National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3300

TDMS Study 05121-07 Pathology Tables

NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96
Route: GAVAGE                                                                                                     Time: 22:04:18




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  6533-68-2

       Lock Date:  06/01/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:18  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          70           60           70           70           70                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Natural Death                                      7            3            3            5            6                        
    Moribund Sacrifice                                 9           10           11            7            7                        
    Dosing Accident                                    2            1                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           36           36           37           38                        

  Animals Examined Microscopically                    61           60           60           60           61                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (61)         (60)         (60)         (60)         (60)                      
      Perforation                                      1 (2%)       1 (2%)                                                          
      Periesophageal Tissue, Inflammation,                                                                                          
          Suppurative                                  3 (5%)       1 (2%)       1 (2%)       2 (3%)                                
   Intestine Large, Rectum                            (61)         (60)         (60)         (60)         (60)                      
      Inflammation, Chronic Active                                                                         1 (2%)                   
   Intestine Small, Duodenum                          (61)         (60)         (59)         (60)         (61)                      
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Jejunum                           (61)         (58)         (59)         (60)         (60)                      
      Hyperplasia, Lymphoid                            2 (3%)       2 (3%)       1 (2%)                    3 (5%)                   
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Liver                                              (61)         (60)         (60)         (60)         (61)                      
      Angiectasis                                      1 (2%)       2 (3%)       1 (2%)       1 (2%)       1 (2%)                   
      Basophilic Focus                                 1 (2%)       1 (2%)       2 (3%)       4 (7%)       3 (5%)                   
      Clear Cell Focus                                              1 (2%)       1 (2%)                                             
      Developmental Malformation                                                 1 (2%)                                             
      Ectopic Tissue                                                1 (2%)                                                          
      Eosinophilic Focus                              17 (28%)      4 (7%)      10 (17%)     13 (22%)      9 (15%)                  
      Fatty Change                                                  1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                   
      Inflammation                                                                                         1 (2%)                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mixed Cell Focus                                 7 (11%)      1 (2%)       7 (12%)      3 (5%)       3 (5%)                   
      Necrosis                                                      3 (5%)       1 (2%)       2 (3%)       2 (3%)                   
      Kupffer Cell, Pigmentation, Hemosiderin                                                 1 (2%)                                
   Mesentery                                          (7)          (5)          (9)          (4)          (5)                       
      Inflammation, Suppurative                                     2 (40%)                                                         
      Artery, Inflammation, Chronic Active                                                    1 (25%)                               
      Fat, Necrosis                                    6 (86%)      1 (20%)      8 (89%)      2 (50%)      2 (40%)                  
   Pancreas                                           (61)         (60)         (60)         (60)         (61)                      

