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TDMS Study 05186-04 Pathology Tables

NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98
Route: GAVAGE                                                                                                     Time: 14:04:04




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  78-44-4

       Lock Date:  04/13/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1



NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Pancreas                                |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                            A                                             |            |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Heart                                   |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                            M                                             |            |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                            M                                             |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Ovary                                   |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Uterus                                  |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                            A                                             |            |

                                            __________________________________________________________________________|____________|
   Spleen                                  |                            +                                             |   1        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 7|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Thymus                                  |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Skin                                    |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Nose                                    |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                            +                                             |   1        |

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    

 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 1| 9| 9| 9| 9| 0| 9| 9|                                            |            |
                                           | 2| 2| 4| 2| 2| 2| 2| 7| 2| 2|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1200                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       A              +                                                   |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       A              +                                                   |   1        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Pancreas                                |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       M              +                                                   |   1        |

                                            __________________________________________________________________________|____________|
   Heart                                   |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Ovary                                   |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Uterus                                  |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Spleen                                  |       +              +                                                   |   2        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 1| 9| 9| 9| 9| 0| 9| 9|                                            |            |
                                           | 2| 2| 4| 2| 2| 2| 2| 7| 2| 2|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1200                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Thymus                                  |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Skin                                    |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Nose                                    |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |       +              +                                                   |   2        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  |       +              +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +              +                                                   |   2        |

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 0| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1600                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |          A                                                               |            |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Pancreas                                |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Heart                                   |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          M                                                               |            |

                                            __________________________________________________________________________|____________|
   Ovary                                   |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Uterus                                  |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Spleen                                  |          +                                                               |   1        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 0| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1600                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Thymus                                  |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Skin                                    |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Nose                                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +                                                               |   1        |

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Pancreas                                |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Heart                                   |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                            M                                             |            |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Prostate                                |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Testes                                  |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                            +                                             |   1        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Spleen                                  |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Thymus                                  |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                            M                                             |            |

                                            __________________________________________________________________________|____________|
   Skin                                    |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Nose                                    |                            +                                             |   1        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |                            +                                             |   1        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                            +                                             |   1        |

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 0| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Pancreas                                |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Heart                                   |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M                                                               |            |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Prostate                                |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Testes                                  |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +                                                               |   1        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 0| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 6| 2| 2| 2| 2| 2| 2|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Spleen                                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Thymus                                  |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M                                                               |            |

                                            __________________________________________________________________________|____________|
   Skin                                    |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Nose                                    |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  |          +                                                               |   1        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +                                                               |   1        |

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1200                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    

 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 1| 9| 0| 1|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 3| 2| 2| 3|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1600                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Heart                                   |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                   M     +  M                                             |   1        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Prostate                                |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Testes                                  |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                   +     +  +                                             |   3        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
NTP Experiment-Test: 05186-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: SUBCHRON 90-DAY                                    CARISOPRODOL                                       Date: 04/06/98  
Route: GAVAGE                                                                                                     Time: 14:04:04  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 1| 9| 0| 1|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 3| 2| 2| 3|                                            |            |

 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1600                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Spleen                                  |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Thymus                                  |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                   M     M  M                                             |            |

                                            __________________________________________________________________________|____________|
   Skin                                    |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Nose                                    |                   +     +  +                                             |   3        |

                                            __________________________________________________________________________|____________|
   Trachea                                 |                   +     +  +                                             |   3        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                   +     +  +                                             |   3        |

 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------