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TDMS Study 96007-05 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                     TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                               DATE: 07/14/03  
EXPERIMENT: 96007 TEST: 05                                                                                        TIME: 14:21:29    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: GAVAGE                                                 NTP:  C96007F     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE COLUMBUS                                TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                  DATE: 07/14/03    
EXPERIMENT: 96007 TEST: 05                                                                                        TIME: 14:35:48    
SPECIES: RATS, SPRAGUE-DAWLEY                                                                                                       
TEST TYPE: TWO YEAR                                 ROUTE: ORAL GAVAGE                                            NTP:  96007F      
CONT: NO1-ES-75411                                                                                                CAS: 57117-31-4   
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                             
                        TWO YEAR ORAL GAVAGE STUDY OF TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                                    
==========================================================================================================================          
WEEK     0 NG/KG                6 NG/KG                  20 NG/KG                 44 NG/KG                 92 NG/KG                 
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B       187.4       98       189.6    101.2    98     188.3    100.5    98     187.8    100.2    98     187.4    100.0    98      
  1       187.4       98       189.6    101.2    98     188.3    100.5    98     187.8    100.2    98     187.4    100.0    98      
  2       205.0       98       208.6    101.8    98     206.0    100.5    98     205.5    100.2    98     204.4     99.7    98      
  3       220.1       98       224.1    101.8    98     221.4    100.6    98     220.7    100.3    98     220.7    100.3    98      
  4       232.2       98       236.9    102.0    98     231.4     99.7    98     234.6    101.0    98     232.6    100.2    98      
  5       240.6       98       244.1    101.5    98     241.0    100.2    98     242.7    100.9    98     241.4    100.3    98      
  6       247.2       98       251.0    101.5    98     248.0    100.3    98     247.8    100.2    98     246.0     99.5    98      
  7       250.0       98       256.6    102.6    98     252.6    101.0    98     253.6    101.4    98     250.7    100.3    98      
  8       254.8       98       259.0    101.6    98     255.3    100.2    98     256.2    100.5    98     254.4     99.8    98      
  9       259.2       98       262.4    101.2    98     260.4    100.5    98     261.3    100.8    98     258.9     99.9    98      
 10       263.9       98       267.7    101.4    98     265.9    100.8    98     263.9    100.0    98     262.1     99.3    98      
 11       264.5       98       268.5    101.5    98     266.5    100.8    98     264.6    100.0    98     264.2     99.9    98      
 12       268.9       98       274.3    102.0    98     273.1    101.6    98     271.3    100.9    98     267.6     99.5    98      
 13       270.4       98       275.0    101.7    98     274.2    101.4    98     273.5    101.1    98     269.4     99.6    98      
 17       278.3       82 (I)   283.6    101.9    82 (I) 282.7    101.6    82 (I) 279.2    100.3    82 (I) 276.7     99.4    82 (I)  
 21       282.7       82       290.1    102.6    82     289.3    102.3    81     285.1    100.8    82     282.1     99.8    81      
 25       287.8       82       297.3    103.3    82     297.4    103.3    81     290.3    100.9    82     286.0     99.4    81      
 29       296.1       82       302.7    102.2    82     301.7    101.9    80     295.4     99.8    82     291.1     98.3    81      
 33       295.3       66 (I)   306.3    103.7    66 (I) 302.3    102.4    63 (I) 295.8    100.2    66 (I) 289.7     98.1    65 (I)  
 37       296.2       66       308.9    104.3    66     306.0    103.3    62     295.8     99.9    66     289.8     97.8    64      
 41       306.7       66       319.8    104.3    66     315.4    102.8    62     302.7     98.7    66     296.9     96.8    63      
 45       306.4       65       321.1    104.8    64     316.4    103.3    59     301.5     98.4    65     298.9     97.6    63      
 49       311.6       63       327.1    105.0    63     320.4    102.8    59     306.3     98.3    65     301.4     96.7    60      
 53       317.3       63 (I)   334.8    105.5    63 (I) 328.5    103.5    59 (I) 312.1     98.4    65 (I) 306.8     96.7    58 (I)  
 57       321.0       49       339.4    105.7    49     331.5    103.3    45     316.8     98.7    52     316.0     98.4    44      
 61       332.5       49       351.0    105.6    48     337.1    101.4    44     324.2     97.5    51     322.4     97.0    43      
 65       335.4       49       353.1    105.3    47     340.3    101.5    44     328.2     97.9    50     324.2     96.7    43      
 69       340.8       49       357.0    104.8    45     341.2    100.1    43     329.6     96.7    46     323.1     94.8    41      
 73       345.3       47       361.9    104.8    43     347.5    100.6    42     331.2     95.9    44     325.6     94.3    39      
 77       349.9       46       369.4    105.6    40     352.5    100.7    41     331.3     94.7    41     324.8     92.8    38      
 81       350.3       44       375.1    107.1    39     356.9    101.9    41     326.8     93.3    40     328.4     93.7    37      
 85       360.8       43       378.1    104.8    38     351.8     97.5    35     339.0     94.0    35     334.6     92.7    35      
 89       358.6       41       383.4    106.9    37     358.8    100.1    34     333.2     92.9    32     336.7     93.9    35      
 93       365.5       39       382.1    104.5    35     363.9     99.6    30     334.4     91.5    31     342.4     93.7    33      
 97       365.7       35       373.0    102.0    27     365.6    100.0    29     335.6     91.8    28     343.9     94.0    29      
