TDMS Study 88034-07 Pathology Tables
NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 02/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5| DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6| | 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Colon | + | Mineralization | 3 | __________________________________________________________________________| Intestine Large, Rectum | + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + +| Degeneration, Cystic | 2 2 | Hepatodiaphragmatic Nodule | X X | Hyperplasia, Focal | 4 | Infiltration Cellular, Mixed Cell | 1 | Necrosis | 3 | Vacuolization Cytoplasmic, Focal | 2 | Vacuolization Cytoplasmic | | Bile Duct, Hyperplasia | 3 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 3 3 3 | __________________________________________________________________________| Pancreas | + | __________________________________________________________________________| Stomach, Forestomach | + | Mineralization | 3 | __________________________________________________________________________| Stomach, Glandular | + | Mineralization | 3 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 3 | __________________________________________________________________________| Heart | + | Mineralization | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + | __________________________________________________________________________| Adrenal Medulla | + + | Hemorrhage | 4 | __________________________________________________________________________| Islets, Pancreatic | + | __________________________________________________________________________| Parathyroid Gland | + | Hyperplasia | 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5| DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6| | 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + | Granuloma Sperm | 3 | __________________________________________________________________________| Preputial Gland | + + + | Inflammation, Chronic Active | 2 3 | Inflammation, Suppurative | 4 | __________________________________________________________________________| Testes | + + + + + + + + + | Atrophy | 4 3 | Interstitial Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + | Infiltration Cellular, Plasma Cell | | Iliac, Infiltration Cellular, Plasma | | Cell | 2 | Pancreatic, Inflammation, | | Granulomatous | 2 | Renal, Hemorrhage | | Renal, Infiltration Cellular, Plasma | | Cell | 3 2 | Renal, Inflammation, Granulomatous | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + M M + M M + + + + + + + + + M + + + + M| Hemorrhage | 2 | Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + | __________________________________________________________________________| Lymph Node, Mesenteric | + + | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + + M| Hemorrhage | 4 | Infiltration Cellular, Plasma Cell | 2 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Congestion | 1 | Fibrosis | 2 2 2 3 2 2| Hematopoietic Cell Proliferation | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + | Galactocele | 3 | Hyperplasia | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 3| Subcutaneous Tissue, Inflammation, | | Chronic | | Subcutaneous Tissue, Skin, Site of | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 6| 5| 5| 6| 5| 6| 7| 6| 7| 5| 6| 6| 7| 6| 5| 6| 7| 6| 5| 4| 5| DAY ON TEST | 4| 0| 0| 3| 3| 4| 8| 1| 6| 9| 3| 3| 3| 6| 0| 2| 3| 6| 5| 9| 0| 5| 5| 8| 6| | 3| 0| 0| 6| 8| 0| 9| 1| 2| 8| 6| 3| 6| 4| 4| 0| 6| 9| 6| 7| 4| 5| 6| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Application, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X| Inflammation, Suppurative | 1 | Metaplasia, Squamous | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Fibrosis, Focal | 2 3 | Hemorrhage | 2 1 1 | Mineralization | 4 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 3 | Interstitium, Inflammation, Chronic, | | Diffuse | 3 2 | Perivascular, Inflammation, Chronic | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 | Goblet Cell, Lateral Wall, | | Hyperplasia | 1 1 1 | Lateral Wall, Hyperplasia | 2 1 1 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1| Olfactory Epithelium, Metaplasia | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 4 | Hemorrhage | 4 | Ciliary Body, Retina, Degeneration | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + +| Cyst | | Hydronephrosis | | Nephropathy | 4 3 2 4 3 3 3 3 4 4 4 3 3| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | | DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | | | 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Colon | | 1 | Mineralization | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Rectum | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + | 26 | Degeneration, Cystic | 2 2 2 | 5 2.0| Hepatodiaphragmatic Nodule | X X | 4 | Hyperplasia, Focal | | 1 4.0| Infiltration Cellular, Mixed Cell | | 1 1.0| Necrosis | | 1 3.0| Vacuolization Cytoplasmic, Focal | | 1 2.0| Vacuolization Cytoplasmic | 2 | 1 2.0| Bile Duct, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Fat, Necrosis | 3 2 3 3 | 7 2.9| __________________________________________________________________________|____________| Pancreas | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | | 1 | Mineralization | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | | 1 | Mineralization | | 1 3.0| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | Aorta, Mineralization | 3 | 2 3.0| __________________________________________________________________________|____________| Heart | | 1 | Mineralization | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + | 4 | __________________________________________________________________________|____________| Adrenal Medulla | + + | 4 | Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + | 2 | Hyperplasia | 4 | 2 3.5| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + M + + + + + + + + | 34 | Pars Distalis, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | | DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | | | 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + | 32 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0| __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | | 1 | Granuloma Sperm | | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + | 8 | Inflammation, Chronic Active | 2 3 3 2 | 6 2.5| Inflammation, Suppurative | | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + | 20 | Atrophy | 3 3 3 3 | 6 3.2| Interstitial Cell, Hyperplasia | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + | 9 | Infiltration Cellular, Plasma Cell | 3 | 1 3.0| Iliac, Infiltration Cellular, Plasma | | | Cell | | 1 2.0| Pancreatic, Inflammation, | | | Granulomatous | | 1 2.0| Renal, Hemorrhage | 2 | 1 2.0| Renal, Infiltration Cellular, Plasma | | | Cell | 2 3 | 4 2.5| Renal, Inflammation, Granulomatous | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + M + + + + + M + + M + M + + + | 38 | Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | 2 | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + I + + + I + + + + + + + + M + + + + M + | 42 | Hemorrhage | 2 | 2 3.0| Infiltration Cellular, Plasma Cell | 2 | 2 