TDMS Study 05180-06 Pathology Tables
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
2 YEAR CHRONIC RATS
Facility: Battelle Northwest
Chemical CAS #: 1303-00-0000
Lock Date: 03/13/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 30 30 23 35
Natural Death 1 3 6 4
Survivors
Terminal Sacrifice 19 17 20 11
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49) (48) (49)
Inflammation, Acute 1 (2%)
Intestine Large, Cecum (50) (49) (48) (49)
Inflammation, Acute 1 (2%)
Intestine Small, Duodenum (50) (48) (48) (49)
Necrosis 1 (2%) 2 (4%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 2 (4%) 5 (10%) 3 (6%)
Basophilic Focus 38 (76%) 36 (72%) 38 (76%) 34 (68%)
Clear Cell Focus 5 (10%) 7 (14%) 8 (16%) 2 (4%)
Degeneration, Cystic 1 (2%)
Eosinophilic Focus 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Fatty Change 12 (24%) 19 (38%) 11 (22%) 12 (24%)
Hepatodiaphragmatic Nodule 3 (6%) 3 (6%) 3 (6%) 4 (8%)
Inflammation, Granulomatous 3 (6%) 1 (2%) 1 (2%)
Mixed Cell Focus 10 (20%) 9 (18%) 6 (12%) 2 (4%)
Necrosis 1 (2%) 1 (2%) 4 (8%) 2 (4%)
Regeneration 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Focal 3 (6%) 2 (4%)
Bile Duct, Hyperplasia 15 (30%) 12 (24%) 7 (14%) 13 (26%)
Centrilobular, Necrosis 6 (12%) 13 (26%) 8 (16%) 17 (34%)
Mesentery (6) (14) (6) (11)
Artery, Inflammation, Chronic Active 1 (7%)
Fat, Necrosis 6 (100%) 13 (93%) 6 (100%) 11 (100%)
Pancreas (50) (50) (50) (49)
Atrophy 15 (30%) 13 (26%) 21 (42%) 14 (29%)
Basophilic Focus 4 (8%) 3 (6%) 1 (2%) 1 (2%)
Hyperplasia 3 (6%) 1 (2%)
Lipomatosis 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 1 (2%)
Hyperplasia, Squamous 1 (2%) 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mineralization 1 (2%)
Necrosis 4 (8%) 7 (14%) 3 (6%) 4 (8%)
Stomach, Glandular (50) (50) (50) (49)
Mineralization 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Necrosis 3 (6%) 6 (12%) 2 (4%) 4 (8%)
Tongue (1) (2)
Hyperplasia, Squamous 1 (100%) 1 (50%)
Tooth (1) (1)
Developmental Malformation 1 (100%)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 34 (68%) 37 (74%) 29 (58%) 31 (62%)
Artery, Mineralization 1 (2%)
Atrium, Thrombosis 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Degeneration, Cystic 4 (8%) 2 (4%) 1 (2%)
Hyperplasia 27 (54%) 23 (46%) 25 (50%) 22 (45%)
Hypertrophy 10 (20%) 11 (22%) 9 (18%) 11 (22%)
Necrosis 4 (8%) 2 (4%) 2 (4%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 2 (4%) 4 (8%) 4 (8%) 3 (6%)
Adrenal Medulla (50) (49) (50) (49)
Hyperplasia 16 (32%) 11 (22%) 15 (30%) 12 (24%)
Bilateral, Hyperplasia 1 (2%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 1 (2%)
Parathyroid Gland (47) (42) (47) (46)
Hyperplasia 3 (7%) 3 (6%) 3 (7%)
Pituitary Gland (50) (50) (50) (49)
Angiectasis 2 (4%) 1 (2%)
Cyst 1 (2%)
Pars Distalis, Angiectasis 2 (4%)
Pars Distalis, Hyperplasia 5 (10%) 3 (6%) 7 (14%) 9 (18%)
Thyroid Gland (50) (49) (48) (49)
C-Cell, Hyperplasia 41 (82%) 41 (84%) 38 (79%) 33 (67%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (48) (47) (48)
Hyperplasia 2 (4%) 4 (8%) 3 (6%) 2 (4%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Metaplasia, Squamous 1 (2%)
Ovary (50) (50) (50) (49)
Cyst 7 (14%) 8 (16%) 10 (20%) 5 (10%)
Uterus (50) (50) (49) (50)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (49)
Hyperplasia, Histiocytic 1 (2%)
Inflammation, Granulomatous 1 (2%)
Myelofibrosis 1 (2%)
Necrosis 1 (2%)
Lymph Node (3) (6) (3) (5)
Renal, Hemorrhage 1 (17%) 1 (33%) 1 (20%)
Lymph Node, Bronchial (36) (36) (39) (40)
Infiltration Cellular, Plasma Cell 1 (3%)
Lymph Node, Mediastinal (34) (39) (39) (39)
