)     25 (50%)     14 (25%)                                            
   Islets, Pancreatic                                 (50)         (50)         (49)                                                
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
   Parathyroid Gland                                  (57)         (49)         (57)                                                
      Hyperplasia, Focal                               1 (2%)                    1 (2%)                                             
      Hypertrophy                                     32 (56%)     30 (61%)     19 (33%)                                            
   Pituitary Gland                                    (54)         (49)         (58)                                                
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Cyst                                                          2 (4%)                                                          
      Hemorrhage                                                                 2 (3%)                                             
      Pigmentation                                     1 (2%)                    1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Pars Distalis, Cyst                              1 (2%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                4 (7%)       3 (6%)      10 (17%)                                            
   Thyroid Gland                                      (58)         (50)         (57)                                                
      C-Cell, Hyperplasia                              7 (12%)      7 (14%)      8 (14%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)          (3)          (2)                                                 
      Hemorrhage                                                                 1 (50%)                                            
      Inflammation, Suppurative                        1 (25%)                                                                      
      Inflammation, Proliferative                                                1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)          (1)                                                              
      Inflammation                                     1 (100%)                                                                     
      Inflammation, Suppurative                                     1 (100%)                                                        
   Epididymis                                         (58)         (48)         (59)                                                
      Degeneration, Focal                             35 (60%)     38 (79%)     31 (53%)                                            
      Fibrosis                                        20 (34%)     20 (42%)     11 (19%)                                            
   Penis                                              (6)          (2)          (2)                                                 
      Inflammation, Acute                              3 (50%)      2 (100%)                                                        
      Thrombosis                                       1 (17%)                                                                      
   Preputial Gland                                    (44)         (46)         (54)                                                
      Abscess                                          2 (5%)       1 (2%)       2 (4%)                                             
      Abscess, Acute                                                1 (2%)                                                          
      Ectasia                                          4 (9%)       1 (2%)       4 (7%)                                             
      Fibrosis                                        21 (48%)     23 (50%)     24 (44%)                                            
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic                                         5 (11%)      3 (6%)                                             
      Duct, Inflammation, Suppurative                  1 (2%)                                                                       
   Prostate                                           (58)         (50)         (58)                                                
      Cyst                                                                       1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                    3 (5%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       2 (3%)                                             
      Inflammation, Suppurative                       29 (50%)     25 (50%)     27 (47%)                                            
   Seminal Vesicle                                    (58)         (50)         (58)                                                
      Atrophy                                         15 (26%)     13 (26%)     12 (21%)                                            
      Depletion Cellular                              17 (29%)     21 (42%)     10 (17%)                                            
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Suppurative                        2 (3%)       4 (8%)       1 (2%)                                             
   Testes                                             (60)         (50)         (59)                                                
      Hypoplasia                                       1 (2%)       1 (2%)       1 (2%)                                             
      Polyarteritis                                    3 (5%)       4 (8%)       4 (7%)                                             
      Interstitial Cell, Hyperplasia                   4 (7%)       1 (2%)       3 (5%)                                             
      Seminiferous Tubule, Atrophy                    23 (38%)     31 (62%)     20 (34%)                                            
      Seminiferous Tubule, Degeneration               14 (23%)      8 (16%)      8 (14%)                                            
      Unilateral, Atrophy                                                        2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (49)         (57)                                                
      Hypoplasia                                       6 (10%)      6 (12%)      3 (5%)                                             
   Lymph Node                                         (60)         (50)         (59)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Mediastinal, Angiectasis                                      2 (4%)                                                          
      Mediastinal, Hemorrhage                          2 (3%)                    1 (2%)                                             
   Lymph Node, Mandibular                             (58)         (50)         (58)                                                
      Hyperplasia                                                   1 (2%)                                                          
   Lymph Node, Mesenteric                             (54)         (50)         (55)                                                
      Angiectasis                                                   1 (2%)                                                          
      Congestion                                                    1 (2%)                                                          
      Hemorrhage                                       3 (6%)       1 (2%)                                                          
      Inflammation, Granulomatous                                                1 (2%)                                             
   Spleen                                             (60)         (50)         (59)                                                
      Congestion                                       3 (5%)                    3 (5%)                                             
      Depletion Lymphoid                               1 (2%)                                                                       
      Fibrosis                                         4 (7%)       4 (8%)       4 (7%)                                             
      Hematopoietic Cell Proliferation                 8 (13%)      9 (18%)      7 (12%)                                            
      Infarct                                                       1 (2%)       2 (3%)                                             
      Pigmentation, Hemosiderin                       26 (43%)     14 (28%)     23 (39%)                                            
      Capsule, Hyperplasia                                          1 (2%)                                                          
      Capsule, Hyperplasia, Focal                                   1 (2%)                                                          
   Thymus                                             (45)         (37)         (44)                                                
      Depletion Lymphoid                               5 (11%)      4 (11%)      7 (16%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Pseudoepitheliomatous                            2 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (38)         (52)                                                
      Abscess                                          1 (2%)                                                                       
      Galactocele                                                   1 (3%)                                                          
      Hyperplasia                                      1 (2%)       3 (8%)       2 (4%)                                             
      Hyperplasia, Cystic                                                        1 (2%)                                             
      Lactation                                       39 (72%)     37 (97%)     40 (77%)                                            
      Duct, Ectasia                                    1 (2%)                                                                       
      Duct, Pigmentation                               1 (2%)                                                                       
   Skin                                               (59)         (56)         (60)                                                