2.0| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + | 35 | Accessory Spleen | | 1 | Congestion | 2 | 2 1.5| Fibrosis | 2 2 2 2 2 2 | 12 2.1| Hematopoietic Cell Proliferation | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | | DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | | | 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + | 4 | Galactocele | 3 | 2 3.0| Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + | 47 | Inflammation, Chronic | | 1 3.0| Subcutaneous Tissue, Inflammation, | | | Chronic | 1 | 1 1.0| Subcutaneous Tissue, Skin, Site of | | | Application, Inflammation, | | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 46 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Foreign Body | X X | 3 | Inflammation, Suppurative | | 1 1.0| Metaplasia, Squamous | | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Congestion | 2 2 | 2 2.0| Fibrosis, Focal | | 2 2.5| Hemorrhage | | 3 1.3| Mineralization | 3 1 | 4 2.3| Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 3.0| Interstitium, Inflammation, Chronic, | | | Diffuse | 2 | 3 2.3| Perivascular, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + M + | 47 | Inflammation, Suppurative | | 1 3.0| Goblet Cell, Lateral Wall, | | | Hyperplasia | | 3 1.0| Lateral Wall, Hyperplasia | 1 | 5 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 6| 4| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 6| 3| 7| 7| 6| 5| 6| 6| 6| | | DAY ON TEST | 6| 6| 7| 0| 3| 8| 6| 3| 0| 1| 8| 4| 3| 1| 1| 2| 2| 3| 9| 7| 2| 7| 1| | | | 4| 6| 2| 6| 6| 1| 3| 6| 9| 7| 5| 1| 6| 5| 1| 7| 4| 6| 2| 6| 0| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Olfactory Epithelium, Degeneration, | | | Hyaline | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 2 1 2 2 1 | 47 1.1| Olfactory Epithelium, Metaplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | Cataract | 2 4 | 3 3.3| Hemorrhage | | 1 4.0| Ciliary Body, Retina, Degeneration | 4 | 2 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + | 27 | Cyst | 3 | 1 3.0| Hydronephrosis | 3 | 1 3.0| Nephropathy | 4 4 4 3 2 4 4 3 3 4 3 3 3 3 | 27 3.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6| DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8| | 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Cecum | + | __________________________________________________________________________| Intestine Small, Ileum | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + +| Angiectasis | | Degeneration, Cystic | 2 | Hepatodiaphragmatic Nodule | X X| Hyperplasia, Focal | 4 | Vacuolization Cytoplasmic, Focal | | Vacuolization Cytoplasmic | 3 | Bile Duct, Hyperplasia | 3 | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + + + + | Fat, Necrosis | 3 3 3 3 3 3 | __________________________________________________________________________| Oral Mucosa | + + | Pharyngeal, Hyperplasia, Squamous | 3 | __________________________________________________________________________| Stomach, Glandular | | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + | Necrosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | | __________________________________________________________________________| Islets, Pancreatic | + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + + | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Preputial Gland | + + + + | Inflammation, Chronic Active | 4 2 | __________________________________________________________________________| Prostate | + | Inflammation, Suppurative | 3 | __________________________________________________________________________| Testes | + + + + + | Atrophy | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6| DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8| | 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Bone Marrow | | __________________________________________________________________________| Lymph Node | + + + + | Renal, Infiltration Cellular, Plasma | | Cell | 2 | Renal, Inflammation, Granulomatous | 2 2 | __________________________________________________________________________| Lymph Node, Bronchial | + M M M + M M M + + M + + + + + + + M + + M + + +| Hemorrhage | 2 | Necrosis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + | Inflammation, Granulomatous | 2 | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + M + + + + + + + + + + + + M M + + + + +| Hemorrhage | | Infiltration Cellular, Plasma Cell | | Necrosis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + | Fibrosis | 2 3 3 2 3 2 | Hematopoietic Cell Proliferation | | Hemorrhage | 3 4 | Necrosis | 4 | __________________________________________________________________________| Thymus | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + | Galactocele | 3 3 4 | Hyperplasia | | Inflammation, Chronic | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Chronic | 3 | Ulcer | 3 3 | Prepuce, Inflammation, Suppurative | | Subcutaneous Tissue, Skin, Site of | | Application, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 4| 4| 6| 7| 5| 4| 5| 7| 6| 6| 4| 7| 6| 6| 7| 5| 5| 5| 6| 6| 6| 6| 5| 5| 6| DAY ON TEST | 1| 7| 1| 3| 8| 6| 4| 1| 8| 2| 6| 3| 6| 4| 0| 8| 0| 1| 3| 5| 2| 3| 8| 5| 8| | 7| 8| 2| 6| 2| 6| 4| 0| 3| 0| 0| 6| 2| 1| 4| 9| 1| 8| 3| 5| 5| 5| 9| 7| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .1MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Foreign Body | X X | Inflammation, Suppurative | 1 2 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Fibrosis, Focal | 2 | Hemorrhage | 3 2 | Alveolar Epithelium, Hyperplasia, | | Atypical | 3 2 2 2 1 1 | Alveolus, Infiltration Cellular, | | Focal, Histiocyte | 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 | Interstitium, Inflammation, Chronic, | | Diffuse | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 | Inflammation, Suppurative | 1 | Lateral Wall, Hyperplasia | 1 2 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1| Olfactory Epithelium, Metaplasia | 1 1 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + | Nephropathy | 4 3 3 3 3 2 3 2 4 4 | __________________________________________________________________________| Urinary Bladder | + + | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | | DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | | | 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Cecum | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + | 27 | Angiectasis | 2 | 1 2.0| Degeneration, Cystic | 2 2 | 3 2.0| Hepatodiaphragmatic Nodule | | 2 | Hyperplasia, Focal | | 1 4.0| Vacuolization Cytoplasmic, Focal | 2 | 1 2.0| Vacuolization Cytoplasmic | 2 2 3 | 4 2.5| Bile Duct, Hyperplasia | 2 | 2 2.5| Centrilobular, Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + + + | 10 | Fat, Necrosis | 2 3 3 | 9 2.9| __________________________________________________________________________|____________| Oral Mucosa | + + | 4 | Pharyngeal, Hyperplasia, Squamous | 3 | 2 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + | 1 | __________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 1 | Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + | 5 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + | 35 | Pars Distalis, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Thyroid Gland | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + | 24 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 | 24 1.