Infiltration Cellular, Polymorphonuclear 1 (3%)
Spleen (50) (50) (50) (49)
Fibrosis 4 (8%) 6 (12%) 5 (10%) 1 (2%)
Hematopoietic Cell Proliferation 5 (10%) 2 (4%) 6 (12%) 1 (2%)
Hemorrhage 1 (2%) 2 (4%)
Necrosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 1 (2%) 2 (4%)
Hyperplasia, Atypical 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%) 2 (4%)
Hyperostosis 7 (14%) 3 (6%) 7 (14%) 9 (18%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (49)
Hyperplasia 3 (6%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 4 (8%) 5 (10%) 3 (6%) 3 (6%)
Metaplasia, Squamous 10 (20%) 5 (10%) 7 (14%) 11 (22%)
Necrosis 1 (2%)
Epiglottis, Hyperplasia 4 (8%) 2 (4%) 3 (6%)
Epiglottis, Inflammation, Chronic Active 4 (8%) 1 (2%) 1 (2%)
Epiglottis, Metaplasia, Squamous 4 (8%) 6 (12%) 1 (2%) 3 (6%)
Lung (50) (50) (50) (50)
Cyst, Squamous 1 (2%)
Hyperplasia, Atypical 9 (18%) 16 (32%)
Inflammation, Chronic Active 11 (22%) 46 (92%) 49 (98%) 50 (100%)
Metaplasia, Squamous 2 (4%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Proteinosis 1 (2%) 24 (48%) 47 (94%) 49 (98%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 14 (28%) 9 (18%) 17 (34%) 14 (28%)
Alveolar Epithelium, Metaplasia 1 (2%) 36 (72%) 41 (82%)
Artery, Mediastinum, Inflammation 1 (2%)
Artery, Mediastinum, Mineralization 1 (2%)
Nose (50) (50) (49) (49)
Hemorrhage 1 (2%)
Inflammation, Suppurative 3 (6%) 4 (8%) 9 (18%) 3 (6%)
Thrombosis 2 (4%) 7 (14%) 4 (8%) 6 (12%)
Olfactory Epithelium, Atrophy 2 (4%)
Olfactory Epithelium, Degeneration, Hyaline 39 (78%) 38 (76%) 33 (67%) 32 (65%)
Olfactory Epithelium, Metaplasia, Respiratory 2 (4%) 2 (4%) 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Trachea (50) (50) (50) (49)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (5) (6) (1)
Cataract 1 (100%) 4 (80%) 1 (17%) 1 (100%)
Degeneration 1 (20%) 4 (67%)
Retina, Atrophy 1 (100%) 4 (80%) 1 (17%) 1 (100%)
Sclera, Inflammation, Acute 1 (17%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Amyloid Deposition 1 (2%)
Angiectasis 1 (2%)
Cyst 1 (2%) 2 (4%)
Hydronephrosis 1 (2%)
Infarct 3 (6%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Nephropathy 48 (96%) 47 (94%) 47 (94%) 45 (92%)
Thrombosis 1 (2%)
Renal Tubule, Hyperplasia 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (50) (50) (50) (49)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 30 29 32 33
Natural Death 7 8 3 4
Survivors
Terminal Sacrifice 13 13 15 13
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (47) (48) (50)
Mineralization 1 (2%)
Intestine Large, Rectum (48) (49) (47) (49)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
Anus, Hyperplasia 1 (2%)
Intestine Large, Cecum (46) (43) (48) (49)
Inflammation, Acute 1 (2%) 1 (2%)
Mineralization 3 (7%)
Necrosis 1 (2%) 1 (2%)
Intestine Small, Duodenum (48) (48) (49) (50)
Inflammation, Acute 1 (2%) 1 (2%)
Necrosis 2 (4%)
Intestine Small, Ileum (44) (43) (48) (49)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%) 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 5 (10%)
Basophilic Focus 21 (42%) 23 (46%) 21 (42%) 15 (30%)
Clear Cell Focus 6 (12%) 3 (6%) 6 (12%) 9 (18%)
Degeneration, Cystic 10 (20%) 9 (18%) 10 (20%) 10 (20%)
Eosinophilic Focus 6 (12%) 4 (8%) 5 (10%) 4 (8%)
Fatty Change 5 (10%) 8 (16%) 8 (16%) 7 (14%)
Hepatodiaphragmatic Nodule 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis 2 (4%) 4 (8%) 1 (2%)
Regeneration 1 (2%) 4 (8%) 5 (10%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia 28 (56%) 27 (54%) 32 (64%) 30 (60%)
Bile Duct, Inflammation, Acute 2 (4%)
