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TDMS Study 88120-04 Pathology Tables

NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99
Route: DOSED FEED                                                                                                 Time: 08:20:21

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  80-07-9

       Lock Date:  08/11/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            9            6            4                                     
    Moribund Sacrifice                                 3            1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           40           43           45                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Lymphoid Tissue, Hyperplasia, Lymphoid           1 (2%)                                                                       
      Serosa, Inflammation, Chronic                    1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             2 (4%)                                 4 (8%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                              1 (2%)                    2 (4%)                                
      Clear Cell Focus                                 2 (4%)       1 (2%)                    1 (2%)                                
      Eosinophilic Focus                               2 (4%)       1 (2%)       4 (8%)      11 (22%)                               
      Eosinophilic Focus, Multiple                                                            3 (6%)                                
      Fatty Change, Diffuse                                         3 (6%)                    1 (2%)                                
      Infiltration Cellular, Mononuclear Cell          8 (16%)      9 (18%)     12 (24%)     10 (20%)                               
      Inflammation, Chronic Active                     4 (8%)       6 (12%)      3 (6%)       9 (18%)                               
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)       1 (2%)                    2 (4%)                                
      Mixed Cell Focus, Multiple                                                 1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Necrosis, Focal                                  2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Tension Lipidosis                                4 (8%)       1 (2%)                                                          
      Vacuolization Cytoplasmic, Focal                 1 (2%)       1 (2%)       2 (4%)                                             
      Bile Duct, Cyst                                                                         1 (2%)                                
      Centrilobular, Fatty Change                                   1 (2%)                                                          
      Centrilobular, Hypertrophy                                                 9 (18%)     29 (58%)                               
      Oval Cell, Hyperplasia                                        1 (2%)                                                          
      Periportal, Degeneration                                      1 (2%)                                                          
      Periportal, Fibrosis                                          1 (2%)                                                          
      Periportal, Hyperplasia, Lymphoid                             1 (2%)                                                          
      Serosa, Hyperplasia, Lymphoid                    1 (2%)                                                                       
   Mesentery                                          (5)          (2)          (5)          (5)                                    
      Fat, Necrosis                                    4 (80%)      1 (50%)      3 (60%)      4 (80%)                               
   Oral Mucosa                                        (31)         (21)         (37)         (37)                                   
      Ulcer                                           14 (45%)      7 (33%)     17 (46%)     18 (49%)                               
      Gingival, Inflammation, Chronic                 31 (100%)    21 (100%)    37 (100%)    36 (97%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Hypertrophy, Focal                                                                      1 (2%)                                
      Inflammation, Chronic                            2 (4%)                    1 (2%)                                             
      Acinus, Atrophy                                               1 (2%)       1 (2%)                                             
      Duct, Cyst                                                                 1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperkeratosis, Focal                                                      1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Epithelium, Hyperplasia, Focal                   2 (4%)                                                                       
      Muscularis, Hyperplasia, Focal                                1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Cyst                                                                        2 (4%)                                
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic                     1 (2%)                                                                       
      Aorta, Mineralization                                                      1 (2%)                                             
      Pulmonary Vein, Inflammation, Chronic            1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Artery, Inflammation, Chronic                    1 (2%)                                 2 (4%)                                
      Epicardium, Inflammation, Chronic                             1 (2%)                                                          
      Myocardium, Degeneration                         1 (2%)                    1 (2%)       2 (4%)                                
      Myocardium, Mineralization                                    1 (2%)                                                          
      Nerve, Inflammation, Chronic                     1 (2%)                                                                       
      Valve, Inflammation                              1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
      Cytoplasmic Alteration, Focal                    1 (2%)                                                                       
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
      Hypertrophy, Diffuse                                                       1 (2%)       1 (2%)                                
      Hypertrophy, Focal                               2 (4%)                                 3 (6%)                                
      Subcapsular, Hyperplasia                        47 (94%)     47 (96%)     50 (100%)    47 (94%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      4 (8%)       2 (4%)       3 (6%)       2 (4%)                                
   Pituitary Gland                                    (48)         (46)         (48)         (48)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
      Pars Distalis, Hemorrhage                                                               1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                5 (10%)      6 (13%)      7 (15%)     11 (23%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Vacuolization Cytoplasmic         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)         (50)         (50)                                   
      Hyperplasia, Focal                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (49)                                   