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:18  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                          6 (10%)      4 (7%)       4 (7%)       4 (7%)                                
      Hypertrophy                                      1 (2%)                                                                       
      Inflammation, Chronic Active                                               2 (3%)                                             
      Duct, Cyst                                       2 (3%)       3 (5%)       4 (7%)       1 (2%)                                
   Salivary Glands                                    (60)         (60)         (60)         (60)         (61)                      
      Atrophy                                                       1 (2%)                                                          
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
      Duct, Hyperplasia                                1 (2%)                                                                       
   Stomach, Forestomach                               (61)         (60)         (60)         (60)         (61)                      
      Cyst                                                          1 (2%)                                                          
      Diverticulum                                                                                         1 (2%)                   
      Hyperplasia, Focal                               8 (13%)     17 (28%)      3 (5%)      12 (20%)     14 (23%)                  
      Infiltration Cellular, Plasma Cell                                                      1 (2%)                                
   Stomach, Glandular                                 (61)         (60)         (60)         (60)         (61)                      
      Erosion                                          2 (3%)       2 (3%)                                                          
      Mineralization                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (61)         (58)         (60)         (60)         (61)                      
      Mineralization                                                1 (2%)                                                          
      Aorta, Inflammation, Chronic Active              1 (2%)                                 1 (2%)                                
   Heart                                              (61)         (60)         (60)         (60)         (61)                      
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   2 (3%)       1 (2%)                    1 (2%)                                
      Artery, Inflammation, Chronic Active                                                    1 (2%)       2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (61)         (60)         (60)         (60)         (61)                      
      Accessory Adrenal Cortical Nodule                1 (2%)       2 (3%)                    2 (3%)       1 (2%)                   
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                      1 (2%)                    1 (2%)       4 (7%)       1 (2%)                   
      Capsule, Hyperplasia, Adenomatous                                          1 (2%)                                             
   Adrenal Medulla                                    (61)         (58)         (59)         (59)         (60)                      
      Hyperplasia                                      3 (5%)       1 (2%)                    2 (3%)                                
   Islets, Pancreatic                                 (61)         (60)         (60)         (60)         (61)                      
      Hyperplasia                                      1 (2%)       1 (2%)       2 (3%)                    1 (2%)                   
   Parathyroid Gland                                  (58)         (48)         (48)         (46)         (53)                      
      Cyst                                             1 (2%)                                                                       
      Cytoplasmic Alteration, Focal                                 1 (2%)                                                          
      Inflammation, Chronic Active                                                            1 (2%)                                
   Pituitary Gland                                    (60)         (58)         (57)         (57)         (56)                      
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Pars Distalis, Hyperplasia                      27 (45%)     11 (19%)     15 (26%)     11 (19%)     14 (25%)                  

