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https://ntp.niehs.nih.gov/go/10620

Incidence Rates Of Nonneoplastic Lesions By Anatomic Site

NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97
Route: SKIN APPLICATION                                                                                           Time: 09:41:16

                                                         2 YEAR CHRONIC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-83-4

       Lock Date:  01/02/96

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25023 Missing
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/KG
                               Include 004    15 MG/KG
                               Include 006    30 MG/KG
                               Include 001    0 MG/KG
                               Include 003    15 MG/KG
                               Include 005    30 MG/KG



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          55           55           55                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8           12            8                                                  
    Natural Death                                      8            8            6                                                  
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           30           35                                                  

  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (49)         (50)         (50)                                                
      Inflammation, Suppurative                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (49)         (50)                                                
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                              1 (2%)       1 (2%)                                             
      Clear Cell Focus                                 3 (6%)       2 (4%)       3 (6%)                                             
      Cyst                                             1 (2%)       1 (2%)                                                          
      Eosinophilic Focus                              11 (22%)      5 (10%)     10 (20%)                                            
      Eosinophilic Focus, Multiple                     4 (8%)       8 (16%)      4 (8%)                                             
      Infarct                                                       1 (2%)                                                          
      Mixed Cell Focus                                 6 (12%)      6 (12%)      6 (12%)                                            
      Mixed Cell Focus, Multiple                       2 (4%)       2 (4%)       1 (2%)                                             
      Necrosis                                         2 (4%)       1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
      Bile Duct, Cyst                                  1 (2%)                                                                       
   Mesentery                                          (12)         (7)          (9)                                                 
      Inflammation, Suppurative                                                  1 (11%)                                            
      Necrosis                                         2 (17%)      2 (29%)      1 (11%)                                            
      Fat, Necrosis                                    9 (75%)      5 (71%)      5 (56%)                                            
   Pancreas                                           (49)         (50)         (50)                                                
      Basophilic Focus                                              1 (2%)                                                          
      Acinus, Atrophy                                                            1 (2%)                                             
      Duct, Cyst                                       1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Hyperkeratosis                                   1 (2%)       1 (2%)                                                          
      Hyperplasia                                                   3 (6%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Mineralization                                                             2 (4%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)                                                
      Aorta, Mineralization                            2 (4%)                                                                       
   Heart                                              (50)         (50)         (50)                                                
      Degeneration                                                               1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mineralization                                   4 (8%)                    1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
      Artery, Mineralization                           1 (2%)                                                                       
      Pericardium, Inflammation, Chronic Active        2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Hypertrophy                                      1 (2%)       1 (2%)                                                          
      Zona Fasciculata, Vacuolization Cytoplasmic      1 (2%)                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)                                                
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
   Islets, Pancreatic                                 (49)         (50)         (50)                                                
      Hyperplasia                                      7 (14%)      8 (16%)      6 (12%)                                            
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Angiectasis                                      4 (8%)                    1 (2%)                                             
      Hypertrophy                                      1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       9 (18%)      6 (12%)      7 (14%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Atrophy                                                       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      C-Cell, Hyperplasia                              1 (2%)                                                                       