      Atrophy                                                                    1 (2%)                                             
      Cyst                                                          1 (2%)       3 (6%)       1 (2%)                                
   Ovary                                              (50)         (48)         (49)         (48)                                   
      Angiectasis                                      2 (4%)       7 (15%)      2 (4%)       1 (2%)                                
      Cyst                                            15 (30%)     11 (23%)     16 (33%)      9 (19%)                               
      Hemorrhage                                       7 (14%)                   4 (8%)                                             
      Inflammation, Granulomatous                                                             1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)       2 (4%)                                
      Thrombosis                                       1 (2%)       4 (8%)                    1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                                                             2 (4%)                                
      Inflammation, Suppurative                        3 (6%)       2 (4%)       7 (14%)     11 (22%)                               
      Thrombosis                                                                              1 (2%)                                
      Ulcer                                            1 (2%)                    1 (2%)       1 (2%)                                
      Endometrium, Hyperplasia, Cystic                41 (82%)     44 (88%)     48 (96%)     47 (94%)                               
      Epithelium, Metaplasia, Squamous                                                        1 (2%)                                
      Serosa, Cyst                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Necrosis                                                      1 (2%)                                                          
   Lymph Node                                         (3)          (6)          (4)          (4)                                    
      Lumbar, Hyperplasia, Lymphoid                                 1 (17%)      2 (50%)      1 (25%)                               
      Renal, Hyperplasia, Lymphoid                                  1 (17%)      1 (25%)      2 (50%)                               
   Lymph Node, Mandibular                             (47)         (47)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (46)         (49)         (46)                                   
      Erythrophagocytosis                              1 (2%)                                 1 (2%)                                
      Hyperplasia, Lymphoid                            4 (8%)       1 (2%)       3 (6%)       1 (2%)                                
      Infiltration Cellular, Plasma Cell               1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Vein, Ectasia                                                              1 (2%)                                             
   Spleen                                             (49)         (49)         (50)         (50)                                   
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                11 (22%)     15 (31%)     11 (22%)     21 (42%)                               
      Lymphoid Follicle, Atrophy                       5 (10%)      7 (14%)      4 (8%)       2 (4%)                                
      Lymphoid Follicle, Hyperplasia                  10 (20%)      9 (18%)     11 (22%)      8 (16%)                               
   Thymus                                             (49)         (48)         (50)         (50)                                   
      Atrophy                                         28 (57%)     25 (52%)     26 (52%)     33 (66%)                               
      Cyst                                             4 (8%)       4 (8%)       4 (8%)       7 (14%)                               
      Hyperplasia, Lymphoid                                                                   2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                1 (2%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Mast Cell                                                        1 (2%)                                
      Subcutaneous Tissue, Edema                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosis                                        10 (20%)      4 (8%)      12 (24%)     15 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
      Hypothalamus, Degeneration                       1 (2%)                    1 (2%)                                             
      Thalamus, Necrosis, Focal                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hyperplasia                                                   1 (2%)                                                          
      Infiltration Cellular, Histiocyte                2 (4%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                                                            2 (4%)                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                                                        1 (2%)                                
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       1 (2%)                    2 (4%)                                
      Bronchiole, Hyperplasia                                                                 1 (2%)                                
      Serosa, Fibrosis                                                                        1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Hemorrhage                                       2 (4%)                                                                       
      Inflammation, Granulomatous                                                             1 (2%)                                
      Respiratory Epithelium, Cytoplasmic                                                                                           
          Alteration                                                                          1 (2%)                                
      Turbinate, Inflammation, Suppurative             1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)          (3)          (1)                                    
      Atrophy                                                       2 (67%)      1 (33%)                                            
      Degeneration                                                  1 (33%)      2 (67%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Glomerulosclerosis                                            1 (2%)                                                          
      Hydronephrosis                                   1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Infarct                                          3 (6%)       2 (4%)       2 (4%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)                    1 (2%)                                
      Inflammation, Focal, Suppurative                              1 (2%)                                                          
      Renal Tubule, Accumulation, Hyaline Droplet      1 (2%)                                                                       
      Renal Tubule, Casts Protein                     32 (64%)     30 (60%)     31 (62%)     38 (76%)                               
      Renal Tubule, Hyperplasia, Focal                 2 (4%)                                                                       
      Renal Tubule, Necrosis, Acute                    1 (2%)                                                                       
