TDMS Study 05210-04 Pathology Tables
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
CORE STUDY
Facility: I. I. T. Research Institute
Chemical CAS #: 100-41-4
Lock Date: 10/02/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 5 6 1 4
Natural Death 9 6 8 9
Accidently Killed 1 1
Survivors
Terminal Sacrifice 34 38 40 37
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (44) (44) (44) (46)
Infiltration Cellular 1 (2%)
Intestine Small, Duodenum (45) (48) (47) (46)
Ulcer 1 (2%)
Intestine Small, Jejunum (46) (46) (46) (45)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Ileum (47) (47) (47) (46)
Peyer's Patch, Hyperplasia 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 3 (6%) 4 (8%) 3 (6%)
Clear Cell Focus 1 (2%) 1 (2%)
Eosinophilic Focus 5 (10%) 7 (14%) 6 (12%) 22 (44%)
Hemorrhage 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%)
Infiltration Cellular 3 (6%)
Inflammation 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%)
Necrosis 1 (2%) 4 (8%) 3 (6%) 4 (8%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Hepatocyte, Hypertrophy 1 (2%)
Hepatocyte, Necrosis 1 (2%)
Hepatocyte, Syncytial Alteration 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 2 (4%) 2 (4%) 1 (2%)
Serosa, Inflammation 1 (2%)
Mesentery (2)
Fat, Necrosis 2 (100%)
Pancreas (50) (50) (50) (49)
Angiectasis 1 (2%)
Atrophy 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cyst 1 (2%)
Degeneration 1 (2%)
Fibrosis 1 (2%)
Infiltration Cellular 7 (14%) 12 (24%) 12 (24%) 10 (20%)
Necrosis 1 (2%)
Acinus, Hyperplasia 1 (2%)
Duct, Cyst 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Infiltration Cellular 30 (60%) 32 (64%) 33 (66%) 30 (60%)
Stomach, Forestomach (50) (49) (48) (50)
Hyperplasia 2 (4%)
Ulcer 1 (2%)
Epithelium, Cyst 2 (4%)
Epithelium, Hyperplasia 2 (4%) 1 (2%)
Stomach, Glandular (50) (49) (48) (50)
Infiltration Cellular 1 (2%)
Glands, Cyst 1 (2%)
Glands, Hyperplasia 1 (2%)
Serosa, Infiltration Cellular 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50) (50)
Cardiomyopathy 10 (20%) 23 (47%) 23 (46%) 15 (30%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (47) (50) (50) (49)
Accessory Adrenal Cortical Nodule 2 (4%) 1 (2%)
Degeneration 12 (26%) 4 (8%) 4 (8%) 5 (10%)
Hemorrhage 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Hyperplasia 3 (6%) 5 (10%) 3 (6%) 3 (6%)
Infiltration Cellular 2 (4%)
Inflammation 3 (6%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Capsule, Hyperplasia 46 (98%) 49 (98%) 48 (96%) 46 (94%)
Adrenal Medulla (47) (50) (50) (49)
Hemorrhage 1 (2%)
Hyperplasia 2 (4%) 3 (6%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 2 (4%) 2 (4%)
Infiltration Cellular 1 (2%) 2 (4%)
Parathyroid Gland (26) (24) (34) (27)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Infiltration Cellular 1 (4%)
Pituitary Gland (48) (49) (47) (49)
Pars Distalis, Angiectasis 4 (9%) 2 (4%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hemorrhage 3 (6%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 10 (21%) 12 (24%) 23 (49%) 22 (45%)
Pars Distalis, Necrosis 1 (2%)
Pars Intermedia, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Infiltration Cellular 1 (2%)
Follicle, Degeneration 1 (2%)
Follicular Cell, Hyperplasia 18 (36%) 23 (46%) 25 (50%) 35 (70%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (6) (4) (1)
Fat, Necrosis 4 (67%) 3 (75%) 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (41) (47) (48) (48)
Atrophy 1 (2%)
Degeneration 1 (2%)
Ovary (49) (50) (49) (49)
Angiectasis 2 (4%) 1 (2%)
Atrophy 1 (2%) 1 (2%)
Cyst 8 (16%) 8 (16%) 10 (20%) 10 (20%)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular 2 (4%)
Mineralization 1 (2%)
Uterus (50) (50) (50) (50)
Angiectasis 1 (2%)