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:18  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Intermedia, Hyperplasia                                                                         1 (2%)                   
   Thyroid Gland                                      (61)         (60)         (59)         (60)         (61)                      
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                    5 (8%)       1 (2%)                   
      Follicular Cell, Hyperplasia                    18 (30%)      5 (8%)      14 (24%)     10 (17%)      8 (13%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (60)         (56)         (58)         (58)                      
      Duct, Ectasia                                                 1 (2%)       1 (2%)                    1 (2%)                   
   Ovary                                              (61)         (59)         (59)         (59)         (61)                      
      Cyst                                            17 (28%)     10 (17%)     17 (29%)     12 (20%)     14 (23%)                  
      Inflammation, Suppurative                                     2 (3%)       1 (2%)                    1 (2%)                   
      Mineralization                                                             1 (2%)                                             
   Uterus                                             (61)         (60)         (60)         (60)         (61)                      
      Angiectasis                                                                1 (2%)       2 (3%)                                
      Hyperplasia, Cystic                             43 (70%)     29 (48%)     37 (62%)     34 (57%)     27 (44%)                  
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (61)         (60)         (60)         (60)         (61)                      
      Myelofibrosis                                   23 (38%)     18 (30%)     23 (38%)     15 (25%)     13 (21%)                  
      Erythroid Cell, Hyperplasia                      3 (5%)       2 (3%)       3 (5%)       4 (7%)                                
      Myeloid Cell, Hyperplasia                        9 (15%)      7 (12%)      5 (8%)       6 (10%)      3 (5%)                   
   Lymph Node                                         (6)          (3)          (5)          (4)          (3)                       
      Bronchial, Inflammation, Chronic Active                       1 (33%)                                                         
      Mediastinal, Hyperplasia, Lymphoid                                                      1 (25%)                               
      Renal, Angiectasis                                                         1 (20%)                                            
   Lymph Node, Mandibular                             (59)         (57)         (55)         (58)         (61)                      
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                    1 (2%)                   
   Lymph Node, Mesenteric                             (60)         (57)         (56)         (59)         (58)                      
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)       1 (2%)       2 (3%)                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Spleen                                             (61)         (60)         (60)         (60)         (61)                      
      Depletion Lymphoid                               2 (3%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation                17 (28%)     11 (18%)     11 (18%)     17 (28%)      7 (11%)                  
      Hyperplasia, Lymphoid                            3 (5%)       2 (3%)                    2 (3%)       2 (3%)                   
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:18  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Thymus                                             (57)         (53)         (53)         (56)         (55)                      
      Atrophy                                          3 (5%)       2 (4%)       7 (13%)      4 (7%)       3 (5%)                   
      Inflammation, Chronic Active                                                                         1 (2%)                   
      Mineralization                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (61)         (59)         (59)         (60)         (61)                      
      Hyperplasia                                      1 (2%)                    3 (5%)       2 (3%)       4 (7%)                   
   Skin                                               (61)         (60)         (60)         (60)         (61)                      
      Cyst Epithelial Inclusion                                                                            1 (2%)                   
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosis, Chronic Active                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (61)         (60)         (60)         (60)         (61)                      
      Infarct                                          1 (2%)                                                                       
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
      Neuron, Necrosis                                 1 (2%)       4 (7%)       1 (2%)                    2 (3%)                   
   Peripheral Nerve                                   (2)          (2)          (2)                                                 
      Degeneration                                     2 (100%)     1 (50%)      1 (50%)                                            
   Spinal Cord                                        (2)          (2)          (2)                       (1)                       
      White Matter, Degeneration                                                 1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (61)         (60)         (60)         (60)         (61)                      
      Inflammation, Chronic Active                     2 (3%)                    2 (3%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    1 (2%)                                             
   Trachea                                            (61)         (60)         (60)         (60)         (61)                      
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:18  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                                                              
      Internal Ear, Inflammation, Chronic Active                    1 (100%)                                                        
   Eye                                                (2)                       (2)          (2)                                    
      Degeneration                                                               1 (50%)      1 (50%)                               
      Cornea, Inflammation, Chronic Active             2 (100%)                                                                     
      Lens, Cataract                                                                          1 (50%)                               
      Retina, Atrophy                                                                         1 (50%)                               
   Harderian Gland                                    (18)         (10)         (15)         (16)         (16)                      
      Inflammation, Chronic Active                                               1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (61)         (60)         (60)         (60)         (61)                      
      Cyst                                             1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Inflammation, Chronic Active                                                                         1 (2%)                   
      Mineralization                                                1 (2%)                                                          
      Nephropathy                                     28 (46%)     25 (42%)     24 (40%)     27 (45%)     12 (20%)                  
      Artery, Inflammation, Chronic Active                                       1 (2%)       1 (2%)       1 (2%)                   
      Renal Tubule, Necrosis, Acute                    1 (2%)                                                                       
   Urinary Bladder                                    (60)         (60)         (58)         (59)         (61)                      
      Inflammation, Chronic Active                                                                         1 (2%)                   
      Artery, Inflammation, Chronic Active                                                    2 (3%)       1 (2%)                   
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:18  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          70           60           70           70           70                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Natural Death                                      6            6            4            5            2                        
    Moribund Sacrifice                                 4            2            7            4            7                        
    Dosing Accident                                                 1                                      1                        
    Accidently Killed                                                                         2            1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           41           39           39           39                        