      Renal Tubule, Regeneration                       1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Serosa, Inflammation, Granulomatous              1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      9            3            4            5                                     
    Moribund Sacrifice                                 1            2            2            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           45           43           42                                     
    Natural Death                                                                1                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (50)         (49)         (50)                                   
      Epithelium, Necrosis                             1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Congestion                                                    1 (2%)                    1 (2%)                                
      Peyer's Patch, Hyperplasia, Lymphoid                                                    1 (2%)                                
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
      Congestion                                                                              1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 3 (6%)       4 (8%)       1 (2%)                                             
      Clear Cell Focus                                 4 (8%)       6 (12%)      3 (6%)       4 (8%)                                
      Clear Cell Focus, Multiple                       1 (2%)                                                                       
      Eosinophilic Focus                               2 (4%)       8 (16%)      6 (12%)      6 (12%)                               
      Eosinophilic Focus, Multiple                     3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Fatty Change, Diffuse                                                                   2 (4%)                                
      Fatty Change, Focal                                                        1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Inflammation, Focal, Suppurative                 4 (8%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                    1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)       3 (6%)                    3 (6%)                                
      Mixed Cell Focus, Multiple                                    1 (2%)                                                          
      Necrosis, Focal                                  1 (2%)       1 (2%)       2 (4%)       4 (8%)                                
      Tension Lipidosis                                4 (8%)       1 (2%)       3 (6%)       1 (2%)                                
      Vacuolization Cytoplasmic                                     1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Bile Duct, Cyst                                               1 (2%)                                                          
      Centrilobular, Degeneration                                                             1 (2%)                                
      Centrilobular, Hypertrophy                       1 (2%)      24 (48%)     43 (86%)     45 (90%)                               
      Centrilobular, Necrosis                          2 (4%)                                                                       
      Vein, Congestion                                                                        1 (2%)                                
   Mesentery                                          (3)          (2)          (1)                                                 
      Inflammation, Granulomatous                      1 (33%)                                                                      

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    2 (67%)      2 (100%)     1 (100%)                                           
   Oral Mucosa                                        (50)         (50)         (50)         (50)                                   
      Ulcer                                           23 (46%)     27 (54%)     25 (50%)     18 (36%)                               
      Gingival, Inflammation, Chronic                 37 (74%)     36 (72%)     34 (68%)     33 (66%)                               
   Pancreas                                           (50)         (49)         (50)         (49)                                   
      Inflammation, Chronic                                         3 (6%)       1 (2%)       1 (2%)                                
      Acinus, Atrophy                                                                         1 (2%)                                
      Acinus, Hypertrophy, Focal                       1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hyperplasia, Diffuse                                                                    1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Hyperplasia, Focal                                             2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                                                    1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Hypertrophy                                                                 1 (2%)                                
   Tooth                                                                        (1)          (1)                                    
      Inflammation, Suppurative                                                  1 (100%)                                           
      Malformation                                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Mineralization                                                                   1 (2%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Focal, Lymphocyte                                   1 (2%)                                             
      Artery, Inflammation, Chronic                                 1 (2%)       1 (2%)       4 (8%)                                
      Artery, Coronary Artery, Thrombosis                           1 (2%)                                                          
      Atrium, Thrombosis                               1 (2%)                                                                       
      Myocardium, Degeneration                                      3 (6%)       1 (2%)       1 (2%)                                
      Myocardium, Mineralization                       3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Cytoplasmic Alteration, Focal                   10 (20%)     13 (26%)     11 (22%)      7 (14%)                               
      Hyperplasia, Focal                               3 (6%)       4 (8%)       1 (2%)       3 (6%)                                
      Hypertrophy, Focal                              14 (29%)     16 (32%)     21 (42%)     15 (30%)                               
      Subcapsular, Hyperplasia                        40 (82%)     42 (84%)     41 (82%)     44 (88%)                               
   Islets, Pancreatic                                 (50)         (49)         (49)         (49)                                   
      Hyperplasia                                     13 (26%)     13 (27%)      7 (14%)      9 (18%)                               
   Parathyroid Gland                                  (39)         (40)         (42)         (39)                                   
      Cyst                                                          1 (3%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Pituitary Gland                                    (49)         (50)         (49)         (50)                                   