Centrilobular, Necrosis 13 (26%) 14 (28%) 16 (32%) 13 (26%)
Mesentery (5) (10) (14) (7)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hemorrhage 1 (10%) 1 (7%)
Artery, Inflammation, Chronic Active 1 (10%)
Artery, Mineralization 3 (60%) 2 (20%) 2 (14%) 2 (29%)
Fat, Inflammation 1 (7%)
Fat, Necrosis 3 (60%) 7 (70%) 11 (79%) 5 (71%)
Oral Mucosa (1) (3) (1)
Pharyngeal, Inflammation, Chronic 1 (100%)
Pancreas (49) (49) (50) (50)
Atrophy 24 (49%) 29 (59%) 25 (50%) 27 (54%)
Basophilic Focus 3 (6%) 3 (6%) 2 (4%) 3 (6%)
Hyperplasia 4 (8%) 3 (6%) 2 (4%) 1 (2%)
Inflammation, Acute 1 (2%)
Metaplasia, Hepatocyte 1 (2%)
Artery, Inflammation 2 (4%) 1 (2%)
Artery, Mineralization 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Duct, Hyperplasia 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Artery, Mineralization 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Hyperplasia, Squamous 1 (2%)
Inflammation, Acute 1 (2%)
Mineralization 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Necrosis 7 (14%) 10 (20%) 9 (18%) 11 (22%)
Stomach, Glandular (49) (49) (50) (50)
Inflammation, Acute 1 (2%)
Mineralization 8 (16%) 6 (12%) 8 (16%) 8 (16%)
Necrosis 4 (8%) 9 (18%) 13 (26%) 13 (26%)
Tooth (2) (1) (3)
Developmental Malformation 2 (100%) 1 (100%) 3 (100%)
Inflammation, Chronic Active 1 (50%) 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (4) (6) (6)
Aorta, Mineralization 3 (100%) 4 (100%) 4 (67%) 6 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 44 (88%) 37 (74%) 41 (82%) 40 (80%)
Necrosis 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Artery, Mineralization 5 (10%) 6 (12%) 5 (10%) 7 (14%)
Atrium, Thrombosis 4 (8%) 1 (2%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (49) (50)
Atrophy 1 (2%) 1 (2%)
Degeneration, Cystic 1 (2%)
Hyperplasia 24 (49%) 24 (49%) 23 (47%) 23 (46%)
Hypertrophy 1 (2%) 3 (6%) 3 (6%) 2 (4%)
Mineralization 1 (2%)
Necrosis 1 (2%) 4 (8%) 3 (6%)
Vacuolization Cytoplasmic 2 (4%) 5 (10%) 2 (4%) 1 (2%)
Adrenal Medulla (50) (49) (49) (50)
Hyperplasia 22 (44%) 25 (51%) 22 (45%) 26 (52%)
Bilateral, Hyperplasia 1 (2%) 1 (2%) 7 (14%)
Islets, Pancreatic (48) (49) (50) (50)
Hyperplasia 1 (2%) 2 (4%) 2 (4%) 4 (8%)
Parathyroid Gland (47) (48) (47) (48)
Hyperplasia 13 (28%) 13 (27%) 17 (36%) 16 (33%)
Pituitary Gland (49) (49) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 17 (35%) 12 (24%) 15 (30%) 12 (24%)
Thyroid Gland (46) (46) (49) (50)
Hyperplasia 1 (2%)
C-Cell, Hyperplasia 26 (57%) 28 (61%) 33 (67%) 29 (58%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Hyperplasia, Atypical 1 (100%)
Epididymis (50) (50) (50) (50)
Atrophy 1 (2%)
Granuloma Sperm 3 (6%)
Preputial Gland (50) (49) (50) (49)
Hyperplasia 1 (2%) 3 (6%) 4 (8%)
Inflammation, Chronic Active 4 (8%) 4 (8%) 8 (16%) 3 (6%)
Prostate (50) (48) (50) (50)
Hyperplasia 12 (24%) 9 (19%) 11 (22%) 7 (14%)
Inflammation, Chronic Active 3 (6%) 1 (2%) 6 (12%) 2 (4%)
Mineralization 1 (2%)
Seminal Vesicle (45) (47) (48) (50)
Inflammation, Chronic Active 1 (2%)
Mineralization 2 (4%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Testes (50) (50) (50) (50)
Atrophy 1 (2%) 2 (4%) 5 (10%) 5 (10%)
Artery, Inflammation, Chronic Active 3 (6%) 4 (8%) 5 (10%) 4 (8%)
Interstitial Cell, Hyperplasia 2 (4%) 3 (6%) 2 (4%) 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (48) (50) (50)
Thrombosis 1 (2%)
Lymph Node (12) (8) (9) (5)
Hemorrhage 1 (8%)
Renal, Ectasia 1 (8%)
Renal, Hemorrhage 1 (8%)
Renal, Infiltration Cellular, Plasma Cell 1 (13%)
Lymph Node, Mandibular (46) (43) (46) (44)
