Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/5206

TDMS Study 88120-04 Pathology Tables

NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99
Route: DOSED FEED                                                                                                 Time: 08:20:21

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  80-07-9

       Lock Date:  08/11/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            9            6            4                                     
    Moribund Sacrifice                                 3            1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           40           43           45                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Lymphoid Tissue, Hyperplasia, Lymphoid           1 (2%)                                                                       
      Serosa, Inflammation, Chronic                    1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             2 (4%)                                 4 (8%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                              1 (2%)                    2 (4%)                                
      Clear Cell Focus                                 2 (4%)       1 (2%)                    1 (2%)                                
      Eosinophilic Focus                               2 (4%)       1 (2%)       4 (8%)      11 (22%)                               
      Eosinophilic Focus, Multiple                                                            3 (6%)                                
      Fatty Change, Diffuse                                         3 (6%)                    1 (2%)                                
      Infiltration Cellular, Mononuclear Cell          8 (16%)      9 (18%)     12 (24%)     10 (20%)                               
      Inflammation, Chronic Active                     4 (8%)       6 (12%)      3 (6%)       9 (18%)                               
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)       1 (2%)                    2 (4%)                                
      Mixed Cell Focus, Multiple                                                 1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Necrosis, Focal                                  2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Tension Lipidosis                                4 (8%)       1 (2%)                                                          
      Vacuolization Cytoplasmic, Focal                 1 (2%)       1 (2%)       2 (4%)                                             
      Bile Duct, Cyst                                                                         1 (2%)                                
      Centrilobular, Fatty Change                                   1 (2%)                                                          
      Centrilobular, Hypertrophy                                                 9 (18%)     29 (58%)                               
      Oval Cell, Hyperplasia                                        1 (2%)                                                          
      Periportal, Degeneration                                      1 (2%)                                                          
      Periportal, Fibrosis                                          1 (2%)                                                          
      Periportal, Hyperplasia, Lymphoid                             1 (2%)                                                          
      Serosa, Hyperplasia, Lymphoid                    1 (2%)                                                                       
   Mesentery                                          (5)          (2)          (5)          (5)                                    
      Fat, Necrosis                                    4 (80%)      1 (50%)      3 (60%)      4 (80%)                               
   Oral Mucosa                                        (31)         (21)         (37)         (37)                                   
      Ulcer                                           14 (45%)      7 (33%)     17 (46%)     18 (49%)                               
      Gingival, Inflammation, Chronic                 31 (100%)    21 (100%)    37 (100%)    36 (97%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Hypertrophy, Focal                                                                      1 (2%)                                
      Inflammation, Chronic                            2 (4%)                    1 (2%)                                             
      Acinus, Atrophy                                               1 (2%)       1 (2%)                                             
      Duct, Cyst                                                                 1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperkeratosis, Focal                                                      1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Epithelium, Hyperplasia, Focal                   2 (4%)                                                                       
      Muscularis, Hyperplasia, Focal                                1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Cyst                                                                        2 (4%)                                
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic                     1 (2%)                                                                       
      Aorta, Mineralization                                                      1 (2%)                                             
      Pulmonary Vein, Inflammation, Chronic            1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Artery, Inflammation, Chronic                    1 (2%)                                 2 (4%)                                
      Epicardium, Inflammation, Chronic                             1 (2%)                                                          
      Myocardium, Degeneration                         1 (2%)                    1 (2%)       2 (4%)                                
      Myocardium, Mineralization                                    1 (2%)                                                          
      Nerve, Inflammation, Chronic                     1 (2%)                                                                       
      Valve, Inflammation                              1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
      Cytoplasmic Alteration, Focal                    1 (2%)                                                                       
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
      Hypertrophy, Diffuse                                                       1 (2%)       1 (2%)                                
      Hypertrophy, Focal                               2 (4%)                                 3 (6%)                                
      Subcapsular, Hyperplasia                        47 (94%)     47 (96%)     50 (100%)    47 (94%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      4 (8%)       2 (4%)       3 (6%)       2 (4%)                                
   Pituitary Gland                                    (48)         (46)         (48)         (48)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
      Pars Distalis, Hemorrhage                                                               1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                5 (10%)      6 (13%)      7 (15%)     11 (23%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Vacuolization Cytoplasmic         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)         (50)         (50)                                   
      Hyperplasia, Focal                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (49)                                   