  Animals Examined Microscopically                    60           60           60           60           60                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)         (60)                      
      Cyst                                             1 (2%)                                                                       
      Periesophageal Tissue, Inflammation,                                                                                          
          Suppurative                                  1 (2%)       2 (3%)                                 1 (2%)                   
   Gallbladder                                        (59)         (60)         (59)         (59)         (58)                      
      Inflammation, Chronic Active                                               1 (2%)                                             
   Intestine Small, Jejunum                           (60)         (60)         (60)         (59)         (60)                      
      Hyperplasia, Lymphoid                                         1 (2%)                                 1 (2%)                   
      Ulcer                                                                                   1 (2%)       1 (2%)                   
   Intestine Small, Ileum                             (59)         (60)         (59)         (60)         (58)                      
      Amyloid Deposition                                                                                   1 (2%)                   
   Liver                                              (60)         (60)         (60)         (60)         (60)                      
      Amyloid Deposition                                                                                   1 (2%)                   
      Basophilic Focus                                 3 (5%)       1 (2%)       4 (7%)       3 (5%)                                
      Clear Cell Focus                                13 (22%)      2 (3%)       5 (8%)       3 (5%)                                
      Eosinophilic Focus                              22 (37%)                  14 (23%)      8 (13%)      2 (3%)                   
      Fatty Change                                     3 (5%)                    5 (8%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (3%)                                              2 (3%)                   
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                 1 (2%)                   
      Mixed Cell Focus                                 6 (10%)      2 (3%)       7 (12%)      9 (15%)      1 (2%)                   
      Necrosis                                         1 (2%)       1 (2%)       2 (3%)       1 (2%)       3 (5%)                   
      Bile Duct, Cyst                                               1 (2%)                                                          
      Bile Duct, Hyperplasia                           1 (2%)                    1 (2%)                                             
      Hepatocyte, Hypertrophy                                                    1 (2%)                                             
   Mesentery                                          (5)          (1)          (3)          (3)          (2)                       
      Infiltration Cellular, Lymphocyte                                                       1 (33%)                               
      Fat, Inflammation, Chronic Active                1 (20%)      1 (100%)                  1 (33%)      1 (50%)                  
      Fat, Necrosis                                    2 (40%)                   2 (67%)      1 (33%)                               
   Pancreas                                           (60)         (60)         (60)         (60)         (60)                      
      Atrophy                                          2 (3%)                    2 (3%)                    2 (3%)                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:18  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atypia Cellular                                               1 (2%)                                                          
      Hyperplasia                                                                             1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      Duct, Cyst                                                                 1 (2%)                    2 (3%)                   
   Salivary Glands                                    (60)         (60)         (60)         (60)         (60)                      
      Atrophy                                                       1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (60)         (60)         (60)                      
      Hyperplasia, Focal                               3 (5%)      17 (28%)      2 (3%)       3 (5%)       8 (13%)                  
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
   Stomach, Glandular                                 (60)         (60)         (60)         (60)         (60)                      
      Dysplasia                                                     1 (2%)                                                          
      Erosion                                                       5 (8%)                                                          
      Inflammation, Chronic Active, Focal                                        1 (2%)                                             
   Tooth                                              (14)                      (4)          (5)          (2)                       
      Dysplasia                                       13 (93%)                   3 (75%)      3 (60%)      1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (60)         (60)         (59)                      
      Aorta, Inflammation, Chronic Active                                                                  1 (2%)                   
   Heart                                              (60)         (60)         (60)         (60)         (60)                      
      Inflammation, Chronic Active                                               2 (3%)       1 (2%)                                
      Mineralization                                   2 (3%)                                                                       
      Artery, Inflammation, Chronic Active                                                                 1 (2%)                   
      Artery, Mineralization                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)         (60)                      
      Accessory Adrenal Cortical Nodule                1 (2%)       1 (2%)                    1 (2%)       1 (2%)                   
      Hyperplasia                                     27 (45%)     12 (20%)     18 (30%)     20 (33%)     27 (45%)                  
      Capsule, Hyperplasia, Adenomatous                8 (13%)      7 (12%)      2 (3%)       8 (13%)      6 (10%)                  
   Adrenal Medulla                                    (59)         (60)         (55)         (60)         (60)                      
      Hyperplasia                                                                3 (5%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)         (60)                      
      Hyperplasia                                     32 (53%)      3 (5%)      30 (50%)     12 (20%)      2 (3%)                   
   Parathyroid Gland                                  (56)         (51)         (49)         (56)         (52)                      
      Hyperplasia                                                                             1 (2%)                                
   Pituitary Gland                                    (58)         (58)         (56)         (55)         (53)                      
      Cyst                                             1 (2%)                                 1 (2%)                                
      Pars Distalis, Hyperplasia                       1 (2%)                                 1 (2%)                                
      Pars Intermedia, Hyperplasia                                                                         1 (2%)                   
   Thyroid Gland                                      (60)         (60)         (60)         (60)         (60)                      

