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https://ntp.niehs.nih.gov/go/3966

TDMS Study 96001-05 Pathology Tables

NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14

                                                           FINAL/RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  64742-88-7

       Lock Date:  09/24/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12           19           15           23                                     
    Natural Death                                      2            1            3            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           30           32           25                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)         (50)                                   
      Periesophageal Tissue, Necrosis, Fatty           1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (49)         (47)         (48)                                   
      Ulcer                                                                      1 (2%)                                             
   Liver                                              (49)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Basophilic Focus                                 2 (4%)       3 (6%)       1 (2%)       1 (2%)                                
      Clear Cell Focus                                 7 (14%)      7 (14%)      6 (12%)      2 (4%)                                
      Clear Cell Focus, Multiple                       2 (4%)                    1 (2%)       1 (2%)                                
      Degeneration, Cystic                                                       1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       5 (10%)      9 (18%)      5 (10%)      6 (12%)                               
      Necrosis                                                                   2 (4%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic                        2 (4%)       5 (10%)      6 (12%)      1 (2%)                                
      Bile Duct, Cyst                                  1 (2%)                                                                       
      Hepatocyte, Regeneration                                                                3 (6%)                                
      Serosa, Fibrosis                                 1 (2%)                                 1 (2%)                                
   Mesentery                                          (11)         (15)         (23)         (14)                                   
      Necrosis                                        11 (100%)    15 (100%)    23 (100%)    13 (93%)                               
   Pancreas                                           (49)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                  2 (4%)       1 (2%)       1 (2%)                                             
      Artery, Thrombosis                                                                      1 (2%)                                
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Ulcer                                                         2 (4%)                    2 (4%)                                
   Stomach, Glandular                                 (49)         (50)         (50)         (50)                                   
      Necrosis                                         1 (2%)                                                                       
   Tongue                                             (1)          (3)                       (1)                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Epithelium, Hyperkeratosis                       1 (100%)                                                                     
      Epithelium, Hyperplasia                                       3 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   1 (2%)                    1 (2%)       2 (4%)                                
      Atrium, Thrombosis                               2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Myocardium, Degeneration                                                                1 (2%)                                
      Ventricle, Hypertrophy                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (2%)                    2 (4%)                                
      Vacuolization Cytoplasmic                        9 (18%)      4 (8%)      15 (30%)     12 (24%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
      Degeneration, Cystic                                                                    1 (2%)                                
      Hyperplasia                                      4 (8%)       2 (4%)       7 (14%)      4 (8%)                                
   Parathyroid Gland                                  (49)         (49)         (49)         (50)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Mineralization                                                             1 (2%)                                             
      Pars Distalis, Angiectasis                       2 (4%)                    2 (4%)       2 (4%)                                
      Pars Distalis, Cyst                              5 (10%)      3 (6%)       3 (6%)       3 (6%)                                
      Pars Distalis, Hemorrhage                                                               1 (2%)                                
      Pars Distalis, Hyperplasia                       9 (18%)      9 (18%)      8 (16%)      8 (16%)                               
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                             11 (22%)      6 (12%)      4 (8%)       5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      2 (4%)       3 (6%)       3 (6%)       1 (2%)                                
      Inflammation, Chronic                                         1 (2%)       1 (2%)       1 (2%)                                
      Metaplasia, Squamous                                          1 (2%)                                                          
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             8 (16%)      9 (18%)      8 (16%)      5 (10%)                               
   Uterus                                             (49)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Decidual Reaction                                                                       1 (2%)                                
      Degeneration                                                                            1 (2%)                                
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Necrosis                                                                                2 (4%)                                
      Prolapse                                                                                1 (2%)                                
      Capillary, Myometrium, Hyperplasia                                                      1 (2%)                                
      Endometrium, Hyperplasia                         1 (2%)                    1 (2%)       1 (2%)                                