      Atrophy                                                                    1 (2%)                                             
      Cyst                                                          1 (2%)       3 (6%)       1 (2%)                                
   Ovary                                              (50)         (48)         (49)         (48)                                   
      Angiectasis                                      2 (4%)       7 (15%)      2 (4%)       1 (2%)                                
      Cyst                                            15 (30%)     11 (23%)     16 (33%)      9 (19%)                               
      Hemorrhage                                       7 (14%)                   4 (8%)                                             
      Inflammation, Granulomatous                                                             1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)       2 (4%)                                
      Thrombosis                                       1 (2%)       4 (8%)                    1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                                                             2 (4%)                                
      Inflammation, Suppurative                        3 (6%)       2 (4%)       7 (14%)     11 (22%)                               
      Thrombosis                                                                              1 (2%)                                
      Ulcer                                            1 (2%)                    1 (2%)       1 (2%)                                
      Endometrium, Hyperplasia, Cystic                41 (82%)     44 (88%)     48 (96%)     47 (94%)                               
      Epithelium, Metaplasia, Squamous                                                        1 (2%)                                
      Serosa, Cyst                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Necrosis                                                      1 (2%)                                                          
   Lymph Node                                         (3)          (6)          (4)          (4)                                    
      Lumbar, Hyperplasia, Lymphoid                                 1 (17%)      2 (50%)      1 (25%)                               
      Renal, Hyperplasia, Lymphoid                                  1 (17%)      1 (25%)      2 (50%)                               
   Lymph Node, Mandibular                             (47)         (47)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (46)         (49)         (46)                                   
      Erythrophagocytosis                              1 (2%)                                 1 (2%)                                
      Hyperplasia, Lymphoid                            4 (8%)       1 (2%)       3 (6%)       1 (2%)                                
      Infiltration Cellular, Plasma Cell               1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Vein, Ectasia                                                              1 (2%)                                             
   Spleen                                             (49)         (49)         (50)         (50)                                   
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                11 (22%)     15 (31%)     11 (22%)     21 (42%)                               
      Lymphoid Follicle, Atrophy                       5 (10%)      7 (14%)      4 (8%)       2 (4%)                                
      Lymphoid Follicle, Hyperplasia                  10 (20%)      9 (18%)     11 (22%)      8 (16%)                               
   Thymus                                             (49)         (48)         (50)         (50)                                   
      Atrophy                                         28 (57%)     25 (52%)     26 (52%)     33 (66%)                               
      Cyst                                             4 (8%)       4 (8%)       4 (8%)       7 (14%)                               
      Hyperplasia, Lymphoid                                                                   2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                1 (2%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Mast Cell                                                        1 (2%)                                
      Subcutaneous Tissue, Edema                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosis                                        10 (20%)      4 (8%)      12 (24%)     15 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
      Hypothalamus, Degeneration                       1 (2%)                    1 (2%)                                             
      Thalamus, Necrosis, Focal                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hyperplasia                                                   1 (2%)                                                          
      Infiltration Cellular, Histiocyte                2 (4%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                                                            2 (4%)                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                                                        1 (2%)                                
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       1 (2%)                    2 (4%)                                
      Bronchiole, Hyperplasia                                                                 1 (2%)                                
      Serosa, Fibrosis                                                                        1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Hemorrhage                                       2 (4%)                                                                       
      Inflammation, Granulomatous                                                             1 (2%)                                
      Respiratory Epithelium, Cytoplasmic                                                                                           
          Alteration                                                                          1 (2%)                                
      Turbinate, Inflammation, Suppurative             1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)          (3)          (1)                                    
      Atrophy                                                       2 (67%)      1 (33%)                                            
      Degeneration                                                  1 (33%)      2 (67%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Glomerulosclerosis                                            1 (2%)                                                          
      Hydronephrosis                                   1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Infarct                                          3 (6%)       2 (4%)       2 (4%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)                    1 (2%)                                
      Inflammation, Focal, Suppurative                              1 (2%)                                                          
      Renal Tubule, Accumulation, Hyaline Droplet      1 (2%)                                                                       
      Renal Tubule, Casts Protein                     32 (64%)     30 (60%)     31 (62%)     38 (76%)                               
      Renal Tubule, Hyperplasia, Focal                 2 (4%)                                                                       
      Renal Tubule, Necrosis, Acute                    1 (2%)                                                                       