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:18  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia                    13 (22%)      1 (2%)      15 (25%)     13 (22%)      5 (8%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)         (60)                      
      Granuloma Sperm                                  1 (2%)                    2 (3%)                                             
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                    1 (2%)                   
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
   Preputial Gland                                    (60)         (60)         (60)         (59)         (60)                      
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       2 (3%)       2 (3%)       3 (5%)                   
      Duct, Ectasia                                   57 (95%)     56 (93%)     58 (97%)     56 (95%)     54 (90%)                  
   Prostate                                           (59)         (59)         (60)         (60)         (60)                      
      Inflammation, Chronic Active                                                            2 (3%)       2 (3%)                   
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
   Seminal Vesicle                                    (60)         (60)         (60)         (60)         (60)                      
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       1 (2%)                                
   Testes                                             (60)         (60)         (60)         (60)         (60)                      
      Atrophy                                          2 (3%)                                                                       
      Hypoplasia                                                    1 (2%)                                                          
      Interstitial Cell, Hyperplasia                                                                       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)         (60)                      
      Thrombosis                                                                                           1 (2%)                   
      Erythroid Cell, Hyperplasia                                   5 (8%)       4 (7%)                    2 (3%)                   
      Myeloid Cell, Hyperplasia                        1 (2%)       1 (2%)       4 (7%)       5 (8%)       5 (8%)                   
   Lymph Node                                         (2)          (1)                       (2)          (3)                       
      Lumbar, Hyperplasia, Lymphoid                                                                        1 (33%)                  
      Mediastinal, Hyperplasia, Lymphoid               1 (50%)                                                                      
   Lymph Node, Mandibular                             (59)         (59)         (58)         (57)         (56)                      
      Hyperplasia, Lymphoid                                                      1 (2%)       1 (2%)       1 (2%)                   
   Lymph Node, Mesenteric                             (58)         (53)         (56)         (56)         (57)                      
      Hematopoietic Cell Proliferation                 2 (3%)                                              1 (2%)                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Plasma Cell                                                                             1 (2%)                   
      Inflammation, Chronic Active                                               1 (2%)                                             
   Spleen                                             (60)         (60)         (60)         (60)         (60)                      
      Amyloid Deposition                                                                                   1 (2%)                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:18  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Depletion Lymphoid                                            5 (8%)       1 (2%)       1 (2%)       3 (5%)                   
      Hematopoietic Cell Proliferation                 8 (13%)      7 (12%)     12 (20%)     14 (23%)     12 (20%)                  
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Thymus                                             (51)         (55)         (54)         (50)         (50)                      
      Atrophy                                          6 (12%)      5 (9%)      12 (22%)      4 (8%)       7 (14%)                  
      Epithelial Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)         (60)                      
      Inflammation, Chronic Active                                                                         1 (2%)                   
      Ulcer                                                                                                1 (2%)                   
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                 2 (3%)                                             
      Subcutaneous Tissue, Lymphangiectasis            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Degeneration                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)         (60)                      
      Hemorrhage, Acute                                                                       1 (2%)                                
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
      Neuron, Necrosis                                 1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)         (60)                      
      Embolus                                          1 (2%)                                                                       
      Granuloma                                                     1 (2%)                                                          
      Hemorrhage, Acute                                                                       1 (2%)                                
      Inflammation, Chronic Active                                                            2 (3%)       1 (2%)                   
      Inflammation, Suppurative                        1 (2%)                                              1 (2%)                   
      Pigmentation, Hemosiderin                                                  1 (2%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 8 (13%)      5 (8%)       3 (5%)       3 (5%)       2 (3%)                   
   Nose                                               (60)         (60)         (60)         (60)         (60)                      
      Hemorrhage, Acute                                                                       1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                    2 (3%)                   
   Trachea                                            (60)         (60)         (60)         (60)         (60)                      
      Peritracheal Tissue, Hemorrhage, Acute                                                  1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05121-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:18  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (3)          (1)          (3)                       
      Degeneration                                                                                         1 (33%)                  
      Cornea, Inflammation, Chronic Active                                       1 (33%)      1 (100%)     1 (33%)                  
      Cornea, Necrosis                                                           1 (33%)                                            
   Harderian Gland                                    (20)         (18)         (20)         (21)         (16)                      
      Hyperplasia                                      1 (5%)                                                                       
      Inflammation, Chronic Active                                                            2 (10%)      2 (13%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)         (60)                      
      Cyst                                             6 (10%)      3 (5%)                    2 (3%)       3 (5%)                   
      Developmental Malformation                                    1 (2%)                                                          
      Hydronephrosis                                                                                       1 (2%)                   
      Infarct                                                                                 1 (2%)                                
      Inflammation, Chronic Active                     2 (3%)                                 2 (3%)       2 (3%)                   
      Necrosis                                                                   1 (2%)                    1 (2%)                   
      Nephropathy                                     58 (97%)     49 (82%)     55 (92%)     52 (87%)     43 (72%)                  
      Artery, Inflammation, Chronic Active                                                    2 (3%)                                
      Glomerulus, Amyloid Deposition                                                                       1 (2%)                   
      Renal Tubule, Hyperplasia                                                  2 (3%)                                             
   Urinary Bladder                                    (60)         (60)         (60)         (60)         (59)                      
      Inflammation, Chronic Active                     2 (3%)                                 2 (3%)       3 (5%)                   
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.