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                    14 (28%)     15 (30%)     15 (30%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (50)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Atrophy                                          5 (10%)                   5 (10%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Follicle, Cyst                                   7 (14%)     11 (22%)     14 (28%)                                            
      Periovarian Tissue, Angiectasis                  1 (2%)                                                                       
      Periovarian Tissue, Cyst                                                   3 (6%)                                             
   Oviduct                                            (1)          (1)                                                              
      Atrophy                                          1 (100%)                                                                     
   Uterus                                             (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Endometrium, Hyperplasia                                                   9 (18%)                                            
      Endometrium, Hyperplasia, Cystic                35 (70%)     20 (40%)     28 (56%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia                                      3 (6%)       1 (2%)       2 (4%)                                             
      Myelofibrosis                                   11 (22%)      9 (18%)      8 (16%)                                            
   Lymph Node                                         (2)          (5)          (8)                                                 
      Lumbar, Hyperplasia, Histiocytic                 1 (50%)                                                                      
      Renal, Angiectasis                                                         1 (13%)                                            
      Renal, Hyperplasia, Lymphoid                                               1 (13%)                                            
   Lymph Node, Mandibular                             (49)         (49)         (47)                                                
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)       3 (6%)                                             
   Lymph Node, Mesenteric                             (49)         (47)         (49)                                                
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Hematopoietic Cell Proliferation                22 (44%)     27 (54%)     15 (30%)                                            
      Hyperplasia, Lymphoid                            4 (8%)       3 (6%)       5 (10%)                                            
   Thymus                                             (41)         (45)         (47)                                                
      Atrophy                                          6 (15%)      4 (9%)       5 (11%)                                            
      Hyperplasia, Lymphoid                                         2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (49)                                                
      Dilatation                                                    1 (2%)                                                          
      Hyperplasia, Cystic                              1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Fibrosis                                         1 (2%)                                                                       
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                             40 (80%)     49 (98%)                                            
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                              43 (86%)     50 (100%)                                           
      Epidermis, Skin, Site of Application,                                                                                         
          Parakeratosis                                                          4 (8%)                                             
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                             39 (78%)     46 (92%)                                            
      Skin, Site of Application, Exudate                                         6 (12%)                                            
      Skin, Site of Application, Hyperkeratosis                    36 (72%)     42 (84%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Arthrosis                                        1 (2%)                                                                       
      Fibrous Osteodystrophy                           1 (2%)                    2 (4%)                                             
      Femur, Fibrous Osteodystrophy                    1 (2%)                                                                       
      Maxilla, Fibrous Osteodystrophy                  1 (2%)                                                                       
      Vertebra, Fibrous Osteodystrophy                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Necrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Accumulation, Hyaline Droplet                    3 (6%)       3 (6%)       3 (6%)                                             
      Mineralization                                   9 (18%)      2 (4%)       2 (4%)                                             
      Nephropathy                                     11 (22%)      6 (12%)     16 (32%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Pigmentation                                                  1 (2%)                                                          
      Pelvis, Dilatation                               1 (2%)                                                                       
      Renal Tubule, Dilatation                         3 (6%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          55           55           55                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 3            8           11                                                  
    Natural Death                                      5            7            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           35           34                                                  
  Missing                                              1                                                                            