      Renal Tubule, Regeneration                       1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Serosa, Inflammation, Granulomatous              1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      9            3            4            5                                     
    Moribund Sacrifice                                 1            2            2            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           45           43           42                                     
    Natural Death                                                                1                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (50)         (49)         (50)                                   
      Epithelium, Necrosis                             1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Congestion                                                    1 (2%)                    1 (2%)                                
      Peyer's Patch, Hyperplasia, Lymphoid                                                    1 (2%)                                
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
      Congestion                                                                              1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 3 (6%)       4 (8%)       1 (2%)                                             
      Clear Cell Focus                                 4 (8%)       6 (12%)      3 (6%)       4 (8%)                                
      Clear Cell Focus, Multiple                       1 (2%)                                                                       
      Eosinophilic Focus                               2 (4%)       8 (16%)      6 (12%)      6 (12%)                               
      Eosinophilic Focus, Multiple                     3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Fatty Change, Diffuse                                                                   2 (4%)                                
      Fatty Change, Focal                                                        1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Inflammation, Focal, Suppurative                 4 (8%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                    1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)       3 (6%)                    3 (6%)                                
      Mixed Cell Focus, Multiple                                    1 (2%)                                                          
      Necrosis, Focal                                  1 (2%)       1 (2%)       2 (4%)       4 (8%)                                
      Tension Lipidosis                                4 (8%)       1 (2%)       3 (6%)       1 (2%)                                
      Vacuolization Cytoplasmic                                     1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Bile Duct, Cyst                                               1 (2%)                                                          
      Centrilobular, Degeneration                                                             1 (2%)                                
      Centrilobular, Hypertrophy                       1 (2%)      24 (48%)     43 (86%)     45 (90%)                               
      Centrilobular, Necrosis                          2 (4%)                                                                       
      Vein, Congestion                                                                        1 (2%)                                
   Mesentery                                          (3)          (2)          (1)                                                 
      Inflammation, Granulomatous                      1 (33%)                                                                      

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    2 (67%)      2 (100%)     1 (100%)                                           
   Oral Mucosa                                        (50)         (50)         (50)         (50)                                   
      Ulcer                                           23 (46%)     27 (54%)     25 (50%)     18 (36%)                               
      Gingival, Inflammation, Chronic                 37 (74%)     36 (72%)     34 (68%)     33 (66%)                               
   Pancreas                                           (50)         (49)         (50)         (49)                                   
      Inflammation, Chronic                                         3 (6%)       1 (2%)       1 (2%)                                
      Acinus, Atrophy                                                                         1 (2%)                                
      Acinus, Hypertrophy, Focal                       1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hyperplasia, Diffuse                                                                    1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Hyperplasia, Focal                                             2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                                                    1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Hypertrophy                                                                 1 (2%)                                
   Tooth                                                                        (1)          (1)                                    
      Inflammation, Suppurative                                                  1 (100%)                                           
      Malformation                                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Mineralization                                                                   1 (2%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Focal, Lymphocyte                                   1 (2%)                                             
      Artery, Inflammation, Chronic                                 1 (2%)       1 (2%)       4 (8%)                                
      Artery, Coronary Artery, Thrombosis                           1 (2%)                                                          
      Atrium, Thrombosis                               1 (2%)                                                                       
      Myocardium, Degeneration                                      3 (6%)       1 (2%)       1 (2%)                                
      Myocardium, Mineralization                       3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Cytoplasmic Alteration, Focal                   10 (20%)     13 (26%)     11 (22%)      7 (14%)                               
      Hyperplasia, Focal                               3 (6%)       4 (8%)       1 (2%)       3 (6%)                                
      Hypertrophy, Focal                              14 (29%)     16 (32%)     21 (42%)     15 (30%)                               
      Subcapsular, Hyperplasia                        40 (82%)     42 (84%)     41 (82%)     44 (88%)                               
   Islets, Pancreatic                                 (50)         (49)         (49)         (49)                                   
      Hyperplasia                                     13 (26%)     13 (27%)      7 (14%)      9 (18%)                               
   Parathyroid Gland                                  (39)         (40)         (42)         (39)                                   
      Cyst                                                          1 (3%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Pituitary Gland                                    (49)         (50)         (49)         (50)                                   