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + + | 4 | Inflammation, Chronic Active | 2 | 2 2.5| __________________________________________________________________________|____________| Preputial Gland | + + | 6 | Inflammation, Chronic Active | | 2 3.0| __________________________________________________________________________|____________| Prostate | + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | | DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | | | 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Suppurative | 4 | 2 3.5| __________________________________________________________________________|____________| Testes | + + + + | 9 | Atrophy | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + | 1 | __________________________________________________________________________|____________| Lymph Node | + + + | 7 | Renal, Infiltration Cellular, Plasma | | | Cell | | 1 2.0| Renal, Inflammation, Granulomatous | | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M M + + + M + + + M + M M + + + + + | 32 | Hemorrhage | | 1 2.0| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 8 | Inflammation, Granulomatous | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + M I M + + M + M + + + + + + + M I | 37 | Hemorrhage | 3 | 1 3.0| Infiltration Cellular, Plasma Cell | 2 | 1 2.0| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 32 | Fibrosis | 2 2 2 2 2 3 3 3 | 14 2.4| Hematopoietic Cell Proliferation | 2 | 1 2.0| Hemorrhage | | 2 3.5| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Thymus | + | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + | 5 | Galactocele | | 3 3.3| Hyperplasia | 3 3 | 2 3.0| Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Hyperkeratosis | 3 3 | 2 3.0| Inflammation, Chronic | | 1 3.0| Ulcer | | 2 3.0| Prepuce, Inflammation, Suppurative | 3 | 1 3.0| Subcutaneous Tissue, Skin, Site of | | | Application, Inflammation, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | | DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | | | 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 47 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Foreign Body | | 2 | Inflammation, Suppurative | 1 1 | 4 1.3| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Congestion | 1 1 | 2 1.0| Fibrosis, Focal | | 1 2.0| Hemorrhage | | 2 2.5| Alveolar Epithelium, Hyperplasia, | | | Atypical | 1 2 2 2 | 10 1.8| Alveolus, Infiltration Cellular, | | | Focal, Histiocyte | | 1 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 2.0| Interstitium, Inflammation, Chronic, | | | Diffuse | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Inflammation, Chronic | | 1 1.0| Inflammation, Suppurative | | 1 1.0| Lateral Wall, Hyperplasia | 1 | 4 1.5| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 2 2 1 2 2 1 1 | 48 1.2| Olfactory Epithelium, Metaplasia | | 4 1.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + | 22 | Nephropathy | 3 3 3 3 4 2 4 3 3 3 3 4 | 22 3.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 6| 4| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 6| 6| 6| 5| 7| 5| | | DAY ON TEST | 7| 3| 1| 5| 9| 4| 0| 1| 1| 0| 6| 3| 1| 3| 3| 7| 2| 3| 7| 4| 5| 3| 5| | | | 9| 6| 5| 5| 7| 4| 4| 7| 6| 1| 3| 6| 3| 9| 6| 3| 9| 5| 1| 1| 1| 6| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .1MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | | 2 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6| DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0| | 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Colon | + | Lymphoid Tissue, Hyperplasia, | | Lymphoid | 2 | __________________________________________________________________________| Intestine Large, Cecum | | Ulcer | | __________________________________________________________________________| Intestine Small, Jejunum | + | __________________________________________________________________________| Intestine Small, Ileum | + | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 3 2 2 | Hepatodiaphragmatic Nodule | | Hyperplasia, Focal | 4 3 4| Necrosis, Focal | 2 2 | Vacuolization Cytoplasmic | 2 2 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 1 3 3 3 | __________________________________________________________________________| Pancreas | | Artery, Inflammation, Chronic | | __________________________________________________________________________| Stomach, Forestomach | +| __________________________________________________________________________| Stomach, Glandular | + +| Necrosis | 2| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | | __________________________________________________________________________| Islets, Pancreatic | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + + + + +| Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + + + +| Inflammation, Chronic Active | 2 2| __________________________________________________________________________| Preputial Gland | + + + + + + | Inflammation, Chronic Active | 2 4 2 2 | __________________________________________________________________________| Seminal Vesicle | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6| DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0| | 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Testes | + + + + + + +| Atrophy | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + +| Pancreatic, Inflammation, | | Granulomatous | 2 | Renal, Hemorrhage | 3 3| Renal, Infiltration Cellular, Plasma | | Cell | 1 2 2 | Renal, Inflammation, Granulomatous | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M M M M M M + + M + I + + + + M M M M M +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + +| Infiltration Cellular, Plasma Cell | 3 2 3| Necrosis | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + M + + + + + + +| Fibrosis | 3 | Hemorrhage | 3 2 | Infiltration Cellular, Plasma Cell | 3 | Necrosis | 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X X | Atrophy | 3 | Fibrosis | 3 3 2 2 2| Hematopoietic Cell Proliferation | 2 | Necrosis | 4 | __________________________________________________________________________| Thymus | + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + | Galactocele | 2 3 3 | Hyperplasia | | Inflammation, Chronic | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 2 3 | Inflammation, Chronic | 2 3 | Inflammation, Suppurative | 3 | Ulcer | 2 | Prepuce, Inflammation, Suppurative | 2 | Subcutaneous Tissue, Skin, Site of | | Application, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 7| 6| 6| 5| 7| 7| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 7| 5| 6| DAY ON TEST | 6| 5| 0| 7| 3| 8| 6| 2| 3| 1| 2| 1| 3| 6| 2| 9| 0| 8| 8| 7| 0| 9| 3| 4| 0| | 2| 1| 3| 8| 6| 3| 3| 8| 6| 5| 9| 7| 9| 1| 9| 0| 3| 3| 7| 9| 4| 5| 6| 4| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| NNK/AIR | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | | Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 1 | Fibrosis, Focal | | Hemorrhage | 2 | Alveolar Epithelium, Hyperplasia, | | Atypical | 1 1 2 4 3 2 1 2 3 2 2 3 2 3 2 