Degeneration 2 (4%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular 1 (2%)
Inflammation 3 (6%) 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia 44 (88%) 46 (92%) 47 (94%) 46 (92%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (50) (50) (50)
Hematopoietic Cell Proliferation 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation 1 (2%)
Myelofibrosis 2 (4%)
Pigmentation, Hemosiderin 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%) 1 (2%)
Lymph Node (3) (7) (2) (5)
Iliac, Hyperplasia 1 (14%)
Inguinal, Hyperplasia 1 (20%)
Inguinal, Pigmentation, Hemosiderin 1 (33%)
Lumbar, Hyperplasia 1 (33%) 2 (29%)
Pancreatic, Hyperplasia 1 (20%)
Renal, Hyperplasia 1 (33%)
Renal, Necrosis 1 (14%)
Lymph Node, Bronchial (32) (40) (29) (38)
Hyperplasia 2 (5%) 1 (3%) 2 (5%)
Lymph Node, Mandibular (47) (48) (47) (44)
Hyperplasia 1 (2%) 2 (4%) 2 (5%)
Lymph Node, Mesenteric (48) (48) (46) (44)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 4 (8%) 3 (6%) 3 (7%) 2 (5%)
Inflammation 2 (4%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Necrosis 1 (2%)
Lymph Node, Mediastinal (34) (42) (41) (31)
Hyperplasia 3 (9%) 4 (10%) 2 (6%)
Hyperplasia, Histiocytic 1 (3%)
Spleen (50) (50) (50) (49)
Hematopoietic Cell Proliferation 4 (8%) 7 (14%) 2 (4%) 1 (2%)
Hyperplasia 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 4 (8%) 1 (2%) 1 (2%) 4 (8%)
Lymphoid Follicle, Hyperplasia 9 (18%) 5 (10%) 1 (2%) 3 (6%)
Thymus (42) (44) (45) (46)
Atrophy 5 (12%) 5 (11%) 5 (11%) 6 (13%)
Thymocyte, Hyperplasia 1 (2%) 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (48) (49)
Galactocele 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Skin (50) (50) (49) (50)
Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation 1 (2%) 2 (4%)
Necrosis 1 (2%)
Ulcer 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Arthrosis 1 (2%)
Fracture 2 (4%)
Periosteum, Femur, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 2 (4%)
Mineralization 19 (38%) 17 (34%) 26 (52%) 25 (50%)
Cerebellum, Atrophy 1 (2%)
Cerebrum, Atrophy 2 (4%) 1 (2%) 2 (4%)
Cerebrum, Gliosis 1 (2%)
Cerebrum, Hemorrhage 1 (2%)
Medulla, Atrophy 1 (2%)
Medulla, Hemorrhage 1 (2%)
Meninges, Infiltration Cellular 2 (4%) 1 (2%)
Spinal Cord (1)
Hemorrhage 1 (100%)
Myelin, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (49) (47) (48)
Degeneration 1 (2%)
Infiltration Cellular 1 (2%) 1 (2%) 1 (2%)
Glands, Degeneration 2 (4%) 2 (4%) 2 (4%)
Glands, Inflammation 1 (2%)
Lung (50) (50) (49) (50)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 3 (6%) 1 (2%)
Alveolar Epithelium, Metaplasia 1 (2%)
Vein, Thrombosis 1 (2%)
Nose (49) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation 3 (6%) 2 (4%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasolacrimal Duct, Inflammation 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Casts Protein 1 (2%) 1 (2%)
Infiltration Cellular 1 (2%)
Mineralization 1 (2%)
Nephropathy 13 (26%) 7 (14%) 9 (18%) 21 (42%)
Cortex, Cyst 1 (2%) 1 (2%)
Cortex, Metaplasia, Osseous 1 (2%)
Urinary Bladder (47) (48) (47) (49)
Hemorrhage 1 (2%)
Infiltration Cellular 4 (9%) 4 (8%) 4 (9%) 5 (10%)
Inflammation 1 (2%)
Ulcer 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 6 2 5 6
Natural Death 15 12 13 13
Accidently Killed 1 1
Survivors
Terminal Sacrifice 28 36 31 30
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (33) (39) (37) (38)
Epithelium, Hyperplasia 1 (3%)
Intestine Small, Duodenum (45) (48) (43) (45)
Parasite Metazoan 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Intestine Small, Jejunum (44) (46) (44) (43)
Cyst 1 (2%)
Epithelium, Dysplasia 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%) 1 (2%)
Intestine Small, Ileum (42) (46) (44) (41)