Infiltration Cellular, Plasma Cell 2 (4%) 1 (2%) 1 (2%) 3 (7%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Chronic Active 1 (2%)
Lymph Node, Mesenteric (48) (48) (50) (48)
Hemorrhage 1 (2%)
Lymph Node, Mediastinal (42) (40) (46) (47)
Hemorrhage 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Pigmentation 1 (2%)
Spleen (50) (50) (50) (50)
Congestion 1 (2%)
Fibrosis 13 (26%) 12 (24%) 17 (34%) 12 (24%)
Hematopoietic Cell Proliferation 4 (8%) 2 (4%) 6 (12%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Granulomatous 2 (4%)
Necrosis 1 (2%) 5 (10%)
Thrombosis 1 (2%)
Thymus (46) (45) (45) (42)
Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (41) (42) (42) (40)
Galactocele 1 (2%) 2 (5%) 1 (2%) 3 (8%)
Skin (50) (49) (50) (50)
Hyperkeratosis 1 (2%) 2 (4%)
Inflammation, Chronic Active 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Callus 1 (2%)
Fibrous Osteodystrophy 8 (16%) 9 (18%) 10 (20%) 11 (22%)
Hyperostosis 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Degeneration 1 (2%)
Gliosis 1 (2%)
Hemorrhage 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (50)
Hyperplasia 3 (6%) 8 (16%) 4 (8%) 11 (22%)
Inflammation, Chronic Active 4 (8%) 3 (6%) 4 (8%) 12 (24%)
Metaplasia, Squamous 1 (2%) 2 (4%) 2 (4%) 10 (20%)
Mineralization 1 (2%) 3 (6%) 1 (2%)
Epiglottis, Hyperplasia 6 (12%) 4 (8%) 5 (10%)
Epiglottis, Inflammation, Chronic Active 1 (2%) 2 (4%) 4 (8%)
Epiglottis, Metaplasia, Squamous 3 (6%)
Epiglottis, Mineralization 1 (2%)
Lung (50) (49) (50) (50)
Cyst, Squamous 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Atypical 2 (4%) 5 (10%) 18 (36%)
Inflammation, Chronic Active 3 (6%) 43 (88%) 50 (100%) 50 (100%)
Metaplasia, Squamous 1 (2%) 2 (4%)
Mineralization 4 (8%) 5 (10%) 3 (6%) 7 (14%)
Proteinosis 22 (45%) 50 (100%) 49 (98%)
Thrombosis 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 12 (24%) 16 (33%) 21 (42%) 21 (42%)
Alveolar Epithelium, Metaplasia 2 (4%) 34 (68%) 41 (82%)
Artery, Mediastinum, Mineralization 4 (8%) 3 (6%) 2 (4%) 5 (10%)
Nose (50) (48) (49) (50)
Inflammation, Suppurative 10 (20%) 5 (10%) 10 (20%) 8 (16%)
Polyp Inflammatory 1 (2%)
Thrombosis 4 (8%) 8 (17%) 8 (16%) 7 (14%)
Olfactory Epithelium, Atrophy 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Olfactory Epithelium, Degeneration, Hyaline 18 (36%) 26 (54%) 32 (65%) 25 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05180-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC GALLIUM ARSENIDE Date: 02/17/99
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:09:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 0.1 1.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Olfactory Epithelium, Metaplasia, Respiratory 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Respiratory Epithelium, Degeneration, Hyaline 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Turbinate, Necrosis 1 (2%)
Trachea (49) (50) (49) (50)
Mineralization 2 (4%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (2) (1) (1)
Cataract 4 (100%) 1 (50%) 1 (100%)
Degeneration 1 (100%)
Retina, Atrophy 4 (100%) 1 (50%) 1 (100%)
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URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cyst 3 (6%) 3 (6%) 1 (2%) 1 (2%)
Infarct 2 (4%) 1 (2%) 2 (4%)
Mineralization 5 (10%) 4 (8%) 5 (10%) 4 (8%)
Nephropathy 48 (98%) 49 (98%) 50 (100%) 50 (100%)
Renal Tubule, Hyperplasia 2 (4%) 1 (2%) 4 (8%) 2 (4%)
Urinary Bladder (48) (50) (50) (50)
Hemorrhage 2 (4%)
Inflammation, Chronic Active 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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