3 2 2 2 2 2 1| Alveolus, Infiltration Cellular, | | Focal, Histiocyte | | Alveolus, Infiltration Cellular, | | Histiocyte | 2 3 3 2 | Serosa, Fibrosis | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 3 3 1 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 1 | Lateral Wall, Hyperplasia | 1 2 3 2 | Nasopharyngeal Duct, Infiltration | | Cellular, Mixed Cell | | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1| Olfactory Epithelium, Metaplasia | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + +| Infarct | 3| Nephropathy | 3 2 3 3 4 4 3 3 3 2 4 4 3| __________________________________________________________________________| Ureter | + | __________________________________________________________________________| Urinary Bladder | | Hemorrhage | | Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | | DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | | | 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Colon | | 1 | Lymphoid Tissue, Hyperplasia, | | | Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + A | 1 | Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 1 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + | 39 | Degeneration, Cystic | 3 2 3 | 7 2.4| Hepatodiaphragmatic Nodule | X | 1 | Hyperplasia, Focal | 4 | 4 3.8| Necrosis, Focal | 3 | 3 2.3| Vacuolization Cytoplasmic | | 2 2.0| __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Fat, Necrosis | 2 2 | 6 2.3| __________________________________________________________________________|____________| Pancreas | + | 1 | Artery, Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + | 3 | Necrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 4 | Vacuolization Cytoplasmic | 3 | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + | 34 | Pars Distalis, Hyperplasia | 2 3 | 2 2.5| __________________________________________________________________________|____________| Thyroid Gland | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + | 32 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | | DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | | | 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Penis | + | 5 | Inflammation, Chronic Active | | 2 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + | 9 | Inflammation, Chronic Active | 4 2 2 | 7 2.6| __________________________________________________________________________|____________| Seminal Vesicle | + | 1 | __________________________________________________________________________|____________| Testes | + + + + + + | 13 | Atrophy | 3 4 | 3 3.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + | 26 | Pancreatic, Inflammation, | | | Granulomatous | | 1 2.0| Renal, Hemorrhage | 3 | 3 3.0| Renal, Infiltration Cellular, Plasma | | | Cell | 3 2 | 5 2.0| Renal, Inflammation, Granulomatous | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + + + M + + M + M + M + + + + + M M | 28 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 14 | Infiltration Cellular, Plasma Cell | | 3 2.7| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 9 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + M + | 45 | Fibrosis | | 1 3.0| Hemorrhage | | 2 2.5| Infiltration Cellular, Plasma Cell | | 1 3.0| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + | 39 | Accessory Spleen | X X | 4 | Atrophy | | 1 3.0| Fibrosis | 2 3 2 2 3 | 10 2.4| Hematopoietic Cell Proliferation | | 1 2.0| Necrosis | 3 4 | 3 3.7| __________________________________________________________________________|____________| Thymus | + | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + | 5 | Galactocele | 4 | 4 3.0| Hyperplasia | 2 | 1 2.0| Inflammation, Chronic | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | | DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | | | 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + | 47 | Hyperkeratosis | 3 | 3 2.7| Inflammation, Chronic | | 2 2.5| Inflammation, Suppurative | | 1 3.0| Ulcer | | 1 2.0| Prepuce, Inflammation, Suppurative | | 1 2.0| Subcutaneous Tissue, Skin, Site of | | | Application, Inflammation, | | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 48 1.1| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + | 1 | Hemorrhage | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Congestion | 1 1 | 3 1.0| Fibrosis, Focal | 3 | 1 3.0| Hemorrhage | 2 4 2 2 | 5 2.4| Alveolar Epithelium, Hyperplasia, | | | Atypical | 2 2 2 2 1 1 2 2 2 2 2 2 3 2 2 3 3 | 39 2.1| Alveolus, Infiltration Cellular, | | | Focal, Histiocyte | 3 | 1 3.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 2 2 3 | 8 2.3| Serosa, Fibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Inflammation, Suppurative | 2 | 5 2.4| Goblet Cell, Lateral Wall, | | | Hyperplasia | 1 | 3 1.3| Lateral Wall, Hyperplasia | 1 | 5 1.8| Nasopharyngeal Duct, Infiltration | | | Cellular, Mixed Cell | 2 | 1 2.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 1 1 1 1 2 1 2 1 1 2 1 1 1 1 2 1 3 2 1 2 1 | 45 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 4| 5| 4| 7| 5| 5| 4| 6| 4| 6| 6| 6| 5| 6| 5| 5| 6| | | DAY ON TEST | 8| 4| 0| 0| 0| 1| 8| 4| 5| 3| 9| 3| 8| 9| 8| 7| 8| 0| 8| 6| 5| 8| 4| | | | 3| 5| 4| 3| 5| 2| 6| 0| 0| 6| 0| 3| 9| 5| 8| 7| 3| 5| 3| 9| 0| 3| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 1 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | NNK/AIR | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Olfactory Epithelium, Metaplasia | 2 | 2 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cataract | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + | 24 | Infarct | 3 | 2 3.0| Nephropathy | 3 3 3 3 3 4 4 3 3 | 22 3.2| __________________________________________________________________________|____________| Ureter | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + | 1 | Hemorrhage | 3 | 1 3.0| Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6| DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1| | 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Colon | | Mineralization | | __________________________________________________________________________| Intestine Large, Rectum | | Mineralization | | __________________________________________________________________________| Intestine Large, Cecum | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + +| Angiectasis | 2| Degeneration, Cystic | 2 2 | Hepatodiaphragmatic Nodule | X | Hyperplasia, Focal | 3 | Necrosis, Focal | | Vacuolization Cytoplasmic | 2 2 2 | Bile Duct, Hyperplasia | 3 | __________________________________________________________________________| Mesentery | + + + + +| Fat, Necrosis | 3 2 3 | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Foreign Body | X | __________________________________________________________________________| Pancreas | + | __________________________________________________________________________| Stomach, Forestomach | + | Mineralization | 3 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + | Mineralization | 3 | Necrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Inflammation, Chronic | 2 | Mineralization | 3 | __________________________________________________________________________| Heart | | Cardiomyopathy | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + +| Angiectasis | 3| __________________________________________________________________________| Islets, Pancreatic | + | __________________________________________________________________________| Parathyroid Gland | | Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + +| __________________________________________________________________________| Thyroid Gland | + | Follicular Cell, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6| DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1| | 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Tissue NOS | + + + + + | Mediastinum, Inflammation, Chronic | | Active, Diffuse | 4 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | +| Calculus Gross Observation | | Calculus Micro Observation Only | | __________________________________________________________________________| Preputial Gland | + + + + + | Inflammation, Chronic Active | 2 4 3 | __________________________________________________________________________| Prostate | + | Inflammation, Suppurative | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + +| Atrophy | 2 | Necrosis | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + | Hyperplasia, Lymphoid | 2 | Pigmentation | 3 | Renal, Hemorrhage | | Renal, Inflammation, Granulomatous | | __________________________________________________________________________| Lymph Node, Bronchial | M M M + + + + M + + + + M + M + + M + M + M M M +| Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + | Infiltration Cellular, Plasma Cell | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | | Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mediastinal | + I + + + + + + + + M + + + + M + M + + + + + + +| Hemorrhage | 3 3 3| Infiltration Cellular, Plasma Cell | 2 1 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + +| Congestion | 2 | Fibrosis | 2 1 | Hematopoietic Cell Proliferation | 3| Necrosis | 4 | __________________________________________________________________________| Thymus | + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + | Galactocele | 3 | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6| DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1| | 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Prepuce, Inflammation, Suppurative | | Subcutaneous Tissue, Skin, Site of | | Application, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X | Inflammation, Suppurative | 2 | Mineralization | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hemorrhage | 1 | Mineralization | 3 | Alveolar Epithelium, Hyperplasia | 2 | Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 2 1 | Bronchus, Inflammation, Suppurative | 3 | Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Interstitium, Inflammation, Chronic, | | Diffuse | 1 | Serosa, Inflammation, Chronic Active | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 2 | Goblet Cell, Lateral Wall, | | Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | Lateral Wall, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2| Olfactory Epithelium, Metaplasia | | Turbinate, Necrosis | | __________________________________________________________________________| Pleura | + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 5| 6| 4| 4| 6| 6| 5| 6| 6| 3| 3| 1| 7| 6| 5| 7| 7| 5| 5| 5| 6| 7| 6| 6| DAY ON TEST | 2| 5| 0| 5| 4| 3| 6| 0| 7| 7| 8| 3| 9| 1| 2| 8| 3| 0| 2| 9| 1| 4| 0| 1| 1| | 5| 6| 3| 8| 0| 6| 9| 2| 8| 3| 9| 3| 2| 2| 4| 9| 6| 9| 3| 2| 5| 5| 4| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| TRIOCT./ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Eye | | Cataract | | Ciliary Body, Retina, Degeneration | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + | Cyst | | Nephropathy | 3 4 3 3 3 3 | __________________________________________________________________________| Urinary Bladder | | Calculus Gross Observation | | Calculus Micro Observation Only | | Hemorrhage | | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | | DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | | | 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Colon | + | 1 | Mineralization | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + | 1 | Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Cecum | A | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + | 28 | Angiectasis | 2 1 | 3 1.7| Degeneration, Cystic | 2 1 | 4 1.8| Hepatodiaphragmatic Nodule | | 1 | Hyperplasia, Focal | | 1 3.0| Necrosis, Focal | 1 | 1 1.0| Vacuolization Cytoplasmic | 2 | 4 2.0| Bile Duct, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + + | 8 | Fat, Necrosis | 2 3 | 5 2.6| __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Foreign Body | | 1 | __________________________________________________________________________|____________| Pancreas | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + | 2 | Mineralization | | 1 3.0| Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + | 3 | Mineralization | 3 | 2 3.0| Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Inflammation, Chronic | | 1 2.0| Mineralization | | 1 3.0| __________________________________________________________________________|____________| Heart | + | 1 | Cardiomyopathy | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 3 | Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + | 1 | Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + | 29 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | | DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | | | 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | | 1 | Follicular Cell, Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + | 30 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0| __________________________________________________________________________|____________| Tissue NOS | | 5 | Mediastinum, Inflammation, Chronic | | | Active, Diffuse | | 1 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + + | 3 | Calculus Gross Observation | X | 1 | Calculus Micro Observation Only | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + | 8 | Inflammation, Chronic Active | 2 3 | 5 2.8| __________________________________________________________________________|____________| Prostate | | 1 | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + | 24 | Atrophy | | 1 2.0| Necrosis | | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + | 10 | Hyperplasia, Lymphoid | | 1 2.0| Pigmentation | | 1 3.0| Renal, Hemorrhage | 2 | 1 2.0| Renal, Inflammation, Granulomatous | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M M M + + M M M M + + + M + M M M M M + M + + | 23 | Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 7 | Infiltration Cellular, Plasma Cell | 2 2 2 2 | 5 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 3 | Hyperplasia, Lymphoid | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + | 43 | Hemorrhage | | 3 3.0| Infiltration Cellular, Plasma Cell | | 2 1.5| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | | DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | | | 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + | 33 | Congestion | 2 | 2 2.0| Fibrosis | 3 3 3 2 2 | 7 2.3| Hematopoietic Cell Proliferation | | 1 3.0| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Thymus | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 2 | Galactocele | 3 | 2 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Inflammation, Suppurative | 3 | 1 3.0| Prepuce, Inflammation, Suppurative | 2 3 3 | 3 2.7| Subcutaneous Tissue, Skin, Site of | | | Application, Inflammation, | | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 48 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Foreign Body | | 2 | Inflammation, Suppurative | 2 1 | 3 1.7| Mineralization | 3 | 1 3.