      Cyst                                                          2 (4%)       1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                             1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  2 (4%)                    2 (4%)       2 (4%)                                
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
      Cyst                                            26 (52%)     23 (46%)     25 (50%)     11 (22%)                               
      Inflammation, Chronic Active                    31 (62%)     29 (58%)     23 (46%)     14 (28%)                               
      Inflammation, Suppurative                        6 (12%)      3 (6%)                    2 (4%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Artery, Inflammation, Chronic                                                           1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Fibrosis, Chronic                                                                       1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Artery, Inflammation, Chronic                                                           1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Fibrosis, Focal                                               1 (2%)                                                          
      Germinal Epithelium, Atrophy                     1 (2%)       1 (2%)       3 (6%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Necrosis                                         1 (2%)                                                                       
   Lymph Node, Mandibular                             (46)         (49)         (48)         (50)                                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       6 (12%)      4 (8%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (48)         (45)         (47)         (46)                                   
      Angiectasis                                                                             1 (2%)                                
      Ectasia                                          1 (2%)                                 1 (2%)                                
      Erythrophagocytosis                              1 (2%)                                 2 (4%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       4 (9%)                                             
      Vein, Ectasia                                    1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Hematopoietic Cell Proliferation                17 (34%)     12 (24%)      9 (18%)     13 (27%)                               
      Capsule, Inflammation, Acute                                               1 (2%)                                             
      Lymphoid Follicle, Atrophy                       8 (16%)      2 (4%)       3 (6%)       8 (16%)                               
      Lymphoid Follicle, Hyperplasia                   1 (2%)       5 (10%)      7 (14%)      2 (4%)                                
   Thymus                                             (45)         (47)         (39)         (44)                                   
      Atrophy                                         25 (56%)     35 (74%)     25 (64%)     20 (45%)                               
      Cyst                                             4 (9%)       6 (13%)      6 (15%)      5 (11%)                               
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)                                                                       
      Sebaceous Gland, Hyperplasia                     1 (2%)                                                                       
      Subcutaneous Tissue, Edema                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosis                                                      1 (2%)                    2 (4%)                                
   Skeletal Muscle                                                                           (1)                                    
      Degeneration, Focal                                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Cerebrum, Necrosis                                                                      1 (2%)                                
   Peripheral Nerve                                                                          (1)                                    
      Axon, Degeneration                                                                      1 (100%)                              
   Spinal Cord                                                                               (1)                                    
      Axon, Degeneration                                                                      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Erythrophagocytosis, Focal                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Inflammation, Chronic, Focal                     1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                                   2 (4%)                    1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                    1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia, Focal                       2 (4%)       2 (4%)       4 (8%)                                
      Bronchus, Foreign Body                                                                  1 (2%)                                
      Bronchus, Inflammation, Suppurative                                        1 (2%)                                             
      Serosa, Inflammation, Chronic, Focal                          1 (2%)                                                          
      Vein, Mineralization                             1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
      Sinus, Inflammation, Chronic                                  1 (2%)                                                          
      Sinus, Inflammation, Suppurative                 2 (4%)                                                                       
      Turbinate, Inflammation, Suppurative             3 (6%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                                                              
      Degeneration                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Infarct                                                       1 (2%)       2 (4%)       1 (2%)                                
      Metaplasia, Osseous                              1 (2%)                                                                       
      Nephropathy                                     36 (72%)     44 (88%)     42 (84%)     36 (72%)                               
      Artery, Inflammation, Chronic                                                           1 (2%)                                
      Pelvis, Inflammation, Chronic Active                          1 (2%)                                                          
      Pelvis, Transitional Epithelium,                                                                                              
          Mineralization                                                                      1 (2%)                                
      Renal Tubule, Cyst                               1 (2%)       3 (6%)                    1 (2%)                                
      Renal Tubule, Necrosis, Acute                                                           3 (6%)                                
   Ureter                                             (1)                                                                           
      Cyst                                             1 (100%)                                                                     
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 73059-73059/73059


--multipart-boundary--