Peyer's Patch, Hyperplasia 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 3 (6%) 3 (6%) 5 (10%) 4 (8%)
Clear Cell Focus 5 (10%) 4 (8%) 7 (14%) 3 (6%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 6 (12%) 8 (16%) 8 (16%) 12 (24%)
Eosinophilic Focus, Multiple 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Hemorrhage 2 (4%)
Hepatodiaphragmatic Nodule 1 (2%)
Inflammation, Chronic 2 (4%)
Mineralization 1 (2%)
Mixed Cell Focus 3 (6%) 2 (4%) 1 (2%)
Necrosis 7 (14%) 8 (16%) 10 (20%) 10 (20%)
Thrombosis 1 (2%)
Hepatocyte, Hyperplasia 1 (2%)
Hepatocyte, Hypertrophy 1 (2%) 17 (34%)
Hepatocyte, Necrosis 1 (2%) 1 (2%) 3 (6%) 10 (20%)
Hepatocyte, Syncytial Alteration 5 (10%) 8 (16%) 23 (46%)
Hepatocyte, Vacuolization Cytoplasmic 4 (8%) 2 (4%) 4 (8%) 3 (6%)
Vein, Thrombosis 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (49) (50) (48) (48)
Inflammation 1 (2%)
Acinus, Hyperplasia 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
Duct, Degeneration 1 (2%)
Duct, Fibrosis 1 (2%)
Salivary Glands (50) (50) (50) (50)
Infiltration Cellular 21 (42%) 26 (52%) 17 (34%) 20 (40%)
Stomach, Forestomach (48) (50) (50) (47)
Cyst 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Serosa, Inflammation 1 (2%)
Stomach, Glandular (48) (50) (50) (47)
Infiltration Cellular 1 (2%)
Inflammation 1 (2%)
Metaplasia 1 (2%)
Mineralization 2 (4%)
Tongue (1)
Inflammation, Granulomatous 1 (100%)
Tooth (1) (1)
Developmental Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 18 (36%) 36 (72%) 29 (58%) 25 (50%)
Inflammation 2 (4%)
Myocardium, Mineralization 1 (2%)
Pericardium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (47) (47) (48) (48)
Accessory Adrenal Cortical Nodule 1 (2%)
Degeneration 1 (2%) 2 (4%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 13 (28%) 8 (17%) 9 (19%) 4 (8%)
Vacuolization Cytoplasmic 1 (2%)
Capsule, Hyperplasia 19 (40%) 22 (47%) 20 (42%) 17 (35%)
Adrenal Medulla (47) (46) (48) (48)
Degeneration 1 (2%)
Hyperplasia 2 (4%)
Mineralization 1 (2%)
Islets, Pancreatic (49) (50) (48) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Degeneration 1 (2%)
Hyperplasia 5 (10%) 5 (10%) 8 (17%) 1 (2%)
Pituitary Gland (44) (45) (45) (47)
Pars Distalis, Cyst 1 (2%) 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 21 (42%) 21 (42%) 29 (58%) 32 (64%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (3) (1) (2)
Cyst 1 (33%)
Fat, Necrosis 2 (67%) 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50) (50) (50)
Atypia Cellular 1 (2%) 1 (2%)
Cyst 1 (2%)
Degeneration 2 (4%)
Fibrosis 1 (2%)
Granuloma Sperm 2 (4%) 1 (2%) 1 (2%)
Infiltration Cellular 1 (2%)
Inflammation 1 (2%)
Mineralization 1 (2%)
Bilateral, Fibrosis 1 (2%)
Penis (1) (2)
Concretion 1 (50%)
Inflammation 1 (100%) 1 (50%)
Preputial Gland (48) (49) (48) (49)
Cyst 1 (2%)
Degeneration 3 (6%) 3 (6%) 9 (19%) 6 (12%)
Degeneration, Cystic 1 (2%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Infiltration Cellular 1 (2%) 5 (10%) 6 (13%) 4 (8%)
Inflammation 6 (13%) 11 (22%) 11 (23%) 13 (27%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Prostate (46) (49) (50) (50)
Atrophy 1 (2%)
Infiltration Cellular 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Inflammation 6 (13%) 5 (10%) 5 (10%) 6 (12%)
Seminal Vesicle (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Atrophy 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Degeneration 19 (39%) 26 (52%) 16 (32%) 22 (44%)
Inflammation 1 (2%) 1 (2%) 2 (4%)
Testes (49) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Mineralization 1 (2%)
Germinal Epithelium, Atrophy 1 (2%)
Germinal Epithelium, Degeneration 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Tunic, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%)
Pigmentation, Hemosiderin 2 (4%) 2 (4%) 1 (2%)