  Animals Examined Microscopically                    49           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (48)         (50)         (50)                                                
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Intestine Small, Jejunum                           (49)         (50)         (50)                                                
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid                          1 (2%)       1 (2%)                                             
   Liver                                              (49)         (50)         (50)                                                
      Basophilic Focus                                 4 (8%)       3 (6%)       3 (6%)                                             
      Clear Cell Focus                                 3 (6%)       3 (6%)       6 (12%)                                            
      Clear Cell Focus, Multiple                       1 (2%)       4 (8%)       2 (4%)                                             
      Eosinophilic Focus                               7 (14%)      5 (10%)      8 (16%)                                            
      Eosinophilic Focus, Multiple                     5 (10%)      4 (8%)       1 (2%)                                             
      Infarct                                          3 (6%)                                                                       
      Mixed Cell Focus                                 3 (6%)       6 (12%)      5 (10%)                                            
      Mixed Cell Focus, Multiple                       1 (2%)       9 (18%)      5 (10%)                                            
      Necrosis                                         7 (14%)      1 (2%)       9 (18%)                                            
      Vacuolization Cytoplasmic                        1 (2%)       1 (2%)       1 (2%)                                             
      Bile Duct, Cyst                                                            1 (2%)                                             
   Mesentery                                          (4)          (4)          (3)                                                 
      Necrosis, Focal                                                            1 (33%)                                            
      Fat, Necrosis                                    2 (50%)      3 (75%)      2 (67%)                                            
   Pancreas                                           (49)         (50)         (50)                                                
      Basophilic Focus                                              1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Duct, Cyst                                                    1 (2%)       1 (2%)                                             
   Stomach, Forestomach                               (49)         (50)         (50)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hyperkeratosis                                                1 (2%)                                                          
      Hyperplasia                                                   2 (4%)       1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
   Stomach, Glandular                                 (49)         (50)         (50)                                                
      Cyst                                             3 (6%)                    1 (2%)                                             
      Erosion                                                                    1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia, Focal                               1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                   1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)                                                
      Cardiomyopathy                                                             1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)                                                
      Hyperplasia                                      2 (4%)       1 (2%)       5 (10%)                                            
      Hypertrophy                                     22 (45%)     12 (24%)     10 (20%)                                            
      Capsule, Hyperplasia                            11 (22%)      7 (14%)      7 (14%)                                            
   Adrenal Medulla                                    (49)         (50)         (50)                                                
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
   Islets, Pancreatic                                 (49)         (50)         (50)                                                
      Hyperplasia                                     30 (61%)     28 (56%)     26 (52%)                                            
   Parathyroid Gland                                  (45)         (42)         (42)                                                
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (49)         (47)         (50)                                                
      Pars Distalis, Hyperplasia                       1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (50)                                                
      Cyst                                                                       1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     8 (16%)      7 (14%)      9 (18%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (48)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                            17 (35%)     12 (24%)     10 (20%)                                            
      Inflammation                                                               1 (2%)                                             
      Inflammation, Chronic Active                     5 (10%)      1 (2%)       2 (4%)                                             
   Seminal Vesicle                                    (49)         (50)         (50)                                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                                          2 (4%)                                                          
      Hypertrophy                                      1 (2%)                                                                       
   Testes                                             (49)         (50)         (50)                                                
      Atrophy                                          1 (2%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)                                                
      Hyperplasia                                      4 (8%)       4 (8%)       6 (12%)                                            
      Myelofibrosis                                                 3 (6%)                                                          
   Lymph Node, Mandibular                             (48)         (46)         (47)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (47)         (48)         (48)                                                
      Angiectasis                                      1 (2%)                    2 (4%)                                             
      Ectasia                                                       1 (2%)                                                          
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
   Spleen                                             (49)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Hematopoietic Cell Proliferation                10 (20%)     12 (24%)     16 (32%)                                            
      Hyperplasia, Lymphoid                                         1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Thymus                                             (45)         (36)         (39)                                                
      Atrophy                                          5 (11%)                   5 (13%)                                            
      Epithelial Cell, Hyperplasia                                               1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (50)         (50)                                                
      Hyperkeratosis                                                             2 (4%)                                             
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                             34 (68%)     50 (100%)                                           
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                  1 (2%)      40 (80%)     47 (94%)                                            
      Epidermis, Skin, Site of Application,                                                                                         
          Inflammation, Suppurative                                              3 (6%)                                             
      Epidermis, Skin, Site of Application,                                                                                         
          Parakeratosis                                             2 (4%)       8 (16%)                                            
      Sebaceous Gland, Hyperplasia                                  1 (2%)                                                          
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                 1 (2%)      21 (42%)     34 (68%)                                            
      Skin, Site of Application, Exudate               1 (2%)       3 (6%)       9 (18%)                                            
      Skin, Site of Application, Hyperkeratosis        1 (2%)      38 (76%)     37 (74%)                                            
      Skin, Site of Application, Ulcer                                           7 (14%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:16  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)                                                
      Hyperostosis                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                                   3 (6%)                                                          
      Alveolar Epithelium, Hyperplasia                 5 (10%)      3 (6%)       8 (16%)                                            
   Nose                                               (49)         (50)         (50)                                                
      Lateral Wall, Inflammation, Chronic Active       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Cornea, Degeneration                                                       1 (100%)                                           
   Harderian Gland                                    (2)          (1)          (5)                                                 
      Hyperplasia                                                                1 (20%)                                            
   Lacrimal Gland                                                               (1)                                                 
      Mineralization                                                             1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Accumulation, Hyaline Droplet                                 1 (2%)                                                          
      Cyst                                             3 (6%)       1 (2%)       3 (6%)                                             
      Mineralization                                  37 (76%)     39 (78%)     28 (56%)                                            
      Nephropathy                                     44 (90%)     38 (76%)     38 (76%)                                            
      Pigmentation                                                               1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 91014-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:16  
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         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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