      Endometrium, Hyperplasia, Cystic                 1 (2%)       5 (10%)      2 (4%)                                             
      Endometrium, Inflammation, Suppurative                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia, Reticulum Cell                                   1 (2%)                                                          
   Lymph Node                                         (5)          (5)          (5)          (4)                                    
      Pancreatic, Infiltration Cellular, Histiocyte                 1 (20%)                                                         
   Lymph Node, Bronchial                              (12)         (7)          (8)          (11)                                   
      Infiltration Cellular, Histiocyte                                                       1 (9%)                                
      Pigmentation                                                               2 (25%)                                            
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
      Necrosis                                                                                1 (2%)                                
   Lymph Node, Mediastinal                            (45)         (39)         (42)         (45)                                   
      Angiectasis                                                   1 (3%)                                                          
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Accessory Spleen                                 1 (2%)                    2 (4%)                                             
      Fibrosis                                                      1 (2%)       1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)       2 (4%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Necrosis                                         2 (4%)       1 (2%)                    3 (6%)                                
      Thrombosis                                                                              1 (2%)                                
   Thymus                                             (47)         (47)         (46)         (48)                                   
      Cyst                                                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Galactocele                                      1 (2%)                    2 (4%)       2 (4%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     1 (2%)       1 (2%)       1 (2%)                                
      Hyperkeratosis                                   1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Ulcer                                                                      1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Compression                                      9 (18%)      8 (16%)      3 (6%)       6 (12%)                               
      Gliosis                                                                    1 (2%)                                             
      Hemorrhage                                       4 (8%)       3 (6%)       6 (12%)      1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
      Cerebellum, Developmental Malformation                                     1 (2%)                                             
      Cerebellum, Gliosis                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (50)         (50)         (49)                                   
      Foreign Body                                     2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic                            3 (6%)       1 (2%)                                                          
      Epiglottis, Metaplasia, Squamous                 1 (2%)                                 1 (2%)                                
      Respiratory Epithelium, Hyperplasia                           1 (2%)                                                          
   Lung                                               (49)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Necrosis                                                                                1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 3 (6%)       1 (2%)       1 (2%)       3 (6%)                                
      Alveolar Epithelium, Metaplasia, Squamous                     1 (2%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte     22 (45%)     14 (28%)     13 (26%)     15 (30%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolus, Proteinosis                                                                   1 (2%)                                
      Bronchiole, Hyperplasia, Focal                                                          1 (2%)                                
      Interstitium, Fibrosis                           2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
      Vein, Fibrosis                                                1 (2%)                                                          
   Nose                                               (49)         (50)         (49)         (50)                                   
      Foreign Body                                     2 (4%)       2 (4%)                                                          
      Inflammation, Suppurative                        1 (2%)       5 (10%)      3 (6%)                                             
      Goblet Cell, Hyperplasia                         1 (2%)       3 (6%)       3 (6%)       1 (2%)                                
      Nasolacrimal Duct, Inflammation, Suppurative     2 (4%)                    1 (2%)       1 (2%)                                
      Olfactory Epithelium, Degeneration, Hyaline     12 (24%)     18 (36%)     15 (31%)     28 (56%)                               
      Olfactory Epithelium, Hyperplasia                             1 (2%)                                                          
      Respiratory Epithelium, Metaplasia, Squamous                  2 (4%)                                                          
   Pleura                                             (48)         (50)         (50)         (50)                                   
      Fibrosis                                        18 (38%)      6 (12%)      9 (18%)     12 (24%)                               
      Inflammation, Chronic                           21 (44%)     20 (40%)     13 (26%)      5 (10%)                               
      Mesothelium, Hyperplasia                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (50)         (50)         (49)                                   
      Atrophy                                                       1 (2%)                                                          
      Anterior Chamber, Inflammation, Suppurative                   1 (2%)                                                          
      Cornea, Hyperplasia                              1 (2%)                                                                       