101       361.4       29       384.6    106.4    24     368.0    101.8    25     334.2     92.5    26     340.1     94.1    25      
TERM. SAC.            25                         22                       24                       25                       20      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
    MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                                            
TWO YEAR ORAL GAVAGE STUDY OF TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF)                                                            
========================================================                                                                            
     200     NG/KG              200 NG/ KG STOP                                                                                     
WEEK ----------------           ----------------                                                                                    
      AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                                                                                 
     (GRAMS)  OF CNTL  (A)     (GRAMS)  OF CNTL  (A)                                                                                
=======================================================                                                                             
  B   188.2    100.4    98     187.1     99.8    50                                                                                 
  1   188.2    100.4    98     187.1     99.8    50                                                                                 
  2   207.5    101.2    98     205.6    100.3    50                                                                                 
  3   222.4    101.0    98     221.2    100.5    50                                                                                 
  4   234.8    101.1    98     231.8     99.8    50                                                                                 
  5   242.2    100.7    98     237.8     98.8    50                                                                                 
  6   248.6    100.6    98     245.6     99.4    50                                                                                 
  7   254.2    101.7    98     250.2    100.1    50                                                                                 
  8   256.7    100.7    98     253.3     99.4    50                                                                                 
  9   259.4    100.1    98     259.7    100.2    50                                                                                 
 10   264.4    100.2    98     260.3     98.6    50                                                                                 
 11   264.9    100.2    98     262.2     99.1    50                                                                                 
 12   270.1    100.4    97     265.5     98.7    50                                                                                 
 13   271.7    100.5    97     268.3     99.2    50                                                                                 
 17   279.8    100.5    81 (I) 272.6     98.0    50                                                                                 
 21   283.2    100.2    81     277.4     98.1    50                                                                                 
 25   287.1     99.8    81     283.6     98.5    50                                                                                 
 29   291.3     98.4    81     285.6     96.5    50                                                                                 
 33   294.5     99.7    65 (I) 285.0     96.5    49                                                                                 
 37   295.3     99.7    65     285.5     96.4    48                                                                                 
 41   300.2     97.9    65     291.3     95.0    47                                                                                 
 45   299.9     97.9    65     294.8     96.2    47                                                                                 
 49   304.3     97.7    63     300.7     96.5    47                                                                                 
 53   308.0     97.1    63 (I) 304.7     96.0    47                                                                                 
 57   308.0     96.0    50     304.6     94.9    45                                                                                 
 61   313.7     94.3    48     310.6     93.4    44                                                                                 
 65   315.6     94.1    45     313.1     93.4    44                                                                                 
 69   314.9     92.4    44     314.1     92.2    41                                                                                 
 73   320.2     92.7    41     316.7     91.7    36                                                                                 
 77   322.0     92.0    39     325.5     93.0    34                                                                                 
 81   322.3     92.0    38     329.0     93.9    33                                                                                 
 85   321.6     89.1    34     340.2     94.3    33                                                                                 
 89   314.1     87.6    31     338.6     94.4    30                                                                                 
 93   311.8     85.3    29     335.0     91.7    26                                                                                 
 97   320.8     87.7    27     347.0     94.9    24                                                                                 
101   321.0     88.8    26     353.7     97.9    19                                                                                 
TERM. SAC.            23                         15                                                                                 
========================================================                                                                            
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.