      Cyst                                                          2 (4%)       1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                             1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  2 (4%)                    2 (4%)       2 (4%)                                
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
      Cyst                                            26 (52%)     23 (46%)     25 (50%)     11 (22%)                               
      Inflammation, Chronic Active                    31 (62%)     29 (58%)     23 (46%)     14 (28%)                               
      Inflammation, Suppurative                        6 (12%)      3 (6%)                    2 (4%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Artery, Inflammation, Chronic                                                           1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Fibrosis, Chronic                                                                       1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Artery, Inflammation, Chronic                                                           1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Fibrosis, Focal                                               1 (2%)                                                          
      Germinal Epithelium, Atrophy                     1 (2%)       1 (2%)       3 (6%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Necrosis                                         1 (2%)                                                                       
   Lymph Node, Mandibular                             (46)         (49)         (48)         (50)                                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       6 (12%)      4 (8%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (48)         (45)         (47)         (46)                                   
      Angiectasis                                                                             1 (2%)                                
      Ectasia                                          1 (2%)                                 1 (2%)                                
      Erythrophagocytosis                              1 (2%)                                 2 (4%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       4 (9%)                                             
      Vein, Ectasia                                    1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Hematopoietic Cell Proliferation                17 (34%)     12 (24%)      9 (18%)     13 (27%)                               
      Capsule, Inflammation, Acute                                               1 (2%)                                             
      Lymphoid Follicle, Atrophy                       8 (16%)      2 (4%)       3 (6%)       8 (16%)                               
      Lymphoid Follicle, Hyperplasia                   1 (2%)       5 (10%)      7 (14%)      2 (4%)                                
   Thymus                                             (45)         (47)         (39)         (44)                                   
      Atrophy                                         25 (56%)     35 (74%)     25 (64%)     20 (45%)                               
      Cyst                                             4 (9%)       6 (13%)      6 (15%)      5 (11%)                               
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)                                                                       
      Sebaceous Gland, Hyperplasia                     1 (2%)                                                                       
      Subcutaneous Tissue, Edema                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosis                                                      1 (2%)                    2 (4%)                                
   Skeletal Muscle                                                                           (1)                                    
      Degeneration, Focal                                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Cerebrum, Necrosis                                                                      1 (2%)                                
   Peripheral Nerve                                                                          (1)                                    
      Axon, Degeneration                                                                      1 (100%)                              
   Spinal Cord                                                                               (1)                                    
      Axon, Degeneration                                                                      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Erythrophagocytosis, Focal                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Inflammation, Chronic, Focal                     1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                                   2 (4%)                    1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                    1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:20:21  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia, Focal                       2 (4%)       2 (4%)       4 (8%)                                
      Bronchus, Foreign Body                                                                  1 (2%)                                
      Bronchus, Inflammation, Suppurative                                        1 (2%)                                             
      Serosa, Inflammation, Chronic, Focal                          1 (2%)                                                          
      Vein, Mineralization                             1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
      Sinus, Inflammation, Chronic                                  1 (2%)                                                          
      Sinus, Inflammation, Suppurative                 2 (4%)                                                                       
      Turbinate, Inflammation, Suppurative             3 (6%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                                                              
      Degeneration                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Infarct                                                       1 (2%)       2 (4%)       1 (2%)                                
      Metaplasia, Osseous                              1 (2%)                                                                       
      Nephropathy                                     36 (72%)     44 (88%)     42 (84%)     36 (72%)                               
      Artery, Inflammation, Chronic                                                           1 (2%)                                
      Pelvis, Inflammation, Chronic Active                          1 (2%)                                                          
      Pelvis, Transitional Epithelium,                                                                                              
          Mineralization                                                                      1 (2%)                                
      Renal Tubule, Cyst                               1 (2%)       3 (6%)                    1 (2%)                                
      Renal Tubule, Necrosis, Acute                                                           3 (6%)                                
   Ureter                                             (1)                                                                           
      Cyst                                             1 (100%)                                                                     
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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