      Lens, Cataract                                   3 (6%)       2 (4%)       1 (2%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Cyst                                                          2 (4%)                    1 (2%)                                
      Fibrosis                                                      1 (2%)                                                          
      Infarct                                                       1 (2%)       1 (2%)                                             
      Nephropathy, Chronic                            42 (86%)     44 (88%)     46 (92%)     44 (88%)                               
      Cortex, Infarct                                  1 (2%)                                                                       
      Cortex, Inflammation, Suppurative                                                       1 (2%)                                
      Cortex, Renal Tubule, Accumulation, Hyaline                                                                                   
        Droplet                                                                               1 (2%)                                
      Cortex, Renal Tubule, Hyperplasia                                          1 (2%)                                             
      Cortex, Renal Tubule, Inflammation               1 (2%)                                                                       
      Papilla, Mineralization                          3 (6%)       1 (2%)       1 (2%)                                             
      Pelvis, Transitional Epithelium, Hyperplasia     4 (8%)       3 (6%)       7 (14%)      3 (6%)                                
      Pelvis, Transitional Epithelium,                                                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      550          1100         2200                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
        Mineralization                                25 (51%)     23 (46%)     27 (54%)     27 (54%)                               
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Muscularis, Hyperplasia                                                                 1 (2%)                                
      Muscularis, Infiltration Cellular, Histiocyte                 1 (2%)                                                          
      Transitional Epithelium, Hyperplasia             1 (2%)                    2 (4%)                                             
      Transitional Epithelium, Ulcer                   1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           27           21           27                                     
    Natural Death                                      3            4            8            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           19           21           16                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
   Intestine Large, Cecum                             (49)         (49)         (48)         (48)                                   
      Atrophy                                                                                 1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Epithelium, Cyst                                              1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                 1 (2%)                                                                       
      Clear Cell Focus                                 6 (12%)      4 (8%)       3 (6%)       3 (6%)                                
      Eosinophilic Focus                                                                      1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       7 (14%)      3 (6%)       5 (10%)      3 (6%)                                
      Inflammation, Granulomatous                      1 (2%)       1 (2%)                    1 (2%)                                
      Necrosis                                         1 (2%)                                 1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Vacuolization Cytoplasmic                        3 (6%)       3 (6%)       1 (2%)       2 (4%)                                
      Bile Duct, Hyperplasia                                                     3 (6%)       2 (4%)                                
      Hepatocyte, Regeneration                                                                1 (2%)                                
      Periportal, Pigmentation                         1 (2%)                    2 (4%)                                             
   Mesentery                                          (7)          (11)         (11)         (13)                                   
      Necrosis                                         7 (100%)    11 (100%)    11 (100%)    12 (92%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Atrophy                                  2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Hyperplasia, Squamous                            1 (2%)                    1 (2%)                                             
      Ulcer                                            2 (4%)       3 (6%)       2 (4%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
      Erosion                                                       1 (2%)       3 (6%)                                             
      Hyperplasia                                                                1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mineralization                                                1 (2%)                                                          
      Ulcer                                                         1 (2%)       1 (2%)       2 (4%)                                
   Tongue                                             (1)          (1)          (3)                                                 
      Epithelium, Hyperkeratosis                                                 1 (33%)                                            
      Epithelium, Hyperplasia                          1 (100%)     1 (100%)     1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Mineralization                                                1 (2%)                                                          
      Pulmonary Artery, Thrombosis                                                            1 (2%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  13 (26%)      4 (8%)       5 (10%)      9 (18%)                               
      Artery, Mineralization                                        1 (2%)                                                          
      Atrium, Thrombosis                               1 (2%)                    1 (2%)       5 (10%)                               
      Myocardium, Thrombosis                                                                  1 (2%)                                
      Ventricle, Thrombosis                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Mineralization                                                             1 (2%)                                             