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Edema | 3 | 1 3.0| Hemorrhage | 2 | 2 1.5| Mineralization | 3 | 2 3.0| Alveolar Epithelium, Hyperplasia | | 1 2.0| Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 35 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 | 7 1.1| Bronchus, Inflammation, Suppurative | | 1 3.0| Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 | 34 1.1| Interstitium, Inflammation, Chronic, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 6| 7| 7| 5| 5| 6| 6| 6| 6| 2| 6| 6| 7| 5| 7| 5| 6| 5| 4| | | DAY ON TEST | 3| 9| 0| 3| 9| 3| 0| 8| 5| 6| 5| 3| 3| 5| 3| 1| 2| 3| 1| 2| 3| 6| 8| | | | 6| 0| 5| 5| 4| 6| 5| 0| 0| 1| 9| 4| 4| 3| 1| 4| 2| 7| 8| 9| 5| 0| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | TRIOCT./ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Diffuse | 3 | 2 2.0| Serosa, Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Inflammation, Suppurative | 2 | 3 2.0| Goblet Cell, Lateral Wall, | | | Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 38 1.0| Lateral Wall, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 46 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 3 2 2 2 2 2 2 3 2 2 1 3 2 1 2 2 2 2 2 2 2 2 2 | 47 2.1| Olfactory Epithelium, Metaplasia | 1 | 1 1.0| Turbinate, Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Pleura | + | 2 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + A + + + + + + | 47 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Cataract | 4 | 1 4.0| Ciliary Body, Retina, Degeneration | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 15 | Cyst | 2 2 | 2 2.0| Nephropathy | 3 4 3 4 4 4 4 4 | 14 3.5| __________________________________________________________________________|____________| Urinary Bladder | + + | 2 | Calculus Gross Observation | X | 1 | Calculus Micro Observation Only | X | 1 | Hemorrhage | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6| DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6| | 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| .1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Cecum | + | __________________________________________________________________________| Intestine Small, Ileum | + | Peyer's Patch, Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Degeneration, Cystic | 2 2 | Hepatodiaphragmatic Nodule | X| Inflammation | | Vacuolization Cytoplasmic | 2 3 | __________________________________________________________________________| Mesentery | + + + + + | Fat, Necrosis | 1 3 3 | __________________________________________________________________________| Stomach, Forestomach | + | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Stomach, Glandular | + | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + | Pericardium, Fibrosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + | __________________________________________________________________________| Parathyroid Gland | + | Hyperplasia | 4 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | | __________________________________________________________________________| Penis | + | Calculus Micro Observation Only | X | __________________________________________________________________________| Preputial Gland | + | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Prostate | + | Inflammation, Suppurative | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + +| Atrophy | 3 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6| DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6| | 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| .1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Bone Marrow | + | __________________________________________________________________________| Lymph Node | + + + + + + + + | Pancreatic, Hyperplasia, Lymphoid | | Renal, Hemorrhage | | Renal, Hyperplasia, Lymphoid | 2 | Renal, Infiltration Cellular, Plasma | | Cell | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + M + + M M + + + M M + M M + M + M + M + + + + M| Hemorrhage | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + | Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + | Inflammation, Granulomatous | 3 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | | Congestion | 2 | Fibrosis | 3 2 3 | __________________________________________________________________________| Thymus | + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 3 | Hyperplasia | | Inflammation, Chronic | 3 | Dermis, Cyst | 3 | Prepuce, Inflammation, Suppurative | 2 3 | Sebaceous Gland, Hyperplasia | | Subcutaneous Tissue, Skin, Site of | | Application, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 6| 4| 6| 6| 6| 5| 5| 2| 7| 6| 6| 6| 5| 5| 5| 4| 6| 5| 7| 6| DAY ON TEST | 3| 0| 7| 4| 3| 9| 6| 7| 9| 6| 8| 6| 3| 1| 0| 6| 8| 6| 5| 6| 4| 8| 5| 1| 6| | 6| 4| 3| 9| 6| 7| 0| 1| 8| 9| 3| 9| 4| 0| 5| 2| 3| 7| 0| 5| 4| 0| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| .1M/KNNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Edema | | Hemorrhage | | Alveolar Epithelium, Hyperplasia, | | Atypical | 2 2 1 2 1 2 2 1 | Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 2 1 | Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 2 | Thrombosis | 4 | Goblet Cell, Lateral Wall, | | Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1| Lateral Wall, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 2 2 2 2 2 2 2 2 3 2 1 2 2 2 3 2 1 2 2 1 2 2 1| Olfactory Epithelium, Metaplasia | | Turbinate, Necrosis | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + | Infarct | 2 | Nephropathy | 2 3 3 4 3 4 4 | Pigmentation, Hemosiderin | | __________________________________________________________________________| Urinary Bladder | + + | Hemorrhage | 3 | Transitional Epithelium, Necrosis | 3 | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | | DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | | | 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A | .1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Cecum | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 1 | Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + | 36 | Angiectasis | 2 2 | 3 2.0| Degeneration, Cystic | 2 2 2 2 1 2 | 8 1.9| Hepatodiaphragmatic Nodule | X X | 3 | Inflammation | 2 | 1 2.0| Vacuolization Cytoplasmic | 3 4 | 4 3.0| __________________________________________________________________________|____________| Mesentery | + + + + + + | 11 | Fat, Necrosis | 2 2 2 2 | 7 2.1| __________________________________________________________________________|____________| Stomach, Forestomach | | 1 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | | 1 | Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Tooth | | 1 | Developmental Malformation | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + | 2 | Pericardium, Fibrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | | 1 | Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 27 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + | 31 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 4 1 1 1 1 | 30 1.1| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + | 1 | __________________________________________________________________________|____________| Penis | | 1 | Calculus Micro Observation Only | | 1 | __________________________________________________________________________|____________| Preputial Gland | + | 2 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Prostate | + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | | DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | | | 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A | .1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Suppurative | 2 | 2 2.5| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + | 25 | Atrophy | 3 4 4 | 5 3.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 1 | __________________________________________________________________________|____________| Lymph Node | + + | 10 | Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0| Renal, Hemorrhage | 2 | 1 2.0| Renal, Hyperplasia, Lymphoid | | 1 2.0| Renal, Infiltration Cellular, Plasma | | | Cell | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + + M M M M + + + I + + + M M M + M M | 26 | Hemorrhage | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 7 | Infiltration Cellular, Plasma Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 11 | Inflammation, Granulomatous | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + M + + + + + + + + + M + + M + M + | 43 | Hemorrhage | 3 | 2 2.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + | 37 | Accessory Spleen | X | 1 | Congestion | | 1 2.0| Fibrosis | 2 3 2 1 2 3 3 3 3 | 12 2.5| __________________________________________________________________________|____________| Thymus | | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Hyperkeratosis | | 1 3.0| Hyperplasia | 3 | 1 3.0| Inflammation, Chronic | | 1 3.0| Dermis, Cyst | | 1 3.0| Prepuce, Inflammation, Suppurative | 2 | 3 2.3| Sebaceous Gland, Hyperplasia | 2 | 1 2.0| Subcutaneous Tissue, Skin, Site of | | | Application, Inflammation, | | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 47 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 6| 7| 6| 6| 5| 4| 7| 4| 5| 6| 6| 6| 7| 6| 7| 7| 6| 7| 4| 6| | | DAY ON TEST | 8| 1| 3| 2| 3| 3| 6| 7| 9| 3| 4| 6| 4| 3| 0| 0| 8| 3| 3| 3| 2| 1| 8| | | | 1| 3| 6| 0| 3| 5| 9| 5| 6| 6| 4| 7| 1| 8| 4| 3| 3| 6| 6| 2| 5| 6| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A | .1M/KNNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Inflammation, Suppurative | 2 2 | 3 1.7| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Congestion | 2 2 1 2 | 5 1.8| Edema | 2 1 1 | 3 1.3| Hemorrhage | 3 | 1 3.0| Alveolar Epithelium, Hyperplasia, | | | Atypical | 2 1 2 2 | 12 1.7| Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 47 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 | 9 1.1| Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 46 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Inflammation, Suppurative | 3 | 3 2.3| Thrombosis | | 1 4.0| Goblet Cell, Lateral Wall, | | | Hyperplasia | 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 | 45 1.1| Lateral Wall, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 48 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 2 2 2 3 1 3 2 2 2 2 1 3 2 2 1 1 2 1 2 3 2 2 | 48 1.9| Olfactory Epithelium, Metaplasia | 3 | 1 3.0| Turbinate, Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + I + + + + + + + + | 47 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + | 20 | Infarct | | 1 2.0| Nephropathy | 3 3 3 3 3 3 4 4 4 3 4 | 18 3.3| Pigmentation, Hemosiderin | 4 | 1 4.0| __________________________________________________________________________|____________| Urinary Bladder | + | 3 | Hemorrhage | 2 | 2 2.5| Transitional Epithelium, Necrosis | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5| DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9| | 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large, Cecum | + | Ulcer | 4 | __________________________________________________________________________| Intestine Small, Ileum | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 3 | Degeneration, Cystic | 2 2 2 2 3 2 3 3 | Hepatodiaphragmatic Nodule | X X X| Hyperplasia, Focal | 3 2 4 3 4 4 | Hyperplasia | 4 | Infiltration Cellular, Mixed Cell | 3 | Necrosis, Focal | 2 3 | Vacuolization Cytoplasmic, Focal | 1 | Vacuolization Cytoplasmic | 3 | Bile Duct, Hyperplasia | 4 | Centrilobular, Necrosis | 3 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 3 3 3 3 | __________________________________________________________________________| Stomach, Forestomach | | Hyperplasia, Squamous | | Inflammation, Chronic Active | | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + | Fibrosis | 2 | Atrium, Thrombosis | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Medulla | + | __________________________________________________________________________| Parathyroid Gland | + | Hyperplasia | 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + +| Pars Distalis, Hemorrhage | | Pars Distalis, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + + + + + + + + + + + +| Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5| DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9| | 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Edema | 2 | __________________________________________________________________________| Preputial Gland | + | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Testes | + + + + + + + + + + | Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + +| Iliac, Infiltration Cellular, Plasma | | Cell | | Iliac, Pigmentation | | Renal, Infiltration Cellular, Plasma | | Cell | | Renal, Inflammation, Granulomatous | | __________________________________________________________________________| Lymph Node, Bronchial | + M + + + + + M + M + + + + M + + + + M + M + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + +| Hyperplasia, Lymphoid | | Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + M + M + M + + +| Infiltration Cellular, Plasma Cell | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Fibrosis | 3 3 3 4 2 3 | Hematopoietic Cell Proliferation | 4 | Necrosis | 3 | Capsule, Fibrosis | | __________________________________________________________________________| Thymus | + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + | Galactocele | 3 | Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 3 | Inflammation, Chronic | | Dermis, Cyst | 3 | Prepuce, Inflammation, Suppurative | 3 2 | Subcutaneous Tissue, Inflammation, | | Chronic | 4 | Subcutaneous Tissue, Necrosis | 4 | Subcutaneous Tissue, Skin, Site of | | Application, Inflammation, | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 _____________________________________________________________________________________________________________________ | 6| 5| 5| 5| 2| 4| 7| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 4| 6| 6| 6| 7| 6| 5| DAY ON TEST | 1| 6| 5| 5| 5| 5| 3| 8| 4| 0| 0| 8| 8| 6| 3| 4| 1| 5| 7| 9| 6| 4| 2| 8| 9| | 7| 2| 8| 7| 3| 6| 6| 3| 1| 3| 3| 7| 3| 9| 6| 0| 0| 5| 0| 7| 1| 0| 5| 3| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1M/K NNK | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| /OZONE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2 | Mineralization | 3| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Hemorrhage | 2 | Alveolar Epithelium, Hyperplasia, | | Atypical | 2 1 1 1 3 2 3 4 3 3 2 2 1 3 2 2 2| Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Alveolus, Infiltration Cellular, | | Histiocyte | 3 1 1 2 2 2 1 1 | Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| Inflammation, Suppurative | | Goblet Cell, Lateral Wall, | | Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Lateral Wall, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 3 1 2 2 1 2 2 3 3 2 2 2 1 2 2 2 1 3 1 2 2 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | +| Cataract | 3| Hemorrhage | | Ciliary Body, Retina, Degeneration | 4| __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + +| Cyst | | Infarct | 2 | Nephropathy | 4 3 3 3 3 4 3 3 4 3| __________________________________________________________________________| Urinary Bladder | | Calculus Micro Observation Only | | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | | DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | | | 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large, Cecum | + | 2 | Ulcer | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + | 42 | Angiectasis | 3 2 3 | 5 2.6| Degeneration, Cystic | 2 3 2 2 2 2 2 3 2 | 17 2.3| Hepatodiaphragmatic Nodule | X X | 5 | Hyperplasia, Focal | 3 | 7 3.3| Hyperplasia | 3 | 2 3.5| Infiltration Cellular, Mixed Cell | | 1 3.0| Necrosis, Focal | 3 | 3 2.7| Vacuolization Cytoplasmic, Focal | | 1 1.0| Vacuolization Cytoplasmic | 2 | 2 2.5| Bile Duct, Hyperplasia | | 1 4.0| Centrilobular, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + + + | 8 | Fat, Necrosis | 3 2 3 2 | 8 2.8| __________________________________________________________________________|____________| Stomach, Forestomach | + + | 2 | Hyperplasia, Squamous | 2 2 | 2 2.0| Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Tooth | | 1 | Developmental Malformation | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 2 | Fibrosis | | 1 2.0| Atrium, Thrombosis | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Medulla | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | | 1 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + | 30 | Pars Distalis, Hemorrhage | 4 | 1 4.0| Pars Distalis, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Thyroid Gland | + | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + | 26 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | | DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | | | 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 26 1.0| __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + | 2 | Edema | 1 | 2 1.5| __________________________________________________________________________|____________| Preputial Gland | + + | 3 | Inflammation, Chronic Active | 2 3 | 3 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + | 19 | Atrophy | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + | 17 | Iliac, Infiltration Cellular, Plasma | | | Cell | 3 | 1 3.0| Iliac, Pigmentation | 2 | 1 2.0| Renal, Infiltration Cellular, Plasma | | | Cell | 2 | 1 2.0| Renal, Inflammation, Granulomatous | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M M + M M M + M + M M M M + + + + M + M + + + | 30 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + | 15 | Hyperplasia, Lymphoid | 2 | 1 2.0| Infiltration Cellular, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + | 43 | Infiltration Cellular, Plasma Cell | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + | 39 | Accessory Spleen | | 1 | Fibrosis | 2 3 3 2 2 3 3 | 13 2.8| Hematopoietic Cell Proliferation | | 1 4.0| Necrosis | | 1 3.0| Capsule, Fibrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Thymus | + | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + | 4 | Galactocele | 3 | 2 3.0| Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | | DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | | | 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Hyperkeratosis | 2 | 2 2.5| Inflammation, Chronic | 2 | 1 2.0| Dermis, Cyst | | 1 3.0| Prepuce, Inflammation, Suppurative | | 2 2.5| Subcutaneous Tissue, Inflammation, | | | Chronic | | 1 4.0| Subcutaneous Tissue, Necrosis | | 1 4.0| Subcutaneous Tissue, Skin, Site of | | | Application, Inflammation, | | | Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 48 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Inflammation, Suppurative | 1 1 1 1 | 6 1.2| Mineralization | | 1 3.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Edema | | 1 2.0| Hemorrhage | 3 1 | 3 2.0| Alveolar Epithelium, Hyperplasia, | | | Atypical | 2 2 2 2 2 1 2 2 2 3 2 2 1 2 3 2 | 33 2.1| Alveolar Epithelium, Metaplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 45 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 2 1 2 2 | 13 1.6| Interstitium, Fibrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 45 1.0| __________________________________________________________________________|____________| Nose | A + + + + + + + + + + + + + + + + + + + + + + | 46 | Inflammation, Suppurative | 2 | 1 2.0| Goblet Cell, Lateral Wall, | | | Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 42 1.0| Lateral Wall, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 46 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 3 2 2 1 2 2 2 2 2 1 2 1 3 2 2 1 2 2 2 1 2 | 46 1.9| __________________________________________________________________________|____________| Trachea | A + + + + + + + + + + + + + + + + + + + + + + | 46 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 88034-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE/NNK Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:17:56 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 6| 7| 7| 4| 6| 5| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 4| 7| | | DAY ON TEST | 0| 3| 5| 3| 0| 3| 1| 3| 1| 0| 8| 6| 8| 7| 1| 8| 3| 8| 0| 8| 7| 0| 0| | | | 3| 6| 7| 6| 5| 5| 2| 6| 6| 2| 5| 9| 0| 1| 3| 2| 5| 7| 0| 1| 8| 3| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1M/K NNK | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | L | /OZONE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Eye | + + + | 4 | Cataract | 2 | 2 2.5| Hemorrhage | 2 | 1 2.0| Ciliary Body, Retina, Degeneration | 3 | 2 3.5| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + | 25 | Cyst | 2 | 1 2.0| Infarct | | 1 2.0| Nephropathy | 3 3 4 3 3 3 3 3 3 3 2 3 | 22 3.1| __________________________________________________________________________|____________| Urinary Bladder | + | 1 | Calculus Micro Observation Only | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------