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TDMS Study 89029-11 Pathology Tables

NTP Experiment-Test: 89029-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                   MAGNETIC FIELDS + DMBA INITIATION PROMOTION                        Date: 01/29/98
Route: MAGNETIC FIELDS                                                                                            Time: 14:01:32


                       10(10MGX1)DMBA V 50HZ/1G 10(10MGX1)DMBA V 50HZ/5G v 10(10MGX1)DMBA V 60HZ/1G 10 10(10MGX1)DMBA        

       Facility:  Battelle Northwest

       Chemical CAS #:  EMF + DMBA

       Lock Date:  10/14/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    10 DMBA CONTROL
                               Include 003    50 HZ/1G 10 DMBA
                               Include 005    50 HZ/5G 10 DMBA
                               Include 004    60 HZ/1G 10 DMBA
                               































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89029-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                   MAGNETIC FIELDS + DMBA INITIATION PROMOTION                        Date: 01/29/98 
Route: MAGNETIC FIELDS                                                                                            Time: 14:01:32 
                                                                                                                                
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                10 DMBA      50 HZ/1G    50 HZ/5G     60 HZ/1G                                 
                                                   CONTROL      10 DMBA     10 DMBA      10 DMBA                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                         100          100          100          100                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6           11           4            3                                    
    Moribund Sacrifice                                 6            4           5            3
  Survivors                                                                                                                         
    Terminal Sacrifice                                88           85           91           94                                  
  Animals Examined Microscopically                   100          100          100          100                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (98)         (99)         (100)        (100)                                  
      Angiectasis                                      6 (6%)       3 (3%)       4 (4%)       3 (3%)                                
      Basophilic Focus                                 4 (4%)       3 (3%)      13 (13%)      7 (7%)                               
      Clear Cell Focus                                 8 (8%)      11 (11%)     14 (14%)      5 (5%)                               
      Cyst                                                          1 (1%)                                                          
      Eosinophilic Focus                               1 (1%)       2 (2%)                                                          
      Fatty Change                                                               2 (2%)                                
      Hematopoietic Cell Proliferation                 7 (7%)       5 (5%)       5 (5%)       4 (4%)                         
      Infiltration Cellular, Mixed Cell                             1 (1%)                                                          
      Mixed Cell Focus                                                           1 (1%)                                
      Necrosis                                                                   2 (2%)                                
      Vacuolization Cytoplasmic                        1 (1%)                                                                       
      Centrilobular, Necrosis                          4 (4%)       6 (6%)       4 (4%)       1 (1%)                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             












                                                             Page    2                                                              

NTP Experiment-Test: 89029-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                   MAGNETIC FIELDS + DMBA INITIATION PROMOTION                        Date: 01/29/98
Route: MAGNETIC FIELDS                                                                                            Time: 14:01:32
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                10 DMBA      50 HZ/1G     50 HZ/5G     60 HZ/1G                                  
                                                   CONTROL      10 DMBA      10 DMBA      10 DMBA                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (3)          (3)                       (1)                                    
      Necrosis                                         1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (100)        (100)        (100)        (100)                                  
      Dilatation                                                    1 (1%)                                                          
      Galactocele                                                   2 (2%)       1 (1%)       3 (3%)                                
      Hyperplasia                                      1 (1%)       1 (1%)                    1 (1%)                                
      Inflammation, Chronic Active                                                            1 (1%)                                
   Skin                                               (19)         (8)           (13)         (10)                                 
      Cyst Epithelial Inclusion                        6 (32%)                   3 (23%)      1 (10%)                               
      Hyperplasia, Basal Cell                          6 (32%)      1 (13%)      1 (8%)                                
      Inflammation, Chronic Active                     1 (5%)                                                                       
      Inflammation, Granulomatous                                                             1 (10%)                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (98)         (100)        (100)        (100)                                  
      Inflammation, Chronic                                         1 (1%)                                                          
      Inflammation, Granulomatous                      1 (1%)                    1 (1%)       1 (1%)                                
      Thrombosis                                       1 (1%)       3 (3%)       1 (1%)       2 (2%)                                
      Alveolar Epithelium, Hyperplasia                21 (21%)     10 (10%)     14 (14%)     10 (10%)                               
      Alveolus, Infiltration Cellular, Histiocyte     21 (21%)     18 (18%)     14 (14%)     15 (15%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             





                                                             Page    3                                                              



NTP Experiment-Test: 89029-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                   MAGNETIC FIELDS + DMBA INITIATION PROMOTION                        Date: 01/29/98
Route: MAGNETIC FIELDS                                                                                            Time: 14:01:32
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                10 DMBA      50 HZ/1G     50 HZ/5G     60 HZ/1G                                  
                                                   CONTROL      10 DMBA      10 DMBA      10 DMBA                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (100)        (98)         (100)        (100)                                  
      Accumulation, Hyaline Droplet                                 1 (1%)                                                          
      Hydronephrosis                                                             1 (1%)                                
      Infarct                                                                    1 (1%)                                
      Infiltration Cellular, Mixed Cell                             1 (1%)                                                          
      Inflammation, Suppurative                                                  1 (1%)                                
      Mineralization                                   1 (1%)       1 (1%)       5 (5%)       3 (3%)                         
      Nephropathy                                     24 (24%)     15 (15%)     27 (27%)     25 (25%)                               
      Thrombosis                                                    1 (1%)                                                          
      Pelvis, Inflammation, Suppurative                                                       1 (1%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             






























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