      Necrosis                                         1 (2%)       1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic                       15 (30%)      5 (10%)     14 (28%)     10 (20%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     12 (24%)     14 (28%)     23 (46%)     15 (30%)                               
      Mineralization                                                                          1 (2%)                                
      Necrosis                                                                                2 (4%)                                
      Thrombosis                                                                 1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Cyst                              1 (2%)                    1 (2%)       1 (2%)                                
      Pars Distalis, Hemorrhage                                     1 (2%)       1 (2%)       3 (6%)                                
      Pars Distalis, Hyperplasia                       4 (8%)       5 (10%)      6 (12%)      5 (10%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                              8 (16%)      4 (8%)       6 (12%)     11 (22%)                               
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (14)         (41)         (41)         (32)                                   
      Inflammation, Granulomatous                                                             1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                                            1 (2%)                                             
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                    2 (4%)                                
      Inflammation, Suppurative                                                  4 (8%)                                             
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                    3 (6%)                                
      Inflammation, Suppurative                       10 (20%)     10 (20%)     14 (28%)     12 (24%)                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Dilatation                                                                 1 (2%)       1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Artery, Inflammation, Chronic Active             2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Germinal Epithelium, Atrophy                    11 (22%)      9 (18%)     15 (30%)     11 (22%)                               
      Interstitial Cell, Hyperplasia                   5 (10%)      4 (8%)       2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Thrombosis                                                                              1 (2%)                                
      Myeloid Cell, Hyperplasia                                                  1 (2%)                                             
   Lymph Node                                         (7)          (16)         (11)         (17)                                   
      Hyperplasia, Lymphoid                                                                   1 (6%)                                
      Deep Cervical, Angiectasis                                                              1 (6%)                                
      Deep Cervical, Ectasia                                        1 (6%)                                                          
      Pancreatic, Angiectasis                          1 (14%)                                                                      
      Pancreatic, Ectasia                              1 (14%)                   1 (9%)                                             
      Pancreatic, Infiltration Cellular, Histiocyte                 1 (6%)                                                          
      Pancreatic, Pigmentation                                      1 (6%)                    1 (6%)                                
      Thoracic, Ectasia                                                                       1 (6%)                                
   Lymph Node, Bronchial                              (15)         (12)         (16)         (13)                                   
      Fibrosis                                         1 (7%)                                                                       
      Hematopoietic Cell Proliferation                 1 (7%)                                                                       
      Hyperplasia, Lymphoid                            1 (7%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infiltration Cellular, Histiocyte                1 (7%)       1 (8%)                                                          
      Pigmentation                                     1 (7%)       1 (8%)                                                          
   Lymph Node, Mandibular                             (2)                                                                           
      Hematopoietic Cell Proliferation                 1 (50%)                                                                      
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Necrosis                                                                   2 (4%)                                             
   Lymph Node, Mediastinal                            (42)         (44)         (43)         (40)                                   
      Angiectasis                                                                2 (5%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)                                             
      Infiltration Cellular                                                      1 (2%)                                             
      Infiltration Cellular, Histiocyte                                                       1 (3%)                                
      Pigmentation                                                               1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                 1 (2%)                    3 (6%)       1 (2%)                                
      Fibrosis                                         2 (4%)       3 (6%)       4 (8%)       6 (12%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                    2 (4%)                                             
      Hemorrhage                                       2 (4%)       2 (4%)       4 (8%)       1 (2%)                                
      Necrosis                                         3 (6%)                    3 (6%)                                             
      Thrombosis                                                                 1 (2%)                                             
   Thymus                                             (49)         (49)         (47)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Galactocele                                      3 (6%)       2 (4%)       3 (6%)       2 (4%)                                
      Hyperplasia                                                   1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        5 (10%)      2 (4%)       2 (4%)       3 (6%)                                