Myeloid Cell, Hyperplasia 2 (4%) 4 (8%) 9 (18%) 4 (8%)
Lymph Node (4) (7) (11) (3)
Inguinal, Hyperplasia 1 (25%) 1 (14%)
Inguinal, Pigmentation 1 (14%)
Lumbar, Congestion 1 (9%)
Lumbar, Hyperplasia 1 (25%) 4 (57%) 4 (36%) 2 (67%)
Lumbar, Inflammation 2 (18%)
Lumbar, Pigmentation 1 (14%) 1 (33%)
Renal, Congestion 2 (18%)
Renal, Hyperplasia 3 (43%) 3 (27%)
Lymph Node, Mandibular (43) (45) (46) (44)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Lymph Node, Mesenteric (45) (46) (47) (48)
Atrophy 1 (2%)
Congestion 1 (2%) 3 (7%) 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 3 (7%)
Hyperplasia 1 (2%) 2 (4%) 3 (6%)
Inflammation 2 (4%) 1 (2%)
Lymph Node, Mediastinal (24) (25) (27) (25)
Hyperplasia 1 (4%)
Spleen (50) (50) (49) (49)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 4 (8%) 2 (4%)
Lymphoid Follicle, Atrophy 2 (4%) 1 (2%) 1 (2%)
Lymphoid Follicle, Hyperplasia 2 (4%)
Thymus (37) (37) (39) (34)
Atrophy 18 (49%) 11 (30%) 20 (51%) 11 (32%)
Cyst 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (3) (2) (3) (3)
Atrophy 1 (33%) 1 (50%) 2 (67%) 1 (33%)
Skin (50) (50) (50) (50)
Cyst 1 (2%)
Infiltration Cellular, Melanocyte 1 (2%)
Inflammation 3 (6%) 6 (12%) 4 (8%) 3 (6%)
Necrosis 1 (2%)
Ulcer 1 (2%) 5 (10%) 2 (4%) 3 (6%)
Hair Follicle, Atrophy 1 (2%)
Prepuce, Degeneration 1 (2%)
Prepuce, Hyperplasia, Lymphoid 1 (2%)
Prepuce, Inflammation 2 (4%)
Prepuce, Ulcer 2 (4%)
Sebaceous Gland, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (50) (50)
Vertebra, Degeneration 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Mineralization 21 (42%) 18 (36%) 19 (38%) 19 (38%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (48) (49) (46) (49)
Foreign Body 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular 1 (2%) 4 (8%) 4 (9%)
Glands, Degeneration 1 (2%) 3 (7%) 2 (4%)
Glands, Inflammation 1 (2%) 2 (4%)
Lung (50) (50) (50) (50)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 2 (4%)
Inflammation 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 5 (10%) 2 (4%) 4 (8%)
Alveolar Epithelium, Metaplasia 1 (2%) 2 (4%) 6 (12%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (50) (50) (50) (50)
Edema 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation 7 (14%) 3 (6%) 4 (8%) 1 (2%)
Polyp, Inflammatory 2 (4%) 1 (2%) 2 (4%)
Nasolacrimal Duct, Inflammation 3 (6%) 1 (2%) 1 (2%)
Respiratory Epithelium, Inflammation 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Trachea (50) (50) (50) (50)
Glands, Cyst 1 (2%)
Glands, Hemorrhage 1 (2%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (50) (50) (50) (50)
Degeneration 1 (2%)
Infarct 1 (2%)
Inflammation 3 (6%) 5 (10%) 5 (10%) 3 (6%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%)
Nephropathy 34 (68%) 38 (76%) 40 (80%) 36 (72%)
Pigmentation, Bile 1 (2%)
Cortex, Cyst 1 (2%) 8 (16%) 5 (10%) 4 (8%)
Papilla, Inflammation 3 (6%) 4 (8%) 3 (6%) 2 (4%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 1 (2%) 2 (4%) 1 (2%) 3 (6%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Ureter (2) (1)
Degeneration 1 (50%) 1 (100%)
Inflammation 1 (50%)
Urinary Bladder (48) (50) (49) (49)
Calculus Micro Observation Only 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Infiltration Cellular 1 (2%) 1 (2%)
Inflammation 7 (15%) 12 (24%) 6 (12%) 8 (16%)
Ulcer 1 (2%)
Muscularis, Inflammation 1 (2%)
Muscularis, Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05210-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 04/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:53:41
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B6C3F1 MICE MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Serosa, Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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