      Abdominal, Edema                                              1 (2%)                                                          
      Abdominal, Exudate                                            1 (2%)                                                          
      Abdominal, Inflammation, Suppurative             1 (2%)                                                                       
      Abdominal, Subcutaneous Tissue, Edema                                      1 (2%)                                             
      Foot, Hemorrhage                                              1 (2%)                                                          
      Other, Cyst Epithelial Inclusion                 1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Other, Inflammation, Acute                                    1 (2%)                                                          
      Other, Inflammation, Suppurative                 3 (5%)                    1 (2%)                                             
      Prepuce, Hyperkeratosis                          1 (2%)                                                                       
      Prepuce, Inflammation                            1 (2%)                                                                       
      Sebaceous Gland, Site of Application-Mass,                                                                                    
           Hyperplasia                                 1 (2%)                                                                       
      Site of Application-Mass, Fibrosis, Focal        1 (2%)                                                                       
      Site of Application-Mass, Hyperplasia,                                                                                        
          Squamous                                     1 (2%)                                                                       
   Skin, Control                                      (60)         (50)         (59)                                                
      Acanthosis                                       1 (2%)                                                                       
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
   Skin, Site of Application-No Mass                  (60)         (55)         (60)                                                
      Acanthosis                                       2 (3%)      10 (18%)     27 (45%)                                            
      Cyst Epithelial Inclusion                        3 (5%)                                                                       
      Exudate                                                       1 (2%)                                                          
      Hyperkeratosis                                                             2 (3%)                                             
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Proliferation Connective Tissue                  1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)         (49)         (58)                                                
      Fibrous Osteodystrophy                          22 (37%)     19 (39%)     11 (19%)                                            
      Hyperostosis                                                  1 (2%)       1 (2%)                                             
      Hypoplasia                                       1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Degeneration, Focal                              1 (100%)                                                                     
      Diaphragm, Inflammation, Proliferative                                     1 (100%)                                           
      Diaphragm, Necrosis, Focal                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (59)                                                
      Compression                                      5 (8%)       8 (16%)      9 (15%)                                            
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hydrocephalus                                                 1 (2%)       1 (2%)                                             
      Infarct                                                       1 (2%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (50)         (60)                                                
      Atelectasis                                      2 (3%)       1 (2%)                                                          
      Congestion                                      18 (30%)     13 (26%)     18 (30%)                                            
      Edema                                                                      1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)       2 (3%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)       3 (6%)       1 (2%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                           22 (37%)     14 (28%)     11 (18%)                                            
      Alveolar Epithelium, Hyperplasia                                           1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal                       1 (2%)                                                          
   Nose                                               (60)         (50)         (58)                                                
      Exudate                                                       1 (2%)                                                          
      Fibrosis, Focal                                               1 (2%)                                                          
      Foreign Body                                     3 (5%)       5 (10%)                                                         
      Fungus                                           4 (7%)       4 (8%)       7 (12%)                                            
      Infiltration Cellular, Diffuse, Lymphocyte       1 (2%)                                                                       
      Infiltration Cellular, Mixed Cell                                          1 (2%)                                             
      Inflammation, Chronic                            4 (7%)       5 (10%)      5 (9%)                                             
      Inflammation, Suppurative                        7 (12%)      2 (4%)       7 (12%)                                            
      Nasolacrimal Duct, Exudate                                                 1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                   1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     2 (3%)       1 (2%)       2 (3%)                                             
      Submucosa, Olfactory Epithelium, Glands,                                                                                      
           Hypertrophy                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)          (3)                                                 
      Hyperkeratosis                                   1 (100%)                                                                     
      Ulcer                                                                      1 (33%)                                            
   Eye                                                (45)         (43)         (42)                                                
      Cataract                                        43 (96%)     43 (100%)    42 (100%)                                           
      Hemorrhage                                       4 (9%)       4 (9%)       1 (2%)                                             
      Synechia                                         1 (2%)                                                                       
      Anterior Chamber, Hemorrhage                     1 (2%)                                                                       
      Anterior Chamber, Inflammation, Suppurative                   1 (2%)       1 (2%)                                             
      Cornea, Inflammation                             5 (11%)      4 (9%)                                                          
      Retina, Atrophy                                 36 (80%)     35 (81%)     34 (81%)                                            
   Zymbal's Gland                                                  (3)                                                              
      Abscess                                                       2 (67%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05106-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 05/19/95  
Route: SKIN APPLICATION                                                                                           Time: 20:47:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0UL/RAT      100UL        300UL                                                  
                                                   UM           RAT LM       RAT HM                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (50)         (60)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Nephropathy                                     60 (100%)    50 (100%)    60 (100%)                                           
      Pelvis, Dilatation                               1 (2%)       2 (4%)                                                          
      Pelvis, Epithelium, Hyperplasia                 30 (50%)     28 (56%)     22 (37%)                                            
      Pelvis, Epithelium, Inflammation                 1 (2%)                                                                       
      Pelvis, Epithelium, Mineralization                            2 (4%)       1 (2%)                                             
      Renal Tubule, Mineralization                     1 (2%)                                                                       
   Urinary Bladder                                    (58)         (50)         (56)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Mucosa, Hyperplasia                              2 (3%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
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                             ----------              END OF REPORT             ----------                                           
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