      Hyperkeratosis                                   1 (2%)                    1 (2%)       2 (4%)                                
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic                                                      2 (4%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
      Ulcer                                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
      Rib, Cartilage, Degeneration                     1 (2%)                                                                       
      Turbinate, Cartilage, Hyperplasia                                                       1 (2%)                                
   Skeletal Muscle                                    (1)          (1)          (1)          (1)                                    
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                     13 (26%)     15 (30%)     10 (20%)      9 (18%)                               
      Hemorrhage                                       4 (8%)       4 (8%)       5 (10%)      3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
      Inflammation, Chronic                                                      2 (4%)                                             
      Inflammation, Suppurative                                     2 (4%)                    2 (4%)                                
      Epiglottis, Metaplasia, Squamous                              1 (2%)                                                          
   Lung                                               (50)         (50)         (50)         (49)                                   
      Foreign Body                                                                            1 (2%)                                
      Hemorrhage                                       5 (10%)      5 (10%)      6 (12%)      4 (8%)                                
      Inflammation, Suppurative                                                               2 (4%)                                
      Alveolar Epithelium, Hyperplasia                10 (20%)      3 (6%)       6 (12%)      7 (14%)                               
      Alveolar Epithelium, Metaplasia, Squamous                                  2 (4%)                                             
      Alveolus, Foreign Body                                                                  1 (2%)                                
      Alveolus, Infiltration Cellular, Histiocyte     13 (26%)     11 (22%)      7 (14%)      5 (10%)                               
      Alveolus, Mineralization                                      1 (2%)                                                          
      Alveolus, Proteinosis                                         1 (2%)                                                          
      Interstitium, Fibrosis                           1 (2%)       5 (10%)      2 (4%)       1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     2 (4%)       3 (6%)       1 (2%)       2 (4%)                                
      Inflammation, Suppurative                        4 (8%)       4 (8%)       2 (4%)       5 (10%)                               
      Glands, Hyperplasia                              1 (2%)                                                                       
      Goblet Cell, Hyperplasia                         1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                                                                       
      Olfactory Epithelium, Degeneration, Hyaline      2 (4%)       8 (16%)      2 (4%)       3 (6%)                                
      Respiratory Epithelium, Hyperplasia              4 (8%)       1 (2%)       1 (2%)       1 (2%)                                
      Turbinate, Hyperplasia, Atypical                                                        1 (2%)                                
      Turbinate, Necrosis                              1 (2%)                                                                       
   Pleura                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                         2 (4%)      12 (24%)      5 (10%)      1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96001-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                    STODDARD SOLVENT (TYPE IIC)                                Date: 01/08/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:03:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      138          550          1100                                      
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic                           11 (22%)      2 (4%)       1 (2%)       5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (49)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Lens, Cataract                                   6 (12%)      1 (2%)       3 (6%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                                                    2 (4%)                                
      Hemorrhage                                                                              1 (2%)                                
      Nephropathy, Chronic                            50 (100%)    49 (98%)     50 (100%)    50 (100%)                              
      Cortex, Infarct                                  2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Cortex, Renal Tubule, Accumulation, Hyaline                                                                                   
        Droplet                                        2 (4%)       5 (10%)      3 (6%)       2 (4%)                                
      Cortex, Renal Tubule, Casts Granular                          1 (2%)       1 (2%)       3 (6%)                                
      Cortex, Renal Tubule, Hyperplasia                             1 (2%)       8 (16%)     23 (46%)                               
      Cortex, Renal Tubule, Mineralization                                                    1 (2%)                                
      Medulla, Casts Granular                                       3 (6%)       1 (2%)       3 (6%)                                
      Papilla, Mineralization                          1 (2%)       8 (16%)     30 (60%)     39 (78%)                               
      Papilla, Necrosis                                             1 (2%)                                                          
      Pelvis, Dilatation                                            1 (2%)       1 (2%)       1 (2%)                                
      Pelvis, Transitional Epithelium, Hyperplasia                  2 (4%)       8 (16%)      5 (10%)                               
      Renal Tubule, Mineralization                                  1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Muscularis, Transitional Epithelium,                                                                                          
        Mineralization                                              1 (2%)                                                          
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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